GPR37L1 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR37L1
Entrez Gene ID	9283
Full Name	G protein-coupled receptor 37 like 1
Synonyms	ET(B)R-LP-2,ETBR-LP-2,ETBRLP2
General protein information	Preferred Names G protein-coupled receptor 37 like 1 Names prosaposin receptor GPR37L1 endothelin B receptor-like protein 2 endothelin type b receptor-like protein 2
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 1 Map Location: 1q32.1
Disorder MIM:	617630

mRNA and Protein(s)

mRNA	Protein	Name
NM_004767.5	NP_004758.3	G-protein coupled receptor 37-like 1 precursor
NM_004767.4	NP_004758.3	prosaposin receptor GPR37L1 precursor
XM_011510158.2	XP_011508460.1	G-protein coupled receptor 37-like 1 isoform X1
NM_004767.3	NP_004758.3	prosaposin receptor GPR37L1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPR37L1	NP_004758.3
Rattus norvegicus (Norway rat)	Gpr37l1	NP_665727.2
	GPR37L1	XP_001106794.1
Canis lupus familiaris (dog)	GPR37L1	XP_849000.3
Mus musculus (house mouse)	Gpr37l1	NP_602320.2
Gallus gallus (chicken)	GPR37L1	XP_419256.4
Danio rerio (zebrafish)	gpr37l1b	XP_696192.2
Xenopus tropicalis (tropical clawed frog)	gpr37l1	NP_001072523.1
Pan troglodytes (chimpanzee)	GPR37L1	XP_514100.2
Bos taurus (cattle)	GPR37L1	NP_001069367.1

Gene Ontology
Bibliography

Related articles in PubMed

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Giddens MM, Wong JC, Schroeder JP, Farrow EG, Smith BM, Owino S, Soden SE, Meyer RC, Saunders C, LePichon JB, Weinshenker D, Escayg A, Hall RA
Neurobiology of disease106181-190(2017 Oct)

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.
Coleman JL, Ngo T, Schmidt J, Mrad N, Liew CK, Jones NM, Graham RM, Smith NJ
Science signaling9(423)ra36(2016 Apr)

The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.
Dutta P, O'Connell KE, Ozkan SB, Sailer AW, Dev KK
Journal of neurochemistry130(3)360-73(2014 Aug)

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Meyer RC, Giddens MM, Schaefer SA, Hall RA
Proceedings of the National Academy of Sciences of the United States of America110(23)9529-34(2013 Jun)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPR37L1) coupled to the G protein Galpha(s) when heterologously expressed in cultured cells.
Title: Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Title: GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.

The following GPR37L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR37L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04588	NM_004767.5 Latest version!	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu62687	XM_011510158.2 Latest version!	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu04588	NM_004767.4	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu04588	NM_004767.3	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR37L1 ( NM_004767.5 ) cDNA ORF clone, Homo sapiens(Human) -> NP_004758.3 Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.

Price & Availability↑

CloneID	OHu04588
Clone ID Related Accession (Same CDS sequence)	NM_004767.5 , NM_004767.4 , NM_004767.3
Accession Version	NM_004767.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 37-like 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL592300.16, AK222639.1 and AL050068.1. On Nov 23, 2018 this sequence version replaced NM_004767.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.94836.1, BC050334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367282.6/ ENSP00000356251.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGTGGC TGTGGCCCCT GGCTGTCTCT CTTGCTGTGA TTTTGGCTGT GGGGCTAAGC 
AGGGTCTCTG GGGGTGCCCC CCTGCACCTG GGCAGGCACA GAGCCGAGAC CCAGGAGCAG 
CAGAGCCGAT CCAAGAGGGG CACCGAGGAT GAGGAGGCCA AGGGCGTGCA GCAGTATGTG 
CCTGAGGAGT GGGCGGAGTA CCCCCGGCCC ATTCACCCTG CTGGCCTGCA GCCAACCAAG 
CCCTTGGTGG CCACCAGCCC TAACCCCGGC AAGGATGGGG GCACCCCAGA CAGTGGGCAG 
GAACTGAGGG GCAATCTGAC AGGAGCACCA GGGCAGAGGC TACAGATCCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGTGCC TATGCCATCA TGCTTCTGGC GCTGGTGGTG 
TTTGCGGTGG GCATTGTGGG CAACCTGTCG GTCATGTGCA TCGTGTGGCA CAGCTACTAC 
CTGAAGAGTG CCTGGAACTC CATCCTTGCC AGCCTGGCCC TCTGGGATTT TCTGGTCCTC 
TTTTTCTGCC TCCCTATTGT CATCTTCAAC GAGATCACCA AGCAGAGGCT ACTGGGTGAC 
GTTTCTTGTC GTGCCGTGCC CTTCATGGAG GTCTCCTCTC TGGGAGTCAC GACTTTCAGC 
CTCTGTGCCC TGGGCATTGA CCGCTTCCAC GTGGCCACCA GCACCCTGCC CAAGGTGAGG 
CCCATCGAGC GGTGCCAATC CATCCTGGCC AAGTTGGCTG TCATCTGGGT GGGCTCCATG 
ACGCTGGCTG TGCCTGAGCT CCTGCTGTGG CAGCTGGCAC AGGAGCCTGC CCCCACCATG 
GGCACCCTGG ACTCATGCAT CATGAAACCC TCAGCCAGCC TGCCCGAGTC CCTGTATTCA 
CTGGTGATGA CCTACCAGAA CGCCCGCATG TGGTGGTACT TTGGCTGCTA CTTCTGCCTG 
CCCATCCTCT TCACAGTCAC CTGCCAGCTG GTGACATGGC GGGTGCGAGG CCCTCCAGGG 
AGGAAGTCAG AGTGCAGGGC CAGCAAGCAC GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTGGGCC TGACCGTGGT CTACGCCTTC TGCACCCTCC CAGAGAACGT CTGCAACATC 
GTGGTGGCCT ACCTCTCCAC CGAGCTGACC CGCCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT CAAGGGCGCC ATCACCCCAG TGCTGCTCCT TTGCATCTGC 
AGGCCGCTGG GCCAGGCCTT CCTGGACTGC TGCTGCTGCT GCTGCTGTGA GGAGTGCGGC 
GGGGCTTCGG AGGCCTCTGC TGCCAATGGG TCGGACAACA AGCTCAAGAC CGAGGTGTCC 
TCTTCCATCT ACTTCCACAA GCCCAGGGAG TCACCCCCAC TCCTGCCCCT GGGCACACCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004758.3
CDS	48..1493
Translation	MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC

Target ORF information:

RefSeq Version	NM_004767.5
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004767.5

ORF Insert Sequence:

ATGCGGTGGC TGTGGCCCCT GGCTGTCTCT CTTGCTGTGA TTTTGGCTGT GGGGCTAAGC 
AGGGTCTCTG GGGGTGCCCC CCTGCACCTG GGCAGGCACA GAGCCGAGAC CCAGGAGCAG 
CAGAGCCGAT CCAAGAGGGG CACCGAGGAT GAGGAGGCCA AGGGCGTGCA GCAGTATGTG 
CCTGAGGAGT GGGCGGAGTA CCCCCGGCCC ATTCACCCTG CTGGCCTGCA GCCAACCAAG 
CCCTTGGTGG CCACCAGCCC TAACCCCGGC AAGGATGGGG GCACCCCAGA CAGTGGGCAG 
GAACTGAGGG GCAATCTGAC AGGAGCACCA GGGCAGAGGC TACAGATCCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGTGCC TATGCCATCA TGCTTCTGGC GCTGGTGGTG 
TTTGCGGTGG GCATTGTGGG CAACCTGTCG GTCATGTGCA TCGTGTGGCA CAGCTACTAC 
CTGAAGAGTG CCTGGAACTC CATCCTTGCC AGCCTGGCCC TCTGGGATTT TCTGGTCCTC 
TTTTTCTGCC TCCCTATTGT CATCTTCAAC GAGATCACCA AGCAGAGGCT ACTGGGTGAC 
GTTTCTTGTC GTGCCGTGCC CTTCATGGAG GTCTCCTCTC TGGGAGTCAC GACTTTCAGC 
CTCTGTGCCC TGGGCATTGA CCGCTTCCAC GTGGCCACCA GCACCCTGCC CAAGGTGAGG 
CCCATCGAGC GGTGCCAATC CATCCTGGCC AAGTTGGCTG TCATCTGGGT GGGCTCCATG 
ACGCTGGCTG TGCCTGAGCT CCTGCTGTGG CAGCTGGCAC AGGAGCCTGC CCCCACCATG 
GGCACCCTGG ACTCATGCAT CATGAAACCC TCAGCCAGCC TGCCCGAGTC CCTGTATTCA 
CTGGTGATGA CCTACCAGAA CGCCCGCATG TGGTGGTACT TTGGCTGCTA CTTCTGCCTG 
CCCATCCTCT TCACAGTCAC CTGCCAGCTG GTGACATGGC GGGTGCGAGG CCCTCCAGGG 
AGGAAGTCAG AGTGCAGGGC CAGCAAGCAC GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTGGGCC TGACCGTGGT CTACGCCTTC TGCACCCTCC CAGAGAACGT CTGCAACATC 
GTGGTGGCCT ACCTCTCCAC CGAGCTGACC CGCCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT CAAGGGCGCC ATCACCCCAG TGCTGCTCCT TTGCATCTGC 
AGGCCGCTGG GCCAGGCCTT CCTGGACTGC TGCTGCTGCT GCTGCTGTGA GGAGTGCGGC 
GGGGCTTCGG AGGCCTCTGC TGCCAATGGG TCGGACAACA AGCTCAAGAC CGAGGTGTCC 
TCTTCCATCT ACTTCCACAA GCCCAGGGAG TCACCCCCAC TCCTGCCCCT GGGCACACCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR37L1 ( NM_004767.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_004758.3 Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.

Price & Availability↑

CloneID	OHu04588
Clone ID Related Accession (Same CDS sequence)	NM_004767.5 , NM_004767.4 , NM_004767.3
Accession Version	NM_004767.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	prosaposin receptor GPR37L1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL592300.16, AK222639.1 and AL050068.1. On Aug 29, 2017 this sequence version replaced NM_004767.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC050334.1, SRR1803611.136874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGTGGC TGTGGCCCCT GGCTGTCTCT CTTGCTGTGA TTTTGGCTGT GGGGCTAAGC 
AGGGTCTCTG GGGGTGCCCC CCTGCACCTG GGCAGGCACA GAGCCGAGAC CCAGGAGCAG 
CAGAGCCGAT CCAAGAGGGG CACCGAGGAT GAGGAGGCCA AGGGCGTGCA GCAGTATGTG 
CCTGAGGAGT GGGCGGAGTA CCCCCGGCCC ATTCACCCTG CTGGCCTGCA GCCAACCAAG 
CCCTTGGTGG CCACCAGCCC TAACCCCGGC AAGGATGGGG GCACCCCAGA CAGTGGGCAG 
GAACTGAGGG GCAATCTGAC AGGAGCACCA GGGCAGAGGC TACAGATCCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGTGCC TATGCCATCA TGCTTCTGGC GCTGGTGGTG 
TTTGCGGTGG GCATTGTGGG CAACCTGTCG GTCATGTGCA TCGTGTGGCA CAGCTACTAC 
CTGAAGAGTG CCTGGAACTC CATCCTTGCC AGCCTGGCCC TCTGGGATTT TCTGGTCCTC 
TTTTTCTGCC TCCCTATTGT CATCTTCAAC GAGATCACCA AGCAGAGGCT ACTGGGTGAC 
GTTTCTTGTC GTGCCGTGCC CTTCATGGAG GTCTCCTCTC TGGGAGTCAC GACTTTCAGC 
CTCTGTGCCC TGGGCATTGA CCGCTTCCAC GTGGCCACCA GCACCCTGCC CAAGGTGAGG 
CCCATCGAGC GGTGCCAATC CATCCTGGCC AAGTTGGCTG TCATCTGGGT GGGCTCCATG 
ACGCTGGCTG TGCCTGAGCT CCTGCTGTGG CAGCTGGCAC AGGAGCCTGC CCCCACCATG 
GGCACCCTGG ACTCATGCAT CATGAAACCC TCAGCCAGCC TGCCCGAGTC CCTGTATTCA 
CTGGTGATGA CCTACCAGAA CGCCCGCATG TGGTGGTACT TTGGCTGCTA CTTCTGCCTG 
CCCATCCTCT TCACAGTCAC CTGCCAGCTG GTGACATGGC GGGTGCGAGG CCCTCCAGGG 
AGGAAGTCAG AGTGCAGGGC CAGCAAGCAC GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTGGGCC TGACCGTGGT CTACGCCTTC TGCACCCTCC CAGAGAACGT CTGCAACATC 
GTGGTGGCCT ACCTCTCCAC CGAGCTGACC CGCCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT CAAGGGCGCC ATCACCCCAG TGCTGCTCCT TTGCATCTGC 
AGGCCGCTGG GCCAGGCCTT CCTGGACTGC TGCTGCTGCT GCTGCTGTGA GGAGTGCGGC 
GGGGCTTCGG AGGCCTCTGC TGCCAATGGG TCGGACAACA AGCTCAAGAC CGAGGTGTCC 
TCTTCCATCT ACTTCCACAA GCCCAGGGAG TCACCCCCAC TCCTGCCCCT GGGCACACCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004758.3
CDS	124..1569
Translation	MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC

Target ORF information:

RefSeq Version	NM_004767.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004767.4

ORF Insert Sequence:

ATGCGGTGGC TGTGGCCCCT GGCTGTCTCT CTTGCTGTGA TTTTGGCTGT GGGGCTAAGC 
AGGGTCTCTG GGGGTGCCCC CCTGCACCTG GGCAGGCACA GAGCCGAGAC CCAGGAGCAG 
CAGAGCCGAT CCAAGAGGGG CACCGAGGAT GAGGAGGCCA AGGGCGTGCA GCAGTATGTG 
CCTGAGGAGT GGGCGGAGTA CCCCCGGCCC ATTCACCCTG CTGGCCTGCA GCCAACCAAG 
CCCTTGGTGG CCACCAGCCC TAACCCCGGC AAGGATGGGG GCACCCCAGA CAGTGGGCAG 
GAACTGAGGG GCAATCTGAC AGGAGCACCA GGGCAGAGGC TACAGATCCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGTGCC TATGCCATCA TGCTTCTGGC GCTGGTGGTG 
TTTGCGGTGG GCATTGTGGG CAACCTGTCG GTCATGTGCA TCGTGTGGCA CAGCTACTAC 
CTGAAGAGTG CCTGGAACTC CATCCTTGCC AGCCTGGCCC TCTGGGATTT TCTGGTCCTC 
TTTTTCTGCC TCCCTATTGT CATCTTCAAC GAGATCACCA AGCAGAGGCT ACTGGGTGAC 
GTTTCTTGTC GTGCCGTGCC CTTCATGGAG GTCTCCTCTC TGGGAGTCAC GACTTTCAGC 
CTCTGTGCCC TGGGCATTGA CCGCTTCCAC GTGGCCACCA GCACCCTGCC CAAGGTGAGG 
CCCATCGAGC GGTGCCAATC CATCCTGGCC AAGTTGGCTG TCATCTGGGT GGGCTCCATG 
ACGCTGGCTG TGCCTGAGCT CCTGCTGTGG CAGCTGGCAC AGGAGCCTGC CCCCACCATG 
GGCACCCTGG ACTCATGCAT CATGAAACCC TCAGCCAGCC TGCCCGAGTC CCTGTATTCA 
CTGGTGATGA CCTACCAGAA CGCCCGCATG TGGTGGTACT TTGGCTGCTA CTTCTGCCTG 
CCCATCCTCT TCACAGTCAC CTGCCAGCTG GTGACATGGC GGGTGCGAGG CCCTCCAGGG 
AGGAAGTCAG AGTGCAGGGC CAGCAAGCAC GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTGGGCC TGACCGTGGT CTACGCCTTC TGCACCCTCC CAGAGAACGT CTGCAACATC 
GTGGTGGCCT ACCTCTCCAC CGAGCTGACC CGCCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT CAAGGGCGCC ATCACCCCAG TGCTGCTCCT TTGCATCTGC 
AGGCCGCTGG GCCAGGCCTT CCTGGACTGC TGCTGCTGCT GCTGCTGTGA GGAGTGCGGC 
GGGGCTTCGG AGGCCTCTGC TGCCAATGGG TCGGACAACA AGCTCAAGAC CGAGGTGTCC 
TCTTCCATCT ACTTCCACAA GCCCAGGGAG TCACCCCCAC TCCTGCCCCT GGGCACACCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR37L1 ( NM_004767.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_004758.3 Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.

Price & Availability↑

CloneID	OHu04588
Clone ID Related Accession (Same CDS sequence)	NM_004767.5 , NM_004767.4 , NM_004767.3
Accession Version	NM_004767.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-28
Organism	Homo sapiens(Human)
Product	prosaposin receptor GPR37L1 precursor
Comment	VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC050334.1, AK222639.1 and AL592300.16. On Mar 28, 2007 this sequence version replaced NM_004767.2. ##Evidence-Data-START## Transcript exon combination :: BC050334.1, SRR1803611.136874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGTGGC TGTGGCCCCT GGCTGTCTCT CTTGCTGTGA TTTTGGCTGT GGGGCTAAGC 
AGGGTCTCTG GGGGTGCCCC CCTGCACCTG GGCAGGCACA GAGCCGAGAC CCAGGAGCAG 
CAGAGCCGAT CCAAGAGGGG CACCGAGGAT GAGGAGGCCA AGGGCGTGCA GCAGTATGTG 
CCTGAGGAGT GGGCGGAGTA CCCCCGGCCC ATTCACCCTG CTGGCCTGCA GCCAACCAAG 
CCCTTGGTGG CCACCAGCCC TAACCCCGGC AAGGATGGGG GCACCCCAGA CAGTGGGCAG 
GAACTGAGGG GCAATCTGAC AGGAGCACCA GGGCAGAGGC TACAGATCCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGTGCC TATGCCATCA TGCTTCTGGC GCTGGTGGTG 
TTTGCGGTGG GCATTGTGGG CAACCTGTCG GTCATGTGCA TCGTGTGGCA CAGCTACTAC 
CTGAAGAGTG CCTGGAACTC CATCCTTGCC AGCCTGGCCC TCTGGGATTT TCTGGTCCTC 
TTTTTCTGCC TCCCTATTGT CATCTTCAAC GAGATCACCA AGCAGAGGCT ACTGGGTGAC 
GTTTCTTGTC GTGCCGTGCC CTTCATGGAG GTCTCCTCTC TGGGAGTCAC GACTTTCAGC 
CTCTGTGCCC TGGGCATTGA CCGCTTCCAC GTGGCCACCA GCACCCTGCC CAAGGTGAGG 
CCCATCGAGC GGTGCCAATC CATCCTGGCC AAGTTGGCTG TCATCTGGGT GGGCTCCATG 
ACGCTGGCTG TGCCTGAGCT CCTGCTGTGG CAGCTGGCAC AGGAGCCTGC CCCCACCATG 
GGCACCCTGG ACTCATGCAT CATGAAACCC TCAGCCAGCC TGCCCGAGTC CCTGTATTCA 
CTGGTGATGA CCTACCAGAA CGCCCGCATG TGGTGGTACT TTGGCTGCTA CTTCTGCCTG 
CCCATCCTCT TCACAGTCAC CTGCCAGCTG GTGACATGGC GGGTGCGAGG CCCTCCAGGG 
AGGAAGTCAG AGTGCAGGGC CAGCAAGCAC GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTGGGCC TGACCGTGGT CTACGCCTTC TGCACCCTCC CAGAGAACGT CTGCAACATC 
GTGGTGGCCT ACCTCTCCAC CGAGCTGACC CGCCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT CAAGGGCGCC ATCACCCCAG TGCTGCTCCT TTGCATCTGC 
AGGCCGCTGG GCCAGGCCTT CCTGGACTGC TGCTGCTGCT GCTGCTGTGA GGAGTGCGGC 
GGGGCTTCGG AGGCCTCTGC TGCCAATGGG TCGGACAACA AGCTCAAGAC CGAGGTGTCC 
TCTTCCATCT ACTTCCACAA GCCCAGGGAG TCACCCCCAC TCCTGCCCCT GGGCACACCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004758.3
CDS	64..1509
Translation	MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC

Target ORF information:

RefSeq Version	NM_004767.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004767.3

ORF Insert Sequence:

ATGCGGTGGC TGTGGCCCCT GGCTGTCTCT CTTGCTGTGA TTTTGGCTGT GGGGCTAAGC 
AGGGTCTCTG GGGGTGCCCC CCTGCACCTG GGCAGGCACA GAGCCGAGAC CCAGGAGCAG 
CAGAGCCGAT CCAAGAGGGG CACCGAGGAT GAGGAGGCCA AGGGCGTGCA GCAGTATGTG 
CCTGAGGAGT GGGCGGAGTA CCCCCGGCCC ATTCACCCTG CTGGCCTGCA GCCAACCAAG 
CCCTTGGTGG CCACCAGCCC TAACCCCGGC AAGGATGGGG GCACCCCAGA CAGTGGGCAG 
GAACTGAGGG GCAATCTGAC AGGAGCACCA GGGCAGAGGC TACAGATCCA GAACCCCCTG 
TATCCGGTGA CCGAGAGCTC CTACAGTGCC TATGCCATCA TGCTTCTGGC GCTGGTGGTG 
TTTGCGGTGG GCATTGTGGG CAACCTGTCG GTCATGTGCA TCGTGTGGCA CAGCTACTAC 
CTGAAGAGTG CCTGGAACTC CATCCTTGCC AGCCTGGCCC TCTGGGATTT TCTGGTCCTC 
TTTTTCTGCC TCCCTATTGT CATCTTCAAC GAGATCACCA AGCAGAGGCT ACTGGGTGAC 
GTTTCTTGTC GTGCCGTGCC CTTCATGGAG GTCTCCTCTC TGGGAGTCAC GACTTTCAGC 
CTCTGTGCCC TGGGCATTGA CCGCTTCCAC GTGGCCACCA GCACCCTGCC CAAGGTGAGG 
CCCATCGAGC GGTGCCAATC CATCCTGGCC AAGTTGGCTG TCATCTGGGT GGGCTCCATG 
ACGCTGGCTG TGCCTGAGCT CCTGCTGTGG CAGCTGGCAC AGGAGCCTGC CCCCACCATG 
GGCACCCTGG ACTCATGCAT CATGAAACCC TCAGCCAGCC TGCCCGAGTC CCTGTATTCA 
CTGGTGATGA CCTACCAGAA CGCCCGCATG TGGTGGTACT TTGGCTGCTA CTTCTGCCTG 
CCCATCCTCT TCACAGTCAC CTGCCAGCTG GTGACATGGC GGGTGCGAGG CCCTCCAGGG 
AGGAAGTCAG AGTGCAGGGC CAGCAAGCAC GAGCAGTGTG AGAGCCAGCT CAACAGCACC 
GTGGTGGGCC TGACCGTGGT CTACGCCTTC TGCACCCTCC CAGAGAACGT CTGCAACATC 
GTGGTGGCCT ACCTCTCCAC CGAGCTGACC CGCCAGACCC TGGACCTCCT GGGCCTCATC 
AACCAGTTCT CCACCTTCTT CAAGGGCGCC ATCACCCCAG TGCTGCTCCT TTGCATCTGC 
AGGCCGCTGG GCCAGGCCTT CCTGGACTGC TGCTGCTGCT GCTGCTGTGA GGAGTGCGGC 
GGGGCTTCGG AGGCCTCTGC TGCCAATGGG TCGGACAACA AGCTCAAGAC CGAGGTGTCC 
TCTTCCATCT ACTTCCACAA GCCCAGGGAG TCACCCCCAC TCCTGCCCCT GGGCACACCT 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR37L1 ( XM_011510158.2 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011508460.1 Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), transcript variant X1, mRNA.

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CloneID	OHu62687
Clone ID Related Accession (Same CDS sequence)	XM_011510158.2
Accession Version	XM_011510158.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 37-like 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510158.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTCTGA ATAGGGGAGA TGGCTCCAGC TTGTCCAGAG AGAGGAATCT TCCTAAAGTA 
GAACTACAGG TCTCCTCTCT GGGAGTCACG ACTTTCAGCC TCTGTGCCCT GGGCATTGAC 
CGCTTCCACG TGGCCACCAG CACCCTGCCC AAGGTGAGGC CCATCGAGCG GTGCCAATCC 
ATCCTGGCCA AGTTGGCTGT CATCTGGGTG GGCTCCATGA CGCTGGCTGT GCCTGAGCTC 
CTGCTGTGGC AGCTGGCACA GGAGCCTGCC CCCACCATGG GCACCCTGGA CTCATGCATC 
ATGAAACCCT CAGCCAGCCT GCCCGAGTCC CTGTATTCAC TGGTGATGAC CTACCAGAAC 
GCCCGCATGT GGTGGTACTT TGGCTGCTAC TTCTGCCTGC CCATCCTCTT CACAGTCACC 
TGCCAGCTGG TGACATGGCG GGTGCGAGGC CCTCCAGGGA GGAAGTCAGA GTGCAGGGCC 
AGCAAGCACG AGCAGTGTGA GAGCCAGCTC AACAGCACCG TGGTGGGCCT GACCGTGGTC 
TACGCCTTCT GCACCCTCCC AGAGAACGTC TGCAACATCG TGGTGGCCTA CCTCTCCACC 
GAGCTGACCC GCCAGACCCT GGACCTCCTG GGCCTCATCA ACCAGTTCTC CACCTTCTTC 
AAGGGCGCCA TCACCCCAGT GCTGCTCCTT TGCATCTGCA GGCCGCTGGG CCAGGCCTTC 
CTGGACTGCT GCTGCTGCTG CTGCTGTGAG GAGTGCGGCG GGGCTTCGGA GGCCTCTGCT 
GCCAATGGGT CGGACAACAA GCTCAAGACC GAGGTGTCCT CTTCCATCTA CTTCCACAAG 
CCCAGGGAGT CACCCCCACT CCTGCCCCTG GGCACACCTT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508460.1
CDS	141..1025
Translation	MLLNRGDGSSLSRERNLPKVELQVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC

Target ORF information:

RefSeq Version	XM_011510158.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510158.2

ORF Insert Sequence:

ATGCTTCTGA ATAGGGGAGA TGGCTCCAGC TTGTCCAGAG AGAGGAATCT TCCTAAAGTA 
GAACTACAGG TCTCCTCTCT GGGAGTCACG ACTTTCAGCC TCTGTGCCCT GGGCATTGAC 
CGCTTCCACG TGGCCACCAG CACCCTGCCC AAGGTGAGGC CCATCGAGCG GTGCCAATCC 
ATCCTGGCCA AGTTGGCTGT CATCTGGGTG GGCTCCATGA CGCTGGCTGT GCCTGAGCTC 
CTGCTGTGGC AGCTGGCACA GGAGCCTGCC CCCACCATGG GCACCCTGGA CTCATGCATC 
ATGAAACCCT CAGCCAGCCT GCCCGAGTCC CTGTATTCAC TGGTGATGAC CTACCAGAAC 
GCCCGCATGT GGTGGTACTT TGGCTGCTAC TTCTGCCTGC CCATCCTCTT CACAGTCACC 
TGCCAGCTGG TGACATGGCG GGTGCGAGGC CCTCCAGGGA GGAAGTCAGA GTGCAGGGCC 
AGCAAGCACG AGCAGTGTGA GAGCCAGCTC AACAGCACCG TGGTGGGCCT GACCGTGGTC 
TACGCCTTCT GCACCCTCCC AGAGAACGTC TGCAACATCG TGGTGGCCTA CCTCTCCACC 
GAGCTGACCC GCCAGACCCT GGACCTCCTG GGCCTCATCA ACCAGTTCTC CACCTTCTTC 
AAGGGCGCCA TCACCCCAGT GCTGCTCCTT TGCATCTGCA GGCCGCTGGG CCAGGCCTTC 
CTGGACTGCT GCTGCTGCTG CTGCTGTGAG GAGTGCGGCG GGGCTTCGGA GGCCTCTGCT 
GCCAATGGGT CGGACAACAA GCTCAAGACC GAGGTGTCCT CTTCCATCTA CTTCCACAAG 
CCCAGGGAGT CACCCCCACT CCTGCCCCTG GGCACACCTT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Neurobiology of disease106181-190(2017 Oct)
Giddens MM,Wong JC,Schroeder JP,Farrow EG,Smith BM,Owino S,Soden SE,Meyer RC,Saunders C,LePichon JB,Weinshenker D,Escayg A,Hall RA

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.
Science signaling9(423)ra36(2016 Apr)
Coleman JL,Ngo T,Schmidt J,Mrad N,Liew CK,Jones NM,Graham RM,Smith NJ

The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.
Journal of neurochemistry130(3)360-73(2014 Aug)
Dutta P,O'Connell KE,Ozkan SB,Sailer AW,Dev KK

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
Proceedings of the National Academy of Sciences of the United States of America110(23)9529-34(2013 Jun)
Meyer RC,Giddens MM,Schaefer SA,Hall RA

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

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GPR37L1 cDNA ORF clone, Homo sapiens(Human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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