GCM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GCM2
Entrez Gene ID	9247
Full Name	glial cells missing homolog 2
Synonyms	GCMB,HRPT4,hGCMb
General protein information	Preferred Names glial cells missing homolog 2 Names chorion-specific transcription factor GCMb GCM motif protein 2 glial cells missing 2 glial cells missing homolog b glide/gcm protein homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p24.2
Summary	This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008].
Disorder MIM:	603716
Disorder Html:	Hypoparathyroidism, familial isolated, 146200 (3); Hyperparathyroidism 4, 617343 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011514991.1	XP_011513293.1	chorion-specific transcription factor GCMb isoform X1
NM_004752.3	NP_004743.1	chorion-specific transcription factor GCMb
NM_004752.4	NP_004743.1	chorion-specific transcription factor GCMb

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	gcm2	XP_002932714.1
	GCM2	XP_001088392.1
Rattus norvegicus (Norway rat)	Gcm2	NP_001099575.1
Danio rerio (zebrafish)	gcm2	NP_001005603.1
Homo sapiens (human)	GCM2	NP_004743.1
Bos taurus (cattle)	GCM2	XP_002697663.2
Mus musculus (house mouse)	Gcm2	NP_032130.2
Gallus gallus (chicken)	GCM2	NP_001008480.1
Pan troglodytes (chimpanzee)	GCM2	XP_518235.2
Canis lupus familiaris (dog)	GCM2	XP_545339.3

Gene Ontology
Bibliography

Related articles in PubMed

Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure.
El Lakis M, Nockel P, Guan B, Agarwal S, Welch J, Simonds WF, Marx S, Li Y, Nilubol N, Patel D, Yang L, Merkel R, Kebebew E
Surgery163(1)31-34(2018 Jan)

Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.
Marchiori E, Pelizzo MR, Herten M, Townsend DM, Rubello D, Boschin IM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie92843-848(2017 Aug)

GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism.
Guan B, Welch JM, Sapp JC, Ling H, Li Y, Johnston JJ, Kebebew E, Biesecker LG, Simonds WF, Marx SJ, Agarwal SK
American journal of human genetics99(5)1034-1044(2016 Nov)

Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
Han SI, Tsunekage Y, Kataoka K
Molecular and cellular endocrinology411113-20(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GCM2-associated primary hyperparathyroidism patients have greater preoperative parathyroid hormone levels, a greater rate of multigland disease, a lesser rate of biochemical cure
Title: Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure.

Our results demonstrate that germline-activating mutations affecting the C-terminal conserved inhibitory domain of GCM2 can cause familial isolated hyperparathyroidism.
Title: GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism.

Gata3 interacted with Gcm2 and MafB, two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH promoter.
Title: Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.

The higher frequency of GCM2 282D in primary hyperparathyroidismand enhanced transcriptional activity of this variant supports the notion that it could contribute causally to parathyroid tumorigenesis
Title: Increased prevalence of the GCM2 polymorphism, Y282D, in primary hyperparathyroidism: analysis of three Italian cohorts.

we identified the genetic defect in 35% of hypoparathyroidism patients in our cohort and discovered novel GCM2 mutations including submicroscopic deletion that was undetectable by array comparative genomic hybridization
Title: Comprehensive next-generation sequencing analyses of hypoparathyroidism: identification of novel GCM2 mutations.

The following GCM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GCM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27272	NM_004752.4 Latest version!	Homo sapiens glial cells missing transcription factor 2 (GCM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27272	XM_011514991.1 Latest version!	Homo sapiens glial cells missing homolog 2 (Drosophila) (GCM2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu27272	NM_004752.3	Homo sapiens glial cells missing transcription factor 2 (GCM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GCM2 ( NM_004752.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004743.1 Homo sapiens glial cells missing transcription factor 2 (GCM2), mRNA.

Price & Availability↑

CloneID	OHu27272
Clone ID Related Accession (Same CDS sequence)	XM_011514991.1 , NM_004752.3 , NM_004752.4
Accession Version	NM_004752.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1521bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	chorion-specific transcription factor GCMb
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF079550.1 and AI028145.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2008 this sequence version replaced NM_004752.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF079550.1, AF091149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGCGG CCGCGGTGCA GGAAGCGGTC GGCGTGTGCT CCTACGGGAT GCAGCTCAGC 
TGGGACATCA ACGATCCGCA GATGCCTCAG GAGCTGGCCC TCTTTGACCA ATTCCGAGAG 
TGGCCTGACG GCTATGTGCG CTTCATCTAC AGCAGCGATG AGAAGAAGGC ACAGCGTCAC 
CTGAGCGGCT GGGCCATGCG CAACACCAAC AACCACAATG GCCACATCCT CAAGAAGTCG 
TGCCTGGGTG TGGTGGTGTG TACACAGGCC TGCACCCTGC CCGACGGTTC CCGCCTGCAG 
CTGAGGCCGG CCATCTGCGA CAAGGCACGG CTGAAACAGC AGAAGAAGGC ATGCCCTAAC 
TGTCATTCTG CTTTGGAGTT GATTCCTTGT CGAGGGCACA GCGGATACCC CGTAACCAAC 
TTTTGGCGGC TTGATGGCAA CGCGATCTTT TTTCAGGCCA AGGGAGTTCA TGATCATCCA 
AGACCAGAGA GCAAATCAGA GACAGAAGCT AGAAGAAGCG CCATCAAGAG ACAAATGGCC 
TCTTTCTACC AACCCCAGAA AAAGAGAATT CGAGAATCCG AGGCAGAAGA AAATCAAGAC 
AGCAGTGGTC ATTTCAGCAA CATACCTCCC TTGGAAAATC CAGAAGACTT TGATATAGTT 
ACTGAAACCA GCTTCCCTAT TCCAGGGCAG CCTTGCCCTT CCTTCCCAAA GTCTGATGTT 
TACAAAGCTA CCTGTGACCT AGCCACCTTT CAAGGAGACA AAATGCCACC CTTCCAGAAA 
TACTCAAGCC CAAGAATCTA TTTGCCTAGG CCACCTTGCA GCTATGAATT GGCAAACCCT 
GGTTATACAA ATTCAAGCCC ATATCCCACC CTTTATAAGG ATTCCACCAG TATCCCTAAT 
GACACAGACT GGGTTCATCT GAACACACTA CAATGTAATG TCAATTCATA CAGCAGCTAT 
GAGAGAAGCT TTGATTTCAC CAACAAACAG CATGGCTGGA AACCAGCTCT TGGAAAACCC 
AGCCTTGTGG AAAGGACTAA CCATGGGCAG TTTCAGGCCA TGGCCACTCG CCCTTATTAT 
AACCCAGAGC TTCCCTGCAG GTACCTCACG ACTCCACCAC CAGGTGCCCC TGCCCTACAA 
ACCGTGATCA CCACCACCAC TAAAGTGTCC TACCAGGCCT ACCAGCCCCC TGCTATGAAA 
TACAGTGACA GTGTGCGAGA GGTGAAGAGC CTTTCGAGCT GTAACTATGC TCCTGAAGAT 
ACTGGGATGT CTGTCTATCC AGAACCCTGG GGTCCTCCGG TGACAGTCAC CAGGGCAGCC 
TCTCCTTCAG GGCCACCTCC TATGAAAATT GCAGGAGATT GCCGGGCCAT CAGACCCACT 
GTGGCTATTC CCCACGAGCC AGTTTCCTCT AGGACAGATG AAGCAGAGAC TTGGGATGTG 
TGTCTGTCTG GGCTGGGCTC CGCAGTCAGT TACTCAGACA GAGTGGGTCC CTTCTTTACC 
TACAACAATG AGGATTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004743.1
CDS	73..1593
Translation	MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF

Target ORF information:

RefSeq Version	NM_004752.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glial cells missing transcription factor 2 (GCM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004752.3

ORF Insert Sequence:

ATGCCGGCGG CCGCGGTGCA GGAAGCGGTC GGCGTGTGCT CCTACGGGAT GCAGCTCAGC 
TGGGACATCA ACGATCCGCA GATGCCTCAG GAGCTGGCCC TCTTTGACCA ATTCCGAGAG 
TGGCCTGACG GCTATGTGCG CTTCATCTAC AGCAGCGATG AGAAGAAGGC ACAGCGTCAC 
CTGAGCGGCT GGGCCATGCG CAACACCAAC AACCACAATG GCCACATCCT CAAGAAGTCG 
TGCCTGGGTG TGGTGGTGTG TACACAGGCC TGCACCCTGC CCGACGGTTC CCGCCTGCAG 
CTGAGGCCGG CCATCTGCGA CAAGGCACGG CTGAAACAGC AGAAGAAGGC ATGCCCTAAC 
TGTCATTCTG CTTTGGAGTT GATTCCTTGT CGAGGGCACA GCGGATACCC CGTAACCAAC 
TTTTGGCGGC TTGATGGCAA CGCGATCTTT TTTCAGGCCA AGGGAGTTCA TGATCATCCA 
AGACCAGAGA GCAAATCAGA GACAGAAGCT AGAAGAAGCG CCATCAAGAG ACAAATGGCC 
TCTTTCTACC AACCCCAGAA AAAGAGAATT CGAGAATCCG AGGCAGAAGA AAATCAAGAC 
AGCAGTGGTC ATTTCAGCAA CATACCTCCC TTGGAAAATC CAGAAGACTT TGATATAGTT 
ACTGAAACCA GCTTCCCTAT TCCAGGGCAG CCTTGCCCTT CCTTCCCAAA GTCTGATGTT 
TACAAAGCTA CCTGTGACCT AGCCACCTTT CAAGGAGACA AAATGCCACC CTTCCAGAAA 
TACTCAAGCC CAAGAATCTA TTTGCCTAGG CCACCTTGCA GCTATGAATT GGCAAACCCT 
GGTTATACAA ATTCAAGCCC ATATCCCACC CTTTATAAGG ATTCCACCAG TATCCCTAAT 
GACACAGACT GGGTTCATCT GAACACACTA CAATGTAATG TCAATTCATA CAGCAGCTAT 
GAGAGAAGCT TTGATTTCAC CAACAAACAG CATGGCTGGA AACCAGCTCT TGGAAAACCC 
AGCCTTGTGG AAAGGACTAA CCATGGGCAG TTTCAGGCCA TGGCCACTCG CCCTTATTAT 
AACCCAGAGC TTCCCTGCAG GTACCTCACG ACTCCACCAC CAGGTGCCCC TGCCCTACAA 
ACCGTGATCA CCACCACCAC TAAAGTGTCC TACCAGGCCT ACCAGCCCCC TGCTATGAAA 
TACAGTGACA GTGTGCGAGA GGTGAAGAGC CTTTCGAGCT GTAACTATGC TCCTGAAGAT 
ACTGGGATGT CTGTCTATCC AGAACCCTGG GGTCCTCCGG TGACAGTCAC CAGGGCAGCC 
TCTCCTTCAG GGCCACCTCC TATGAAAATT GCAGGAGATT GCCGGGCCAT CAGACCCACT 
GTGGCTATTC CCCACGAGCC AGTTTCCTCT AGGACAGATG AAGCAGAGAC TTGGGATGTG 
TGTCTGTCTG GGCTGGGCTC CGCAGTCAGT TACTCAGACA GAGTGGGTCC CTTCTTTACC 
TACAACAATG AGGATTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GCM2 ( NM_004752.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004743.1 Homo sapiens glial cells missing transcription factor 2 (GCM2), mRNA.

Price & Availability↑

CloneID	OHu27272
Clone ID Related Accession (Same CDS sequence)	XM_011514991.1 , NM_004752.3 , NM_004752.4
Accession Version	NM_004752.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1521bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	chorion-specific transcription factor GCMb
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL357497.17 and AL024498.13. This sequence is a reference standard in the RefSeqGene project. On Jul 19, 2019 this sequence version replaced NM_004752.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF079550.1, AF091149.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGCGG CCGCGGTGCA GGAAGCGGTC GGCGTGTGCT CCTACGGGAT GCAGCTCAGC 
TGGGACATCA ACGATCCGCA GATGCCTCAG GAGCTGGCCC TCTTTGACCA ATTCCGAGAG 
TGGCCTGACG GCTATGTGCG CTTCATCTAC AGCAGCGATG AGAAGAAGGC ACAGCGTCAC 
CTGAGCGGCT GGGCCATGCG CAACACCAAC AACCACAATG GCCACATCCT CAAGAAGTCG 
TGCCTGGGTG TGGTGGTGTG TACACAGGCC TGCACCCTGC CCGACGGTTC CCGCCTGCAG 
CTGAGGCCGG CCATCTGCGA CAAGGCACGG CTGAAACAGC AGAAGAAGGC ATGCCCTAAC 
TGTCATTCTG CTTTGGAGTT GATTCCTTGT CGAGGGCACA GCGGATACCC CGTAACCAAC 
TTTTGGCGGC TTGATGGCAA CGCGATCTTT TTTCAGGCCA AGGGAGTTCA TGATCATCCA 
AGACCAGAGA GCAAATCAGA GACAGAAGCT AGAAGAAGCG CCATCAAGAG ACAAATGGCC 
TCTTTCTACC AACCCCAGAA AAAGAGAATT CGAGAATCCG AGGCAGAAGA AAATCAAGAC 
AGCAGTGGTC ATTTCAGCAA CATACCTCCC TTGGAAAATC CAGAAGACTT TGATATAGTT 
ACTGAAACCA GCTTCCCTAT TCCAGGGCAG CCTTGCCCTT CCTTCCCAAA GTCTGATGTT 
TACAAAGCTA CCTGTGACCT AGCCACCTTT CAAGGAGACA AAATGCCACC CTTCCAGAAA 
TACTCAAGCC CAAGAATCTA TTTGCCTAGG CCACCTTGCA GCTATGAATT GGCAAACCCT 
GGTTATACAA ATTCAAGCCC ATATCCCACC CTTTATAAGG ATTCCACCAG TATCCCTAAT 
GACACAGACT GGGTTCATCT GAACACACTA CAATGTAATG TCAATTCATA CAGCAGCTAT 
GAGAGAAGCT TTGATTTCAC CAACAAACAG CATGGCTGGA AACCAGCTCT TGGAAAACCC 
AGCCTTGTGG AAAGGACTAA CCATGGGCAG TTTCAGGCCA TGGCCACTCG CCCTTATTAT 
AACCCAGAGC TTCCCTGCAG GTACCTCACG ACTCCACCAC CAGGTGCCCC TGCCCTACAA 
ACCGTGATCA CCACCACCAC TAAAGTGTCC TACCAGGCCT ACCAGCCCCC TGCTATGAAA 
TACAGTGACA GTGTGCGAGA GGTGAAGAGC CTTTCGAGCT GTAACTATGC TCCTGAAGAT 
ACTGGGATGT CTGTCTATCC AGAACCCTGG GGTCCTCCGG TGACAGTCAC CAGGGCAGCC 
TCTCCTTCAG GGCCACCTCC TATGAAAATT GCAGGAGATT GCCGGGCCAT CAGACCCACT 
GTGGCTATTC CCCACGAGCC AGTTTCCTCT AGGACAGATG AAGCAGAGAC TTGGGATGTG 
TGTCTGTCTG GGCTGGGCTC CGCAGTCAGT TACTCAGACA GAGTGGGTCC CTTCTTTACC 
TACAACAATG AGGATTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004743.1
CDS	249..1769
Translation	MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF

Target ORF information:

RefSeq Version	NM_004752.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glial cells missing transcription factor 2 (GCM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004752.4

ORF Insert Sequence:

ATGCCGGCGG CCGCGGTGCA GGAAGCGGTC GGCGTGTGCT CCTACGGGAT GCAGCTCAGC 
TGGGACATCA ACGATCCGCA GATGCCTCAG GAGCTGGCCC TCTTTGACCA ATTCCGAGAG 
TGGCCTGACG GCTATGTGCG CTTCATCTAC AGCAGCGATG AGAAGAAGGC ACAGCGTCAC 
CTGAGCGGCT GGGCCATGCG CAACACCAAC AACCACAATG GCCACATCCT CAAGAAGTCG 
TGCCTGGGTG TGGTGGTGTG TACACAGGCC TGCACCCTGC CCGACGGTTC CCGCCTGCAG 
CTGAGGCCGG CCATCTGCGA CAAGGCACGG CTGAAACAGC AGAAGAAGGC ATGCCCTAAC 
TGTCATTCTG CTTTGGAGTT GATTCCTTGT CGAGGGCACA GCGGATACCC CGTAACCAAC 
TTTTGGCGGC TTGATGGCAA CGCGATCTTT TTTCAGGCCA AGGGAGTTCA TGATCATCCA 
AGACCAGAGA GCAAATCAGA GACAGAAGCT AGAAGAAGCG CCATCAAGAG ACAAATGGCC 
TCTTTCTACC AACCCCAGAA AAAGAGAATT CGAGAATCCG AGGCAGAAGA AAATCAAGAC 
AGCAGTGGTC ATTTCAGCAA CATACCTCCC TTGGAAAATC CAGAAGACTT TGATATAGTT 
ACTGAAACCA GCTTCCCTAT TCCAGGGCAG CCTTGCCCTT CCTTCCCAAA GTCTGATGTT 
TACAAAGCTA CCTGTGACCT AGCCACCTTT CAAGGAGACA AAATGCCACC CTTCCAGAAA 
TACTCAAGCC CAAGAATCTA TTTGCCTAGG CCACCTTGCA GCTATGAATT GGCAAACCCT 
GGTTATACAA ATTCAAGCCC ATATCCCACC CTTTATAAGG ATTCCACCAG TATCCCTAAT 
GACACAGACT GGGTTCATCT GAACACACTA CAATGTAATG TCAATTCATA CAGCAGCTAT 
GAGAGAAGCT TTGATTTCAC CAACAAACAG CATGGCTGGA AACCAGCTCT TGGAAAACCC 
AGCCTTGTGG AAAGGACTAA CCATGGGCAG TTTCAGGCCA TGGCCACTCG CCCTTATTAT 
AACCCAGAGC TTCCCTGCAG GTACCTCACG ACTCCACCAC CAGGTGCCCC TGCCCTACAA 
ACCGTGATCA CCACCACCAC TAAAGTGTCC TACCAGGCCT ACCAGCCCCC TGCTATGAAA 
TACAGTGACA GTGTGCGAGA GGTGAAGAGC CTTTCGAGCT GTAACTATGC TCCTGAAGAT 
ACTGGGATGT CTGTCTATCC AGAACCCTGG GGTCCTCCGG TGACAGTCAC CAGGGCAGCC 
TCTCCTTCAG GGCCACCTCC TATGAAAATT GCAGGAGATT GCCGGGCCAT CAGACCCACT 
GTGGCTATTC CCCACGAGCC AGTTTCCTCT AGGACAGATG AAGCAGAGAC TTGGGATGTG 
TGTCTGTCTG GGCTGGGCTC CGCAGTCAGT TACTCAGACA GAGTGGGTCC CTTCTTTACC 
TACAACAATG AGGATTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GCM2 ( XM_011514991.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513293.1 Homo sapiens glial cells missing homolog 2 (Drosophila) (GCM2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu27272
Clone ID Related Accession (Same CDS sequence)	XM_011514991.1 , NM_004752.3 , NM_004752.4
Accession Version	XM_011514991.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1521bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	chorion-specific transcription factor GCMb isoform X1
Comment

ATGCCGGCGG CCGCGGTGCA GGAAGCGGTC GGCGTGTGCT CCTACGGGAT GCAGCTCAGC 
TGGGACATCA ACGATCCGCA GATGCCTCAG GAGCTGGCCC TCTTTGACCA ATTCCGAGAG 
TGGCCTGACG GCTATGTGCG CTTCATCTAC AGCAGCGATG AGAAGAAGGC ACAGCGTCAC 
CTGAGCGGCT GGGCCATGCG CAACACCAAC AACCACAATG GCCACATCCT CAAGAAGTCG 
TGCCTGGGTG TGGTGGTGTG TACACAGGCC TGCACCCTGC CCGACGGTTC CCGCCTGCAG 
CTGAGGCCGG CCATCTGCGA CAAGGCACGG CTGAAACAGC AGAAGAAGGC ATGCCCTAAC 
TGTCATTCTG CTTTGGAGTT GATTCCTTGT CGAGGGCACA GCGGATACCC CGTAACCAAC 
TTTTGGCGGC TTGATGGCAA CGCGATCTTT TTTCAGGCCA AGGGAGTTCA TGATCATCCA 
AGACCAGAGA GCAAATCAGA GACAGAAGCT AGAAGAAGCG CCATCAAGAG ACAAATGGCC 
TCTTTCTACC AACCCCAGAA AAAGAGAATT CGAGAATCCG AGGCAGAAGA AAATCAAGAC 
AGCAGTGGTC ATTTCAGCAA CATACCTCCC TTGGAAAATC CAGAAGACTT TGATATAGTT 
ACTGAAACCA GCTTCCCTAT TCCAGGGCAG CCTTGCCCTT CCTTCCCAAA GTCTGATGTT 
TACAAAGCTA CCTGTGACCT AGCCACCTTT CAAGGAGACA AAATGCCACC CTTCCAGAAA 
TACTCAAGCC CAAGAATCTA TTTGCCTAGG CCACCTTGCA GCTATGAATT GGCAAACCCT 
GGTTATACAA ATTCAAGCCC ATATCCCACC CTTTATAAGG ATTCCACCAG TATCCCTAAT 
GACACAGACT GGGTTCATCT GAACACACTA CAATGTAATG TCAATTCATA CAGCAGCTAT 
GAGAGAAGCT TTGATTTCAC CAACAAACAG CATGGCTGGA AACCAGCTCT TGGAAAACCC 
AGCCTTGTGG AAAGGACTAA CCATGGGCAG TTTCAGGCCA TGGCCACTCG CCCTTATTAT 
AACCCAGAGC TTCCCTGCAG GTACCTCACG ACTCCACCAC CAGGTGCCCC TGCCCTACAA 
ACCGTGATCA CCACCACCAC TAAAGTGTCC TACCAGGCCT ACCAGCCCCC TGCTATGAAA 
TACAGTGACA GTGTGCGAGA GGTGAAGAGC CTTTCGAGCT GTAACTATGC TCCTGAAGAT 
ACTGGGATGT CTGTCTATCC AGAACCCTGG GGTCCTCCGG TGACAGTCAC CAGGGCAGCC 
TCTCCTTCAG GGCCACCTCC TATGAAAATT GCAGGAGATT GCCGGGCCAT CAGACCCACT 
GTGGCTATTC CCCACGAGCC AGTTTCCTCT AGGACAGATG AAGCAGAGAC TTGGGATGTG 
TGTCTGTCTG GGCTGGGCTC CGCAGTCAGT TACTCAGACA GAGTGGGTCC CTTCTTTACC 
TACAACAATG AGGATTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011513293.1

Translation

MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF

Target ORF information:

RefSeq Version	XM_011514991.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens glial cells missing homolog 2 (Drosophila) (GCM2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514991.1

ORF Insert Sequence:

ATGCCGGCGG CCGCGGTGCA GGAAGCGGTC GGCGTGTGCT CCTACGGGAT GCAGCTCAGC 
TGGGACATCA ACGATCCGCA GATGCCTCAG GAGCTGGCCC TCTTTGACCA ATTCCGAGAG 
TGGCCTGACG GCTATGTGCG CTTCATCTAC AGCAGCGATG AGAAGAAGGC ACAGCGTCAC 
CTGAGCGGCT GGGCCATGCG CAACACCAAC AACCACAATG GCCACATCCT CAAGAAGTCG 
TGCCTGGGTG TGGTGGTGTG TACACAGGCC TGCACCCTGC CCGACGGTTC CCGCCTGCAG 
CTGAGGCCGG CCATCTGCGA CAAGGCACGG CTGAAACAGC AGAAGAAGGC ATGCCCTAAC 
TGTCATTCTG CTTTGGAGTT GATTCCTTGT CGAGGGCACA GCGGATACCC CGTAACCAAC 
TTTTGGCGGC TTGATGGCAA CGCGATCTTT TTTCAGGCCA AGGGAGTTCA TGATCATCCA 
AGACCAGAGA GCAAATCAGA GACAGAAGCT AGAAGAAGCG CCATCAAGAG ACAAATGGCC 
TCTTTCTACC AACCCCAGAA AAAGAGAATT CGAGAATCCG AGGCAGAAGA AAATCAAGAC 
AGCAGTGGTC ATTTCAGCAA CATACCTCCC TTGGAAAATC CAGAAGACTT TGATATAGTT 
ACTGAAACCA GCTTCCCTAT TCCAGGGCAG CCTTGCCCTT CCTTCCCAAA GTCTGATGTT 
TACAAAGCTA CCTGTGACCT AGCCACCTTT CAAGGAGACA AAATGCCACC CTTCCAGAAA 
TACTCAAGCC CAAGAATCTA TTTGCCTAGG CCACCTTGCA GCTATGAATT GGCAAACCCT 
GGTTATACAA ATTCAAGCCC ATATCCCACC CTTTATAAGG ATTCCACCAG TATCCCTAAT 
GACACAGACT GGGTTCATCT GAACACACTA CAATGTAATG TCAATTCATA CAGCAGCTAT 
GAGAGAAGCT TTGATTTCAC CAACAAACAG CATGGCTGGA AACCAGCTCT TGGAAAACCC 
AGCCTTGTGG AAAGGACTAA CCATGGGCAG TTTCAGGCCA TGGCCACTCG CCCTTATTAT 
AACCCAGAGC TTCCCTGCAG GTACCTCACG ACTCCACCAC CAGGTGCCCC TGCCCTACAA 
ACCGTGATCA CCACCACCAC TAAAGTGTCC TACCAGGCCT ACCAGCCCCC TGCTATGAAA 
TACAGTGACA GTGTGCGAGA GGTGAAGAGC CTTTCGAGCT GTAACTATGC TCCTGAAGAT 
ACTGGGATGT CTGTCTATCC AGAACCCTGG GGTCCTCCGG TGACAGTCAC CAGGGCAGCC 
TCTCCTTCAG GGCCACCTCC TATGAAAATT GCAGGAGATT GCCGGGCCAT CAGACCCACT 
GTGGCTATTC CCCACGAGCC AGTTTCCTCT AGGACAGATG AAGCAGAGAC TTGGGATGTG 
TGTCTGTCTG GGCTGGGCTC CGCAGTCAGT TACTCAGACA GAGTGGGTCC CTTCTTTACC 
TACAACAATG AGGATTTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure.
Surgery163(1)31-34(2018 Jan)
El Lakis M,Nockel P,Guan B,Agarwal S,Welch J,Simonds WF,Marx S,Li Y,Nilubol N,Patel D,Yang L,Merkel R,Kebebew E

Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie92843-848(2017 Aug)
Marchiori E,Pelizzo MR,Herten M,Townsend DM,Rubello D,Boschin IM

GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism.
American journal of human genetics99(5)1034-1044(2016 Nov)
Guan B,Welch JM,Sapp JC,Ling H,Li Y,Johnston JJ,Kebebew E,Biesecker LG,Simonds WF,Marx SJ,Agarwal SK

Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
Molecular and cellular endocrinology411113-20(2015 Aug)
Han SI,Tsunekage Y,Kataoka K

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GCM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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