KCNB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNB2
Entrez Gene ID	9312
Full Name	potassium voltage-gated channel subfamily B member 2
Synonyms	KV2.2
General protein information	Preferred Names potassium voltage-gated channel subfamily B member 2 Names potassium voltage-gated channel subfamily B member 2 delayed rectifier potassium channel protein potassium channel Kv2.2 potassium channel, voltage gated Shab related subfamily B, member 2 potassium voltage-gated channel, Shab-related subfamily, member 2 voltage-gated potassium channel subunit Kv2.2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.11
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	607738

mRNA and Protein(s)

mRNA	Protein	Name
XM_017013981.1	XP_016869470.1	potassium voltage-gated channel subfamily B member 2 isoform X1
NM_004770.3	NP_004761.2	potassium voltage-gated channel subfamily B member 2
XM_017013982.1	XP_016869471.1	potassium voltage-gated channel subfamily B member 2 isoform X1
NM_004770.2	NP_004761.2	potassium voltage-gated channel subfamily B member 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNB2	NP_004761.2
Danio rerio (zebrafish)	LOC566883	XP_695259.4
	KCNB2	XP_001083422.1
Rattus norvegicus (Norway rat)	Kcnb2	NP_446452.2
Gallus gallus (chicken)	KCNB2	XP_003640873.1
Xenopus tropicalis (tropical clawed frog)	kcnb2	XP_002937117.2
Pan troglodytes (chimpanzee)	KCNB2	XP_528164.2
Canis lupus familiaris (dog)	KCNB2	NP_001003247.1
Bos taurus (cattle)	KCNB2	NP_001019734.1
Mus musculus (house mouse)	Kcnb2	NP_001091998.1

Gene Ontology
Bibliography

Related articles in PubMed

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human ?-Cell Dysfunction.
Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE
Diabetes66(7)1890-1900(2017 07)

Pore size matters for potassium channel conductance.
Naranjo D, Moldenhauer H, Pincuntureo M, D?az-Franulic I
The Journal of general physiology148(4)277-91(2016 Oct)

Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome.
Juang JM, Lu TP, Lai LC, Ho CC, Liu YB, Tsai CT, Lin LY, Yu CC, Chen WJ, Chiang FT, Yeh SF, Lai LP, Chuang EY, Lin JL
Scientific reports46733(2014 Oct)

Genome-wide association studies of maximum number of drinks.
Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, Wang W, Zuo L, Wang KS
Journal of psychiatric research47(11)1717-24(2013 Nov)

Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.
Hristov KL, Chen M, Afeli SA, Cheng Q, Rovner ES, Petkov GV
American journal of physiology. Cell physiology302(11)C1599-608(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kv2.1, but not Kv2.2 (KCNB2), forms clusters of 6-12 tetrameric channels at the plasma membrane and facilitates insulin exocytosis
Title: Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human ?-Cell Dysfunction.

Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three Brugada syndrome patients
Title: Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome.

The rs2128158 in KCNB2 showed significant associations with MaxDrinks.
Title: Genome-wide association studies of maximum number of drinks.

stromatoxin-1 -sensitive KV2-containing channels are expressed in detrusor smooth muscle (DSM); they control DSM excitability, intracellular Ca2+ levels, and myogenic and nerve-evoked contractions
Title: Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following KCNB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu98289	XM_017013982.1 Latest version!	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$391.30 $559.00
OHu98289	XM_017013981.1 Latest version!	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$391.30 $559.00
OHu25595	NM_004770.3 Latest version!	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$643.30 $919.00
View Old Accession Versions >>
OHu25595	NM_004770.2	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$643.30 $919.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNB2 ( XM_017013981.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016869470.1 Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu98289
Clone ID Related Accession (Same CDS sequence)	XM_017013981.1 , XM_017013982.1
Accession Version	XM_017013981.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily B member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTACC TTTTGCGATT CTTATCCTCA CCAAATAAAT GGAAGTTCTT CAAAGGCCCA 
CTGAATGTCA TTGATTTGCT GGCCATCTTG CCGTACTATG TCACCATTTT TCTGACGGAG 
TCCAACAAGA GCGTGCTGCA GTTCCAAAAC GTGAGGCGCG TGGTCCAGAT CTTCCGAATC 
ATGCGCATCC TCAGGATCCT GAAACTCGCC AGGCATTCGA CAGGCCTGCA GTCTCTGGGT 
TTCACCCTTA GGCGGAGTTA CAATGAATTG GGCTTGTTGA TATTGTTTCT GGCCATGGGG 
ATAATGATAT TTTCCAGCCT GGTATTTTTT GCTGAGAAGG ATGAAGATGC TACCAAGTTC 
ACCAGTATCC CTGCATCATT TTGGTGGGCC ACCATCACCA TGACCACTGT TGGCTATGGT 
GACATTTACC CTAAAACATT ACTAGGGAAA ATTGTGGGAG GTCTGTGCTG TATTGCTGGG 
GTTCTGGTTA TTGCCCTTCC TATCCCAATT ATTGTGAACA ATTTTTCTGA GTTTTACAAG 
GAGCAGAAAC GCCAAGAGAA AGCAATTAAA AGGAGGGAGG CTCTTGAGCG GGCCAAAAGG 
AACGGAAGCA TCGTTTCTAT GAACTTAAAA GATGCCTTCG CTCGAAGTAT GGAACTGATA 
GATGTGGCTG TTGAGAAGGC CGGAGAGTCC GCCAACACAA AGGACTCCGC CGACGATAAT 
CACCTGTCGC CAAGCCGGTG GAAGTGGGCC AGGAAGGCTC TGTCGGAAAC AAGCTCCAAC 
AAGTCTTTCG AGAATAAGTA CCAGGAGGTT AGCCAAAAAG ACTCCCACGA GCAGCTGAAC 
AACACGTCTT CCTCCAGCCC ACAGCATCTG AGTGCCCAGA AACTGGAGAT GCTATACAAT 
GAAATCACCA AGACACAGCC TCATTCTCAC CCAAACCCAG ACTGCCAAGA AAAGCCTGAG 
AGGCCATCTG CATATGAAGA AGAGATTGAA ATGGAAGAAG TGGTGTGTCC ACAGGAGCAG 
CTGGCCGTGG CACAGACCGA GGTCATTGTG GACATGAAGA GCACCTCCAG CATCGACAGC 
TTCACCAGCT GTGCCACCGA CTTCACAGAG ACAGAGAGAT CGCCGCTGCC GCCGCCCTCC 
GCCTCTCACT TGCAGATGAA GTTCCCAACC GACCTCCCAG GGACAGAAGA GCACCAAAGA 
GCTAGGGGCC CCCCGTTTCT AACTCTATCC AGAGAGAAAG GACCTGCTGC CAGGGATGGC 
ACGCTGGAGT ATGCCCCAGT TGACATAACT GTGAACCTCG ATGCCAGTGG CTCCCAGTGT 
GGGCTACATA GTCCTTTGCA GTCTGACAAT GCCACCGACA GTCCTAAGAG CTCTCTAAAA 
GGCAGCAACC CACTAAAGTC CAGATCCCTC AAAGTGAACT TTAAGGAAAA TAGAGGCAGT 
GCACCACAGA CCCCGCCCAG CACAGCCAGG CCACTGCCAG TCACCACAGC TGACTTTTCG 
CTCACTACCC CGCAGCACAT CAGTACCATC CTCTTAGAAG AAACCCCCTC CCAGGGAGAC 
AGACCCTTGC TGGGCACTGA GGTTTCAGCG CCTTGTCAGG GACCTTCCAA AGGGCTGTCC 
CCCAGGTTTC CCAAGCAGAA ACTGTTCCCT TTCTCTTCAA GAGAGAGGAG GAGCTTCACT 
GAAATAGATA CTGGTGACGA CGAAGACTTC TTAGAGCTCC CAGGGGCAAG GGAGGAGAAG 
CAGGTGGACT CCAGCCCAAA TTGCTTTGCA GATAAGCCTA GTGATGGGAG AGACCCTTTA 
AGAGAAGAGG GCAGTGTGGG CTCTTCCTCC CCGCAGGACA CAGGTCACAA CTGTAGGCAA 
GACATTTACC ATGCTGTGAG TGAAGTCAAA AAGGACAGTA GTCAAGAAGG GTGCAAGATG 
GAAAATCACT TGTTTGCCCC AGAAATTCAT TCCAACCCAG GAGACACAGG TTATTGTCCC 
ACACGTGAAA CCAGCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016869470.1
CDS	1302..3302
Translation	MEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM

Target ORF information:

RefSeq Version	XM_017013981.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013981.1

ORF Insert Sequence:

ATGGAGTACC TTTTGCGATT CTTATCCTCA CCAAATAAAT GGAAGTTCTT CAAAGGCCCA 
CTGAATGTCA TTGATTTGCT GGCCATCTTG CCGTACTATG TCACCATTTT TCTGACGGAG 
TCCAACAAGA GCGTGCTGCA GTTCCAAAAC GTGAGGCGCG TGGTCCAGAT CTTCCGAATC 
ATGCGCATCC TCAGGATCCT GAAACTCGCC AGGCATTCGA CAGGCCTGCA GTCTCTGGGT 
TTCACCCTTA GGCGGAGTTA CAATGAATTG GGCTTGTTGA TATTGTTTCT GGCCATGGGG 
ATAATGATAT TTTCCAGCCT GGTATTTTTT GCTGAGAAGG ATGAAGATGC TACCAAGTTC 
ACCAGTATCC CTGCATCATT TTGGTGGGCC ACCATCACCA TGACCACTGT TGGCTATGGT 
GACATTTACC CTAAAACATT ACTAGGGAAA ATTGTGGGAG GTCTGTGCTG TATTGCTGGG 
GTTCTGGTTA TTGCCCTTCC TATCCCAATT ATTGTGAACA ATTTTTCTGA GTTTTACAAG 
GAGCAGAAAC GCCAAGAGAA AGCAATTAAA AGGAGGGAGG CTCTTGAGCG GGCCAAAAGG 
AACGGAAGCA TCGTTTCTAT GAACTTAAAA GATGCCTTCG CTCGAAGTAT GGAACTGATA 
GATGTGGCTG TTGAGAAGGC CGGAGAGTCC GCCAACACAA AGGACTCCGC CGACGATAAT 
CACCTGTCGC CAAGCCGGTG GAAGTGGGCC AGGAAGGCTC TGTCGGAAAC AAGCTCCAAC 
AAGTCTTTCG AGAATAAGTA CCAGGAGGTT AGCCAAAAAG ACTCCCACGA GCAGCTGAAC 
AACACGTCTT CCTCCAGCCC ACAGCATCTG AGTGCCCAGA AACTGGAGAT GCTATACAAT 
GAAATCACCA AGACACAGCC TCATTCTCAC CCAAACCCAG ACTGCCAAGA AAAGCCTGAG 
AGGCCATCTG CATATGAAGA AGAGATTGAA ATGGAAGAAG TGGTGTGTCC ACAGGAGCAG 
CTGGCCGTGG CACAGACCGA GGTCATTGTG GACATGAAGA GCACCTCCAG CATCGACAGC 
TTCACCAGCT GTGCCACCGA CTTCACAGAG ACAGAGAGAT CGCCGCTGCC GCCGCCCTCC 
GCCTCTCACT TGCAGATGAA GTTCCCAACC GACCTCCCAG GGACAGAAGA GCACCAAAGA 
GCTAGGGGCC CCCCGTTTCT AACTCTATCC AGAGAGAAAG GACCTGCTGC CAGGGATGGC 
ACGCTGGAGT ATGCCCCAGT TGACATAACT GTGAACCTCG ATGCCAGTGG CTCCCAGTGT 
GGGCTACATA GTCCTTTGCA GTCTGACAAT GCCACCGACA GTCCTAAGAG CTCTCTAAAA 
GGCAGCAACC CACTAAAGTC CAGATCCCTC AAAGTGAACT TTAAGGAAAA TAGAGGCAGT 
GCACCACAGA CCCCGCCCAG CACAGCCAGG CCACTGCCAG TCACCACAGC TGACTTTTCG 
CTCACTACCC CGCAGCACAT CAGTACCATC CTCTTAGAAG AAACCCCCTC CCAGGGAGAC 
AGACCCTTGC TGGGCACTGA GGTTTCAGCG CCTTGTCAGG GACCTTCCAA AGGGCTGTCC 
CCCAGGTTTC CCAAGCAGAA ACTGTTCCCT TTCTCTTCAA GAGAGAGGAG GAGCTTCACT 
GAAATAGATA CTGGTGACGA CGAAGACTTC TTAGAGCTCC CAGGGGCAAG GGAGGAGAAG 
CAGGTGGACT CCAGCCCAAA TTGCTTTGCA GATAAGCCTA GTGATGGGAG AGACCCTTTA 
AGAGAAGAGG GCAGTGTGGG CTCTTCCTCC CCGCAGGACA CAGGTCACAA CTGTAGGCAA 
GACATTTACC ATGCTGTGAG TGAAGTCAAA AAGGACAGTA GTCAAGAAGG GTGCAAGATG 
GAAAATCACT TGTTTGCCCC AGAAATTCAT TCCAACCCAG GAGACACAGG TTATTGTCCC 
ACACGTGAAA CCAGCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNB2 ( XM_017013982.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016869471.1 Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu98289
Clone ID Related Accession (Same CDS sequence)	XM_017013981.1 , XM_017013982.1
Accession Version	XM_017013982.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily B member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTACC TTTTGCGATT CTTATCCTCA CCAAATAAAT GGAAGTTCTT CAAAGGCCCA 
CTGAATGTCA TTGATTTGCT GGCCATCTTG CCGTACTATG TCACCATTTT TCTGACGGAG 
TCCAACAAGA GCGTGCTGCA GTTCCAAAAC GTGAGGCGCG TGGTCCAGAT CTTCCGAATC 
ATGCGCATCC TCAGGATCCT GAAACTCGCC AGGCATTCGA CAGGCCTGCA GTCTCTGGGT 
TTCACCCTTA GGCGGAGTTA CAATGAATTG GGCTTGTTGA TATTGTTTCT GGCCATGGGG 
ATAATGATAT TTTCCAGCCT GGTATTTTTT GCTGAGAAGG ATGAAGATGC TACCAAGTTC 
ACCAGTATCC CTGCATCATT TTGGTGGGCC ACCATCACCA TGACCACTGT TGGCTATGGT 
GACATTTACC CTAAAACATT ACTAGGGAAA ATTGTGGGAG GTCTGTGCTG TATTGCTGGG 
GTTCTGGTTA TTGCCCTTCC TATCCCAATT ATTGTGAACA ATTTTTCTGA GTTTTACAAG 
GAGCAGAAAC GCCAAGAGAA AGCAATTAAA AGGAGGGAGG CTCTTGAGCG GGCCAAAAGG 
AACGGAAGCA TCGTTTCTAT GAACTTAAAA GATGCCTTCG CTCGAAGTAT GGAACTGATA 
GATGTGGCTG TTGAGAAGGC CGGAGAGTCC GCCAACACAA AGGACTCCGC CGACGATAAT 
CACCTGTCGC CAAGCCGGTG GAAGTGGGCC AGGAAGGCTC TGTCGGAAAC AAGCTCCAAC 
AAGTCTTTCG AGAATAAGTA CCAGGAGGTT AGCCAAAAAG ACTCCCACGA GCAGCTGAAC 
AACACGTCTT CCTCCAGCCC ACAGCATCTG AGTGCCCAGA AACTGGAGAT GCTATACAAT 
GAAATCACCA AGACACAGCC TCATTCTCAC CCAAACCCAG ACTGCCAAGA AAAGCCTGAG 
AGGCCATCTG CATATGAAGA AGAGATTGAA ATGGAAGAAG TGGTGTGTCC ACAGGAGCAG 
CTGGCCGTGG CACAGACCGA GGTCATTGTG GACATGAAGA GCACCTCCAG CATCGACAGC 
TTCACCAGCT GTGCCACCGA CTTCACAGAG ACAGAGAGAT CGCCGCTGCC GCCGCCCTCC 
GCCTCTCACT TGCAGATGAA GTTCCCAACC GACCTCCCAG GGACAGAAGA GCACCAAAGA 
GCTAGGGGCC CCCCGTTTCT AACTCTATCC AGAGAGAAAG GACCTGCTGC CAGGGATGGC 
ACGCTGGAGT ATGCCCCAGT TGACATAACT GTGAACCTCG ATGCCAGTGG CTCCCAGTGT 
GGGCTACATA GTCCTTTGCA GTCTGACAAT GCCACCGACA GTCCTAAGAG CTCTCTAAAA 
GGCAGCAACC CACTAAAGTC CAGATCCCTC AAAGTGAACT TTAAGGAAAA TAGAGGCAGT 
GCACCACAGA CCCCGCCCAG CACAGCCAGG CCACTGCCAG TCACCACAGC TGACTTTTCG 
CTCACTACCC CGCAGCACAT CAGTACCATC CTCTTAGAAG AAACCCCCTC CCAGGGAGAC 
AGACCCTTGC TGGGCACTGA GGTTTCAGCG CCTTGTCAGG GACCTTCCAA AGGGCTGTCC 
CCCAGGTTTC CCAAGCAGAA ACTGTTCCCT TTCTCTTCAA GAGAGAGGAG GAGCTTCACT 
GAAATAGATA CTGGTGACGA CGAAGACTTC TTAGAGCTCC CAGGGGCAAG GGAGGAGAAG 
CAGGTGGACT CCAGCCCAAA TTGCTTTGCA GATAAGCCTA GTGATGGGAG AGACCCTTTA 
AGAGAAGAGG GCAGTGTGGG CTCTTCCTCC CCGCAGGACA CAGGTCACAA CTGTAGGCAA 
GACATTTACC ATGCTGTGAG TGAAGTCAAA AAGGACAGTA GTCAAGAAGG GTGCAAGATG 
GAAAATCACT TGTTTGCCCC AGAAATTCAT TCCAACCCAG GAGACACAGG TTATTGTCCC 
ACACGTGAAA CCAGCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016869471.1
CDS	434..2434
Translation	MEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM

Target ORF information:

RefSeq Version	XM_017013982.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013982.1

ORF Insert Sequence:

ATGGAGTACC TTTTGCGATT CTTATCCTCA CCAAATAAAT GGAAGTTCTT CAAAGGCCCA 
CTGAATGTCA TTGATTTGCT GGCCATCTTG CCGTACTATG TCACCATTTT TCTGACGGAG 
TCCAACAAGA GCGTGCTGCA GTTCCAAAAC GTGAGGCGCG TGGTCCAGAT CTTCCGAATC 
ATGCGCATCC TCAGGATCCT GAAACTCGCC AGGCATTCGA CAGGCCTGCA GTCTCTGGGT 
TTCACCCTTA GGCGGAGTTA CAATGAATTG GGCTTGTTGA TATTGTTTCT GGCCATGGGG 
ATAATGATAT TTTCCAGCCT GGTATTTTTT GCTGAGAAGG ATGAAGATGC TACCAAGTTC 
ACCAGTATCC CTGCATCATT TTGGTGGGCC ACCATCACCA TGACCACTGT TGGCTATGGT 
GACATTTACC CTAAAACATT ACTAGGGAAA ATTGTGGGAG GTCTGTGCTG TATTGCTGGG 
GTTCTGGTTA TTGCCCTTCC TATCCCAATT ATTGTGAACA ATTTTTCTGA GTTTTACAAG 
GAGCAGAAAC GCCAAGAGAA AGCAATTAAA AGGAGGGAGG CTCTTGAGCG GGCCAAAAGG 
AACGGAAGCA TCGTTTCTAT GAACTTAAAA GATGCCTTCG CTCGAAGTAT GGAACTGATA 
GATGTGGCTG TTGAGAAGGC CGGAGAGTCC GCCAACACAA AGGACTCCGC CGACGATAAT 
CACCTGTCGC CAAGCCGGTG GAAGTGGGCC AGGAAGGCTC TGTCGGAAAC AAGCTCCAAC 
AAGTCTTTCG AGAATAAGTA CCAGGAGGTT AGCCAAAAAG ACTCCCACGA GCAGCTGAAC 
AACACGTCTT CCTCCAGCCC ACAGCATCTG AGTGCCCAGA AACTGGAGAT GCTATACAAT 
GAAATCACCA AGACACAGCC TCATTCTCAC CCAAACCCAG ACTGCCAAGA AAAGCCTGAG 
AGGCCATCTG CATATGAAGA AGAGATTGAA ATGGAAGAAG TGGTGTGTCC ACAGGAGCAG 
CTGGCCGTGG CACAGACCGA GGTCATTGTG GACATGAAGA GCACCTCCAG CATCGACAGC 
TTCACCAGCT GTGCCACCGA CTTCACAGAG ACAGAGAGAT CGCCGCTGCC GCCGCCCTCC 
GCCTCTCACT TGCAGATGAA GTTCCCAACC GACCTCCCAG GGACAGAAGA GCACCAAAGA 
GCTAGGGGCC CCCCGTTTCT AACTCTATCC AGAGAGAAAG GACCTGCTGC CAGGGATGGC 
ACGCTGGAGT ATGCCCCAGT TGACATAACT GTGAACCTCG ATGCCAGTGG CTCCCAGTGT 
GGGCTACATA GTCCTTTGCA GTCTGACAAT GCCACCGACA GTCCTAAGAG CTCTCTAAAA 
GGCAGCAACC CACTAAAGTC CAGATCCCTC AAAGTGAACT TTAAGGAAAA TAGAGGCAGT 
GCACCACAGA CCCCGCCCAG CACAGCCAGG CCACTGCCAG TCACCACAGC TGACTTTTCG 
CTCACTACCC CGCAGCACAT CAGTACCATC CTCTTAGAAG AAACCCCCTC CCAGGGAGAC 
AGACCCTTGC TGGGCACTGA GGTTTCAGCG CCTTGTCAGG GACCTTCCAA AGGGCTGTCC 
CCCAGGTTTC CCAAGCAGAA ACTGTTCCCT TTCTCTTCAA GAGAGAGGAG GAGCTTCACT 
GAAATAGATA CTGGTGACGA CGAAGACTTC TTAGAGCTCC CAGGGGCAAG GGAGGAGAAG 
CAGGTGGACT CCAGCCCAAA TTGCTTTGCA GATAAGCCTA GTGATGGGAG AGACCCTTTA 
AGAGAAGAGG GCAGTGTGGG CTCTTCCTCC CCGCAGGACA CAGGTCACAA CTGTAGGCAA 
GACATTTACC ATGCTGTGAG TGAAGTCAAA AAGGACAGTA GTCAAGAAGG GTGCAAGATG 
GAAAATCACT TGTTTGCCCC AGAAATTCAT TCCAACCCAG GAGACACAGG TTATTGTCCC 
ACACGTGAAA CCAGCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNB2 ( NM_004770.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004761.2 Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA.

Price & Availability↑

CloneID	OHu25595
Clone ID Related Accession (Same CDS sequence)	NM_004770.3 , NM_004770.2
Accession Version	NM_004770.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily B member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011131.6 and AC022893.6. On Nov 26, 2018 this sequence version replaced NM_004770.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF338730.1, SRR1660803.155026.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000523207.2/ ENSP00000430846.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGAAA AGGCTCCCCC GGGCTTAAAC AGGAAGACTT CAAGGTCGAC ACTTTCCCTT 
CCTCCAGAGC CTGTGGACAT TATCCGGAGC AAAACATGCT CCAGGAGAGT TAAGATCAAT 
GTGGGGGGCC TCAACCACGA AGTCCTGTGG AGAACGCTGG ACAGGCTGCC CAGGACGCGC 
CTGGGGAAGC TTCGAGACTG CAACACACAC GAGAGCCTCC TGGAAGTGTG CGACGACTAT 
AATCTGAACG AGAACGAGTA TTTCTTTGAT CGGCATCCAG GAGCCTTCAC TTCCATTTTA 
AATTTCTACC GGACCGGGAA ACTCCATATG ATGGAAGAAA TGTGTGCACT TTCGTTTGGC 
CAAGAACTTG ATTACTGGGG GATTGATGAG ATCTACTTGG AGTCCTGCTG CCAGGCCAGA 
TATCATCAAA AAAAAGAACA AATGAACGAA GAACTGAGGC GAGAGGCAGA GACTATGCGA 
GAGCGAGAAG GAGAAGAGTT TGATAATACC TGCTGCCCTG ATAAAAGGAA GAAACTGTGG 
GACTTGCTGG AGAAACCTAA CTCATCAGTG GCTGCAAAGA TCCTGGCCAT CGTGTCTATC 
CTGTTCATTG TGCTTTCCAC CATTGCTTTG TCTCTCAATA CGCTGCCGGA GCTGCAGGAA 
ACGGACGAAT TTGGACAACT CAATGACAAC CGCCAATTAG CACACGTGGA GGCTGTGTGT 
ATTGCATGGT TTACCATGGA GTACCTTTTG CGATTCTTAT CCTCACCAAA TAAATGGAAG 
TTCTTCAAAG GCCCACTGAA TGTCATTGAT TTGCTGGCCA TCTTGCCGTA CTATGTCACC 
ATTTTTCTGA CGGAGTCCAA CAAGAGCGTG CTGCAGTTCC AAAACGTGAG GCGCGTGGTC 
CAGATCTTCC GAATCATGCG CATCCTCAGG ATCCTGAAAC TCGCCAGGCA TTCGACAGGC 
CTGCAGTCTC TGGGTTTCAC CCTTAGGCGG AGTTACAATG AATTGGGCTT GTTGATATTG 
TTTCTGGCCA TGGGGATAAT GATATTTTCC AGCCTGGTAT TTTTTGCTGA GAAGGATGAA 
GATGCTACCA AGTTCACCAG TATCCCTGCA TCATTTTGGT GGGCCACCAT CACCATGACC 
ACTGTTGGCT ATGGTGACAT TTACCCTAAA ACATTACTAG GGAAAATTGT GGGAGGTCTG 
TGCTGTATTG CTGGGGTTCT GGTTATTGCC CTTCCTATCC CAATTATTGT GAACAATTTT 
TCTGAGTTTT ACAAGGAGCA GAAACGCCAA GAGAAAGCAA TTAAAAGGAG GGAGGCTCTT 
GAGCGGGCCA AAAGGAACGG AAGCATCGTT TCTATGAACT TAAAAGATGC CTTCGCTCGA 
AGTATGGAAC TGATAGATGT GGCTGTTGAG AAGGCCGGAG AGTCCGCCAA CACAAAGGAC 
TCCGCCGACG ATAATCACCT GTCGCCAAGC CGGTGGAAGT GGGCCAGGAA GGCTCTGTCG 
GAAACAAGCT CCAACAAGTC TTTCGAGAAT AAGTACCAGG AGGTTAGCCA AAAAGACTCC 
CACGAGCAGC TGAACAACAC GTCTTCCTCC AGCCCACAGC ATCTGAGTGC CCAGAAACTG 
GAGATGCTAT ACAATGAAAT CACCAAGACA CAGCCTCATT CTCACCCAAA CCCAGACTGC 
CAAGAAAAGC CTGAGAGGCC ATCTGCATAT GAAGAAGAGA TTGAAATGGA AGAAGTGGTG 
TGTCCACAGG AGCAGCTGGC CGTGGCACAG ACCGAGGTCA TTGTGGACAT GAAGAGCACC 
TCCAGCATCG ACAGCTTCAC CAGCTGTGCC ACCGACTTCA CAGAGACAGA GAGATCGCCG 
CTGCCGCCGC CCTCCGCCTC TCACTTGCAG ATGAAGTTCC CAACCGACCT CCCAGGGACA 
GAAGAGCACC AAAGAGCTAG GGGCCCCCCG TTTCTAACTC TATCCAGAGA GAAAGGACCT 
GCTGCCAGGG ATGGCACGCT GGAGTATGCC CCAGTTGACA TAACTGTGAA CCTCGATGCC 
AGTGGCTCCC AGTGTGGGCT ACATAGTCCT TTGCAGTCTG ACAATGCCAC CGACAGTCCT 
AAGAGCTCTC TAAAAGGCAG CAACCCACTA AAGTCCAGAT CCCTCAAAGT GAACTTTAAG 
GAAAATAGAG GCAGTGCACC ACAGACCCCG CCCAGCACAG CCAGGCCACT GCCAGTCACC 
ACAGCTGACT TTTCGCTCAC TACCCCGCAG CACATCAGTA CCATCCTCTT AGAAGAAACC 
CCCTCCCAGG GAGACAGACC CTTGCTGGGC ACTGAGGTTT CAGCGCCTTG TCAGGGACCT 
TCCAAAGGGC TGTCCCCCAG GTTTCCCAAG CAGAAACTGT TCCCTTTCTC TTCAAGAGAG 
AGGAGGAGCT TCACTGAAAT AGATACTGGT GACGACGAAG ACTTCTTAGA GCTCCCAGGG 
GCAAGGGAGG AGAAGCAGGT GGACTCCAGC CCAAATTGCT TTGCAGATAA GCCTAGTGAT 
GGGAGAGACC CTTTAAGAGA AGAGGGCAGT GTGGGCTCTT CCTCCCCGCA GGACACAGGT 
CACAACTGTA GGCAAGACAT TTACCATGCT GTGAGTGAAG TCAAAAAGGA CAGTAGTCAA 
GAAGGGTGCA AGATGGAAAA TCACTTGTTT GCCCCAGAAA TTCATTCCAA CCCAGGAGAC 
ACAGGTTATT GTCCCACACG TGAAACCAGC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004761.2
CDS	755..3490
Translation	MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM

Target ORF information:

RefSeq Version	NM_004770.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004770.3

ORF Insert Sequence:

ATGGCAGAAA AGGCTCCCCC GGGCTTAAAC AGGAAGACTT CAAGGTCGAC ACTTTCCCTT 
CCTCCAGAGC CTGTGGACAT TATCCGGAGC AAAACATGCT CCAGGAGAGT TAAGATCAAT 
GTGGGGGGCC TCAACCACGA AGTCCTGTGG AGAACGCTGG ACAGGCTGCC CAGGACGCGC 
CTGGGGAAGC TTCGAGACTG CAACACACAC GAGAGCCTCC TGGAAGTGTG CGACGACTAT 
AATCTGAACG AGAACGAGTA TTTCTTTGAT CGGCATCCAG GAGCCTTCAC TTCCATTTTA 
AATTTCTACC GGACCGGGAA ACTCCATATG ATGGAAGAAA TGTGTGCACT TTCGTTTGGC 
CAAGAACTTG ATTACTGGGG GATTGATGAG ATCTACTTGG AGTCCTGCTG CCAGGCCAGA 
TATCATCAAA AAAAAGAACA AATGAACGAA GAACTGAGGC GAGAGGCAGA GACTATGCGA 
GAGCGAGAAG GAGAAGAGTT TGATAATACC TGCTGCCCTG ATAAAAGGAA GAAACTGTGG 
GACTTGCTGG AGAAACCTAA CTCATCAGTG GCTGCAAAGA TCCTGGCCAT CGTGTCTATC 
CTGTTCATTG TGCTTTCCAC CATTGCTTTG TCTCTCAATA CGCTGCCGGA GCTGCAGGAA 
ACGGACGAAT TTGGACAACT CAATGACAAC CGCCAATTAG CACACGTGGA GGCTGTGTGT 
ATTGCATGGT TTACCATGGA GTACCTTTTG CGATTCTTAT CCTCACCAAA TAAATGGAAG 
TTCTTCAAAG GCCCACTGAA TGTCATTGAT TTGCTGGCCA TCTTGCCGTA CTATGTCACC 
ATTTTTCTGA CGGAGTCCAA CAAGAGCGTG CTGCAGTTCC AAAACGTGAG GCGCGTGGTC 
CAGATCTTCC GAATCATGCG CATCCTCAGG ATCCTGAAAC TCGCCAGGCA TTCGACAGGC 
CTGCAGTCTC TGGGTTTCAC CCTTAGGCGG AGTTACAATG AATTGGGCTT GTTGATATTG 
TTTCTGGCCA TGGGGATAAT GATATTTTCC AGCCTGGTAT TTTTTGCTGA GAAGGATGAA 
GATGCTACCA AGTTCACCAG TATCCCTGCA TCATTTTGGT GGGCCACCAT CACCATGACC 
ACTGTTGGCT ATGGTGACAT TTACCCTAAA ACATTACTAG GGAAAATTGT GGGAGGTCTG 
TGCTGTATTG CTGGGGTTCT GGTTATTGCC CTTCCTATCC CAATTATTGT GAACAATTTT 
TCTGAGTTTT ACAAGGAGCA GAAACGCCAA GAGAAAGCAA TTAAAAGGAG GGAGGCTCTT 
GAGCGGGCCA AAAGGAACGG AAGCATCGTT TCTATGAACT TAAAAGATGC CTTCGCTCGA 
AGTATGGAAC TGATAGATGT GGCTGTTGAG AAGGCCGGAG AGTCCGCCAA CACAAAGGAC 
TCCGCCGACG ATAATCACCT GTCGCCAAGC CGGTGGAAGT GGGCCAGGAA GGCTCTGTCG 
GAAACAAGCT CCAACAAGTC TTTCGAGAAT AAGTACCAGG AGGTTAGCCA AAAAGACTCC 
CACGAGCAGC TGAACAACAC GTCTTCCTCC AGCCCACAGC ATCTGAGTGC CCAGAAACTG 
GAGATGCTAT ACAATGAAAT CACCAAGACA CAGCCTCATT CTCACCCAAA CCCAGACTGC 
CAAGAAAAGC CTGAGAGGCC ATCTGCATAT GAAGAAGAGA TTGAAATGGA AGAAGTGGTG 
TGTCCACAGG AGCAGCTGGC CGTGGCACAG ACCGAGGTCA TTGTGGACAT GAAGAGCACC 
TCCAGCATCG ACAGCTTCAC CAGCTGTGCC ACCGACTTCA CAGAGACAGA GAGATCGCCG 
CTGCCGCCGC CCTCCGCCTC TCACTTGCAG ATGAAGTTCC CAACCGACCT CCCAGGGACA 
GAAGAGCACC AAAGAGCTAG GGGCCCCCCG TTTCTAACTC TATCCAGAGA GAAAGGACCT 
GCTGCCAGGG ATGGCACGCT GGAGTATGCC CCAGTTGACA TAACTGTGAA CCTCGATGCC 
AGTGGCTCCC AGTGTGGGCT ACATAGTCCT TTGCAGTCTG ACAATGCCAC CGACAGTCCT 
AAGAGCTCTC TAAAAGGCAG CAACCCACTA AAGTCCAGAT CCCTCAAAGT GAACTTTAAG 
GAAAATAGAG GCAGTGCACC ACAGACCCCG CCCAGCACAG CCAGGCCACT GCCAGTCACC 
ACAGCTGACT TTTCGCTCAC TACCCCGCAG CACATCAGTA CCATCCTCTT AGAAGAAACC 
CCCTCCCAGG GAGACAGACC CTTGCTGGGC ACTGAGGTTT CAGCGCCTTG TCAGGGACCT 
TCCAAAGGGC TGTCCCCCAG GTTTCCCAAG CAGAAACTGT TCCCTTTCTC TTCAAGAGAG 
AGGAGGAGCT TCACTGAAAT AGATACTGGT GACGACGAAG ACTTCTTAGA GCTCCCAGGG 
GCAAGGGAGG AGAAGCAGGT GGACTCCAGC CCAAATTGCT TTGCAGATAA GCCTAGTGAT 
GGGAGAGACC CTTTAAGAGA AGAGGGCAGT GTGGGCTCTT CCTCCCCGCA GGACACAGGT 
CACAACTGTA GGCAAGACAT TTACCATGCT GTGAGTGAAG TCAAAAAGGA CAGTAGTCAA 
GAAGGGTGCA AGATGGAAAA TCACTTGTTT GCCCCAGAAA TTCATTCCAA CCCAGGAGAC 
ACAGGTTATT GTCCCACACG TGAAACCAGC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNB2 ( NM_004770.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004761.2 Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA.

Price & Availability↑

CloneID	OHu25595
Clone ID Related Accession (Same CDS sequence)	NM_004770.3 , NM_004770.2
Accession Version	NM_004770.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily B member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF338730.1. On Dec 31, 2002 this sequence version replaced NM_004770.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF338730.1, SRR1660803.155026.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAAA AGGCTCCCCC GGGCTTAAAC AGGAAGACTT CAAGGTCGAC ACTTTCCCTT 
CCTCCAGAGC CTGTGGACAT TATCCGGAGC AAAACATGCT CCAGGAGAGT TAAGATCAAT 
GTGGGGGGCC TCAACCACGA AGTCCTGTGG AGAACGCTGG ACAGGCTGCC CAGGACGCGC 
CTGGGGAAGC TTCGAGACTG CAACACACAC GAGAGCCTCC TGGAAGTGTG CGACGACTAT 
AATCTGAACG AGAACGAGTA TTTCTTTGAT CGGCATCCAG GAGCCTTCAC TTCCATTTTA 
AATTTCTACC GGACCGGGAA ACTCCATATG ATGGAAGAAA TGTGTGCACT TTCGTTTGGC 
CAAGAACTTG ATTACTGGGG GATTGATGAG ATCTACTTGG AGTCCTGCTG CCAGGCCAGA 
TATCATCAAA AAAAAGAACA AATGAACGAA GAACTGAGGC GAGAGGCAGA GACTATGCGA 
GAGCGAGAAG GAGAAGAGTT TGATAATACC TGCTGCCCTG ATAAAAGGAA GAAACTGTGG 
GACTTGCTGG AGAAACCTAA CTCATCAGTG GCTGCAAAGA TCCTGGCCAT CGTGTCTATC 
CTGTTCATTG TGCTTTCCAC CATTGCTTTG TCTCTCAATA CGCTGCCGGA GCTGCAGGAA 
ACGGACGAAT TTGGACAACT CAATGACAAC CGCCAATTAG CACACGTGGA GGCTGTGTGT 
ATTGCATGGT TTACCATGGA GTACCTTTTG CGATTCTTAT CCTCACCAAA TAAATGGAAG 
TTCTTCAAAG GCCCACTGAA TGTCATTGAT TTGCTGGCCA TCTTGCCGTA CTATGTCACC 
ATTTTTCTGA CGGAGTCCAA CAAGAGCGTG CTGCAGTTCC AAAACGTGAG GCGCGTGGTC 
CAGATCTTCC GAATCATGCG CATCCTCAGG ATCCTGAAAC TCGCCAGGCA TTCGACAGGC 
CTGCAGTCTC TGGGTTTCAC CCTTAGGCGG AGTTACAATG AATTGGGCTT GTTGATATTG 
TTTCTGGCCA TGGGGATAAT GATATTTTCC AGCCTGGTAT TTTTTGCTGA GAAGGATGAA 
GATGCTACCA AGTTCACCAG TATCCCTGCA TCATTTTGGT GGGCCACCAT CACCATGACC 
ACTGTTGGCT ATGGTGACAT TTACCCTAAA ACATTACTAG GGAAAATTGT GGGAGGTCTG 
TGCTGTATTG CTGGGGTTCT GGTTATTGCC CTTCCTATCC CAATTATTGT GAACAATTTT 
TCTGAGTTTT ACAAGGAGCA GAAACGCCAA GAGAAAGCAA TTAAAAGGAG GGAGGCTCTT 
GAGCGGGCCA AAAGGAACGG AAGCATCGTT TCTATGAACT TAAAAGATGC CTTCGCTCGA 
AGTATGGAAC TGATAGATGT GGCTGTTGAG AAGGCCGGAG AGTCCGCCAA CACAAAGGAC 
TCCGCCGACG ATAATCACCT GTCGCCAAGC CGGTGGAAGT GGGCCAGGAA GGCTCTGTCG 
GAAACAAGCT CCAACAAGTC TTTCGAGAAT AAGTACCAGG AGGTTAGCCA AAAAGACTCC 
CACGAGCAGC TGAACAACAC GTCTTCCTCC AGCCCACAGC ATCTGAGTGC CCAGAAACTG 
GAGATGCTAT ACAATGAAAT CACCAAGACA CAGCCTCATT CTCACCCAAA CCCAGACTGC 
CAAGAAAAGC CTGAGAGGCC ATCTGCATAT GAAGAAGAGA TTGAAATGGA AGAAGTGGTG 
TGTCCACAGG AGCAGCTGGC CGTGGCACAG ACCGAGGTCA TTGTGGACAT GAAGAGCACC 
TCCAGCATCG ACAGCTTCAC CAGCTGTGCC ACCGACTTCA CAGAGACAGA GAGATCGCCG 
CTGCCGCCGC CCTCCGCCTC TCACTTGCAG ATGAAGTTCC CAACCGACCT CCCAGGGACA 
GAAGAGCACC AAAGAGCTAG GGGCCCCCCG TTTCTAACTC TATCCAGAGA GAAAGGACCT 
GCTGCCAGGG ATGGCACGCT GGAGTATGCC CCAGTTGACA TAACTGTGAA CCTCGATGCC 
AGTGGCTCCC AGTGTGGGCT ACATAGTCCT TTGCAGTCTG ACAATGCCAC CGACAGTCCT 
AAGAGCTCTC TAAAAGGCAG CAACCCACTA AAGTCCAGAT CCCTCAAAGT GAACTTTAAG 
GAAAATAGAG GCAGTGCACC ACAGACCCCG CCCAGCACAG CCAGGCCACT GCCAGTCACC 
ACAGCTGACT TTTCGCTCAC TACCCCGCAG CACATCAGTA CCATCCTCTT AGAAGAAACC 
CCCTCCCAGG GAGACAGACC CTTGCTGGGC ACTGAGGTTT CAGCGCCTTG TCAGGGACCT 
TCCAAAGGGC TGTCCCCCAG GTTTCCCAAG CAGAAACTGT TCCCTTTCTC TTCAAGAGAG 
AGGAGGAGCT TCACTGAAAT AGATACTGGT GACGACGAAG ACTTCTTAGA GCTCCCAGGG 
GCAAGGGAGG AGAAGCAGGT GGACTCCAGC CCAAATTGCT TTGCAGATAA GCCTAGTGAT 
GGGAGAGACC CTTTAAGAGA AGAGGGCAGT GTGGGCTCTT CCTCCCCGCA GGACACAGGT 
CACAACTGTA GGCAAGACAT TTACCATGCT GTGAGTGAAG TCAAAAAGGA CAGTAGTCAA 
GAAGGGTGCA AGATGGAAAA TCACTTGTTT GCCCCAGAAA TTCATTCCAA CCCAGGAGAC 
ACAGGTTATT GTCCCACACG TGAAACCAGC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004761.2
CDS	589..3324
Translation	MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM

Target ORF information:

RefSeq Version	NM_004770.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004770.2

ORF Insert Sequence:

ATGGCAGAAA AGGCTCCCCC GGGCTTAAAC AGGAAGACTT CAAGGTCGAC ACTTTCCCTT 
CCTCCAGAGC CTGTGGACAT TATCCGGAGC AAAACATGCT CCAGGAGAGT TAAGATCAAT 
GTGGGGGGCC TCAACCACGA AGTCCTGTGG AGAACGCTGG ACAGGCTGCC CAGGACGCGC 
CTGGGGAAGC TTCGAGACTG CAACACACAC GAGAGCCTCC TGGAAGTGTG CGACGACTAT 
AATCTGAACG AGAACGAGTA TTTCTTTGAT CGGCATCCAG GAGCCTTCAC TTCCATTTTA 
AATTTCTACC GGACCGGGAA ACTCCATATG ATGGAAGAAA TGTGTGCACT TTCGTTTGGC 
CAAGAACTTG ATTACTGGGG GATTGATGAG ATCTACTTGG AGTCCTGCTG CCAGGCCAGA 
TATCATCAAA AAAAAGAACA AATGAACGAA GAACTGAGGC GAGAGGCAGA GACTATGCGA 
GAGCGAGAAG GAGAAGAGTT TGATAATACC TGCTGCCCTG ATAAAAGGAA GAAACTGTGG 
GACTTGCTGG AGAAACCTAA CTCATCAGTG GCTGCAAAGA TCCTGGCCAT CGTGTCTATC 
CTGTTCATTG TGCTTTCCAC CATTGCTTTG TCTCTCAATA CGCTGCCGGA GCTGCAGGAA 
ACGGACGAAT TTGGACAACT CAATGACAAC CGCCAATTAG CACACGTGGA GGCTGTGTGT 
ATTGCATGGT TTACCATGGA GTACCTTTTG CGATTCTTAT CCTCACCAAA TAAATGGAAG 
TTCTTCAAAG GCCCACTGAA TGTCATTGAT TTGCTGGCCA TCTTGCCGTA CTATGTCACC 
ATTTTTCTGA CGGAGTCCAA CAAGAGCGTG CTGCAGTTCC AAAACGTGAG GCGCGTGGTC 
CAGATCTTCC GAATCATGCG CATCCTCAGG ATCCTGAAAC TCGCCAGGCA TTCGACAGGC 
CTGCAGTCTC TGGGTTTCAC CCTTAGGCGG AGTTACAATG AATTGGGCTT GTTGATATTG 
TTTCTGGCCA TGGGGATAAT GATATTTTCC AGCCTGGTAT TTTTTGCTGA GAAGGATGAA 
GATGCTACCA AGTTCACCAG TATCCCTGCA TCATTTTGGT GGGCCACCAT CACCATGACC 
ACTGTTGGCT ATGGTGACAT TTACCCTAAA ACATTACTAG GGAAAATTGT GGGAGGTCTG 
TGCTGTATTG CTGGGGTTCT GGTTATTGCC CTTCCTATCC CAATTATTGT GAACAATTTT 
TCTGAGTTTT ACAAGGAGCA GAAACGCCAA GAGAAAGCAA TTAAAAGGAG GGAGGCTCTT 
GAGCGGGCCA AAAGGAACGG AAGCATCGTT TCTATGAACT TAAAAGATGC CTTCGCTCGA 
AGTATGGAAC TGATAGATGT GGCTGTTGAG AAGGCCGGAG AGTCCGCCAA CACAAAGGAC 
TCCGCCGACG ATAATCACCT GTCGCCAAGC CGGTGGAAGT GGGCCAGGAA GGCTCTGTCG 
GAAACAAGCT CCAACAAGTC TTTCGAGAAT AAGTACCAGG AGGTTAGCCA AAAAGACTCC 
CACGAGCAGC TGAACAACAC GTCTTCCTCC AGCCCACAGC ATCTGAGTGC CCAGAAACTG 
GAGATGCTAT ACAATGAAAT CACCAAGACA CAGCCTCATT CTCACCCAAA CCCAGACTGC 
CAAGAAAAGC CTGAGAGGCC ATCTGCATAT GAAGAAGAGA TTGAAATGGA AGAAGTGGTG 
TGTCCACAGG AGCAGCTGGC CGTGGCACAG ACCGAGGTCA TTGTGGACAT GAAGAGCACC 
TCCAGCATCG ACAGCTTCAC CAGCTGTGCC ACCGACTTCA CAGAGACAGA GAGATCGCCG 
CTGCCGCCGC CCTCCGCCTC TCACTTGCAG ATGAAGTTCC CAACCGACCT CCCAGGGACA 
GAAGAGCACC AAAGAGCTAG GGGCCCCCCG TTTCTAACTC TATCCAGAGA GAAAGGACCT 
GCTGCCAGGG ATGGCACGCT GGAGTATGCC CCAGTTGACA TAACTGTGAA CCTCGATGCC 
AGTGGCTCCC AGTGTGGGCT ACATAGTCCT TTGCAGTCTG ACAATGCCAC CGACAGTCCT 
AAGAGCTCTC TAAAAGGCAG CAACCCACTA AAGTCCAGAT CCCTCAAAGT GAACTTTAAG 
GAAAATAGAG GCAGTGCACC ACAGACCCCG CCCAGCACAG CCAGGCCACT GCCAGTCACC 
ACAGCTGACT TTTCGCTCAC TACCCCGCAG CACATCAGTA CCATCCTCTT AGAAGAAACC 
CCCTCCCAGG GAGACAGACC CTTGCTGGGC ACTGAGGTTT CAGCGCCTTG TCAGGGACCT 
TCCAAAGGGC TGTCCCCCAG GTTTCCCAAG CAGAAACTGT TCCCTTTCTC TTCAAGAGAG 
AGGAGGAGCT TCACTGAAAT AGATACTGGT GACGACGAAG ACTTCTTAGA GCTCCCAGGG 
GCAAGGGAGG AGAAGCAGGT GGACTCCAGC CCAAATTGCT TTGCAGATAA GCCTAGTGAT 
GGGAGAGACC CTTTAAGAGA AGAGGGCAGT GTGGGCTCTT CCTCCCCGCA GGACACAGGT 
CACAACTGTA GGCAAGACAT TTACCATGCT GTGAGTGAAG TCAAAAAGGA CAGTAGTCAA 
GAAGGGTGCA AGATGGAAAA TCACTTGTTT GCCCCAGAAA TTCATTCCAA CCCAGGAGAC 
ACAGGTTATT GTCCCACACG TGAAACCAGC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human ?-Cell Dysfunction.
Diabetes66(7)1890-1900(2017 07)
Fu J,Dai X,Plummer G,Suzuki K,Bautista A,Githaka JM,Senior L,Jensen M,Greitzer-Antes D,Manning Fox JE,Gaisano HY,Newgard CB,Touret N,MacDonald PE

Pore size matters for potassium channel conductance.
The Journal of general physiology148(4)277-91(2016 Oct)
Naranjo D,Moldenhauer H,Pincuntureo M,D?az-Franulic I

Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome.
Scientific reports46733(2014 Oct)
Juang JM,Lu TP,Lai LC,Ho CC,Liu YB,Tsai CT,Lin LY,Yu CC,Chen WJ,Chiang FT,Yeh SF,Lai LP,Chuang EY,Lin JL

Genome-wide association studies of maximum number of drinks.
Journal of psychiatric research47(11)1717-24(2013 Nov)
Pan Y,Luo X,Liu X,Wu LY,Zhang Q,Wang L,Wang W,Zuo L,Wang KS

Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.
American journal of physiology. Cell physiology302(11)C1599-608(2012 Jun)
Hristov KL,Chen M,Afeli SA,Cheng Q,Rovner ES,Petkov GV

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KCNB2 cDNA ORF clone, Homo sapiens(human)

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Clones

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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