HTRA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTRA3
Entrez Gene ID	94031
Full Name	HtrA serine peptidase 3
Synonyms	Prsp,Tasp
General protein information	Preferred Names HtrA serine peptidase 3 Names serine protease HTRA3 high-temperature requirement factor A3 pregnancy-related serine protease probable serine protease HTRA3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.1
Disorder MIM:	608785

mRNA and Protein(s)

mRNA	Protein	Name
NM_053044.4	NP_444272.1	serine protease HTRA3 isoform 1 precursor
NM_001297559.1	NP_001284488.1	serine protease HTRA3 isoform 2 precursor
NM_001297559.2	NP_001284488.1	serine protease HTRA3 isoform 2 precursor
XM_011513596.2	XP_011511898.1	serine protease HTRA3 isoform X1
NM_053044.5	NP_444272.1	serine protease HTRA3 isoform 1 precursor
XM_011513596.3	XP_011511898.1	serine protease HTRA3 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HTRA3	XP_005618790.1
Mus musculus (house mouse)	Htra3	NP_084403.2
Gallus gallus (chicken)	HTRA3	XP_420813.3
Homo sapiens (human)	HTRA3	NP_444272.1
Pan troglodytes (chimpanzee)	HTRA3	XP_517597.3
	HTRA3	XP_002804039.1
Bos taurus (cattle)	HTRA3	XP_002688528.2
Rattus norvegicus (Norway rat)	Htra3	NP_001257956.1
Danio rerio (zebrafish)	LOC573378	XP_692974.6
Xenopus tropicalis (tropical clawed frog)	htra3	XP_002938688.1

Gene Ontology
Bibliography

Related articles in PubMed

Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.
Sun ML, Sun LM, Wang YQ
Journal of molecular recognition : JMR(2017 Dec)

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
Li Y, Gong L, Qi R, Sun Q, Xia X, He H, Ren J, Zhu O, Zhuo D
Drug design, development and therapy112481-2491(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Removal of the 6 additional LB loop residues caused a complete loss of the proper trimeric structure. Impairing their interactions with the PDZ domain decreased the amount of the trimers. The LB loop helps stabilize the DeltaN-HtrA3L oligomer structure suggesting involvement of the LB-PDZ interactions in the stabilization. A monomeric form of the DeltaN-HtrA3L is proteolytically inactive.
Title: The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.

HtrA3 expression in the peritumoral stroma of patients with stage II colorectal cancer is associated with high-grade tumor budding and may be a novel marker of poor outcome.
Title: HtrA3 stromal expression is correlated with tumor budding in stage II colorectal cancer.

HTRA3 suppresses tumor cell invasiveness and may serve as a prognostic biomarker for postoperative recurrence or survival in NSCLC
Title: High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer.

HtrA3 is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cance
Title: The high-temperature requirement factor A3 (HtrA3) is associated with acquisition of the invasive phenotype in oral squamous cell carcinoma cells.

New insights into the structure and function of DeltaN-HtrA3, which seems to have a unique combination of features among human HtrA proteases.
Title: Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains.

The following HTRA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTRA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28769	NM_053044.5 Latest version!	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu28801	NM_001297559.2 Latest version!	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu74609	XM_011513596.3 Latest version!	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu28801	NM_001297559.1	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu28769	NM_053044.4	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu74609	XM_011513596.2	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTRA3 ( NM_053044.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_444272.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28769
Clone ID Related Accession (Same CDS sequence)	NM_053044.4 , NM_053044.5
Accession Version	NM_053044.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC035717.1. On Jul 3, 2014 this sequence version replaced NM_053044.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035717.1, AY280665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444272.1
CDS	205..1566
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

Target ORF information:

RefSeq Version	NM_053044.4
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053044.4

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( NM_053044.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_444272.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28769
Clone ID Related Accession (Same CDS sequence)	NM_053044.4 , NM_053044.5
Accession Version	NM_053044.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113611.3 and BC035717.1. On Nov 23, 2018 this sequence version replaced NM_053044.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279870.1338.1, BC034390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307358.7/ ENSP00000303766.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444272.1
CDS	216..1577
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

Target ORF information:

RefSeq Version	NM_053044.5
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053044.5

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GACTGGAAGA AGCGCTTCAT CGGCATACGG 
ATGCGGACGA TCACACCAAG CCTGGTGGAT GAGCTGAAGG CCAGCAACCC GGACTTCCCA 
GAGGTCAGCA GTGGAATTTA TGTGCAAGAG GTTGCGCCGA ATTCACCTTC TCAGAGAGGC 
GGCATCCAAG ATGGTGACAT CATCGTCAAG GTCAACGGGC GTCCTCTAGT GGACTCGAGT 
GAGCTGCAGG AGGCCGTGCT GACCGAGTCT CCTCTCCTAC TGGAGGTGCG GCGGGGGAAC 
GACGACCTCC TCTTCAGCAT CGCACCTGAG GTGGTCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( NM_001297559.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284488.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28801
Clone ID Related Accession (Same CDS sequence)	NM_001297559.1 , NM_001297559.2
Accession Version	NM_001297559.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN996853.1, AY280666.1 and AW072765.1. On Jul 4, 2014 this sequence version replaced XM_005248040.1. Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.9424.1, AY280666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284488.1
CDS	205..1278
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH

Target ORF information:

RefSeq Version	NM_001297559.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297559.1

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( NM_001297559.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284488.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

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CloneID	OHu28801
Clone ID Related Accession (Same CDS sequence)	NM_001297559.1 , NM_001297559.2
Accession Version	NM_001297559.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113611.3, DN996853.1, AY280666.1 and AW072765.1. On May 31, 2019 this sequence version replaced NM_001297559.1. Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY280666.1, ERR279835.9424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284488.1
CDS	216..1289
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH

Target ORF information:

RefSeq Version	NM_001297559.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297559.2

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCCCCTCAC TGGCAGTTCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( XM_011513596.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511898.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

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CloneID	OHu74609
Clone ID Related Accession (Same CDS sequence)	XM_011513596.2 , XM_011513596.3
Accession Version	XM_011513596.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513596.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511898.1
CDS	213..1334
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAKHMDPSAAKAGAMRAGHMKSCC

Target ORF information:

RefSeq Version	XM_011513596.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513596.2

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA3 ( XM_011513596.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511898.1 Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74609
Clone ID Related Accession (Same CDS sequence)	XM_011513596.2 , XM_011513596.3
Accession Version	XM_011513596.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine protease HTRA3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011513596.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511898.1
CDS	258..1379
Translation	MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAKHMDPSAAKAGAMRAGHMKSCC

Target ORF information:

RefSeq Version	XM_011513596.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513596.3

ORF Insert Sequence:

ATGCAGGCGC GAGCGCTGCT CCTGGCCGCG TTGGCCGCGC TGGCGCTGGC CCGGGAGCCC 
CCTGCGGCGC CGTGTCCCGC GCGCTGCGAC GTGTCGCGGT GTCCCAGCCC CCGCTGCCCC 
GGCGGCTACG TGCCCGACCT CTGCAACTGC TGCCTGGTGT GCGCCGCCAG CGAGGGCGAG 
CCCTGTGGCG GCCCTCTGGA CTCGCCTTGC GGCGAGAGCC TGGAGTGCGT GCGCGGCCTA 
TGCCGCTGCC GCTGGTCGCA CGCCGTGTGT GGCACCGACG GGCACACCTA TGCCAACGTG 
TGCGCGCTGC AGGCGGCCAG CCGCCGCGCG CTGCAGCTCT CCGGGACGCC CGTGCGCCAG 
CTGCAGAAGG GCGCCTGCCC GTTGGGTCTC CACCAGCTGA GCAGCCCGCG CTACAAGTTC 
AACTTCATTG CTGACGTGGT GGAGAAGATC GCACCAGCCG TGGTCCACAT AGAGCTCTTC 
CTGAGACACC CGCTGTTTGG CCGCAACGTG CCCCTGTCCA GCGGTTCTGG CTTCATCATG 
TCAGAGGCCG GCCTGATCAT CACCAATGCC CACGTGGTGT CCAGCAACAG TGCTGCCCCG 
GGCAGGCAGC AGCTCAAGGT GCAGCTACAG AATGGGGACT CCTATGAGGC CACCATCAAA 
GACATCGACA AGAAGTCGGA CATTGCCACC ATCAAGATCC ATCCCAAGAA AAAGCTCCCT 
GTGTTGTTGC TGGGTCACTC GGCCGACCTG CGGCCTGGGG AGTTTGTGGT GGCCATCGGC 
AGTCCCTTCG CCCTACAGAA CACAGTGACA ACGGGCATCG TCAGCACTGC CCAGCGGGAG 
GGCAGGGAGC TGGGCCTCCG GGACTCCGAC ATGGACTACA TCCAGACGGA TGCCATCATC 
AACTACGGGA ACTCCGGGGG ACCACTGGTG AACCTGGATG GCGAGGTCAT TGGCATCAAC 
ACGCTCAAGG TCACGGCTGG CATCTCCTTT GCCATCCCCT CAGACCGCAT CACACGGTTC 
CTCACAGAGT TCCAAGACAA GCAGATCAAA GCCAAGCACA TGGACCCCAG TGCAGCCAAG 
GCTGGTGCCA TGAGGGCTGG TCACATGAAG AGCTGCTGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.
Journal of molecular recognition : JMR(2017 Dec)
Sun ML,Sun LM,Wang YQ

Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
Drug design, development and therapy112481-2491(2017)
Li Y,Gong L,Qi R,Sun Q,Xia X,He H,Ren J,Zhu O,Zhuo D

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HTRA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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