CYTH3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYTH3
Entrez Gene ID	9265
Full Name	cytohesin 3
Synonyms	ARNO3,GRP1,PSCD3,cytohesin-3
General protein information	Preferred Names cytohesin 3 Names cytohesin-3 ARF nucleotide-binding site opener 3 PH, SEC7 and coiled-coil domain-containing protein 3 general receptor of phosphoinositides 1 pleckstrin homology, Sec7 and coiled-coil domains 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p22.1
Summary	This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008].
Disorder MIM:	605081

mRNA and Protein(s)

mRNA	Protein	Name
NM_004227.3	NP_004218.1	cytohesin-3
NM_004227.4	NP_004218.1	cytohesin-3 isoform a
NM_001367580.1	NP_001354509.1	cytohesin-3 isoform b
NM_001367581.1	NP_001354510.1	cytohesin-3 isoform c
NM_001367582.1	NP_001354511.1	cytohesin-3 isoform c

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CYTH3	NP_001238790.1
	LOC717713	XP_001109483.2
Danio rerio (zebrafish)	LOC100537448	XP_003198225.2
Homo sapiens (human)	CYTH3	NP_004218.1
Bos taurus (cattle)	LOC618488	XP_002698196.2
Gallus gallus (chicken)	CYTH3	XP_004945363.1
Xenopus tropicalis (tropical clawed frog)	cyth3	NP_001072881.1
Rattus norvegicus (Norway rat)	Cyth3	NP_446364.2
Canis lupus familiaris (dog)	CYTH3	XP_005621179.1
Mus musculus (house mouse)	Cyth3	NP_035312.3
Danio rerio (zebrafish)	cyth3	XP_001342037.2
Caenorhabditis elegans (roundworm)	grp-1	NP_498764.1

Gene Ontology
Bibliography

Related articles in PubMed

Cytohesin-3 is upregulated in hepatocellular carcinoma and contributes to tumor growth and vascular invasion.
Fu Y, Li J, Feng MX, Yang XM, Wang YH, Zhang YL, Qin W, Xia Q, Zhang ZG
International journal of clinical and experimental pathology7(5)2123-32(2014)

Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.
Malaby AW, van den Berg B, Lambright DG
Proceedings of the National Academy of Sciences of the United States of America110(35)14213-8(2013 Aug)

Phosphoinositide specificity determines which cytohesins regulate ?1 integrin recycling.
Oh SJ, Santy LC
Journal of cell science125(Pt 13)3195-201(2012 Jul)

The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).
Pilling C, Landgraf KE, Falke JJ
Biochemistry50(45)9845-56(2011 Nov)

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H
Nature cell biology10(1)85-92(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cytohesin-3 was upregulated in hepatocellular carcinoma tissues, correlating with overall survival/relapse-free survival and tumor size/vascular invasion.
Title: Cytohesin-3 is upregulated in hepatocellular carcinoma and contributes to tumor growth and vascular invasion.

The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin.
Title: Phosphoinositide specificity determines which cytohesins regulate ?1 integrin recycling.

incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells
Title: The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).

GRP1 is a new corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements
Title: General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding.

The following CYTH3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYTH3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19460	NM_004227.4 Latest version!	Homo sapiens cytohesin 3 (CYTH3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu107433	NM_001367581.1 Latest version!	Homo sapiens cytohesin 3 (CYTH3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107433	NM_001367582.1 Latest version!	Homo sapiens cytohesin 3 (CYTH3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu107434	NM_001367580.1 Latest version!	Homo sapiens cytohesin 3 (CYTH3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu19460	NM_004227.3	Homo sapiens cytohesin 3 (CYTH3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYTH3 ( NM_004227.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004218.1 Homo sapiens cytohesin 3 (CYTH3), mRNA.

Price & Availability↑

CloneID	OHu19460
Clone ID Related Accession (Same CDS sequence)	NM_004227.3 , NM_004227.4
Accession Version	NM_004227.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	cytohesin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988199.1, AJ223957.1, BG620295.1 and BC028717.1. This sequence is a reference standard in the RefSeqGene project. On Aug 20, 2003 this sequence version replaced NM_004227.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028717.1, SRR1803616.73428.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAG ACGGCGGCGG CGAGGGTGGT GGCGTGCCTG AAGACCTCTC ATTAGAAGAG 
AGAGAAGAAC TTCTAGACAT TCGTCGAAGA AAAAAGGAAC TTATTGATGA CATTGAGAGG 
CTGAAATATG AAATTGCAGA GGTGATGACA GAGATCGACA ATCTAACTTC CGTAGAGGAG 
AGCAAAACGA CTCAGAGGAA CAAACAGATA GCCATGGGAA GAAAGAAATT CAACATGGAT 
CCCAAAAAGG GAATTCAGTT TCTAATAGAA AATGACCTGC TACAGAGTTC CCCAGAAGAC 
GTCGCCCAGT TCCTTTATAA AGGAGAAGGC CTAAATAAGA CCGTCATTGG GGACTACCTG 
GGTGAAAGGG ATGAATTTAA TATTAAAGTT CTTCAAGCCT TTGTTGAACT CCATGAGTTT 
GCTGATCTCA ACCTTGTACA AGCCTTAAGG CAGTTCTTAT GGAGCTTCAG GCTGCCCGGG 
GAGGCGCAGA AGATTGATCG CATGATGGAG GCTTTCGCTT CTCGCTACTG CCTGTGCAAC 
CCCGGGGTCT TCCAGTCCAC AGACACGTGC TACGTGCTGT CATTCGCCAT CATCATGCTC 
AACACCAGCC TCCACAACCA CAACGTGCGT GACAAGCCCA CGGCAGAACG GTTCATCGCC 
ATGAACCGCG GCATCAACGA GGGCGGGGAC CTCCCTGAGG AGCTGCTGAG GAATTTGTAT 
GAGAGCATTA AGAACGAGCC ATTTAAGATC CCGGAGGACG ACGGGAACGA CCTGACCCAC 
ACCTTCTTCA ACCCCGACCG CGAGGGCTGG CTCCTGAAGC TGGGAGGGCG TGTGAAGACC 
TGGAAGCGCC GGTGGTTCAT CCTGACCGAT AACTGCCTCT ATTACTTTGA ATACACAACA 
GATAAGGAGC CCAGGGGAAT CATCCCGTTG GAAAACCTCA GCATCAGGGA GGTGGAGGAC 
CCCCGGAAAC CCAACTGTTT TGAGCTCTAC AATCCCAGCC ACAAAGGGCA GGTCATCAAG 
GCCTGTAAGA CTGAGGCCGA CGGCCGCGTG GTAGAGGGGA ACCATGTGGT GTACCGGATC 
TCAGCCCCGA GCCCGGAGGA GAAGGAGGAG TGGATGAAAT CCATCAAAGC CAGTATCAGC 
AGAGATCCCT TCTATGACAT GTTGGCAACG AGGAAACGAA GGATTGCCAA TAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004218.1
CDS	105..1304
Translation	MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Target ORF information:

RefSeq Version	NM_004227.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytohesin 3 (CYTH3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004227.3

ORF Insert Sequence:

ATGGATGAAG ACGGCGGCGG CGAGGGTGGT GGCGTGCCTG AAGACCTCTC ATTAGAAGAG 
AGAGAAGAAC TTCTAGACAT TCGTCGAAGA AAAAAGGAAC TTATTGATGA CATTGAGAGG 
CTGAAATATG AAATTGCAGA GGTGATGACA GAGATCGACA ATCTAACTTC CGTAGAGGAG 
AGCAAAACGA CTCAGAGGAA CAAACAGATA GCCATGGGAA GAAAGAAATT CAACATGGAT 
CCCAAAAAGG GAATTCAGTT TCTAATAGAA AATGACCTGC TACAGAGTTC CCCAGAAGAC 
GTCGCCCAGT TCCTTTATAA AGGAGAAGGC CTAAATAAGA CCGTCATTGG GGACTACCTG 
GGTGAAAGGG ATGAATTTAA TATTAAAGTT CTTCAAGCCT TTGTTGAACT CCATGAGTTT 
GCTGATCTCA ACCTTGTACA AGCCTTAAGG CAGTTCTTAT GGAGCTTCAG GCTGCCCGGG 
GAGGCGCAGA AGATTGATCG CATGATGGAG GCTTTCGCTT CTCGCTACTG CCTGTGCAAC 
CCCGGGGTCT TCCAGTCCAC AGACACGTGC TACGTGCTGT CATTCGCCAT CATCATGCTC 
AACACCAGCC TCCACAACCA CAACGTGCGT GACAAGCCCA CGGCAGAACG GTTCATCGCC 
ATGAACCGCG GCATCAACGA GGGCGGGGAC CTCCCTGAGG AGCTGCTGAG GAATTTGTAT 
GAGAGCATTA AGAACGAGCC ATTTAAGATC CCGGAGGACG ACGGGAACGA CCTGACCCAC 
ACCTTCTTCA ACCCCGACCG CGAGGGCTGG CTCCTGAAGC TGGGAGGGCG TGTGAAGACC 
TGGAAGCGCC GGTGGTTCAT CCTGACCGAT AACTGCCTCT ATTACTTTGA ATACACAACA 
GATAAGGAGC CCAGGGGAAT CATCCCGTTG GAAAACCTCA GCATCAGGGA GGTGGAGGAC 
CCCCGGAAAC CCAACTGTTT TGAGCTCTAC AATCCCAGCC ACAAAGGGCA GGTCATCAAG 
GCCTGTAAGA CTGAGGCCGA CGGCCGCGTG GTAGAGGGGA ACCATGTGGT GTACCGGATC 
TCAGCCCCGA GCCCGGAGGA GAAGGAGGAG TGGATGAAAT CCATCAAAGC CAGTATCAGC 
AGAGATCCCT TCTATGACAT GTTGGCAACG AGGAAACGAA GGATTGCCAA TAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYTH3 ( NM_004227.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004218.1 Homo sapiens cytohesin 3 (CYTH3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19460
Clone ID Related Accession (Same CDS sequence)	NM_004227.3 , NM_004227.4
Accession Version	NM_004227.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cytohesin-3 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009412.6, CB988199.1, AJ223957.1, BG620295.1 and BC028717.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004227.3. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028717.1, SRR1803616.73428.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000350796.8/ ENSP00000297044.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATGAAG ACGGCGGCGG CGAGGGTGGT GGCGTGCCTG AAGACCTCTC ATTAGAAGAG 
AGAGAAGAAC TTCTAGACAT TCGTCGAAGA AAAAAGGAAC TTATTGATGA CATTGAGAGG 
CTGAAATATG AAATTGCAGA GGTGATGACA GAGATCGACA ATCTAACTTC CGTAGAGGAG 
AGCAAAACGA CTCAGAGGAA CAAACAGATA GCCATGGGAA GAAAGAAATT CAACATGGAT 
CCCAAAAAGG GAATTCAGTT TCTAATAGAA AATGACCTGC TACAGAGTTC CCCAGAAGAC 
GTCGCCCAGT TCCTTTATAA AGGAGAAGGC CTAAATAAGA CCGTCATTGG GGACTACCTG 
GGTGAAAGGG ATGAATTTAA TATTAAAGTT CTTCAAGCCT TTGTTGAACT CCATGAGTTT 
GCTGATCTCA ACCTTGTACA AGCCTTAAGG CAGTTCTTAT GGAGCTTCAG GCTGCCCGGG 
GAGGCGCAGA AGATTGATCG CATGATGGAG GCTTTCGCTT CTCGCTACTG CCTGTGCAAC 
CCCGGGGTCT TCCAGTCCAC AGACACGTGC TACGTGCTGT CATTCGCCAT CATCATGCTC 
AACACCAGCC TCCACAACCA CAACGTGCGT GACAAGCCCA CGGCAGAACG GTTCATCGCC 
ATGAACCGCG GCATCAACGA GGGCGGGGAC CTCCCTGAGG AGCTGCTGAG GAATTTGTAT 
GAGAGCATTA AGAACGAGCC ATTTAAGATC CCGGAGGACG ACGGGAACGA CCTGACCCAC 
ACCTTCTTCA ACCCCGACCG CGAGGGCTGG CTCCTGAAGC TGGGAGGGCG TGTGAAGACC 
TGGAAGCGCC GGTGGTTCAT CCTGACCGAT AACTGCCTCT ATTACTTTGA ATACACAACA 
GATAAGGAGC CCAGGGGAAT CATCCCGTTG GAAAACCTCA GCATCAGGGA GGTGGAGGAC 
CCCCGGAAAC CCAACTGTTT TGAGCTCTAC AATCCCAGCC ACAAAGGGCA GGTCATCAAG 
GCCTGTAAGA CTGAGGCCGA CGGCCGCGTG GTAGAGGGGA ACCATGTGGT GTACCGGATC 
TCAGCCCCGA GCCCGGAGGA GAAGGAGGAG TGGATGAAAT CCATCAAAGC CAGTATCAGC 
AGAGATCCCT TCTATGACAT GTTGGCAACG AGGAAACGAA GGATTGCCAA TAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004218.1
CDS	118..1317
Translation	MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Target ORF information:

RefSeq Version	NM_004227.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytohesin 3 (CYTH3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004227.4

ORF Insert Sequence:

ATGGATGAAG ACGGCGGCGG CGAGGGTGGT GGCGTGCCTG AAGACCTCTC ATTAGAAGAG 
AGAGAAGAAC TTCTAGACAT TCGTCGAAGA AAAAAGGAAC TTATTGATGA CATTGAGAGG 
CTGAAATATG AAATTGCAGA GGTGATGACA GAGATCGACA ATCTAACTTC CGTAGAGGAG 
AGCAAAACGA CTCAGAGGAA CAAACAGATA GCCATGGGAA GAAAGAAATT CAACATGGAT 
CCCAAAAAGG GAATTCAGTT TCTAATAGAA AATGACCTGC TACAGAGTTC CCCAGAAGAC 
GTCGCCCAGT TCCTTTATAA AGGAGAAGGC CTAAATAAGA CCGTCATTGG GGACTACCTG 
GGTGAAAGGG ATGAATTTAA TATTAAAGTT CTTCAAGCCT TTGTTGAACT CCATGAGTTT 
GCTGATCTCA ACCTTGTACA AGCCTTAAGG CAGTTCTTAT GGAGCTTCAG GCTGCCCGGG 
GAGGCGCAGA AGATTGATCG CATGATGGAG GCTTTCGCTT CTCGCTACTG CCTGTGCAAC 
CCCGGGGTCT TCCAGTCCAC AGACACGTGC TACGTGCTGT CATTCGCCAT CATCATGCTC 
AACACCAGCC TCCACAACCA CAACGTGCGT GACAAGCCCA CGGCAGAACG GTTCATCGCC 
ATGAACCGCG GCATCAACGA GGGCGGGGAC CTCCCTGAGG AGCTGCTGAG GAATTTGTAT 
GAGAGCATTA AGAACGAGCC ATTTAAGATC CCGGAGGACG ACGGGAACGA CCTGACCCAC 
ACCTTCTTCA ACCCCGACCG CGAGGGCTGG CTCCTGAAGC TGGGAGGGCG TGTGAAGACC 
TGGAAGCGCC GGTGGTTCAT CCTGACCGAT AACTGCCTCT ATTACTTTGA ATACACAACA 
GATAAGGAGC CCAGGGGAAT CATCCCGTTG GAAAACCTCA GCATCAGGGA GGTGGAGGAC 
CCCCGGAAAC CCAACTGTTT TGAGCTCTAC AATCCCAGCC ACAAAGGGCA GGTCATCAAG 
GCCTGTAAGA CTGAGGCCGA CGGCCGCGTG GTAGAGGGGA ACCATGTGGT GTACCGGATC 
TCAGCCCCGA GCCCGGAGGA GAAGGAGGAG TGGATGAAAT CCATCAAAGC CAGTATCAGC 
AGAGATCCCT TCTATGACAT GTTGGCAACG AGGAAACGAA GGATTGCCAA TAAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYTH3 ( NM_001367581.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001354510.1 Homo sapiens cytohesin 3 (CYTH3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu107433
Clone ID Related Accession (Same CDS sequence)	NM_001367581.1 , NM_001367582.1
Accession Version	NM_001367581.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	cytohesin-3 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009412.6 and AC004895.3. Transcript Variant: This variant (3), as well as variant 4, encodes isoform c. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1803616.73428.1, SRR1803616.59478.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATGGAGG CTTTCGCTTC TCGCTACTGC CTGTGCAACC CCGGGGTCTT CCAGTCCACA 
GACACGTGCT ACGTGCTGTC ATTCGCCATC ATCATGCTCA ACACCAGCCT CCACAACCAC 
AACGTGCGTG ACAAGCCCAC GGCAGAACGG TTCATCGCCA TGAACCGCGG CATCAACGAG 
GGCGGGGACC TCCCTGAGGA GCTGCTGAGG AATTTGTATG AGAGCATTAA GAACGAGCCA 
TTTAAGATCC CGGAGGACGA CGGGAACGAC CTGACCCACA CCTTCTTCAA CCCCGACCGC 
GAGGGCTGGC TCCTGAAGCT GGGAGGGCGT GTGAAGACCT GGAAGCGCCG GTGGTTCATC 
CTGACCGATA ACTGCCTCTA TTACTTTGAA TACACAACAG ATAAGGAGCC CAGGGGAATC 
ATCCCGTTGG AAAACCTCAG CATCAGGGAG GTGGAGGACC CCCGGAAACC CAACTGTTTT 
GAGCTCTACA ATCCCAGCCA CAAAGGGCAG GTCATCAAGG CCTGTAAGAC TGAGGCCGAC 
GGCCGCGTGG TAGAGGGGAA CCATGTGGTG TACCGGATCT CAGCCCCGAG CCCGGAGGAG 
AAGGAGGAGT GGATGAAATC CATCAAAGCC AGTATCAGCA GAGATCCCTT CTATGACATG 
TTGGCAACGA GGAAACGAAG GATTGCCAAT AAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001354510.1
CDS	842..1540
Translation	MMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Target ORF information:

RefSeq Version	NM_001367581.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytohesin 3 (CYTH3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001367581.1

ORF Insert Sequence:

ATGATGGAGG CTTTCGCTTC TCGCTACTGC CTGTGCAACC CCGGGGTCTT CCAGTCCACA 
GACACGTGCT ACGTGCTGTC ATTCGCCATC ATCATGCTCA ACACCAGCCT CCACAACCAC 
AACGTGCGTG ACAAGCCCAC GGCAGAACGG TTCATCGCCA TGAACCGCGG CATCAACGAG 
GGCGGGGACC TCCCTGAGGA GCTGCTGAGG AATTTGTATG AGAGCATTAA GAACGAGCCA 
TTTAAGATCC CGGAGGACGA CGGGAACGAC CTGACCCACA CCTTCTTCAA CCCCGACCGC 
GAGGGCTGGC TCCTGAAGCT GGGAGGGCGT GTGAAGACCT GGAAGCGCCG GTGGTTCATC 
CTGACCGATA ACTGCCTCTA TTACTTTGAA TACACAACAG ATAAGGAGCC CAGGGGAATC 
ATCCCGTTGG AAAACCTCAG CATCAGGGAG GTGGAGGACC CCCGGAAACC CAACTGTTTT 
GAGCTCTACA ATCCCAGCCA CAAAGGGCAG GTCATCAAGG CCTGTAAGAC TGAGGCCGAC 
GGCCGCGTGG TAGAGGGGAA CCATGTGGTG TACCGGATCT CAGCCCCGAG CCCGGAGGAG 
AAGGAGGAGT GGATGAAATC CATCAAAGCC AGTATCAGCA GAGATCCCTT CTATGACATG 
TTGGCAACGA GGAAACGAAG GATTGCCAAT AAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYTH3 ( NM_001367582.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001354511.1 Homo sapiens cytohesin 3 (CYTH3), transcript variant 4, mRNA.

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CloneID	OHu107433
Clone ID Related Accession (Same CDS sequence)	NM_001367581.1 , NM_001367582.1
Accession Version	NM_001367582.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	cytohesin-3 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004895.3. Transcript Variant: This variant (4), as well as variant 3, encodes isoform c. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.167270.1, SRR1803613.33984.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATGGAGG CTTTCGCTTC TCGCTACTGC CTGTGCAACC CCGGGGTCTT CCAGTCCACA 
GACACGTGCT ACGTGCTGTC ATTCGCCATC ATCATGCTCA ACACCAGCCT CCACAACCAC 
AACGTGCGTG ACAAGCCCAC GGCAGAACGG TTCATCGCCA TGAACCGCGG CATCAACGAG 
GGCGGGGACC TCCCTGAGGA GCTGCTGAGG AATTTGTATG AGAGCATTAA GAACGAGCCA 
TTTAAGATCC CGGAGGACGA CGGGAACGAC CTGACCCACA CCTTCTTCAA CCCCGACCGC 
GAGGGCTGGC TCCTGAAGCT GGGAGGGCGT GTGAAGACCT GGAAGCGCCG GTGGTTCATC 
CTGACCGATA ACTGCCTCTA TTACTTTGAA TACACAACAG ATAAGGAGCC CAGGGGAATC 
ATCCCGTTGG AAAACCTCAG CATCAGGGAG GTGGAGGACC CCCGGAAACC CAACTGTTTT 
GAGCTCTACA ATCCCAGCCA CAAAGGGCAG GTCATCAAGG CCTGTAAGAC TGAGGCCGAC 
GGCCGCGTGG TAGAGGGGAA CCATGTGGTG TACCGGATCT CAGCCCCGAG CCCGGAGGAG 
AAGGAGGAGT GGATGAAATC CATCAAAGCC AGTATCAGCA GAGATCCCTT CTATGACATG 
TTGGCAACGA GGAAACGAAG GATTGCCAAT AAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001354511.1
CDS	208..906
Translation	MMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Target ORF information:

RefSeq Version	NM_001367582.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytohesin 3 (CYTH3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001367582.1

ORF Insert Sequence:

ATGATGGAGG CTTTCGCTTC TCGCTACTGC CTGTGCAACC CCGGGGTCTT CCAGTCCACA 
GACACGTGCT ACGTGCTGTC ATTCGCCATC ATCATGCTCA ACACCAGCCT CCACAACCAC 
AACGTGCGTG ACAAGCCCAC GGCAGAACGG TTCATCGCCA TGAACCGCGG CATCAACGAG 
GGCGGGGACC TCCCTGAGGA GCTGCTGAGG AATTTGTATG AGAGCATTAA GAACGAGCCA 
TTTAAGATCC CGGAGGACGA CGGGAACGAC CTGACCCACA CCTTCTTCAA CCCCGACCGC 
GAGGGCTGGC TCCTGAAGCT GGGAGGGCGT GTGAAGACCT GGAAGCGCCG GTGGTTCATC 
CTGACCGATA ACTGCCTCTA TTACTTTGAA TACACAACAG ATAAGGAGCC CAGGGGAATC 
ATCCCGTTGG AAAACCTCAG CATCAGGGAG GTGGAGGACC CCCGGAAACC CAACTGTTTT 
GAGCTCTACA ATCCCAGCCA CAAAGGGCAG GTCATCAAGG CCTGTAAGAC TGAGGCCGAC 
GGCCGCGTGG TAGAGGGGAA CCATGTGGTG TACCGGATCT CAGCCCCGAG CCCGGAGGAG 
AAGGAGGAGT GGATGAAATC CATCAAAGCC AGTATCAGCA GAGATCCCTT CTATGACATG 
TTGGCAACGA GGAAACGAAG GATTGCCAAT AAAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYTH3 ( NM_001367580.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001354509.1 Homo sapiens cytohesin 3 (CYTH3), transcript variant 2, mRNA.

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CloneID	OHu107434
Clone ID Related Accession (Same CDS sequence)	NM_001367580.1
Accession Version	NM_001367580.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	cytohesin-3 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009412.6 and AC004895.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK295163.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCTTAC CTCAACTGCA GACTGCAATG TTGGCAGCGT TTTTGTGGGA CCCTCGTGAT 
GTTGTGCTCA CAGCGCAGCC TGGGGCTGAA CAGTGCGCTG AGAGTTCGCA ACATATAAGA 
ATCCTGCAGC CGCAGTTCAG GCTTATCAGA TTGCGTTTCT GGAAGCTGTA CATCCAGAGA 
AGGGTGCAGG CCTGGCAGTT CTTATGGAGC TTCAGGCTGC CCGGGGAGGC GCAGAAGATT 
GATCGCATGA TGGAGGCTTT CGCTTCTCGC TACTGCCTGT GCAACCCCGG GGTCTTCCAG 
TCCACAGACA CGTGCTACGT GCTGTCATTC GCCATCATCA TGCTCAACAC CAGCCTCCAC 
AACCACAACG TGCGTGACAA GCCCACGGCA GAACGGTTCA TCGCCATGAA CCGCGGCATC 
AACGAGGGCG GGGACCTCCC TGAGGAGCTG CTGAGGAATT TGTATGAGAG CATTAAGAAC 
GAGCCATTTA AGATCCCGGA GGACGACGGG AACGACCTGA CCCACACCTT CTTCAACCCC 
GACCGCGAGG GCTGGCTCCT GAAGCTGGGA GGGCGTGTGA AGACCTGGAA GCGCCGGTGG 
TTCATCCTGA CCGATAACTG CCTCTATTAC TTTGAATACA CAACAGATAA GGAGCCCAGG 
GGAATCATCC CGTTGGAAAA CCTCAGCATC AGGGAGGTGG AGGACCCCCG GAAACCCAAC 
TGTTTTGAGC TCTACAATCC CAGCCACAAA GGGCAGGTCA TCAAGGCCTG TAAGACTGAG 
GCCGACGGCC GCGTGGTAGA GGGGAACCAT GTGGTGTACC GGATCTCAGC CCCGAGCCCG 
GAGGAGAAGG AGGAGTGGAT GAAATCCATC AAAGCCAGTA TCAGCAGAGA TCCCTTCTAT 
GACATGTTGG CAACGAGGAA ACGAAGGATT GCCAATAAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001354509.1
CDS	1295..2239
Translation	MALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Target ORF information:

RefSeq Version	NM_001367580.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytohesin 3 (CYTH3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001367580.1

ORF Insert Sequence:

ATGGCCTTAC CTCAACTGCA GACTGCAATG TTGGCAGCGT TTTTGTGGGA CCCTCGTGAT 
GTTGTGCTCA CAGCGCAGCC TGGGGCTGAA CAGTGCGCTG AGAGTTCGCA ACATATAAGA 
ATCCTGCAGC CGCAGTTCAG GCTTATCAGA TTGCGTTTCT GGAAGCTGTA CATCCAGAGA 
AGGGTGCAGG CCTGGCAGTT CTTATGGAGC TTCAGGCTGC CCGGGGAGGC GCAGAAGATT 
GATCGCATGA TGGAGGCTTT CGCTTCTCGC TACTGCCTGT GCAACCCCGG GGTCTTCCAG 
TCCACAGACA CGTGCTACGT GCTGTCATTC GCCATCATCA TGCTCAACAC CAGCCTCCAC 
AACCACAACG TGCGTGACAA GCCCACGGCA GAACGGTTCA TCGCCATGAA CCGCGGCATC 
AACGAGGGCG GGGACCTCCC TGAGGAGCTG CTGAGGAATT TGTATGAGAG CATTAAGAAC 
GAGCCATTTA AGATCCCGGA GGACGACGGG AACGACCTGA CCCACACCTT CTTCAACCCC 
GACCGCGAGG GCTGGCTCCT GAAGCTGGGA GGGCGTGTGA AGACCTGGAA GCGCCGGTGG 
TTCATCCTGA CCGATAACTG CCTCTATTAC TTTGAATACA CAACAGATAA GGAGCCCAGG 
GGAATCATCC CGTTGGAAAA CCTCAGCATC AGGGAGGTGG AGGACCCCCG GAAACCCAAC 
TGTTTTGAGC TCTACAATCC CAGCCACAAA GGGCAGGTCA TCAAGGCCTG TAAGACTGAG 
GCCGACGGCC GCGTGGTAGA GGGGAACCAT GTGGTGTACC GGATCTCAGC CCCGAGCCCG 
GAGGAGAAGG AGGAGTGGAT GAAATCCATC AAAGCCAGTA TCAGCAGAGA TCCCTTCTAT 
GACATGTTGG CAACGAGGAA ACGAAGGATT GCCAATAAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytohesin-3 is upregulated in hepatocellular carcinoma and contributes to tumor growth and vascular invasion.
International journal of clinical and experimental pathology7(5)2123-32(2014)
Fu Y,Li J,Feng MX,Yang XM,Wang YH,Zhang YL,Qin W,Xia Q,Zhang ZG

Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.
Proceedings of the National Academy of Sciences of the United States of America110(35)14213-8(2013 Aug)
Malaby AW,van den Berg B,Lambright DG

Phosphoinositide specificity determines which cytohesins regulate ?1 integrin recycling.
Journal of cell science125(Pt 13)3195-201(2012 Jul)
Oh SJ,Santy LC

The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).
Biochemistry50(45)9845-56(2011 Nov)
Pilling C,Landgraf KE,Falke JJ

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
Nature cell biology10(1)85-92(2008 Jan)
Morishige M,Hashimoto S,Ogawa E,Toda Y,Kotani H,Hirose M,Wei S,Hashimoto A,Yamada A,Yano H,Mazaki Y,Kodama H,Nio Y,Manabe T,Wada H,Kobayashi H,Sabe H

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CYTH3 cDNA ORF clone, Homo sapiens(human)

Gene

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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