KCNG4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNG4
Entrez Gene ID	93107
Full Name	potassium voltage-gated channel modifier subfamily G member 4
Synonyms	KV6.3,KV6.4
General protein information	Preferred Names potassium voltage-gated channel modifier subfamily G member 4 Names potassium voltage-gated channel subfamily G member 4 potassium channel, voltage gated modifier subfamily G, member 4 potassium voltage-gated channel, subfamily G, member 4 voltage-gated potassium channel Kv6.3 voltage-gated potassium channel subunit Kv6.4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.1
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008].
Disorder MIM:	607603

mRNA and Protein(s)

mRNA	Protein	Name
NM_172347.2	NP_758857.1	potassium voltage-gated channel subfamily G member 4

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Kcng4	NP_080010.2
Rattus norvegicus (Norway rat)	Kcng4	NP_001100905.1
Xenopus tropicalis (tropical clawed frog)	kcng4	XP_002934997.1
Pan troglodytes (chimpanzee)	KCNG4	XP_523443.2
	KCNG4	XP_001112505.1
Homo sapiens (human)	KCNG4	NP_758857.1
Gallus gallus (chicken)	KCNG4	XP_425129.2
Danio rerio (zebrafish)	LOC566228	XP_694589.3
Canis lupus familiaris (dog)	KCNG4	XP_546803.1
Bos taurus (cattle)	KCNG4	XP_002694789.3
Danio rerio (zebrafish)	kcng4a	NP_001103499.1

Gene Ontology
Bibliography

Related articles in PubMed

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
David JP, Stas JI, Schmitt N, Bocksteins E
Scientific reports512813(2015 Aug)

Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.
Stas JI, Bocksteins E, Labro AJ, Snyders DJ
PloS one10(10)e0141349(2015)

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, , , , Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB
PLoS genetics8(5)e1002695(2012)

Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.
Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ
The Journal of biological chemistry284(46)31625-34(2009 Nov)

Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
Mederos Y Schnitzler M, Rinn? S, Skrobek L, Renigunta V, Schlichth?rl G, Derst C, Gudermann T, Daut J, Preisig-M?ller R
The Journal of biological chemistry284(7)4695-704(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KCNE5 subunits may affect Kv2.1 homotetramers and Kv2.1/Kv6.4 heterotetramers in vivo, resulting in more tissue-specific fine-tuning mechanisms.
Title: Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.

KvS subunits modify the pharmacological response of Kv2 subunits when assembled in heterotetramers and illustrate the potential of KvS subunits to provide unique properties to the heterotetramers, as is the case for 4-AP on Kv2.1/Kv6.4 channels.
Title: Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
Title: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.

This study suggests that the silent behaviour of Kv6.3 is largely caused by the C-terminal part of its sixth transmembrane domain that causes ER retention of the subunit.
Title: Domain analysis of Kv6.3, an electrically silent channel.

The following KCNG4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNG4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu21914	NM_172347.2 Latest version!	Homo sapiens potassium voltage-gated channel modifier subfamily G member 4 (KCNG4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNG4 ( NM_172347.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_758857.1 Homo sapiens potassium voltage-gated channel modifier subfamily G member 4 (KCNG4), mRNA.

Price & Availability↑

CloneID	OHu21914
Clone ID Related Accession (Same CDS sequence)	NM_172347.2
Accession Version	NM_172347.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily G member 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008969.2, BC109203.2, AC009123.7 and BQ185567.1. On Dec 7, 2010 this sequence version replaced NM_172347.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC109203.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCATGC CTTCCAGAGA CGGGGGCCTG CATCCCAGAC ACCACCACTA TGGTTCCCAC 
AGCCCTTGGA GTCAGCTCCT GTCCAGCCCC ATGGAGACGC CGTCCATCAA GGGCCTTTAC 
TACCGGAGGG TGCGGAAGGT GGGTGCCCTG GACGCCTCCC CAGTGGACCT GAAGAAGGAG 
ATCCTGATCA ACGTGGGGGG CAGGAGGTAT CTCCTCCCCT GGAGCACACT GGACCGGTTC 
CCGCTGAGCC GCCTGAGCAA ACTCAGGCTC TGTCGGAGCT ACGAGGAGAT CGTGCAGCTC 
TGCGATGATT ACGACGAGGA CAGCCAGGAG TTCTTCTTCG ACAGGAGCCC CAGCGCCTTC 
GGGGTGATCG TGAGCTTCCT GGCGGCCGGG AAGCTGGTGC TTCTGCAGGA GATGTGCGCG 
CTGTCCTTCC AGGAGGAGCT GGCCTACTGG GGCATCGAGG AGGCCCACCT GGAGAGGTGC 
TGCCTGCGGA AGCTGCTGAG GAAGCTGGAG GAGCTGGAGG AGCTGGCCAA GCTGCACAGG 
GAGGACGTAC TGAGGCAGCA GAGGGAGACC CGCCGCCCCG CCTCGCACTC CTCGCGCTGG 
GGCCTGTGCA TGAACCGGCT GCGCGAGATG GTGGAAAACC CGCAGTCCGG GCTGCCCGGG 
AAGGTCTTCG CTTGCCTCTC CATCCTCTTC GTGGCCACCA CAGCCGTCAG CCTGTGTGTC 
AGCACCATGC CCGACCTCAG GGCAGAGGAG GACCAGGGCG AATGCTCTCG GAAGTGCTAC 
TATATTTTCA TCGTGGAGAC CATCTGCGTG GCCTGGTTCT CCCTGGAGTT CTGCCTGCGG 
TTTGTCCAGG CCCAAGACAA GTGTCAGTTC TTCCAGGGGC CCCTGAACAT CATCGACATC 
CTGGCCATCT CCCCATACTA CGTGTCGCTG GCGGTGTCTG AGGAGCCCCC GGAGGACGGC 
GAGAGGCCGA GCGGGAGCTC CTACCTGGAG AAGGTGGGGC TGGTCCTGCG TGTGCTGCGA 
GCGCTGCGCA TCCTCTACGT GATGCGCCTG GCTCGCCACT CGCTGGGGCT GCAGACGCTG 
GGGCTCACCG TGCGCCGTTG CACACGTGAG TTCGGCCTGC TCCTTCTCTT CCTGGCCGTG 
GCCATCACCC TCTTCTCCCC TTTGGTCTAC GTGGCCGAGA AGGAGTCCGG GCGGGTGCTG 
GAGTTCACCA GCATCCCCGC CTCCTATTGG TGGGCCATCA TCTCCATGAC AACGGTGGGC 
TACGGGGACA TGGTGCCCCG CAGTGTGCCA GGCCAGATGG TGGCCCTCAG CAGCATCCTG 
AGCGGGATCC TCATCATGGC CTTCCCGGCC ACGTCTATCT TCCACACCTT CTCCCACTCC 
TACCTGGAGC TCAAGAAGGA GCAGGAGCAG CTTCAGGCCC GCCTCCGCCA CCTCCAAAAC 
ACCGGTCCAG CCAGTGAATG TGAACTCCTG GACCCCCATG TGGCCAGTGA ACATGAGCTC 
ATGAACGATG TCAATGACCT AATCCTGGAG GGCCCAGCCT TGCCTATCAT GCACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758857.1
CDS	122..1681
Translation	MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM

Target ORF information:

RefSeq Version	NM_172347.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily G member 4 (KCNG4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172347.2

ORF Insert Sequence:

ATGCCCATGC CTTCCAGAGA CGGGGGCCTG CATCCCAGAC ACCACCACTA TGGTTCCCAC 
AGCCCTTGGA GTCAGCTCCT GTCCAGCCCC ATGGAGACGC CGTCCATCAA GGGCCTTTAC 
TACCGGAGGG TGCGGAAGGT GGGTGCCCTG GACGCCTCCC CAGTGGACCT GAAGAAGGAG 
ATCCTGATCA ACGTGGGGGG CAGGAGGTAT CTCCTCCCCT GGAGCACACT GGACCGGTTC 
CCGCTGAGCC GCCTGAGCAA ACTCAGGCTC TGTCGGAGCT ACGAGGAGAT CGTGCAGCTC 
TGCGATGATT ACGACGAGGA CAGCCAGGAG TTCTTCTTCG ACAGGAGCCC CAGCGCCTTC 
GGGGTGATCG TGAGCTTCCT GGCGGCCGGG AAGCTGGTGC TTCTGCAGGA GATGTGCGCG 
CTGTCCTTCC AGGAGGAGCT GGCCTACTGG GGCATCGAGG AGGCCCACCT GGAGAGGTGC 
TGCCTGCGGA AGCTGCTGAG GAAGCTGGAG GAGCTGGAGG AGCTGGCCAA GCTGCACAGG 
GAGGACGTAC TGAGGCAGCA GAGGGAGACC CGCCGCCCCG CCTCGCACTC CTCGCGCTGG 
GGCCTGTGCA TGAACCGGCT GCGCGAGATG GTGGAAAACC CGCAGTCCGG GCTGCCCGGG 
AAGGTCTTCG CTTGCCTCTC CATCCTCTTC GTGGCCACCA CAGCCGTCAG CCTGTGTGTC 
AGCACCATGC CCGACCTCAG GGCAGAGGAG GACCAGGGCG AATGCTCTCG GAAGTGCTAC 
TATATTTTCA TCGTGGAGAC CATCTGCGTG GCCTGGTTCT CCCTGGAGTT CTGCCTGCGG 
TTTGTCCAGG CCCAAGACAA GTGTCAGTTC TTCCAGGGGC CCCTGAACAT CATCGACATC 
CTGGCCATCT CCCCATACTA CGTGTCGCTG GCGGTGTCTG AGGAGCCCCC GGAGGACGGC 
GAGAGGCCGA GCGGGAGCTC CTACCTGGAG AAGGTGGGGC TGGTCCTGCG TGTGCTGCGA 
GCGCTGCGCA TCCTCTACGT GATGCGCCTG GCTCGCCACT CGCTGGGGCT GCAGACGCTG 
GGGCTCACCG TGCGCCGTTG CACACGTGAG TTCGGCCTGC TCCTTCTCTT CCTGGCCGTG 
GCCATCACCC TCTTCTCCCC TTTGGTCTAC GTGGCCGAGA AGGAGTCCGG GCGGGTGCTG 
GAGTTCACCA GCATCCCCGC CTCCTATTGG TGGGCCATCA TCTCCATGAC AACGGTGGGC 
TACGGGGACA TGGTGCCCCG CAGTGTGCCA GGCCAGATGG TGGCCCTCAG CAGCATCCTG 
AGCGGGATCC TCATCATGGC CTTCCCGGCC ACGTCTATCT TCCACACCTT CTCCCACTCC 
TACCTGGAGC TCAAGAAGGA GCAGGAGCAG CTTCAGGCCC GCCTCCGCCA CCTCCAAAAC 
ACCGGTCCAG CCAGTGAATG TGAACTCCTG GACCCCCATG TGGCCAGTGA ACATGAGCTC 
ATGAACGATG TCAATGACCT AATCCTGGAG GGCCCAGCCT TGCCTATCAT GCACATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
Scientific reports512813(2015 Aug)
David JP,Stas JI,Schmitt N,Bocksteins E

Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.
PloS one10(10)e0141349(2015)
Stas JI,Bocksteins E,Labro AJ,Snyders DJ

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
PLoS genetics8(5)e1002695(2012)
Fox CS,Liu Y,White CC,Feitosa M,Smith AV,Heard-Costa N,Lohman K,,,,Johnson AD,Foster MC,Greenawalt DM,Griffin P,Ding J,Newman AB,Tylavsky F,Miljkovic I,Kritchevsky SB,Launer L,Garcia M,Eiriksdottir G,Carr JJ,Gudnason V,Harris TB,Cupples LA,Borecki IB

Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.
The Journal of biological chemistry284(46)31625-34(2009 Nov)
Bocksteins E,Labro AJ,Mayeur E,Bruyns T,Timmermans JP,Adriaensen D,Snyders DJ

Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
The Journal of biological chemistry284(7)4695-704(2009 Feb)
Mederos Y Schnitzler M,Rinn? S,Skrobek L,Renigunta V,Schlichth?rl G,Derst C,Gudermann T,Daut J,Preisig-M?ller R

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

KCNG4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報