TMPRSS11D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMPRSS11D
Entrez Gene ID	9407
Full Name	transmembrane serine protease 11D
Synonyms	HAT
General protein information	Preferred Names transmembrane serine protease 11D Names transmembrane protease serine 11D airway trypsin-like protease transmembrane protease, serine 11D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.2
Summary	This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008].
Disorder MIM:	605369

mRNA and Protein(s)

mRNA	Protein	Name
NM_004262.3	NP_004253.1	transmembrane protease serine 11D
XM_005265710.4	XP_005265767.1	transmembrane protease serine 11D isoform X1
XM_017008851.1	XP_016864340.1	transmembrane protease serine 11D isoform X2
NM_004262.2	NP_004253.1	transmembrane protease serine 11D

Pathways from BioSystems

Homologies

Homo sapiens (human)	TMPRSS11D	NP_004253.1
	TMPRSS11D	XP_001109114.1
Canis lupus familiaris (dog)	TMPRSS11D	XP_854470.1
Bos taurus (cattle)	TMPRSS11D	XP_002688359.1
Rattus norvegicus (Norway rat)	Tmprss11d	NP_001028824.1
Anopheles gambiae (African malaria mosquito)	TRY1_ANOGA	XP_317170.2
Anopheles gambiae (African malaria mosquito)	TRY4_ANOGA	XP_317173.2
Pan troglodytes (chimpanzee)	TMPRSS11D	XP_526607.2
Anopheles gambiae (African malaria mosquito)	TRY6_ANOGA	XP_317175.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012842	XP_001230353.1
Anopheles gambiae (African malaria mosquito)	TRY7_ANOGA	XP_317172.2
Mus musculus (house mouse)	Tmprss11d	NP_663536.1
Anopheles gambiae (African malaria mosquito)	TRY5_ANOGA	XP_317174.2
Anopheles gambiae (African malaria mosquito)	TRY3_ANOGA	XP_317171.2
Anopheles gambiae (African malaria mosquito)	TRY2_ANOGA	XP_555167.1

Gene Ontology
Bibliography

Related articles in PubMed

Human airway trypsin-like protease exerts potent, antifibrotic action in pulmonary fibrosis.
Menou A, Flajolet P, Duitman J, Justet A, Moog S, Jaillet M, Tab?ze L, Solhonne B, Garnier M, Mal H, Mordant P, Castier Y, Cazes A, Sallenave JM, Mailleux AA, Crestani B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Nov)

High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer.
Cao X, Tang Z, Huang F, Jin Q, Zhou X, Shi J
Oncotarget8(8)12812-12819(2017 Feb)

Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.
Duhaime MJ, Page KO, Varela FA, Murray AS, Silverman ME, Zoratti GL, List K
Journal of cellular physiology231(7)1476-83(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we conclude that TMPRSS11D could play a role in non-small cell lung cancer development and progression
Title: High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer.

HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas
Title: Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.

H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity.
Title: Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.

HAT cleaves proMSP at the physiological activation site
Title: Activation of macrophage-stimulating protein by human airway trypsin-like protease.

TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
Title: Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

The following TMPRSS11D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMPRSS11D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04628	NM_004262.3 Latest version!	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu39232	XM_005265710.4 Latest version!	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu95555	XM_017008851.1 Latest version!	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu04628	NM_004262.2	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMPRSS11D ( NM_004262.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004253.1 Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.

Price & Availability↑

CloneID	OHu04628
Clone ID Related Accession (Same CDS sequence)	NM_004262.3 , NM_004262.2
Accession Version	NM_004262.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	transmembrane protease serine 11D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096653.1, AL603214.1, AB002134.1, AK094054.1 and BC033295.1. On May 17, 2019 this sequence version replaced NM_004262.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC125196.1, AB002134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000283916.11/ ENSP00000283916.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTATAGGC CAGCACGTGT AACTTCGACT TCAAGATTTC TGAATCCATA TGTAGTATGT 
TTCATTGTCG TCGCAGGGGT AGTGATCCTG GCAGTCACCA TAGCTCTACT TGTTTACTTT 
TTAGCTTTTG ATCAAAAATC TTACTTTTAT AGGAGCAGTT TTCAACTCCT AAATGTTGAA 
TATAATAGTC AGTTAAATTC ACCAGCTACA CAGGAATACA GGACTTTGAG TGGAAGAATT 
GAATCTCTGA TTACTAAAAC ATTCAAAGAA TCAAATTTAA GAAATCAGTT CATCAGAGCT 
CATGTTGCCA AACTGAGGCA AGATGGTAGT GGTGTGAGAG CGGATGTTGT CATGAAATTT 
CAATTCACTA GAAATAACAA TGGAGCATCA ATGAAAAGCA GAATTGAGTC TGTTTTACGA 
CAAATGCTGA ATAACTCTGG AAACCTGGAA ATAAACCCTT CAACTGAGAT AACATCACTT 
ACTGACCAGG CTGCAGCAAA TTGGCTTATT AATGAATGTG GGGCCGGTCC AGACCTAATA 
ACATTGTCTG AGCAGAGAAT CCTTGGAGGC ACTGAGGCTG AGGAGGGAAG CTGGCCGTGG 
CAAGTCAGTC TGCGGCTCAA TAATGCCCAC CACTGTGGAG GCAGCCTGAT CAATAACATG 
TGGATCCTGA CAGCAGCTCA CTGCTTCAGA AGCAACTCTA ATCCTCGTGA CTGGATTGCC 
ACGTCTGGTA TTTCCACAAC ATTTCCTAAA CTAAGAATGA GAGTAAGAAA TATTTTAATT 
CATAACAATT ATAAATCTGC AACTCATGAA AATGACATTG CACTTGTGAG ACTTGAGAAC 
AGTGTCACCT TTACCAAAGA TATCCATAGT GTGTGTCTCC CAGCTGCTAC CCAGAATATT 
CCACCTGGCT CTACTGCTTA TGTAACAGGA TGGGGCGCTC AAGAATATGC TGGCCACACA 
GTTCCAGAGC TAAGGCAAGG ACAGGTCAGA ATAATAAGTA ATGATGTATG TAATGCACCA 
CATAGTTATA ATGGAGCCAT CTTGTCTGGA ATGCTGTGTG CTGGAGTACC TCAAGGTGGA 
GTGGACGCAT GTCAGGGTGA CTCTGGTGGC CCACTAGTAC AAGAAGACTC ACGGCGGCTT 
TGGTTTATTG TGGGGATAGT AAGCTGGGGA GATCAGTGTG GCCTGCCGGA TAAGCCAGGA 
GTGTATACTC GAGTGACAGC CTACCTTGAC TGGATTAGGC AACAAACTGG GATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004253.1
CDS	70..1326
Translation	MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI

Target ORF information:

RefSeq Version	NM_004262.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004262.3

ORF Insert Sequence:

ATGTATAGGC CAGCACGTGT AACTTCGACT TCAAGATTTC TGAATCCATA TGTAGTATGT 
TTCATTGTCG TCGCAGGGGT AGTGATCCTG GCAGTCACCA TAGCTCTACT TGTTTACTTT 
TTAGCTTTTG ATCAAAAATC TTACTTTTAT AGGAGCAGTT TTCAACTCCT AAATGTTGAA 
TATAATAGTC AGTTAAATTC ACCAGCTACA CAGGAATACA GGACTTTGAG TGGAAGAATT 
GAATCTCTGA TTACTAAAAC ATTCAAAGAA TCAAATTTAA GAAATCAGTT CATCAGAGCT 
CATGTTGCCA AACTGAGGCA AGATGGTAGT GGTGTGAGAG CGGATGTTGT CATGAAATTT 
CAATTCACTA GAAATAACAA TGGAGCATCA ATGAAAAGCA GAATTGAGTC TGTTTTACGA 
CAAATGCTGA ATAACTCTGG AAACCTGGAA ATAAACCCTT CAACTGAGAT AACATCACTT 
ACTGACCAGG CTGCAGCAAA TTGGCTTATT AATGAATGTG GGGCCGGTCC AGACCTAATA 
ACATTGTCTG AGCAGAGAAT CCTTGGAGGC ACTGAGGCTG AGGAGGGAAG CTGGCCGTGG 
CAAGTCAGTC TGCGGCTCAA TAATGCCCAC CACTGTGGAG GCAGCCTGAT CAATAACATG 
TGGATCCTGA CAGCAGCTCA CTGCTTCAGA AGCAACTCTA ATCCTCGTGA CTGGATTGCC 
ACGTCTGGTA TTTCCACAAC ATTTCCTAAA CTAAGAATGA GAGTAAGAAA TATTTTAATT 
CATAACAATT ATAAATCTGC AACTCATGAA AATGACATTG CACTTGTGAG ACTTGAGAAC 
AGTGTCACCT TTACCAAAGA TATCCATAGT GTGTGTCTCC CAGCTGCTAC CCAGAATATT 
CCACCTGGCT CTACTGCTTA TGTAACAGGA TGGGGCGCTC AAGAATATGC TGGCCACACA 
GTTCCAGAGC TAAGGCAAGG ACAGGTCAGA ATAATAAGTA ATGATGTATG TAATGCACCA 
CATAGTTATA ATGGAGCCAT CTTGTCTGGA ATGCTGTGTG CTGGAGTACC TCAAGGTGGA 
GTGGACGCAT GTCAGGGTGA CTCTGGTGGC CCACTAGTAC AAGAAGACTC ACGGCGGCTT 
TGGTTTATTG TGGGGATAGT AAGCTGGGGA GATCAGTGTG GCCTGCCGGA TAAGCCAGGA 
GTGTATACTC GAGTGACAGC CTACCTTGAC TGGATTAGGC AACAAACTGG GATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS11D ( NM_004262.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004253.1 Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.

Price & Availability↑

CloneID	OHu04628
Clone ID Related Accession (Same CDS sequence)	NM_004262.3 , NM_004262.2
Accession Version	NM_004262.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	transmembrane protease serine 11D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL603214.1, AB002134.1, AK094054.1 and BC033295.1. On Mar 24, 2005 this sequence version replaced NM_004262.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC125195.1, AB002134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTATAGGC CAGCACGTGT AACTTCGACT TCAAGATTTC TGAATCCATA TGTAGTATGT 
TTCATTGTCG TCGCAGGGGT AGTGATCCTG GCAGTCACCA TAGCTCTACT TGTTTACTTT 
TTAGCTTTTG ATCAAAAATC TTACTTTTAT AGGAGCAGTT TTCAACTCCT AAATGTTGAA 
TATAATAGTC AGTTAAATTC ACCAGCTACA CAGGAATACA GGACTTTGAG TGGAAGAATT 
GAATCTCTGA TTACTAAAAC ATTCAAAGAA TCAAATTTAA GAAATCAGTT CATCAGAGCT 
CATGTTGCCA AACTGAGGCA AGATGGTAGT GGTGTGAGAG CGGATGTTGT CATGAAATTT 
CAATTCACTA GAAATAACAA TGGAGCATCA ATGAAAAGCA GAATTGAGTC TGTTTTACGA 
CAAATGCTGA ATAACTCTGG AAACCTGGAA ATAAACCCTT CAACTGAGAT AACATCACTT 
ACTGACCAGG CTGCAGCAAA TTGGCTTATT AATGAATGTG GGGCCGGTCC AGACCTAATA 
ACATTGTCTG AGCAGAGAAT CCTTGGAGGC ACTGAGGCTG AGGAGGGAAG CTGGCCGTGG 
CAAGTCAGTC TGCGGCTCAA TAATGCCCAC CACTGTGGAG GCAGCCTGAT CAATAACATG 
TGGATCCTGA CAGCAGCTCA CTGCTTCAGA AGCAACTCTA ATCCTCGTGA CTGGATTGCC 
ACGTCTGGTA TTTCCACAAC ATTTCCTAAA CTAAGAATGA GAGTAAGAAA TATTTTAATT 
CATAACAATT ATAAATCTGC AACTCATGAA AATGACATTG CACTTGTGAG ACTTGAGAAC 
AGTGTCACCT TTACCAAAGA TATCCATAGT GTGTGTCTCC CAGCTGCTAC CCAGAATATT 
CCACCTGGCT CTACTGCTTA TGTAACAGGA TGGGGCGCTC AAGAATATGC TGGCCACACA 
GTTCCAGAGC TAAGGCAAGG ACAGGTCAGA ATAATAAGTA ATGATGTATG TAATGCACCA 
CATAGTTATA ATGGAGCCAT CTTGTCTGGA ATGCTGTGTG CTGGAGTACC TCAAGGTGGA 
GTGGACGCAT GTCAGGGTGA CTCTGGTGGC CCACTAGTAC AAGAAGACTC ACGGCGGCTT 
TGGTTTATTG TGGGGATAGT AAGCTGGGGA GATCAGTGTG GCCTGCCGGA TAAGCCAGGA 
GTGTATACTC GAGTGACAGC CTACCTTGAC TGGATTAGGC AACAAACTGG GATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004253.1
CDS	66..1322
Translation	MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI

Target ORF information:

RefSeq Version	NM_004262.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004262.2

ORF Insert Sequence:

ATGTATAGGC CAGCACGTGT AACTTCGACT TCAAGATTTC TGAATCCATA TGTAGTATGT 
TTCATTGTCG TCGCAGGGGT AGTGATCCTG GCAGTCACCA TAGCTCTACT TGTTTACTTT 
TTAGCTTTTG ATCAAAAATC TTACTTTTAT AGGAGCAGTT TTCAACTCCT AAATGTTGAA 
TATAATAGTC AGTTAAATTC ACCAGCTACA CAGGAATACA GGACTTTGAG TGGAAGAATT 
GAATCTCTGA TTACTAAAAC ATTCAAAGAA TCAAATTTAA GAAATCAGTT CATCAGAGCT 
CATGTTGCCA AACTGAGGCA AGATGGTAGT GGTGTGAGAG CGGATGTTGT CATGAAATTT 
CAATTCACTA GAAATAACAA TGGAGCATCA ATGAAAAGCA GAATTGAGTC TGTTTTACGA 
CAAATGCTGA ATAACTCTGG AAACCTGGAA ATAAACCCTT CAACTGAGAT AACATCACTT 
ACTGACCAGG CTGCAGCAAA TTGGCTTATT AATGAATGTG GGGCCGGTCC AGACCTAATA 
ACATTGTCTG AGCAGAGAAT CCTTGGAGGC ACTGAGGCTG AGGAGGGAAG CTGGCCGTGG 
CAAGTCAGTC TGCGGCTCAA TAATGCCCAC CACTGTGGAG GCAGCCTGAT CAATAACATG 
TGGATCCTGA CAGCAGCTCA CTGCTTCAGA AGCAACTCTA ATCCTCGTGA CTGGATTGCC 
ACGTCTGGTA TTTCCACAAC ATTTCCTAAA CTAAGAATGA GAGTAAGAAA TATTTTAATT 
CATAACAATT ATAAATCTGC AACTCATGAA AATGACATTG CACTTGTGAG ACTTGAGAAC 
AGTGTCACCT TTACCAAAGA TATCCATAGT GTGTGTCTCC CAGCTGCTAC CCAGAATATT 
CCACCTGGCT CTACTGCTTA TGTAACAGGA TGGGGCGCTC AAGAATATGC TGGCCACACA 
GTTCCAGAGC TAAGGCAAGG ACAGGTCAGA ATAATAAGTA ATGATGTATG TAATGCACCA 
CATAGTTATA ATGGAGCCAT CTTGTCTGGA ATGCTGTGTG CTGGAGTACC TCAAGGTGGA 
GTGGACGCAT GTCAGGGTGA CTCTGGTGGC CCACTAGTAC AAGAAGACTC ACGGCGGCTT 
TGGTTTATTG TGGGGATAGT AAGCTGGGGA GATCAGTGTG GCCTGCCGGA TAAGCCAGGA 
GTGTATACTC GAGTGACAGC CTACCTTGAC TGGATTAGGC AACAAACTGG GATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS11D ( XM_005265710.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005265767.1 Homo sapiens transmembrane serine protease 11D (TMPRSS11D), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39232
Clone ID Related Accession (Same CDS sequence)	XM_005265710.4
Accession Version	XM_005265710.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protease serine 11D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005265710.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAATTTC AATTCACTAG AAATAACAAT GGAGCATCAA TGAAAAGCAG AATTGAGTCT 
GTTTTACGAC AAATGCTGAA TAACTCTGGA AACCTGGAAA TAAACCCTTC AACTGAGATA 
ACATCACTTA CTGACCAGGC TGCAGCAAAT TGGCTTATTA ATGAATGTGG GGCCGGTCCA 
GACCTAATAA CATTGTCTGA GCAGAGAATC CTTGGAGGCA CTGAGGCTGA GGAGGGAAGC 
TGGCCGTGGC AAGTCAGTCT GCGGCTCAAT AATGCCCACC ACTGTGGAGG CAGCCTGATC 
AATAACATGT GGATCCTGAC AGCAGCTCAC TGCTTCAGAA GCAACTCTAA TCCTCGTGAC 
TGGATTGCCA CGTCTGGTAT TTCCACAACA TTTCCTAAAC TAAGAATGAG AGTAAGAAAT 
ATTTTAATTC ATAACAATTA TAAATCTGCA ACTCATGAAA ATGACATTGC ACTTGTGAGA 
CTTGAGAACA GTGTCACCTT TACCAAAGAT ATCCATAGTG TGTGTCTCCC AGCTGCTACC 
CAGAATATTC CACCTGGCTC TACTGCTTAT GTAACAGGAT GGGGCGCTCA AGAATATGCT 
GGCCACACAG TTCCAGAGCT AAGGCAAGGA CAGGTCAGAA TAATAAGTAA TGATGTATGT 
AATGCACCAC ATAGTTATAA TGGAGCCATC TTGTCTGGAA TGCTGTGTGC TGGAGTACCT 
CAAGGTGGAG TGGACGCATG TCAGGGTGAC TCTGGTGGCC CACTAGTACA AGAAGACTCA 
CGGCGGCTTT GGTTTATTGT GGGGATAGTA AGCTGGGGAG ATCAGTGTGG CCTGCCGGAT 
AAGCCAGGAG TGTATACTCG AGTGACAGCC TACCTTGACT GGATTAGGCA ACAAACTGGG 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005265767.1
CDS	1360..2265
Translation	MKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI

Target ORF information:

RefSeq Version	XM_005265710.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005265710.4

ORF Insert Sequence:

ATGAAATTTC AATTCACTAG AAATAACAAT GGAGCATCAA TGAAAAGCAG AATTGAGTCT 
GTTTTACGAC AAATGCTGAA TAACTCTGGA AACCTGGAAA TAAACCCTTC AACTGAGATA 
ACATCACTTA CTGACCAGGC TGCAGCAAAT TGGCTTATTA ATGAATGTGG GGCCGGTCCA 
GACCTAATAA CATTGTCTGA GCAGAGAATC CTTGGAGGCA CTGAGGCTGA GGAGGGAAGC 
TGGCCGTGGC AAGTCAGTCT GCGGCTCAAT AATGCCCACC ACTGTGGAGG CAGCCTGATC 
AATAACATGT GGATCCTGAC AGCAGCTCAC TGCTTCAGAA GCAACTCTAA TCCTCGTGAC 
TGGATTGCCA CGTCTGGTAT TTCCACAACA TTTCCTAAAC TAAGAATGAG AGTAAGAAAT 
ATTTTAATTC ATAACAATTA TAAATCTGCA ACTCATGAAA ATGACATTGC ACTTGTGAGA 
CTTGAGAACA GTGTCACCTT TACCAAAGAT ATCCATAGTG TGTGTCTCCC AGCTGCTACC 
CAGAATATTC CACCTGGCTC TACTGCTTAT GTAACAGGAT GGGGCGCTCA AGAATATGCT 
GGCCACACAG TTCCAGAGCT AAGGCAAGGA CAGGTCAGAA TAATAAGTAA TGATGTATGT 
AATGCACCAC ATAGTTATAA TGGAGCCATC TTGTCTGGAA TGCTGTGTGC TGGAGTACCT 
CAAGGTGGAG TGGACGCATG TCAGGGTGAC TCTGGTGGCC CACTAGTACA AGAAGACTCA 
CGGCGGCTTT GGTTTATTGT GGGGATAGTA AGCTGGGGAG ATCAGTGTGG CCTGCCGGAT 
AAGCCAGGAG TGTATACTCG AGTGACAGCC TACCTTGACT GGATTAGGCA ACAAACTGGG 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMPRSS11D ( XM_017008851.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864340.1 Homo sapiens transmembrane serine protease 11D (TMPRSS11D), transcript variant X2, mRNA.

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CloneID	OHu95555
Clone ID Related Accession (Same CDS sequence)	XM_017008851.1
Accession Version	XM_017008851.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protease serine 11D isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAATCC TTGGAGGCAC TGAGGCTGAG GAGGGAAGCT GGCCGTGGCA AGTCAGTCTG 
CGGCTCAATA ATGCCCACCA CTGTGGAGGC AGCCTGATCA ATAACATGTG GATCCTGACA 
GCAGCTCACT GCTTCAGAAG CAACTCTAAT CCTCGTGACT GGATTGCCAC GTCTGGTATT 
TCCACAACAT TTCCTAAACT AAGAATGAGA GTAAGAAATA TTTTAATTCA TAACAATTAT 
AAATCTGCAA CTCATGAAAA TGACATTGCA CTTGTGAGAC TTGAGAACAG TGTCACCTTT 
ACCAAAGATA TCCATAGTGT GTGTCTCCCA GCTGCTACCC AGAATATTCC ACCTGGCTCT 
ACTGCTTATG TAACAGGATG GGGCGCTCAA GAATATGCTG GCCACACAGT TCCAGAGCTA 
AGGCAAGGAC AGGTCAGAAT AATAAGTAAT GATGTATGTA ATGCACCACA TAGTTATAAT 
GGAGCCATCT TGTCTGGAAT GCTGTGTGCT GGAGTACCTC AAGGTGGAGT GGACGCATGT 
CAGGGTGACT CTGGTGGCCC ACTAGTACAA GAAGACTCAC GGCGGCTTTG GTTTATTGTG 
GGGATAGTAA GCTGGGGAGA TCAGTGTGGC CTGCCGGATA AGCCAGGAGT GTATACTCGA 
GTGACAGCCT ACCTTGACTG GATTAGGCAA CAAACTGGGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864340.1
CDS	81..785
Translation	MRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI

Target ORF information:

RefSeq Version	XM_017008851.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane serine protease 11D (TMPRSS11D), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017008851.1

ORF Insert Sequence:

ATGAGAATCC TTGGAGGCAC TGAGGCTGAG GAGGGAAGCT GGCCGTGGCA AGTCAGTCTG 
CGGCTCAATA ATGCCCACCA CTGTGGAGGC AGCCTGATCA ATAACATGTG GATCCTGACA 
GCAGCTCACT GCTTCAGAAG CAACTCTAAT CCTCGTGACT GGATTGCCAC GTCTGGTATT 
TCCACAACAT TTCCTAAACT AAGAATGAGA GTAAGAAATA TTTTAATTCA TAACAATTAT 
AAATCTGCAA CTCATGAAAA TGACATTGCA CTTGTGAGAC TTGAGAACAG TGTCACCTTT 
ACCAAAGATA TCCATAGTGT GTGTCTCCCA GCTGCTACCC AGAATATTCC ACCTGGCTCT 
ACTGCTTATG TAACAGGATG GGGCGCTCAA GAATATGCTG GCCACACAGT TCCAGAGCTA 
AGGCAAGGAC AGGTCAGAAT AATAAGTAAT GATGTATGTA ATGCACCACA TAGTTATAAT 
GGAGCCATCT TGTCTGGAAT GCTGTGTGCT GGAGTACCTC AAGGTGGAGT GGACGCATGT 
CAGGGTGACT CTGGTGGCCC ACTAGTACAA GAAGACTCAC GGCGGCTTTG GTTTATTGTG 
GGGATAGTAA GCTGGGGAGA TCAGTGTGGC CTGCCGGATA AGCCAGGAGT GTATACTCGA 
GTGACAGCCT ACCTTGACTG GATTAGGCAA CAAACTGGGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human airway trypsin-like protease exerts potent, antifibrotic action in pulmonary fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Nov)
Menou A,Flajolet P,Duitman J,Justet A,Moog S,Jaillet M,Tab?ze L,Solhonne B,Garnier M,Mal H,Mordant P,Castier Y,Cazes A,Sallenave JM,Mailleux AA,Crestani B

High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer.
Oncotarget8(8)12812-12819(2017 Feb)
Cao X,Tang Z,Huang F,Jin Q,Zhou X,Shi J

Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.
Journal of cellular physiology231(7)1476-83(2016 Jul)
Duhaime MJ,Page KO,Varela FA,Murray AS,Silverman ME,Zoratti GL,List K

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TMPRSS11D cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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