ORAI3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ORAI3
Entrez Gene ID	93129
Full Name	ORAI calcium release-activated calcium modulator 3
Synonyms	TMEM142C
General protein information	Preferred Names ORAI calcium release-activated calcium modulator 3 Names protein orai-3 transmembrane protein 142C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Disorder MIM:	610930

mRNA and Protein(s)

mRNA	Protein	Name
NM_152288.3	NP_689501.1	protein orai-3
NM_152288.2	NP_689501.1	protein orai-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ORAI3	XP_003315113.1
Canis lupus familiaris (dog)	ORAI3	XP_849021.1
Mus musculus (house mouse)	Orai3	NP_940816.1
	ORAI3	XP_001111639.1
Homo sapiens (human)	ORAI3	NP_689501.1
Rattus norvegicus (Norway rat)	Orai3	NP_001014046.1
Bos taurus (cattle)	ORAI3	NP_001180131.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005071	XP_001688479.1

Gene Ontology
Bibliography

Related articles in PubMed

Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection.
Hasna J, Hague F, Rodat-Despoix L, Geerts D, Leroy C, Tulasne D, Ouadid-Ahidouch H, Kischel P
Cell death and differentiation(2018 Jan)

Communication between N-terminus and Loop2 tunes Orai activation.
Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I
The Journal of biological chemistry(2017 Dec)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.
Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C
The Journal of biological chemistry(2017 Dec)

ORAI channels are critical for receptor-mediated endocytosis of albumin.
Zeng B, Chen GL, Garcia-Vaz E, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, Xu ZH, Nair V, Nelson RG, Ju W, Kretzler M, Atkin SL, Gomez MF, Xu SZ
Nature communications8(1)1920(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.

Overall high Orai3/Orai1 ratios in human prostate epithelial cells and androgen-insensitive cancer cells contribute to their ROS resistance and thereby may have a share in making the prostate one of the most prominent cancer susceptible organs
Title: Differential Redox Regulation of Ca?? Signaling and Viability in Normal and Malignant Prostate Cells.

Orai3 down-tunes efficient STIM1 gating when in a heteromeric complex with Orai1.
Title: Facilitation of Orai3 targeting and store-operated function by Orai1.

Suggest disrupted dynamic equilibrium of channel-forming ORAI proteins as an oncogenic mechanism in prostate cancer.
Title: Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer.

A channel chimera of Orai3 with the N terminus of Orai1 was able to couple local Ca(2+) entry to NFAT activation, identifying the N-terminal domain of Orai1 as central to Ca(2+) nanodomain-transcription coupling.
Title: Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.

The following ORAI3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORAI3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13559	NM_152288.2 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu107394	NM_152288.3 Latest version!	Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ORAI3 ( NM_152288.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_689501.1 Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3), mRNA.

Price & Availability↑

CloneID	OHu13559
Clone ID Related Accession (Same CDS sequence)	NM_152288.2
Accession Version	NM_152288.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein orai-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI561433.1, BC022786.1 and BC016150.1. On Dec 5, 2008 this sequence version replaced NM_152288.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015555.1, SRR1660803.90188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC 
CCTGCAGGCT CGGCCACGTA CCGGGAGTTC GTGCACCGCG GCTACCTGGA CCTCATGGGG 
GCCAGTCAGC ACTCGCTGCG GGCGCTCAGC TGGCGCCGCC TCTACCTCAG CCGGGCCAAG 
CTCAAAGCTT CCAGCCGCAC GTCTGCCTTG CTCTCGGGCT TCGCCATGGT GGCCATGGTG 
GAGGTGCAGC TGGAGAGTGA CCACGAGTAC CCACCAGGCC TGCTGGTGGC CTTCAGTGCC 
TGCACCACCG TGCTGGTGGC TGTGCACCTC TTTGCACTCA TGGTCTCCAC GTGTCTGCTG 
CCCCACATTG AAGCTGTGAG CAACATCCAC AACCTCAACT CTGTCCACCA GTCGCCACAC 
CAGAGACTGC ACCGCTACGT GGAGCTGGCC TGGGGCTTCT CCACTGCCCT GGGCACCTTT 
CTCTTCCTTG CTGAAGTTGT CCTGGTTGGT TGGGTCAAGT TTGTGCCCAT TGGGGCTCCC 
TTGGACACAC CGACCCCCAT GGTGCCCACA TCCCGGGTGC CCGGGACTCT GGCACCAGTG 
GCTACCTCCC TTAGTCCAGC TTCCAATCTC CCACGGTCCT CTGCGTCTGC AGCACCGTCC 
CAGGCTGAGC CAGCCTGCCC ACCCCGGCAA GCCTGTGGTG GTGGTGGGGC CCATGGGCCA 
GGCTGGCAAG CAGCCATGGC CTCCACAGCC ATCATGGTAC CCGTGGGGCT CGTGTTTGTG 
GCCTTTGCCC TGCATTTCTA CCGCTCCTTG GTGGCACACA AGACAGACCG CTACAAGCAG 
GAACTAGAGG AACTGAATCG CCTGCAGGGG GAGCTGCAGG CTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689501.1
CDS	207..1094
Translation	MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV

Target ORF information:

RefSeq Version	NM_152288.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152288.2

ORF Insert Sequence:

ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC 
CCTGCAGGCT CGGCCACGTA CCGGGAGTTC GTGCACCGCG GCTACCTGGA CCTCATGGGG 
GCCAGTCAGC ACTCGCTGCG GGCGCTCAGC TGGCGCCGCC TCTACCTCAG CCGGGCCAAG 
CTCAAAGCTT CCAGCCGCAC GTCTGCCTTG CTCTCGGGCT TCGCCATGGT GGCCATGGTG 
GAGGTGCAGC TGGAGAGTGA CCACGAGTAC CCACCAGGCC TGCTGGTGGC CTTCAGTGCC 
TGCACCACCG TGCTGGTGGC TGTGCACCTC TTTGCACTCA TGGTCTCCAC GTGTCTGCTG 
CCCCACATTG AAGCTGTGAG CAACATCCAC AACCTCAACT CTGTCCACCA GTCGCCACAC 
CAGAGACTGC ACCGCTACGT GGAGCTGGCC TGGGGCTTCT CCACTGCCCT GGGCACCTTT 
CTCTTCCTTG CTGAAGTTGT CCTGGTTGGT TGGGTCAAGT TTGTGCCCAT TGGGGCTCCC 
TTGGACACAC CGACCCCCAT GGTGCCCACA TCCCGGGTGC CCGGGACTCT GGCACCAGTG 
GCTACCTCCC TTAGTCCAGC TTCCAATCTC CCACGGTCCT CTGCGTCTGC AGCACCGTCC 
CAGGCTGAGC CAGCCTGCCC ACCCCGGCAA GCCTGTGGTG GTGGTGGGGC CCATGGGCCA 
GGCTGGCAAG CAGCCATGGC CTCCACAGCC ATCATGGTAC CCGTGGGGCT CGTGTTTGTG 
GCCTTTGCCC TGCATTTCTA CCGCTCCTTG GTGGCACACA AGACAGACCG CTACAAGCAG 
GAACTAGAGG AACTGAATCG CCTGCAGGGG GAGCTGCAGG CTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORAI3 ( NM_152288.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689501.1 Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3), mRNA.

Price & Availability↑

CloneID	OHu107394
Clone ID Related Accession (Same CDS sequence)	NM_152288.3
Accession Version	NM_152288.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	protein orai-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC135048.2. On Nov 23, 2018 this sequence version replaced NM_152288.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015555.1, SRR1660807.216679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000318663.5/ ENSP00000322249.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC 
CCTGCAGGCT CGGCCACGTA CCGGGAGTTC GTGCACCGCG GCTACCTGGA CCTCATGGGG 
GCCAGTCAGC ACTCGCTGCG GGCGCTCAGC TGGCGCCGCC TCTACCTCAG CCGGGCCAAG 
CTCAAAGCTT CCAGCCGCAC GTCTGCCTTG CTCTCGGGCT TCGCCATGGT GGCCATGGTG 
GAGGTGCAGC TGGAGAGTGA CCACGAGTAC CCACCAGGCC TGCTGGTGGC CTTCAGTGCC 
TGCACCACCG TGCTGGTGGC TGTGCACCTC TTTGCACTCA TGGTCTCCAC GTGTCTGCTG 
CCCCACATTG AAGCTGTGAG CAACATCCAC AACCTCAACT CTGTCCACCA GTCGCCACAC 
CAGAGACTGC ACCGCTACGT GGAGCTGGCC TGGGGCTTCT CCACTGCCCT GGGCACCTTT 
CTCTTCCTTG CTGAAGTTGT CCTGGTTGGT TGGGTCAAGT TTGTGCCCAT TGGGGCTCCC 
TTGGACACAC CGACCCCCAT GGTGCCCACA TCCCGGGTGC CCGGGACTCT GGCACCAGTG 
GCTACCTCCC TTAGTCCAGC TTCCAATCTC CCACGGTCCT CTGCGTCTGC AGCACCGTCC 
CAAGCTGAGC CAGCCTGCCC ACCCCGGCAA GCCTGTGGTG GTGGTGGGGC CCATGGGCCA 
GGCTGGCAAG CAGCCATGGC CTCCACAGCC ATCATGGTAC CCGTGGGGCT CGTGTTTGTG 
GCCTTTGCCC TGCATTTCTA CCGCTCCTTG GTGGCACACA AGACAGACCG CTACAAGCAG 
GAACTAGAGG AACTGAATCG CCTGCAGGGG GAGCTGCAGG CTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689501.1
CDS	223..1110
Translation	MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV

Target ORF information:

RefSeq Version	NM_152288.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152288.3

ORF Insert Sequence:

ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC 
CCTGCAGGCT CGGCCACGTA CCGGGAGTTC GTGCACCGCG GCTACCTGGA CCTCATGGGG 
GCCAGTCAGC ACTCGCTGCG GGCGCTCAGC TGGCGCCGCC TCTACCTCAG CCGGGCCAAG 
CTCAAAGCTT CCAGCCGCAC GTCTGCCTTG CTCTCGGGCT TCGCCATGGT GGCCATGGTG 
GAGGTGCAGC TGGAGAGTGA CCACGAGTAC CCACCAGGCC TGCTGGTGGC CTTCAGTGCC 
TGCACCACCG TGCTGGTGGC TGTGCACCTC TTTGCACTCA TGGTCTCCAC GTGTCTGCTG 
CCCCACATTG AAGCTGTGAG CAACATCCAC AACCTCAACT CTGTCCACCA GTCGCCACAC 
CAGAGACTGC ACCGCTACGT GGAGCTGGCC TGGGGCTTCT CCACTGCCCT GGGCACCTTT 
CTCTTCCTTG CTGAAGTTGT CCTGGTTGGT TGGGTCAAGT TTGTGCCCAT TGGGGCTCCC 
TTGGACACAC CGACCCCCAT GGTGCCCACA TCCCGGGTGC CCGGGACTCT GGCACCAGTG 
GCTACCTCCC TTAGTCCAGC TTCCAATCTC CCACGGTCCT CTGCGTCTGC AGCACCGTCC 
CAAGCTGAGC CAGCCTGCCC ACCCCGGCAA GCCTGTGGTG GTGGTGGGGC CCATGGGCCA 
GGCTGGCAAG CAGCCATGGC CTCCACAGCC ATCATGGTAC CCGTGGGGCT CGTGTTTGTG 
GCCTTTGCCC TGCATTTCTA CCGCTCCTTG GTGGCACACA AGACAGACCG CTACAAGCAG 
GAACTAGAGG AACTGAATCG CCTGCAGGGG GAGCTGCAGG CTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection.
Cell death and differentiation(2018 Jan)
Hasna J,Hague F,Rodat-Despoix L,Geerts D,Leroy C,Tulasne D,Ouadid-Ahidouch H,Kischel P

Communication between N-terminus and Loop2 tunes Orai activation.
The Journal of biological chemistry(2017 Dec)
Fahrner M,Pandey SK,Muik M,Traxler L,Butorac C,Stadlbauer M,Zayats V,Krizova A,Plenk P,Frischauf I,Schindl R,Gruber HJ,Hinterdorfer P,Ettrich R,Romanin C,Derler I

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.
The Journal of biological chemistry(2017 Dec)
Derler I,Butorac C,Krizova A,Stadlbauer M,Muik M,Fahrner M,Frischauf I,Romanin C

ORAI channels are critical for receptor-mediated endocytosis of albumin.
Nature communications8(1)1920(2017 Dec)
Zeng B,Chen GL,Garcia-Vaz E,Bhandari S,Daskoulidou N,Berglund LM,Jiang H,Hallett T,Zhou LP,Huang L,Xu ZH,Nair V,Nelson RG,Ju W,Kretzler M,Atkin SL,Gomez MF,Xu SZ

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

ORAI3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報