SOCS6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOCS6
Entrez Gene ID	9306
Full Name	suppressor of cytokine signaling 6
Synonyms	CIS-4,CIS4,HSPC060,SOCS-4,SOCS-6,SOCS4,SSI4,STAI4,STATI4
General protein information	Preferred Names suppressor of cytokine signaling 6 Names suppressor of cytokine signaling 6 STAT induced STAT inhibitor-4 cytokine-inducible SH2 protein 4 suppressor of cytokine signaling 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q22.2
Summary	The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].
Disorder MIM:	605118

mRNA and Protein(s)

mRNA	Protein	Name
XM_017026086.1	XP_016881575.1	suppressor of cytokine signaling 6 isoform X1
XM_017026087.1	XP_016881576.1	suppressor of cytokine signaling 6 isoform X1
NM_004232.3	NP_004223.2	suppressor of cytokine signaling 6
XM_005266783.2	XP_005266840.1	suppressor of cytokine signaling 6 isoform X1
NM_004232.4	NP_004223.2	suppressor of cytokine signaling 6
XM_005266783.3	XP_005266840.1	suppressor of cytokine signaling 6 isoform X1
XM_005266783.4	XP_005266840.1	suppressor of cytokine signaling 6 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Socs6	NP_001258078.1
Danio rerio (zebrafish)	LOC558703	XP_687041.2
Xenopus tropicalis (tropical clawed frog)	socs6	NP_001096240.1
Gallus gallus (chicken)	SOCS6	NP_001120784.1
Pan troglodytes (chimpanzee)	SOCS6	XP_512211.2
Mus musculus (house mouse)	Socs6	NP_061291.2
Homo sapiens (human)	SOCS6	NP_004223.2
Canis lupus familiaris (dog)	LOC100856303	XP_005615384.1

Gene Ontology
Bibliography

Related articles in PubMed

SOCS6 functions as a tumor suppressor by inducing apoptosis and inhibiting angiogenesis in human prostate cancer.
Yuan D, Wang W, Su J, Zhang Y, Luan B, Rao H, Cheng T, Zhang W, Xiao S, Zhang M, Jiang FN, Sun Z, Jia Z, Zhong WD, Zhu J
Current cancer drug targets(2018 Jan)

miR-19 promotes osteosarcoma progression by targeting SOCS6.
Sun Z, Liu Q, Hong H, Zhang H, Zhang T
Biochemical and biophysical research communications495(1)1363-1369(2018 01)

PTENP1 inhibits the growth of esophageal squamous cell carcinoma by regulating SOCS6 expression and correlates with disease prognosis.
Gong T, Zheng S, Huang S, Fu S, Zhang X, Pan S, Yang T, Sun Y, Wang Y, Hui B, Guo J, Zhang X
Molecular carcinogenesis56(12)2610-2619(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Together, our data provide important evidence for miR-19 mediated SOCS6 in OS growth and revealed miR-19/SOCS6/JAK2/STAT3 pathway as a potential therapeutic strategy for OS patients.
Title: miR-19 promotes osteosarcoma progression by targeting SOCS6.

Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples.
Title: PTENP1 inhibits the growth of esophageal squamous cell carcinoma by regulating SOCS6 expression and correlates with disease prognosis.

our results describe for the first time the role of miR-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients.
Title: miR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6.

miR-142-3p regulates NPC development by down-regulating SOCS6 expression and suggest that modulation of miR-142-3p expression could be a therapeutic strategy for NPC
Title: MiR-142-3p Suppresses SOCS6 Expression and Promotes Cell Proliferation in Nasopharyngeal Carcinoma.

Stage-independent downregulation of SOCS2 and SOCS6 correlate with disease-free survival in colorectal cancer.
Title: Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.

The following SOCS6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOCS6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04592	NM_004232.4 Latest version!	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu04592	XM_017026086.1 Latest version!	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu04592	XM_005266783.4 Latest version!	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu04592	XM_017026087.1 Latest version!	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu04592	NM_004232.3	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu04592	XM_005266783.2	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu04592	XM_005266783.3	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOCS6 ( NM_004232.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004223.2 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.

Price & Availability↑

CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	NM_004232.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023395.8 and BC020082.1. On Nov 24, 2006 this sequence version replaced NM_004232.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB479505.1, SRR1660809.123018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004223.2
CDS	317..1924
Translation	MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	NM_004232.3
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004232.3

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS6 ( NM_004232.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004223.2 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.

Price & Availability↑

CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	NM_004232.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020082.1 and AC023395.8. On Nov 22, 2018 this sequence version replaced NM_004232.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.214235.1, SRR1660807.205991.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397942.4/ ENSP00000381034.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004223.2
CDS	173..1780
Translation	MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	NM_004232.4
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004232.4

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS6 ( XM_017026086.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881575.1 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	XM_017026086.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881575.1
CDS	323..1930
Translation	MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	XM_017026086.1
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026086.1

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS6 ( XM_017026087.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881576.1 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	XM_017026087.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881576.1
CDS	256..1863
Translation	MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	XM_017026087.1
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026087.1

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS6 ( XM_005266783.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005266840.1 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	XM_005266783.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	suppressor of cytokine signaling 6 isoform X1
Comment

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005266840.1

Translation

MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	XM_005266783.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005266783.2

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS6 ( XM_005266783.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005266840.1 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	XM_005266783.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005266783.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005266840.1
CDS	279..1886
Translation	MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	XM_005266783.3
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005266783.3

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS6 ( XM_005266783.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005266840.1 Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.

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CloneID	OHu04592
Clone ID Related Accession (Same CDS sequence)	XM_017026086.1 , XM_017026087.1 , NM_004232.3 , XM_005266783.2 , NM_004232.4 , XM_005266783.3 , XM_005266783.4
Accession Version	XM_005266783.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005266783.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005266840.1
CDS	280..1887
Translation	MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Target ORF information:

RefSeq Version	XM_005266783.4
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 6 (SOCS6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005266783.4

ORF Insert Sequence:

ATGAAGAAAA TTAGTCTTAA AACCTTACGG AAATCTTTTA ACTTGAATAA AAGTAAAGAA 
GAAACTGATT TCATGGTAGT ACAACAACCA TCGCTAGCCA GTGACTTTGG AAAAGATGAT 
TCCTTATTTG GTAGCTGCTA TGGTAAAGAT ATGGCCAGCT GCGATATCAA CGGTGAAGAT 
GAAAAAGGCG GAAAAAACAG ATCAAAAAGC GAGAGCCTGA TGGGTACGCT AAAAAGGCGG 
CTTTCTGCAA AACAGAAGTC AAAAGGCAAG GCGGGCACAC CCTCTGGGAG CTCTGCCGAC 
GAGGACACCT TCTCCTCCTC CTCAGCACCC ATAGTCTTTA AAGACGTGAG AGCTCAGAGG 
CCGATAAGGT CCACGTCGCT CCGCAGCCAT CACTACAGTC CCGCGCCGTG GCCTCTGCGG 
CCCACAAACT CCGAGGAGAC CTGCATCAAG ATGGAGGTGA GAGTCAAGGC CTTGGTTCAC 
TCTTCCAGCC CGAGTCCAGC CCTGAATGGC GTCCGGAAGG ATTTCCACGA CCTCCAGTCT 
GAGACCACGT GCCAGGAGCA AGCCAATTCA CTGAAGAGCT CGGCTTCTCA TAATGGAGAC 
CTGCATCTTC ACCTGGATGA ACATGTGCCT GTCGTTATTG GACTTATGCC TCAGGACTAC 
ATTCAGTATA CTGTGCCTTT AGATGAGGGG ATGTATCCTT TGGAAGGATC ACGGAGCTAT 
TGTCTGGACA GCTCTTCTCC CATGGAAGTC TCTGCGGTTC CTCCTCAAGT GGGAGGGCGC 
GCTTTCCCCG AGGATGAGAG TCAGGTAGAC CAGGACCTAG TTGTCGCCCC AGAGATCTTC 
GTGGATCAGT CCGTGAATGG CTTGTTGATT GGCACCACGG GAGTCATGTT GCAGAGCCCG 
AGAGCGGGTC ACGATGATGT CCCTCCACTC TCACCATTGC TACCTCCAAT GCAGAATAAT 
CAAATCCAAA GGAACTTCAG TGGACTCACT GGCACAGAAG CCCACGTGGC TGAAAGTATG 
CGCTGTCATT TGAATTTTGA TCCGAACTCT GCTCCTGGGG TTGCAAGAGT TTATGACTCA 
GTGCAAAGTA GTGGTCCCAT GGTTGTGACA AGCCTTACAG AGGAGCTGAA AAAACTTGCA 
AAGCAAGGAT GGTACTGGGG ACCAATCACA CGTTGGGAGG CAGAAGGGAA GCTAGCAAAC 
GTGCCAGATG GTTCTTTTCT TGTTCGGGAC AGTTCTGACG ACCGTTACCT TTTAAGCTTG 
AGCTTTCGCT CCCATGGTAA AACACTTCAC ACTAGAATTG AGCACTCAAA TGGTAGGTTT 
AGCTTTTATG AACAGCCAGA TGTGGAAGGA CATACGTCCA TAGTTGATCT AATTGAGCAT 
TCAATCAGGG ACTCTGAAAA TGGAGCTTTT TGTTATTCAA GGTCTCGGCT GCCTGGATCT 
GCAACTTACC CCGTCAGACT GACCAACCCA GTGTCCCGGT TCATGCAGGT GCGCTCGTTG 
CAGTACCTGT GTCGTTTTGT TATACGTCAG TATACCAGAA TAGACTTAAT TCAGAAACTG 
CCTTTGCCAA ACAAAATGAA GGATTATTTA CAGGAGAAGC ACTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SOCS6 functions as a tumor suppressor by inducing apoptosis and inhibiting angiogenesis in human prostate cancer.
Current cancer drug targets(2018 Jan)
Yuan D,Wang W,Su J,Zhang Y,Luan B,Rao H,Cheng T,Zhang W,Xiao S,Zhang M,Jiang FN,Sun Z,Jia Z,Zhong WD,Zhu J

miR-19 promotes osteosarcoma progression by targeting SOCS6.
Biochemical and biophysical research communications495(1)1363-1369(2018 01)
Sun Z,Liu Q,Hong H,Zhang H,Zhang T

PTENP1 inhibits the growth of esophageal squamous cell carcinoma by regulating SOCS6 expression and correlates with disease prognosis.
Molecular carcinogenesis56(12)2610-2619(2017 Dec)
Gong T,Zheng S,Huang S,Fu S,Zhang X,Pan S,Yang T,Sun Y,Wang Y,Hui B,Guo J,Zhang X

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SOCS6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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