SLC22A8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC22A8
Entrez Gene ID	9376
Full Name	solute carrier family 22 member 8
Synonyms	OAT3
General protein information	Preferred Names solute carrier family 22 member 8 Names solute carrier family 22 member 8 hOAT3 organic anion transporter 3 solute carrier family 22 (organic anion transporter), member 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010].
Disorder MIM:	607581

mRNA and Protein(s)

mRNA	Protein	Name
NM_001184733.1	NP_001171662.1	solute carrier family 22 member 8 isoform 2
XM_011545364.1	XP_011543666.1	solute carrier family 22 member 8 isoform X1
NM_001184736.1	NP_001171665.1	solute carrier family 22 member 8 isoform 3
NM_004254.3	NP_004245.2	solute carrier family 22 member 8 isoform 1
NM_001184732.1	NP_001171661.1	solute carrier family 22 member 8 isoform 1
NM_004254.4	NP_004245.2	solute carrier family 22 member 8 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC22A8	XP_508510.4
	SLC22A8	XP_001115852.1
Canis lupus familiaris (dog)	SLC22A8	XP_005631652.1
Mus musculus (house mouse)	Slc22a8	NP_001158107.1
Rattus norvegicus (Norway rat)	Slc22a8	NP_112622.1
Homo sapiens (human)	SLC22A8	NP_001171661.1
Bos taurus (cattle)	SLC22A8	NP_001193175.1

Gene Ontology
Bibliography

Related articles in PubMed

Endogenous metabolites-mediated communication between OAT1/OAT3 and OATP1B1 may explain the association between SLCO1B1 SNPs and methotrexate toxicity.
Martinez D, Muhrez K, Woillard JB, Berthelot A, Gyan E, Choquet S, Andr?s CR, Marquet P, Barin-Le Guellec C
Clinical pharmacology and therapeutics(2017 Dec)

SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.
Wang H, You G
Biopharmaceutics & drug disposition38(8)449-457(2017 Nov)

Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand M?ori and Pacific Men.
Tanner C, Boocock J, Stahl EA, Dobbyn A, Mandal AK, Cadzow M, Phipps-Green AJ, Topless RK, Hindmarsh JH, Stamp LK, Dalbeth N, Choi HK, Mount DB, Merriman TR
Arthritis & rheumatology (Hoboken, N.J.)69(7)1461-1469(2017 07)

Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.
Favretto G, Souza LM, Greg?rio PC, Cunha RS, Maciel RAP, Sassaki GL, Toledo MG, Pecoits-Filho R, Souza WM, Stinghen AEM
Journal of vascular research54(3)170-179(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
Title: Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand M?ori and Pacific Men.

Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1/OAT3.
Title: Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.

The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.
Title: Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.

The putative promoter sequences from hOAT1 (SLC22A6) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
Title: Regulation of Expression of Renal Organic Anion Transporters OAT1 and OAT3 in a Model of Ischemia/Reperfusion Injury.

PPIs inhibit [(3)H]MTX transport via hOAT3 inhibition.
Title: Proton pump inhibitors inhibit methotrexate transport by renal basolateral organic anion transporter hOAT3.

The following SLC22A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC22A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09648	NM_001184733.1 Latest version!	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09653	NM_001184736.1 Latest version!	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu09699	NM_001184732.1 Latest version!	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09699	NM_004254.4 Latest version!	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09653	XM_011545364.1 Latest version!	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu09699	NM_004254.3	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC22A8 ( NM_001184733.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171662.1 Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09648
Clone ID Related Accession (Same CDS sequence)	NM_001184733.1
Accession Version	NM_001184733.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA628705.1, AK298341.1, BP276255.1 and AB042505.1. Transcript Variant: This variant (3) uses a different splice site and lacks a portion of the 5' coding region, with the result of translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.121760.1, AK298341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCAT GCCTGGATGG CTGGGTCTAC AACAGCACCA AGGACTCCAT TGTGACAGAG 
TGGGACTTGG TGTGCAACTC CAACAAACTG AAGGAGATGG CCCAGTCTAT CTTCATGGCA 
GGTATACTGA TTGGAGGGCT CGTGCTTGGA GACCTGTCTG ACAGGTTTGG CCGCAGGCCC 
ATCCTGACCT GCAGCTACCT GCTGCTGGCA GCCAGCGGCT CCGGTGCAGC CTTCAGCCCC 
ACCTTCCCCA TCTACATGGT CTTCCGCTTC CTGTGTGGCT TTGGCATCTC AGGCATTACC 
CTGAGCACCG TCATCTTGAA TGTGGAATGG GTGCCTACCC GGATGCGGGC CATCATGTCG 
ACAGCACTCG GGTACTGCTA CACCTTTGGC CAGTTCATTC TGCCCGGCCT GGCCTACGCC 
ATCCCCCAGT GGCGTTGGCT GCAGTTAACT GTGTCCATTC CCTTCTTCGT CTTCTTCCTA 
TCATCCTGGT GGACACCAGA GTCCATACGC TGGTTGGTCT TGTCTGGAAA GTCCTCGAAG 
GCCCTGAAGA TACTCCGGCG GGTGGCTGTC TTCAATGGCA AGAAGGAAGA GGGAGAAAGG 
CTCAGCTTGG AGGAGCTCAA ACTCAACCTG CAGAAGGAGA TCTCCTTGGC CAAGGCCAAG 
TACACCGCAA GTGACCTGTT CCGGATACCC ATGCTGCGCC GCATGACCTT CTGTCTTTCC 
CTGGCCTGGT TTGCTACCGG TTTTGCCTAC TATAGTTTGG CTATGGGTGT GGAAGAATTT 
GGAGTCAACC TCTACATCCT CCAGATCATC TTTGGTGGGG TCGATGTCCC AGCCAAGTTC 
ATCACCATCC TCTCCTTAAG CTACCTGGGC CGGCATACCA CTCAGGCCGC TGCCCTGCTC 
CTGGCAGGAG GGGCCATCTT GGCTCTCACC TTTGTGCCCT TGGACTTGCA GACCGTGAGG 
ACAGTATTGG CTGTGTTTGG GAAGGGATGC CTATCCAGCT CCTTCAGCTG CCTCTTCCTC 
TACACAAGTG AATTATACCC CACAGTCATC AGGCAAACAG GTATGGGCGT AAGTAACCTG 
TGGACCCGCG TGGGAAGCAT GGTGTCCCCG CTGGTGAAAA TCACGGGTGA GGTACAGCCC 
TTCATCCCCA ATATCATCTA CGGGATCACC GCCCTCCTCG GGGGCAGTGC TGCCCTCTTC 
CTGCCTGAGA CCCTGAATCA GCCCTTGCCA GAGACTATCG AAGACCTGGA AAACTGGTCC 
CTGCGGGCAA AGAAGCCAAA GCAGGAGCCA GAGGTGGAAA AGGCCTCCCA GAGGATCCCT 
CTACAGCCTC ACGGACCAGG CCTGGGCTCC AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171662.1
CDS	143..1498
Translation	MEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

Target ORF information:

RefSeq Version	NM_001184733.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184733.1

ORF Insert Sequence:

ATGGAGCCAT GCCTGGATGG CTGGGTCTAC AACAGCACCA AGGACTCCAT TGTGACAGAG 
TGGGACTTGG TGTGCAACTC CAACAAACTG AAGGAGATGG CCCAGTCTAT CTTCATGGCA 
GGTATACTGA TTGGAGGGCT CGTGCTTGGA GACCTGTCTG ACAGGTTTGG CCGCAGGCCC 
ATCCTGACCT GCAGCTACCT GCTGCTGGCA GCCAGCGGCT CCGGTGCAGC CTTCAGCCCC 
ACCTTCCCCA TCTACATGGT CTTCCGCTTC CTGTGTGGCT TTGGCATCTC AGGCATTACC 
CTGAGCACCG TCATCTTGAA TGTGGAATGG GTGCCTACCC GGATGCGGGC CATCATGTCG 
ACAGCACTCG GGTACTGCTA CACCTTTGGC CAGTTCATTC TGCCCGGCCT GGCCTACGCC 
ATCCCCCAGT GGCGTTGGCT GCAGTTAACT GTGTCCATTC CCTTCTTCGT CTTCTTCCTA 
TCATCCTGGT GGACACCAGA GTCCATACGC TGGTTGGTCT TGTCTGGAAA GTCCTCGAAG 
GCCCTGAAGA TACTCCGGCG GGTGGCTGTC TTCAATGGCA AGAAGGAAGA GGGAGAAAGG 
CTCAGCTTGG AGGAGCTCAA ACTCAACCTG CAGAAGGAGA TCTCCTTGGC CAAGGCCAAG 
TACACCGCAA GTGACCTGTT CCGGATACCC ATGCTGCGCC GCATGACCTT CTGTCTTTCC 
CTGGCCTGGT TTGCTACCGG TTTTGCCTAC TATAGTTTGG CTATGGGTGT GGAAGAATTT 
GGAGTCAACC TCTACATCCT CCAGATCATC TTTGGTGGGG TCGATGTCCC AGCCAAGTTC 
ATCACCATCC TCTCCTTAAG CTACCTGGGC CGGCATACCA CTCAGGCCGC TGCCCTGCTC 
CTGGCAGGAG GGGCCATCTT GGCTCTCACC TTTGTGCCCT TGGACTTGCA GACCGTGAGG 
ACAGTATTGG CTGTGTTTGG GAAGGGATGC CTATCCAGCT CCTTCAGCTG CCTCTTCCTC 
TACACAAGTG AATTATACCC CACAGTCATC AGGCAAACAG GTATGGGCGT AAGTAACCTG 
TGGACCCGCG TGGGAAGCAT GGTGTCCCCG CTGGTGAAAA TCACGGGTGA GGTACAGCCC 
TTCATCCCCA ATATCATCTA CGGGATCACC GCCCTCCTCG GGGGCAGTGC TGCCCTCTTC 
CTGCCTGAGA CCCTGAATCA GCCCTTGCCA GAGACTATCG AAGACCTGGA AAACTGGTCC 
CTGCGGGCAA AGAAGCCAAA GCAGGAGCCA GAGGTGGAAA AGGCCTCCCA GAGGATCCCT 
CTACAGCCTC ACGGACCAGG CCTGGGCTCC AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC22A8 ( NM_001184736.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171665.1 Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu09653
Clone ID Related Accession (Same CDS sequence)	XM_011545364.1 , NM_001184736.1
Accession Version	NM_001184736.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 8 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA628705.1, AK307850.1, BC022387.1 and AB042505.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK307850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGT CTATCTTCAT GGCAGGTATA CTGATTGGAG GGCTCGTGCT TGGAGACCTG 
TCTGACAGGT TTGGCCGCAG GCCCATCCTG ACCTGCAGCT ACCTGCTGCT GGCAGCCAGC 
GGCTCCGGTG CAGCCTTCAG CCCCACCTTC CCCATCTACA TGGTCTTCCG CTTCCTGTGT 
GGCTTTGGCA TCTCAGGCAT TACCCTGAGC ACCGTCATCT TGAATGTGGA ATGGGTGCCT 
ACCCGGATGC GGGCCATCAT GTCGACAGCA CTCGGGTACT GCTACACCTT TGGCCAGTTC 
ATTCTGCCCG GCCTGGCCTA CGCCATCCCC CAGTGGCGTT GGCTGCAGTT AACTGTGTCC 
ATTCCCTTCT TCGTCTTCTT CCTATCATCC TGGTGGACAC CAGAGTCCAT ACGCTGGTTG 
GTCTTGTCTG GAAAGTCCTC GAAGGCCCTG AAGATACTCC GGCGGGTGGC TGTCTTCAAT 
GGCAAGAAGG AAGAGGGAGA AAGGCTCAGC TTGGAGGAGC TCAAACTCAA CCTGCAGAAG 
GAGATCTCCT TGGCCAAGGC CAAGTACACC GCAAGTGACC TGTTCCGGAT ACCCATGCTG 
CGCCGCATGA CCTTCTGTCT TTCCCTGGCC TGGTTTGCTA CCGGTTTTGC CTACTATAGT 
TTGGCTATGG GTGTGGAAGA ATTTGGAGTC AACCTCTACA TCCTCCAGAT CATCTTTGGT 
GGGGTCGATG TCCCAGCCAA GTTCATCACC ATCCTCTCCT TAAGCTACCT GGGCCGGCAT 
ACCACTCAGG CCGCTGCCCT GCTCCTGGCA GGAGGGGCCA TCTTGGCTCT CACCTTTGTG 
CCCTTGGACT TGCAGACCGT GAGGACAGTA TTGGCTGTGT TTGGGAAGGG ATGCCTATCC 
AGCTCCTTCA GCTGCCTCTT CCTCTACACA AGTGAATTAT ACCCCACAGT CATCAGGCAA 
ACAGGTATGG GCGTAAGTAA CCTGTGGACC CGCGTGGGAA GCATGGTGTC CCCGCTGGTG 
AAAATCACGG GTGAGGTACA GCCCTTCATC CCCAATATCA TCTACGGGAT CACCGCCCTC 
CTCGGGGGCA GTGCTGCCCT CTTCCTGCCT GAGACCCTGA ATCAGCCCTT GCCAGAGACT 
ATCGAAGACC TGGAAAACTG GTCCCTGCGG GCAAAGAAGC CAAAGCAGGA GCCAGAGGTG 
GAAAAGGCCT CCCAGAGGAT CCCTCTACAG CCTCACGGAC CAGGCCTGGG CTCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171665.1
CDS	154..1413
Translation	MAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

Target ORF information:

RefSeq Version	NM_001184736.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184736.1

ORF Insert Sequence:

ATGGCCCAGT CTATCTTCAT GGCAGGTATA CTGATTGGAG GGCTCGTGCT TGGAGACCTG 
TCTGACAGGT TTGGCCGCAG GCCCATCCTG ACCTGCAGCT ACCTGCTGCT GGCAGCCAGC 
GGCTCCGGTG CAGCCTTCAG CCCCACCTTC CCCATCTACA TGGTCTTCCG CTTCCTGTGT 
GGCTTTGGCA TCTCAGGCAT TACCCTGAGC ACCGTCATCT TGAATGTGGA ATGGGTGCCT 
ACCCGGATGC GGGCCATCAT GTCGACAGCA CTCGGGTACT GCTACACCTT TGGCCAGTTC 
ATTCTGCCCG GCCTGGCCTA CGCCATCCCC CAGTGGCGTT GGCTGCAGTT AACTGTGTCC 
ATTCCCTTCT TCGTCTTCTT CCTATCATCC TGGTGGACAC CAGAGTCCAT ACGCTGGTTG 
GTCTTGTCTG GAAAGTCCTC GAAGGCCCTG AAGATACTCC GGCGGGTGGC TGTCTTCAAT 
GGCAAGAAGG AAGAGGGAGA AAGGCTCAGC TTGGAGGAGC TCAAACTCAA CCTGCAGAAG 
GAGATCTCCT TGGCCAAGGC CAAGTACACC GCAAGTGACC TGTTCCGGAT ACCCATGCTG 
CGCCGCATGA CCTTCTGTCT TTCCCTGGCC TGGTTTGCTA CCGGTTTTGC CTACTATAGT 
TTGGCTATGG GTGTGGAAGA ATTTGGAGTC AACCTCTACA TCCTCCAGAT CATCTTTGGT 
GGGGTCGATG TCCCAGCCAA GTTCATCACC ATCCTCTCCT TAAGCTACCT GGGCCGGCAT 
ACCACTCAGG CCGCTGCCCT GCTCCTGGCA GGAGGGGCCA TCTTGGCTCT CACCTTTGTG 
CCCTTGGACT TGCAGACCGT GAGGACAGTA TTGGCTGTGT TTGGGAAGGG ATGCCTATCC 
AGCTCCTTCA GCTGCCTCTT CCTCTACACA AGTGAATTAT ACCCCACAGT CATCAGGCAA 
ACAGGTATGG GCGTAAGTAA CCTGTGGACC CGCGTGGGAA GCATGGTGTC CCCGCTGGTG 
AAAATCACGG GTGAGGTACA GCCCTTCATC CCCAATATCA TCTACGGGAT CACCGCCCTC 
CTCGGGGGCA GTGCTGCCCT CTTCCTGCCT GAGACCCTGA ATCAGCCCTT GCCAGAGACT 
ATCGAAGACC TGGAAAACTG GTCCCTGCGG GCAAAGAAGC CAAAGCAGGA GCCAGAGGTG 
GAAAAGGCCT CCCAGAGGAT CCCTCTACAG CCTCACGGAC CAGGCCTGGG CTCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC22A8 ( NM_004254.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004245.2 Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09699
Clone ID Related Accession (Same CDS sequence)	NM_004254.3 , NM_001184732.1 , NM_004254.4
Accession Version	NM_004254.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1629bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA628705.1, BC022387.1 and AB042505.1. On May 15, 2010 this sequence version replaced NM_004254.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022387.1, SRR1803616.206902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCTTCT CGGAGATCCT GGACCGTGTG GGAAGCATGG GCCATTTCCA GTTCCTGCAT 
GTAGCCATAC TGGGCCTCCC GATCCTCAAC ATGGCCAACC ACAACCTGCT GCAGATCTTC 
ACAGCCGCCA CCCCTGTCCA CCACTGTCGC CCGCCCCACA ATGCCTCCAC AGGGCCTTGG 
GTGCTCCCCA TGGGCCCAAA TGGGAAGCCT GAGAGGTGCC TCCGTTTTGT ACATCCGCCC 
AATGCCAGCC TGCCCAATGA CACCCAGAGG GCCATGGAGC CATGCCTGGA TGGCTGGGTC 
TACAACAGCA CCAAGGACTC CATTGTGACA GAGTGGGACT TGGTGTGCAA CTCCAACAAA 
CTGAAGGAGA TGGCCCAGTC TATCTTCATG GCAGGTATAC TGATTGGAGG GCTCGTGCTT 
GGAGACCTGT CTGACAGGTT TGGCCGCAGG CCCATCCTGA CCTGCAGCTA CCTGCTGCTG 
GCAGCCAGCG GCTCCGGTGC AGCCTTCAGC CCCACCTTCC CCATCTACAT GGTCTTCCGC 
TTCCTGTGTG GCTTTGGCAT CTCAGGCATT ACCCTGAGCA CCGTCATCTT GAATGTGGAA 
TGGGTGCCTA CCCGGATGCG GGCCATCATG TCGACAGCAC TCGGGTACTG CTACACCTTT 
GGCCAGTTCA TTCTGCCCGG CCTGGCCTAC GCCATCCCCC AGTGGCGTTG GCTGCAGTTA 
ACTGTGTCCA TTCCCTTCTT CGTCTTCTTC CTATCATCCT GGTGGACACC AGAGTCCATA 
CGCTGGTTGG TCTTGTCTGG AAAGTCCTCG AAGGCCCTGA AGATACTCCG GCGGGTGGCT 
GTCTTCAATG GCAAGAAGGA AGAGGGAGAA AGGCTCAGCT TGGAGGAGCT CAAACTCAAC 
CTGCAGAAGG AGATCTCCTT GGCCAAGGCC AAGTACACCG CAAGTGACCT GTTCCGGATA 
CCCATGCTGC GCCGCATGAC CTTCTGTCTT TCCCTGGCCT GGTTTGCTAC CGGTTTTGCC 
TACTATAGTT TGGCTATGGG TGTGGAAGAA TTTGGAGTCA ACCTCTACAT CCTCCAGATC 
ATCTTTGGTG GGGTCGATGT CCCAGCCAAG TTCATCACCA TCCTCTCCTT AAGCTACCTG 
GGCCGGCATA CCACTCAGGC CGCTGCCCTG CTCCTGGCAG GAGGGGCCAT CTTGGCTCTC 
ACCTTTGTGC CCTTGGACTT GCAGACCGTG AGGACAGTAT TGGCTGTGTT TGGGAAGGGA 
TGCCTATCCA GCTCCTTCAG CTGCCTCTTC CTCTACACAA GTGAATTATA CCCCACAGTC 
ATCAGGCAAA CAGGTATGGG CGTAAGTAAC CTGTGGACCC GCGTGGGAAG CATGGTGTCC 
CCGCTGGTGA AAATCACGGG TGAGGTACAG CCCTTCATCC CCAATATCAT CTACGGGATC 
ACCGCCCTCC TCGGGGGCAG TGCTGCCCTC TTCCTGCCTG AGACCCTGAA TCAGCCCTTG 
CCAGAGACTA TCGAAGACCT GGAAAACTGG TCCCTGCGGG CAAAGAAGCC AAAGCAGGAG 
CCAGAGGTGG AAAAGGCCTC CCAGAGGATC CCTCTACAGC CTCACGGACC AGGCCTGGGC 
TCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004245.2
CDS	143..1771
Translation	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

Target ORF information:

RefSeq Version	NM_004254.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004254.3

ORF Insert Sequence:

ATGACCTTCT CGGAGATCCT GGACCGTGTG GGAAGCATGG GCCATTTCCA GTTCCTGCAT 
GTAGCCATAC TGGGCCTCCC GATCCTCAAC ATGGCCAACC ACAACCTGCT GCAGATCTTC 
ACAGCCGCCA CCCCTGTCCA CCACTGTCGC CCGCCCCACA ATGCCTCCAC AGGGCCTTGG 
GTGCTCCCCA TGGGCCCAAA TGGGAAGCCT GAGAGGTGCC TCCGTTTTGT ACATCCGCCC 
AATGCCAGCC TGCCCAATGA CACCCAGAGG GCCATGGAGC CATGCCTGGA TGGCTGGGTC 
TACAACAGCA CCAAGGACTC CATTGTGACA GAGTGGGACT TGGTGTGCAA CTCCAACAAA 
CTGAAGGAGA TGGCCCAGTC TATCTTCATG GCAGGTATAC TGATTGGAGG GCTCGTGCTT 
GGAGACCTGT CTGACAGGTT TGGCCGCAGG CCCATCCTGA CCTGCAGCTA CCTGCTGCTG 
GCAGCCAGCG GCTCCGGTGC AGCCTTCAGC CCCACCTTCC CCATCTACAT GGTCTTCCGC 
TTCCTGTGTG GCTTTGGCAT CTCAGGCATT ACCCTGAGCA CCGTCATCTT GAATGTGGAA 
TGGGTGCCTA CCCGGATGCG GGCCATCATG TCGACAGCAC TCGGGTACTG CTACACCTTT 
GGCCAGTTCA TTCTGCCCGG CCTGGCCTAC GCCATCCCCC AGTGGCGTTG GCTGCAGTTA 
ACTGTGTCCA TTCCCTTCTT CGTCTTCTTC CTATCATCCT GGTGGACACC AGAGTCCATA 
CGCTGGTTGG TCTTGTCTGG AAAGTCCTCG AAGGCCCTGA AGATACTCCG GCGGGTGGCT 
GTCTTCAATG GCAAGAAGGA AGAGGGAGAA AGGCTCAGCT TGGAGGAGCT CAAACTCAAC 
CTGCAGAAGG AGATCTCCTT GGCCAAGGCC AAGTACACCG CAAGTGACCT GTTCCGGATA 
CCCATGCTGC GCCGCATGAC CTTCTGTCTT TCCCTGGCCT GGTTTGCTAC CGGTTTTGCC 
TACTATAGTT TGGCTATGGG TGTGGAAGAA TTTGGAGTCA ACCTCTACAT CCTCCAGATC 
ATCTTTGGTG GGGTCGATGT CCCAGCCAAG TTCATCACCA TCCTCTCCTT AAGCTACCTG 
GGCCGGCATA CCACTCAGGC CGCTGCCCTG CTCCTGGCAG GAGGGGCCAT CTTGGCTCTC 
ACCTTTGTGC CCTTGGACTT GCAGACCGTG AGGACAGTAT TGGCTGTGTT TGGGAAGGGA 
TGCCTATCCA GCTCCTTCAG CTGCCTCTTC CTCTACACAA GTGAATTATA CCCCACAGTC 
ATCAGGCAAA CAGGTATGGG CGTAAGTAAC CTGTGGACCC GCGTGGGAAG CATGGTGTCC 
CCGCTGGTGA AAATCACGGG TGAGGTACAG CCCTTCATCC CCAATATCAT CTACGGGATC 
ACCGCCCTCC TCGGGGGCAG TGCTGCCCTC TTCCTGCCTG AGACCCTGAA TCAGCCCTTG 
CCAGAGACTA TCGAAGACCT GGAAAACTGG TCCCTGCGGG CAAAGAAGCC AAAGCAGGAG 
CCAGAGGTGG AAAAGGCCTC CCAGAGGATC CCTCTACAGC CTCACGGACC AGGCCTGGGC 
TCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC22A8 ( NM_001184732.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001171661.1 Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 2, mRNA.

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CloneID	OHu09699
Clone ID Related Accession (Same CDS sequence)	NM_004254.3 , NM_001184732.1 , NM_004254.4
Accession Version	NM_001184732.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1629bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA628705.1, AK313187.1, DA633836.1, BC022387.1 and AB042505.1. Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.197561.1, SRR1660805.209789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145774 [ECO:0000348] ##Evidence-Data-END##

ATGACCTTCT CGGAGATCCT GGACCGTGTG GGAAGCATGG GCCATTTCCA GTTCCTGCAT 
GTAGCCATAC TGGGCCTCCC GATCCTCAAC ATGGCCAACC ACAACCTGCT GCAGATCTTC 
ACAGCCGCCA CCCCTGTCCA CCACTGTCGC CCGCCCCACA ATGCCTCCAC AGGGCCTTGG 
GTGCTCCCCA TGGGCCCAAA TGGGAAGCCT GAGAGGTGCC TCCGTTTTGT ACATCCGCCC 
AATGCCAGCC TGCCCAATGA CACCCAGAGG GCCATGGAGC CATGCCTGGA TGGCTGGGTC 
TACAACAGCA CCAAGGACTC CATTGTGACA GAGTGGGACT TGGTGTGCAA CTCCAACAAA 
CTGAAGGAGA TGGCCCAGTC TATCTTCATG GCAGGTATAC TGATTGGAGG GCTCGTGCTT 
GGAGACCTGT CTGACAGGTT TGGCCGCAGG CCCATCCTGA CCTGCAGCTA CCTGCTGCTG 
GCAGCCAGCG GCTCCGGTGC AGCCTTCAGC CCCACCTTCC CCATCTACAT GGTCTTCCGC 
TTCCTGTGTG GCTTTGGCAT CTCAGGCATT ACCCTGAGCA CCGTCATCTT GAATGTGGAA 
TGGGTGCCTA CCCGGATGCG GGCCATCATG TCGACAGCAC TCGGGTACTG CTACACCTTT 
GGCCAGTTCA TTCTGCCCGG CCTGGCCTAC GCCATCCCCC AGTGGCGTTG GCTGCAGTTA 
ACTGTGTCCA TTCCCTTCTT CGTCTTCTTC CTATCATCCT GGTGGACACC AGAGTCCATA 
CGCTGGTTGG TCTTGTCTGG AAAGTCCTCG AAGGCCCTGA AGATACTCCG GCGGGTGGCT 
GTCTTCAATG GCAAGAAGGA AGAGGGAGAA AGGCTCAGCT TGGAGGAGCT CAAACTCAAC 
CTGCAGAAGG AGATCTCCTT GGCCAAGGCC AAGTACACCG CAAGTGACCT GTTCCGGATA 
CCCATGCTGC GCCGCATGAC CTTCTGTCTT TCCCTGGCCT GGTTTGCTAC CGGTTTTGCC 
TACTATAGTT TGGCTATGGG TGTGGAAGAA TTTGGAGTCA ACCTCTACAT CCTCCAGATC 
ATCTTTGGTG GGGTCGATGT CCCAGCCAAG TTCATCACCA TCCTCTCCTT AAGCTACCTG 
GGCCGGCATA CCACTCAGGC CGCTGCCCTG CTCCTGGCAG GAGGGGCCAT CTTGGCTCTC 
ACCTTTGTGC CCTTGGACTT GCAGACCGTG AGGACAGTAT TGGCTGTGTT TGGGAAGGGA 
TGCCTATCCA GCTCCTTCAG CTGCCTCTTC CTCTACACAA GTGAATTATA CCCCACAGTC 
ATCAGGCAAA CAGGTATGGG CGTAAGTAAC CTGTGGACCC GCGTGGGAAG CATGGTGTCC 
CCGCTGGTGA AAATCACGGG TGAGGTACAG CCCTTCATCC CCAATATCAT CTACGGGATC 
ACCGCCCTCC TCGGGGGCAG TGCTGCCCTC TTCCTGCCTG AGACCCTGAA TCAGCCCTTG 
CCAGAGACTA TCGAAGACCT GGAAAACTGG TCCCTGCGGG CAAAGAAGCC AAAGCAGGAG 
CCAGAGGTGG AAAAGGCCTC CCAGAGGATC CCTCTACAGC CTCACGGACC AGGCCTGGGC 
TCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171661.1
CDS	122..1750
Translation	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

Target ORF information:

RefSeq Version	NM_001184732.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184732.1

ORF Insert Sequence:

ATGACCTTCT CGGAGATCCT GGACCGTGTG GGAAGCATGG GCCATTTCCA GTTCCTGCAT 
GTAGCCATAC TGGGCCTCCC GATCCTCAAC ATGGCCAACC ACAACCTGCT GCAGATCTTC 
ACAGCCGCCA CCCCTGTCCA CCACTGTCGC CCGCCCCACA ATGCCTCCAC AGGGCCTTGG 
GTGCTCCCCA TGGGCCCAAA TGGGAAGCCT GAGAGGTGCC TCCGTTTTGT ACATCCGCCC 
AATGCCAGCC TGCCCAATGA CACCCAGAGG GCCATGGAGC CATGCCTGGA TGGCTGGGTC 
TACAACAGCA CCAAGGACTC CATTGTGACA GAGTGGGACT TGGTGTGCAA CTCCAACAAA 
CTGAAGGAGA TGGCCCAGTC TATCTTCATG GCAGGTATAC TGATTGGAGG GCTCGTGCTT 
GGAGACCTGT CTGACAGGTT TGGCCGCAGG CCCATCCTGA CCTGCAGCTA CCTGCTGCTG 
GCAGCCAGCG GCTCCGGTGC AGCCTTCAGC CCCACCTTCC CCATCTACAT GGTCTTCCGC 
TTCCTGTGTG GCTTTGGCAT CTCAGGCATT ACCCTGAGCA CCGTCATCTT GAATGTGGAA 
TGGGTGCCTA CCCGGATGCG GGCCATCATG TCGACAGCAC TCGGGTACTG CTACACCTTT 
GGCCAGTTCA TTCTGCCCGG CCTGGCCTAC GCCATCCCCC AGTGGCGTTG GCTGCAGTTA 
ACTGTGTCCA TTCCCTTCTT CGTCTTCTTC CTATCATCCT GGTGGACACC AGAGTCCATA 
CGCTGGTTGG TCTTGTCTGG AAAGTCCTCG AAGGCCCTGA AGATACTCCG GCGGGTGGCT 
GTCTTCAATG GCAAGAAGGA AGAGGGAGAA AGGCTCAGCT TGGAGGAGCT CAAACTCAAC 
CTGCAGAAGG AGATCTCCTT GGCCAAGGCC AAGTACACCG CAAGTGACCT GTTCCGGATA 
CCCATGCTGC GCCGCATGAC CTTCTGTCTT TCCCTGGCCT GGTTTGCTAC CGGTTTTGCC 
TACTATAGTT TGGCTATGGG TGTGGAAGAA TTTGGAGTCA ACCTCTACAT CCTCCAGATC 
ATCTTTGGTG GGGTCGATGT CCCAGCCAAG TTCATCACCA TCCTCTCCTT AAGCTACCTG 
GGCCGGCATA CCACTCAGGC CGCTGCCCTG CTCCTGGCAG GAGGGGCCAT CTTGGCTCTC 
ACCTTTGTGC CCTTGGACTT GCAGACCGTG AGGACAGTAT TGGCTGTGTT TGGGAAGGGA 
TGCCTATCCA GCTCCTTCAG CTGCCTCTTC CTCTACACAA GTGAATTATA CCCCACAGTC 
ATCAGGCAAA CAGGTATGGG CGTAAGTAAC CTGTGGACCC GCGTGGGAAG CATGGTGTCC 
CCGCTGGTGA AAATCACGGG TGAGGTACAG CCCTTCATCC CCAATATCAT CTACGGGATC 
ACCGCCCTCC TCGGGGGCAG TGCTGCCCTC TTCCTGCCTG AGACCCTGAA TCAGCCCTTG 
CCAGAGACTA TCGAAGACCT GGAAAACTGG TCCCTGCGGG CAAAGAAGCC AAAGCAGGAG 
CCAGAGGTGG AAAAGGCCTC CCAGAGGATC CCTCTACAGC CTCACGGACC AGGCCTGGGC 
TCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC22A8 ( NM_004254.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004245.2 Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 1, mRNA.

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CloneID	OHu09699
Clone ID Related Accession (Same CDS sequence)	NM_004254.3 , NM_001184732.1 , NM_004254.4
Accession Version	NM_004254.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1629bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA628705.1, BC022387.1 and AB042505.1. On Nov 22, 2018 this sequence version replaced NM_004254.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022387.1, SRR1803616.206902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000336232.7/ ENSP00000337335.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCTTCT CGGAGATCCT GGACCGTGTG GGAAGCATGG GCCATTTCCA GTTCCTGCAT 
GTAGCCATAC TGGGCCTCCC GATCCTCAAC ATGGCCAACC ACAACCTGCT GCAGATCTTC 
ACAGCCGCCA CCCCTGTCCA CCACTGTCGC CCGCCCCACA ATGCCTCCAC AGGGCCTTGG 
GTGCTCCCCA TGGGCCCAAA TGGGAAGCCT GAGAGGTGCC TCCGTTTTGT ACATCCGCCC 
AATGCCAGCC TGCCCAATGA CACCCAGAGG GCCATGGAGC CATGCCTGGA TGGCTGGGTC 
TACAACAGCA CCAAGGACTC CATTGTGACA GAGTGGGACT TGGTGTGCAA CTCCAACAAA 
CTGAAGGAGA TGGCCCAGTC TATCTTCATG GCAGGTATAC TGATTGGAGG GCTCGTGCTT 
GGAGACCTGT CTGACAGGTT TGGCCGCAGG CCCATCCTGA CCTGCAGCTA CCTGCTGCTG 
GCAGCCAGCG GCTCCGGTGC AGCCTTCAGC CCCACCTTCC CCATCTACAT GGTCTTCCGC 
TTCCTGTGTG GCTTTGGCAT CTCAGGCATT ACCCTGAGCA CCGTCATCTT GAATGTGGAA 
TGGGTGCCTA CCCGGATGCG GGCCATCATG TCGACAGCAC TCGGGTACTG CTACACCTTT 
GGCCAGTTCA TTCTGCCCGG CCTGGCCTAC GCCATCCCCC AGTGGCGTTG GCTGCAGTTA 
ACTGTGTCCA TTCCCTTCTT CGTCTTCTTC CTATCATCCT GGTGGACACC AGAGTCCATA 
CGCTGGTTGG TCTTGTCTGG AAAGTCCTCG AAGGCCCTGA AGATACTCCG GCGGGTGGCT 
GTCTTCAATG GCAAGAAGGA AGAGGGAGAA AGGCTCAGCT TGGAGGAGCT CAAACTCAAC 
CTGCAGAAGG AGATCTCCTT GGCCAAGGCC AAGTACACCG CAAGTGACCT GTTCCGGATA 
CCCATGCTGC GCCGCATGAC CTTCTGTCTT TCCCTGGCCT GGTTTGCTAC CGGTTTTGCC 
TACTATAGTT TGGCTATGGG TGTGGAAGAA TTTGGAGTCA ACCTCTACAT CCTCCAGATC 
ATCTTTGGTG GGGTCGATGT CCCAGCCAAG TTCATCACCA TCCTCTCCTT AAGCTACCTG 
GGCCGGCATA CCACTCAGGC CGCTGCCCTG CTCCTGGCAG GAGGGGCCAT CTTGGCTCTC 
ACCTTTGTGC CCTTGGACTT GCAGACCGTG AGGACAGTAT TGGCTGTGTT TGGGAAGGGA 
TGCCTATCCA GCTCCTTCAG CTGCCTCTTC CTCTACACAA GTGAATTATA CCCCACAGTC 
ATCAGGCAAA CAGGTATGGG CGTAAGTAAC CTGTGGACCC GCGTGGGAAG CATGGTGTCC 
CCGCTGGTGA AAATCACGGG TGAGGTACAG CCCTTCATCC CCAATATCAT CTACGGGATC 
ACCGCCCTCC TCGGGGGCAG TGCTGCCCTC TTCCTGCCTG AGACCCTGAA TCAGCCCTTG 
CCAGAGACTA TCGAAGACCT GGAAAACTGG TCCCTGCGGG CAAAGAAGCC AAAGCAGGAG 
CCAGAGGTGG AAAAGGCCTC CCAGAGGATC CCTCTACAGC CTCACGGACC AGGCCTGGGC 
TCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004245.2
CDS	139..1767
Translation	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

Target ORF information:

RefSeq Version	NM_004254.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004254.4

ORF Insert Sequence:

ATGACCTTCT CGGAGATCCT GGACCGTGTG GGAAGCATGG GCCATTTCCA GTTCCTGCAT 
GTAGCCATAC TGGGCCTCCC GATCCTCAAC ATGGCCAACC ACAACCTGCT GCAGATCTTC 
ACAGCCGCCA CCCCTGTCCA CCACTGTCGC CCGCCCCACA ATGCCTCCAC AGGGCCTTGG 
GTGCTCCCCA TGGGCCCAAA TGGGAAGCCT GAGAGGTGCC TCCGTTTTGT ACATCCGCCC 
AATGCCAGCC TGCCCAATGA CACCCAGAGG GCCATGGAGC CATGCCTGGA TGGCTGGGTC 
TACAACAGCA CCAAGGACTC CATTGTGACA GAGTGGGACT TGGTGTGCAA CTCCAACAAA 
CTGAAGGAGA TGGCCCAGTC TATCTTCATG GCAGGTATAC TGATTGGAGG GCTCGTGCTT 
GGAGACCTGT CTGACAGGTT TGGCCGCAGG CCCATCCTGA CCTGCAGCTA CCTGCTGCTG 
GCAGCCAGCG GCTCCGGTGC AGCCTTCAGC CCCACCTTCC CCATCTACAT GGTCTTCCGC 
TTCCTGTGTG GCTTTGGCAT CTCAGGCATT ACCCTGAGCA CCGTCATCTT GAATGTGGAA 
TGGGTGCCTA CCCGGATGCG GGCCATCATG TCGACAGCAC TCGGGTACTG CTACACCTTT 
GGCCAGTTCA TTCTGCCCGG CCTGGCCTAC GCCATCCCCC AGTGGCGTTG GCTGCAGTTA 
ACTGTGTCCA TTCCCTTCTT CGTCTTCTTC CTATCATCCT GGTGGACACC AGAGTCCATA 
CGCTGGTTGG TCTTGTCTGG AAAGTCCTCG AAGGCCCTGA AGATACTCCG GCGGGTGGCT 
GTCTTCAATG GCAAGAAGGA AGAGGGAGAA AGGCTCAGCT TGGAGGAGCT CAAACTCAAC 
CTGCAGAAGG AGATCTCCTT GGCCAAGGCC AAGTACACCG CAAGTGACCT GTTCCGGATA 
CCCATGCTGC GCCGCATGAC CTTCTGTCTT TCCCTGGCCT GGTTTGCTAC CGGTTTTGCC 
TACTATAGTT TGGCTATGGG TGTGGAAGAA TTTGGAGTCA ACCTCTACAT CCTCCAGATC 
ATCTTTGGTG GGGTCGATGT CCCAGCCAAG TTCATCACCA TCCTCTCCTT AAGCTACCTG 
GGCCGGCATA CCACTCAGGC CGCTGCCCTG CTCCTGGCAG GAGGGGCCAT CTTGGCTCTC 
ACCTTTGTGC CCTTGGACTT GCAGACCGTG AGGACAGTAT TGGCTGTGTT TGGGAAGGGA 
TGCCTATCCA GCTCCTTCAG CTGCCTCTTC CTCTACACAA GTGAATTATA CCCCACAGTC 
ATCAGGCAAA CAGGTATGGG CGTAAGTAAC CTGTGGACCC GCGTGGGAAG CATGGTGTCC 
CCGCTGGTGA AAATCACGGG TGAGGTACAG CCCTTCATCC CCAATATCAT CTACGGGATC 
ACCGCCCTCC TCGGGGGCAG TGCTGCCCTC TTCCTGCCTG AGACCCTGAA TCAGCCCTTG 
CCAGAGACTA TCGAAGACCT GGAAAACTGG TCCCTGCGGG CAAAGAAGCC AAAGCAGGAG 
CCAGAGGTGG AAAAGGCCTC CCAGAGGATC CCTCTACAGC CTCACGGACC AGGCCTGGGC 
TCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC22A8 ( XM_011545364.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543666.1 Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu09653
Clone ID Related Accession (Same CDS sequence)	XM_011545364.1 , NM_001184736.1
Accession Version	XM_011545364.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	solute carrier family 22 member 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCAGT CTATCTTCAT GGCAGGTATA CTGATTGGAG GGCTCGTGCT TGGAGACCTG 
TCTGACAGGT TTGGCCGCAG GCCCATCCTG ACCTGCAGCT ACCTGCTGCT GGCAGCCAGC 
GGCTCCGGTG CAGCCTTCAG CCCCACCTTC CCCATCTACA TGGTCTTCCG CTTCCTGTGT 
GGCTTTGGCA TCTCAGGCAT TACCCTGAGC ACCGTCATCT TGAATGTGGA ATGGGTGCCT 
ACCCGGATGC GGGCCATCAT GTCGACAGCA CTCGGGTACT GCTACACCTT TGGCCAGTTC 
ATTCTGCCCG GCCTGGCCTA CGCCATCCCC CAGTGGCGTT GGCTGCAGTT AACTGTGTCC 
ATTCCCTTCT TCGTCTTCTT CCTATCATCC TGGTGGACAC CAGAGTCCAT ACGCTGGTTG 
GTCTTGTCTG GAAAGTCCTC GAAGGCCCTG AAGATACTCC GGCGGGTGGC TGTCTTCAAT 
GGCAAGAAGG AAGAGGGAGA AAGGCTCAGC TTGGAGGAGC TCAAACTCAA CCTGCAGAAG 
GAGATCTCCT TGGCCAAGGC CAAGTACACC GCAAGTGACC TGTTCCGGAT ACCCATGCTG 
CGCCGCATGA CCTTCTGTCT TTCCCTGGCC TGGTTTGCTA CCGGTTTTGC CTACTATAGT 
TTGGCTATGG GTGTGGAAGA ATTTGGAGTC AACCTCTACA TCCTCCAGAT CATCTTTGGT 
GGGGTCGATG TCCCAGCCAA GTTCATCACC ATCCTCTCCT TAAGCTACCT GGGCCGGCAT 
ACCACTCAGG CCGCTGCCCT GCTCCTGGCA GGAGGGGCCA TCTTGGCTCT CACCTTTGTG 
CCCTTGGACT TGCAGACCGT GAGGACAGTA TTGGCTGTGT TTGGGAAGGG ATGCCTATCC 
AGCTCCTTCA GCTGCCTCTT CCTCTACACA AGTGAATTAT ACCCCACAGT CATCAGGCAA 
ACAGGTATGG GCGTAAGTAA CCTGTGGACC CGCGTGGGAA GCATGGTGTC CCCGCTGGTG 
AAAATCACGG GTGAGGTACA GCCCTTCATC CCCAATATCA TCTACGGGAT CACCGCCCTC 
CTCGGGGGCA GTGCTGCCCT CTTCCTGCCT GAGACCCTGA ATCAGCCCTT GCCAGAGACT 
ATCGAAGACC TGGAAAACTG GTCCCTGCGG GCAAAGAAGC CAAAGCAGGA GCCAGAGGTG 
GAAAAGGCCT CCCAGAGGAT CCCTCTACAG CCTCACGGAC CAGGCCTGGG CTCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543666.1
CDS	87..1346
Translation	MAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS

Target ORF information:

RefSeq Version	XM_011545364.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 22 member 8 (SLC22A8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545364.1

ORF Insert Sequence:

ATGGCCCAGT CTATCTTCAT GGCAGGTATA CTGATTGGAG GGCTCGTGCT TGGAGACCTG 
TCTGACAGGT TTGGCCGCAG GCCCATCCTG ACCTGCAGCT ACCTGCTGCT GGCAGCCAGC 
GGCTCCGGTG CAGCCTTCAG CCCCACCTTC CCCATCTACA TGGTCTTCCG CTTCCTGTGT 
GGCTTTGGCA TCTCAGGCAT TACCCTGAGC ACCGTCATCT TGAATGTGGA ATGGGTGCCT 
ACCCGGATGC GGGCCATCAT GTCGACAGCA CTCGGGTACT GCTACACCTT TGGCCAGTTC 
ATTCTGCCCG GCCTGGCCTA CGCCATCCCC CAGTGGCGTT GGCTGCAGTT AACTGTGTCC 
ATTCCCTTCT TCGTCTTCTT CCTATCATCC TGGTGGACAC CAGAGTCCAT ACGCTGGTTG 
GTCTTGTCTG GAAAGTCCTC GAAGGCCCTG AAGATACTCC GGCGGGTGGC TGTCTTCAAT 
GGCAAGAAGG AAGAGGGAGA AAGGCTCAGC TTGGAGGAGC TCAAACTCAA CCTGCAGAAG 
GAGATCTCCT TGGCCAAGGC CAAGTACACC GCAAGTGACC TGTTCCGGAT ACCCATGCTG 
CGCCGCATGA CCTTCTGTCT TTCCCTGGCC TGGTTTGCTA CCGGTTTTGC CTACTATAGT 
TTGGCTATGG GTGTGGAAGA ATTTGGAGTC AACCTCTACA TCCTCCAGAT CATCTTTGGT 
GGGGTCGATG TCCCAGCCAA GTTCATCACC ATCCTCTCCT TAAGCTACCT GGGCCGGCAT 
ACCACTCAGG CCGCTGCCCT GCTCCTGGCA GGAGGGGCCA TCTTGGCTCT CACCTTTGTG 
CCCTTGGACT TGCAGACCGT GAGGACAGTA TTGGCTGTGT TTGGGAAGGG ATGCCTATCC 
AGCTCCTTCA GCTGCCTCTT CCTCTACACA AGTGAATTAT ACCCCACAGT CATCAGGCAA 
ACAGGTATGG GCGTAAGTAA CCTGTGGACC CGCGTGGGAA GCATGGTGTC CCCGCTGGTG 
AAAATCACGG GTGAGGTACA GCCCTTCATC CCCAATATCA TCTACGGGAT CACCGCCCTC 
CTCGGGGGCA GTGCTGCCCT CTTCCTGCCT GAGACCCTGA ATCAGCCCTT GCCAGAGACT 
ATCGAAGACC TGGAAAACTG GTCCCTGCGG GCAAAGAAGC CAAAGCAGGA GCCAGAGGTG 
GAAAAGGCCT CCCAGAGGAT CCCTCTACAG CCTCACGGAC CAGGCCTGGG CTCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endogenous metabolites-mediated communication between OAT1/OAT3 and OATP1B1 may explain the association between SLCO1B1 SNPs and methotrexate toxicity.
Clinical pharmacology and therapeutics(2017 Dec)
Martinez D,Muhrez K,Woillard JB,Berthelot A,Gyan E,Choquet S,Andr?s CR,Marquet P,Barin-Le Guellec C

SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3.
Biopharmaceutics & drug disposition38(8)449-457(2017 Nov)
Wang H,You G

Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand M?ori and Pacific Men.
Arthritis & rheumatology (Hoboken, N.J.)69(7)1461-1469(2017 07)
Tanner C,Boocock J,Stahl EA,Dobbyn A,Mandal AK,Cadzow M,Phipps-Green AJ,Topless RK,Hindmarsh JH,Stamp LK,Dalbeth N,Choi HK,Mount DB,Merriman TR

Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.
Journal of vascular research54(3)170-179(2017)
Favretto G,Souza LM,Greg?rio PC,Cunha RS,Maciel RAP,Sassaki GL,Toledo MG,Pecoits-Filho R,Souza WM,Stinghen AEM

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SLC22A8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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