HS6ST1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HS6ST1
Entrez Gene ID	9394
Full Name	heparan sulfate 6-O-sulfotransferase 1
Synonyms	HH15,HS6ST
General protein information	Preferred Names heparan sulfate 6-O-sulfotransferase 1 Names heparan-sulfate 6-O-sulfotransferase 1 HS6ST-1 heparan-sulfate 6-sulfotransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q14.3
Summary	The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	604846
Disorder Html:	{Hypogonadotropic hypogonadism 15 with or without anosmia}, 614880 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004807.2	NP_004798.3	heparan-sulfate 6-O-sulfotransferase 1
NM_004807.3	NP_004798.3	heparan-sulfate 6-O-sulfotransferase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HS6ST1	NP_004798.3
	LOC715479	XP_001105734.2
Xenopus tropicalis (tropical clawed frog)	hs6st1	NP_001017317.1
Gallus gallus (chicken)	HS6ST1	NP_989813.1
Danio rerio (zebrafish)	hs6st1b	NP_001073672.1
Drosophila melanogaster (fruit fly)	Hs6st	NP_001262750.1
Bos taurus (cattle)	HS6ST1	NP_001179420.1
Mus musculus (house mouse)	Hs6st1	NP_056633.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001444	XP_321686.5
Rattus norvegicus (Norway rat)	Hs6st1	NP_001101680.1
Danio rerio (zebrafish)	hs6st1a	NP_001018344.2
Pan troglodytes (chimpanzee)	HS6ST1	XP_001141733.1

Gene Ontology
Bibliography

Related articles in PubMed

Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.
Ushakov VS, Tsidulko AY, de La Bourdonnaye G, Kazanskaya GM, Volkov AM, Kiselev RS, Kobozev VV, Kostromskaya DV, Gaytan AS, Krivoshapkin AL, Aidagulova SV, Grigorieva EV
International journal of molecular sciences18(11)(2017 Nov)

Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.
Cole CL, Rushton G, Jayson GC, Avizienyte E
The Journal of biological chemistry289(15)10488-501(2014 Apr)

Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.
Clegg JM, Conway CD, Howe KM, Price DJ, Mason JO, Turnbull JE, Basson MA, Pratt T
The Journal of neuroscience : the official journal of the Society for Neuroscience34(6)2389-401(2014 Feb)

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Wu JH, Lemaitre RN, Manichaikul A, Guan W, Tanaka T, Foy M, Kabagambe EK, Djousse L, Siscovick D, Fretts AM, Johnson C, King IB, Psaty BM, McKnight B, Rich SS, Chen YD, Nettleton JA, Tang W, Bandinelli S, Jacobs DR Jr, Browning BL, Laurie CC, Gu X, Tsai MY, Steffen LM, Ferrucci L, Fornage M, Mozaffarian D
Circulation. Cardiovascular genetics6(2)171-83(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HS6ST-1 and HS6ST-2 have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF signaling and subsequent expression of angiogenic cytokines by cancer cells
Title: Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.

Hs6st1 and Hs2st generate conditions conducive to corpus callosum development.
Title: Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.

idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development
Title: Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

we have characterized HS6ST-2 and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity.
Title: Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

The following HS6ST1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HS6ST1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17774	NM_004807.3 Latest version!	Homo sapiens heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu17774	NM_004807.2	Homo sapiens heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HS6ST1 ( NM_004807.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004798.3 Homo sapiens heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), mRNA.

Price & Availability↑

CloneID	OHu17774
Clone ID Related Accession (Same CDS sequence)	NM_004807.2 , NM_004807.3
Accession Version	NM_004807.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	heparan-sulfate 6-O-sulfotransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC017079.5, DR005030.1, BP219645.1, CV569969.1, BC001196.1 and BC063521.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004807.2. ##Evidence-Data-START## Transcript exon combination :: AB006179.1, BC096239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259241.7/ ENSP00000259241.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGCGGC GGCGCGCCGG CGGCAGGACC ATGGTTGAGC GCGCCAGCAA GTTCGTGCTG 
GTGGTGGCGG GCTCGGTGTG CTTCATGCTC ATCTTGTACC AGTACGCGGG CCCAGGACTG 
AGCCTGGGCG CGCCCGGCGG CCGCGCGCCG CCCGACGACC TGGACCTGTT CCCCACACCC 
GACCCCCACT ACGAGAAGAA GTACTACTTC CCGGTCCGCG AGCTGGAGCG CTCGCTGCGC 
TTCGACATGA AGGGCGACGA CGTGATCGTC TTCCTGCACA TCCAGAAGAC GGGCGGCACC 
ACCTTCGGCC GCCACCTCGT GCAGAACGTA CGCCTCGAGG TGCCGTGCGA CTGCCGGCCC 
GGCCAGAAGA AGTGCACCTG CTACCGGCCC AACCGCCGCG AGACTTGGCT CTTCTCCCGC 
TTCTCCACCG GCTGGAGCTG CGGGCTGCAC GCCGACTGGA CCGAGCTCAC CAACTGCGTG 
CCCGGCGTGC TGGACCGCCG CGACTCCGCC GCGCTGCGCA CGCCCAGGAA GTTCTACTAC 
ATCACCCTGC TACGAGACCC CGTGTCCCGC TACCTGAGCG AGTGGCGGCA TGTGCAGAGG 
GGTGCCACGT GGAAGACGTC GTTGCATATG TGTGATGGGC GCACGCCCAC GCCTGAGGAG 
CTGCCGCCCT GCTACGAGGG CACGGACTGG TCGGGCTGCA CGCTACAGGA GTTCATGGAC 
TGCCCGTACA ACCTGGCCAA CAACCGCCAG GTGCGCATGC TGGCCGACCT GAGCCTGGTG 
GGCTGCTACA ACCTGTCCTT CATCCCCGAG GGCAAGCGGG CCCAGCTGCT GCTCGAGAGC 
GCCAAGAAGA ACCTGCGGGG CATGGCCTTC TTCGGCCTGA CCGAGTTCCA GCGCAAGACG 
CAGTACCTGT TCGAGCGGAC GTTCAACCTC AAGTTCATCC GGCCCTTCAT GCAGTACAAT 
AGCACGCGGG CGGGCGGCGT GGAGGTGGAT GAAGACACCA TCCGGCGCAT CGAGGAGCTC 
AACGACCTGG ACATGCAGCT GTACGACTAC GCCAAGGACC TCTTCCAGCA GCGCTACCAG 
TACAAGCGGC AGCTGGAGCG CAGGGAGCAG CGCCTGAGGA GCCGCGAGGA GCGTCTGCTG 
CACCGGGCCA AGGAGGCACT GCCGCGGGAG GATGCCGACG AGCCGGGCCG CGTGCCCACC 
GAGGACTACA TGAGCCACAT CATTGAGAAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004798.3
CDS	306..1541
Translation	MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW

Target ORF information:

RefSeq Version	NM_004807.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004807.3

ORF Insert Sequence:

ATGCGGCGGC GGCGCGCCGG CGGCAGGACC ATGGTTGAGC GCGCCAGCAA GTTCGTGCTG 
GTGGTGGCGG GCTCGGTGTG CTTCATGCTC ATCTTGTACC AGTACGCGGG CCCAGGACTG 
AGCCTGGGCG CGCCCGGCGG CCGCGCGCCG CCCGACGACC TGGACCTGTT CCCCACACCC 
GACCCCCACT ACGAGAAGAA GTACTACTTC CCGGTCCGCG AGCTGGAGCG CTCGCTGCGC 
TTCGACATGA AGGGCGACGA CGTGATCGTC TTCCTGCACA TCCAGAAGAC GGGCGGCACC 
ACCTTCGGCC GCCACCTCGT GCAGAACGTA CGCCTCGAGG TGCCGTGCGA CTGCCGGCCC 
GGCCAGAAGA AGTGCACCTG CTACCGGCCC AACCGCCGCG AGACTTGGCT CTTCTCCCGC 
TTCTCCACCG GCTGGAGCTG CGGGCTGCAC GCCGACTGGA CCGAGCTCAC CAACTGCGTG 
CCCGGCGTGC TGGACCGCCG CGACTCCGCC GCGCTGCGCA CGCCCAGGAA GTTCTACTAC 
ATCACCCTGC TACGAGACCC CGTGTCCCGC TACCTGAGCG AGTGGCGGCA TGTGCAGAGG 
GGTGCCACGT GGAAGACGTC GTTGCATATG TGTGATGGGC GCACGCCCAC GCCTGAGGAG 
CTGCCGCCCT GCTACGAGGG CACGGACTGG TCGGGCTGCA CGCTACAGGA GTTCATGGAC 
TGCCCGTACA ACCTGGCCAA CAACCGCCAG GTGCGCATGC TGGCCGACCT GAGCCTGGTG 
GGCTGCTACA ACCTGTCCTT CATCCCCGAG GGCAAGCGGG CCCAGCTGCT GCTCGAGAGC 
GCCAAGAAGA ACCTGCGGGG CATGGCCTTC TTCGGCCTGA CCGAGTTCCA GCGCAAGACG 
CAGTACCTGT TCGAGCGGAC GTTCAACCTC AAGTTCATCC GGCCCTTCAT GCAGTACAAT 
AGCACGCGGG CGGGCGGCGT GGAGGTGGAT GAAGACACCA TCCGGCGCAT CGAGGAGCTC 
AACGACCTGG ACATGCAGCT GTACGACTAC GCCAAGGACC TCTTCCAGCA GCGCTACCAG 
TACAAGCGGC AGCTGGAGCG CAGGGAGCAG CGCCTGAGGA GCCGCGAGGA GCGTCTGCTG 
CACCGGGCCA AGGAGGCACT GCCGCGGGAG GATGCCGACG AGCCGGGCCG CGTGCCCACC 
GAGGACTACA TGAGCCACAT CATTGAGAAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HS6ST1 ( NM_004807.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004798.3 Homo sapiens heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), mRNA.

Price & Availability↑

CloneID	OHu17774
Clone ID Related Accession (Same CDS sequence)	NM_004807.2 , NM_004807.3
Accession Version	NM_004807.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	heparan-sulfate 6-O-sulfotransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR005030.1, BP219645.1, CV569969.1, BC001196.1 and BC063521.1. This sequence is a reference standard in the RefSeqGene project. On Jun 11, 2007 this sequence version replaced NM_004807.1. ##Evidence-Data-START## Transcript exon combination :: AB006179.1, BC096239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCGGC GGCGCGCCGG CGGCAGGACC ATGGTTGAGC GCGCCAGCAA GTTCGTGCTG 
GTGGTGGCGG GCTCGGTGTG CTTCATGCTC ATCTTGTACC AGTACGCGGG CCCAGGACTG 
AGCCTGGGCG CGCCCGGCGG CCGCGCGCCG CCCGACGACC TGGACCTGTT CCCCACACCC 
GACCCCCACT ACGAGAAGAA GTACTACTTC CCGGTCCGCG AGCTGGAGCG CTCGCTGCGC 
TTCGACATGA AGGGCGACGA CGTGATCGTC TTCCTGCACA TCCAGAAGAC GGGCGGCACC 
ACCTTCGGCC GCCACCTCGT GCAGAACGTA CGCCTCGAGG TGCCGTGCGA CTGCCGGCCC 
GGCCAGAAGA AGTGCACCTG CTACCGGCCC AACCGCCGCG AGACTTGGCT CTTCTCCCGC 
TTCTCCACCG GCTGGAGCTG CGGGCTGCAC GCCGACTGGA CCGAGCTCAC CAACTGCGTG 
CCCGGCGTGC TGGACCGCCG CGACTCCGCC GCGCTGCGCA CGCCCAGGAA GTTCTACTAC 
ATCACCCTGC TACGAGACCC CGTGTCCCGC TACCTGAGCG AGTGGCGGCA TGTGCAGAGG 
GGTGCCACGT GGAAGACGTC GTTGCATATG TGTGATGGGC GCACGCCCAC GCCTGAGGAG 
CTGCCGCCCT GCTACGAGGG CACGGACTGG TCGGGCTGCA CGCTACAGGA GTTCATGGAC 
TGCCCGTACA ACCTGGCCAA CAACCGCCAG GTGCGCATGC TGGCCGACCT GAGCCTGGTG 
GGCTGCTACA ACCTGTCCTT CATCCCCGAG GGCAAGCGGG CCCAGCTGCT GCTCGAGAGC 
GCCAAGAAGA ACCTGCGGGG CATGGCCTTC TTCGGCCTGA CCGAGTTCCA GCGCAAGACG 
CAGTACCTGT TCGAGCGGAC GTTCAACCTC AAGTTCATCC GGCCCTTCAT GCAGTACAAT 
AGCACGCGGG CGGGCGGCGT GGAGGTGGAT GAAGACACCA TCCGGCGCAT CGAGGAGCTC 
AACGACCTGG ACATGCAGCT GTACGACTAC GCCAAGGACC TCTTCCAGCA GCGCTACCAG 
TACAAGCGGC AGCTGGAGCG CAGGGAGCAG CGCCTGAGGA GCCGCGAGGA GCGTCTGCTG 
CACCGGGCCA AGGAGGCACT GCCGCGGGAG GATGCCGACG AGCCGGGCCG CGTGCCCACC 
GAGGACTACA TGAGCCACAT CATTGAGAAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004798.3
CDS	35..1270
Translation	MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW

Target ORF information:

RefSeq Version	NM_004807.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004807.2

ORF Insert Sequence:

ATGCGGCGGC GGCGCGCCGG CGGCAGGACC ATGGTTGAGC GCGCCAGCAA GTTCGTGCTG 
GTGGTGGCGG GCTCGGTGTG CTTCATGCTC ATCTTGTACC AGTACGCGGG CCCAGGACTG 
AGCCTGGGCG CGCCCGGCGG CCGCGCGCCG CCCGACGACC TGGACCTGTT CCCCACACCC 
GACCCCCACT ACGAGAAGAA GTACTACTTC CCGGTCCGCG AGCTGGAGCG CTCGCTGCGC 
TTCGACATGA AGGGCGACGA CGTGATCGTC TTCCTGCACA TCCAGAAGAC GGGCGGCACC 
ACCTTCGGCC GCCACCTCGT GCAGAACGTA CGCCTCGAGG TGCCGTGCGA CTGCCGGCCC 
GGCCAGAAGA AGTGCACCTG CTACCGGCCC AACCGCCGCG AGACTTGGCT CTTCTCCCGC 
TTCTCCACCG GCTGGAGCTG CGGGCTGCAC GCCGACTGGA CCGAGCTCAC CAACTGCGTG 
CCCGGCGTGC TGGACCGCCG CGACTCCGCC GCGCTGCGCA CGCCCAGGAA GTTCTACTAC 
ATCACCCTGC TACGAGACCC CGTGTCCCGC TACCTGAGCG AGTGGCGGCA TGTGCAGAGG 
GGTGCCACGT GGAAGACGTC GTTGCATATG TGTGATGGGC GCACGCCCAC GCCTGAGGAG 
CTGCCGCCCT GCTACGAGGG CACGGACTGG TCGGGCTGCA CGCTACAGGA GTTCATGGAC 
TGCCCGTACA ACCTGGCCAA CAACCGCCAG GTGCGCATGC TGGCCGACCT GAGCCTGGTG 
GGCTGCTACA ACCTGTCCTT CATCCCCGAG GGCAAGCGGG CCCAGCTGCT GCTCGAGAGC 
GCCAAGAAGA ACCTGCGGGG CATGGCCTTC TTCGGCCTGA CCGAGTTCCA GCGCAAGACG 
CAGTACCTGT TCGAGCGGAC GTTCAACCTC AAGTTCATCC GGCCCTTCAT GCAGTACAAT 
AGCACGCGGG CGGGCGGCGT GGAGGTGGAT GAAGACACCA TCCGGCGCAT CGAGGAGCTC 
AACGACCTGG ACATGCAGCT GTACGACTAC GCCAAGGACC TCTTCCAGCA GCGCTACCAG 
TACAAGCGGC AGCTGGAGCG CAGGGAGCAG CGCCTGAGGA GCCGCGAGGA GCGTCTGCTG 
CACCGGGCCA AGGAGGCACT GCCGCGGGAG GATGCCGACG AGCCGGGCCG CGTGCCCACC 
GAGGACTACA TGAGCCACAT CATTGAGAAG TGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.
International journal of molecular sciences18(11)(2017 Nov)
Ushakov VS,Tsidulko AY,de La Bourdonnaye G,Kazanskaya GM,Volkov AM,Kiselev RS,Kobozev VV,Kostromskaya DV,Gaytan AS,Krivoshapkin AL,Aidagulova SV,Grigorieva EV

Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.
The Journal of biological chemistry289(15)10488-501(2014 Apr)
Cole CL,Rushton G,Jayson GC,Avizienyte E

Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(6)2389-401(2014 Feb)
Clegg JM,Conway CD,Howe KM,Price DJ,Mason JO,Turnbull JE,Basson MA,Pratt T

Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
Circulation. Cardiovascular genetics6(2)171-83(2013 Apr)
Wu JH,Lemaitre RN,Manichaikul A,Guan W,Tanaka T,Foy M,Kabagambe EK,Djousse L,Siscovick D,Fretts AM,Johnson C,King IB,Psaty BM,McKnight B,Rich SS,Chen YD,Nettleton JA,Tang W,Bandinelli S,Jacobs DR Jr,Browning BL,Laurie CC,Gu X,Tsai MY,Steffen LM,Ferrucci L,Fornage M,Mozaffarian D

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HS6ST1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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