CHMP4C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHMP4C
Entrez Gene ID	92421
Full Name	charged multivesicular body protein 4C
Synonyms	SNF7-3,Shax3,VPS32C
General protein information	Preferred Names charged multivesicular body protein 4C Names charged multivesicular body protein 4c SNF7 homolog associated with Alix 3 Snf7 homologue associated with Alix 3 chromatin modifying protein 4C chromatin-modifying protein 4c hSnf7-3 hVps32-3 vacuolar protein sorting-associated protein 32-3 vps32-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.13
Summary	CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610899

mRNA and Protein(s)

mRNA	Protein	Name
NM_152284.3	NP_689497.1	charged multivesicular body protein 4c
NM_152284.4	NP_689497.1	charged multivesicular body protein 4c

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CHMP4C	XP_528179.3
Canis lupus familiaris (dog)	CHMP4C	XP_535115.1
Gallus gallus (chicken)	CHMP4C	NP_001186404.1
Bos taurus (cattle)	CHMP4C	NP_001039441.1
Homo sapiens (human)	CHMP4C	NP_689497.1
Rattus norvegicus (Norway rat)	Chmp4c	NP_001017466.2
	CHMP4C	XP_001093735.1
Mus musculus (house mouse)	Chmp4c	NP_079795.1
Danio rerio (zebrafish)	chmp4c	NP_001017844.1
Xenopus tropicalis (tropical clawed frog)	chmp4c	XP_004915215.1

Gene Ontology
Bibliography

Related articles in PubMed

Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.
Capalbo L, Mela I, Abad MA, Jeyaprakash AA, Edwardson JM, D'Avino PP
Open biology6(10)(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that CHMP4C, under the regulation of the chromosomal passenger complex, binds to highly curved membranes and promotes the closure of membrane gaps. Two distinctly localized pools of phosphorylated CHMP4C exist during cytokinesisI but the phosphorylation is not required for its assembly into spiral filaments. Also, the centralspindlin complex associates preferentially with the with unphosphorylated form.
Title: Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.

The ESCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge.
Title: ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission.

CHMP4C mediates radiation resistance in lung cancer cells.
Title: CHMP4C Disruption Sensitizes the Human Lung Cancer Cells to Irradiation.

Single nucleotide polymorphisms in CHMP4C gene is associated with ovarian cancer.
Title: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

AURKB phosphorylates CHMP4C at 3 serines its C-terminal tail.Phosphorylation at these sites appears essential for CHMP4C function because their mutation leads to cytokinesis defects.
Title: The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.

The following CHMP4C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHMP4C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17149	NM_152284.4 Latest version!	Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17149	NM_152284.3	Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHMP4C ( NM_152284.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689497.1 Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.

Price & Availability↑

CloneID	OHu17149
Clone ID Related Accession (Same CDS sequence)	NM_152284.3 , NM_152284.4
Accession Version	NM_152284.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	charged multivesicular body protein 4c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC014321.1 and AC132219.3. On Apr 12, 2005 this sequence version replaced NM_152284.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000049.1, ERR279843.350.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCAAGT TGGGCAAGTT CTTTAAAGGG GGCGGCTCTT CTAAGAGCCG AGCCGCTCCC 
AGTCCCCAGG AGGCCCTGGT CCGACTTCGG GAGACTGAGG AGATGCTGGG CAAGAAACAA 
GAGTACCTGG AAAATCGAAT CCAGAGAGAA ATCGCCCTGG CCAAGAAGCA CGGCACGCAG 
AATAAGCGAG CTGCATTACA GGCACTAAAG AGAAAGAAGA GGTTCGAGAA ACAGCTCACT 
CAGATTGATG GCACACTTTC TACCATTGAG TTCCAGAGAG AAGCCCTGGA GAACTCACAC 
ACCAACACTG AGGTGTTGAG GAACATGGGC TTTGCAGCAA AAGCGATGAA ATCTGTTCAT 
GAAAACATGG ATCTGAACAA AATAGATGAT TTGATGCAAG AGATCACAGA GCAACAGGAT 
ATCGCCCAAG AAATCTCAGA AGCATTTTCT CAACGGGTTG GCTTTGGTGA TGACTTTGAT 
GAGGATGAGT TGATGGCAGA ACTTGAAGAA TTGGAACAGG AGGAATTAAA TAAGAAGATG 
ACAAATATCC GCCTTCCAAA TGTGCCTTCC TCTTCTCTCC CAGCACAGCC AAATAGAAAA 
CCAGGCATGT CGTCCACTGC ACGTCGATCC CGAGCAGCAT CTTCCCAGAG GGCAGAAGAA 
GAGGATGATG ATATCAAACA ATTGGCAGCT TGGGCTACCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689497.1
CDS	175..876
Translation	MSKLGKFFKGGGSSKSRAAPSPQEALVRLRETEEMLGKKQEYLENRIQREIALAKKHGTQNKRAALQALKRKKRFEKQLTQIDGTLSTIEFQREALENSHTNTEVLRNMGFAAKAMKSVHENMDLNKIDDLMQEITEQQDIAQEISEAFSQRVGFGDDFDEDELMAELEELEQEELNKKMTNIRLPNVPSSSLPAQPNRKPGMSSTARRSRAASSQRAEEEDDDIKQLAAWAT

Target ORF information:

RefSeq Version	NM_152284.3
Organism	Homo sapiens(human)
Definition	Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152284.3

ORF Insert Sequence:

ATGAGCAAGT TGGGCAAGTT CTTTAAAGGG GGCGGCTCTT CTAAGAGCCG AGCCGCTCCC 
AGTCCCCAGG AGGCCCTGGT CCGACTTCGG GAGACTGAGG AGATGCTGGG CAAGAAACAA 
GAGTACCTGG AAAATCGAAT CCAGAGAGAA ATCGCCCTGG CCAAGAAGCA CGGCACGCAG 
AATAAGCGAG CTGCATTACA GGCACTAAAG AGAAAGAAGA GGTTCGAGAA ACAGCTCACT 
CAGATTGATG GCACACTTTC TACCATTGAG TTCCAGAGAG AAGCCCTGGA GAACTCACAC 
ACCAACACTG AGGTGTTGAG GAACATGGGC TTTGCAGCAA AAGCGATGAA ATCTGTTCAT 
GAAAACATGG ATCTGAACAA AATAGATGAT TTGATGCAAG AGATCACAGA GCAACAGGAT 
ATCGCCCAAG AAATCTCAGA AGCATTTTCT CAACGGGTTG GCTTTGGTGA TGACTTTGAT 
GAGGATGAGT TGATGGCAGA ACTTGAAGAA TTGGAACAGG AGGAATTAAA TAAGAAGATG 
ACAAATATCC GCCTTCCAAA TGTGCCTTCC TCTTCTCTCC CAGCACAGCC AAATAGAAAA 
CCAGGCATGT CGTCCACTGC ACGTCGATCC CGAGCAGCAT CTTCCCAGAG GGCAGAAGAA 
GAGGATGATG ATATCAAACA ATTGGCAGCT TGGGCTACCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHMP4C ( NM_152284.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689497.1 Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.

Price & Availability↑

CloneID	OHu17149
Clone ID Related Accession (Same CDS sequence)	NM_152284.3 , NM_152284.4
Accession Version	NM_152284.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	charged multivesicular body protein 4c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132219.3 and BC014321.1. On Nov 22, 2018 this sequence version replaced NM_152284.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000049.1, SRR5189655.54306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297265.5/ ENSP00000297265.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCAAGT TGGGCAAGTT CTTTAAAGGG GGCGGCTCTT CTAAGAGCCG AGCCGCTCCC 
AGTCCCCAGG AGGCCCTGGT CCGACTTCGG GAGACTGAGG AGATGCTGGG CAAGAAACAA 
GAGTACCTGG AAAATCGAAT CCAGAGAGAA ATCGCCCTGG CCAAGAAGCA CGGCACGCAG 
AATAAGCGAG CTGCATTACA GGCACTAAAG AGAAAGAAGA GGTTCGAGAA ACAGCTCACT 
CAGATTGATG GCACACTTTC TACCATTGAG TTCCAGAGAG AAGCCCTGGA GAACTCACAC 
ACCAACACTG AGGTGTTGAG GAACATGGGC TTTGCAGCAA AAGCGATGAA ATCTGTTCAT 
GAAAACATGG ATCTGAACAA AATAGATGAT TTGATGCAAG AGATCACAGA GCAACAGGAT 
ATCGCCCAAG AAATCTCAGA AGCATTTTCT CAACGGGTTG GCTTTGGTGA TGACTTTGAT 
GAGGATGAGT TGATGGCAGA ACTTGAAGAA TTGGAACAGG AGGAATTAAA TAAGAAGATG 
ACAAATATCC GCCTTCCAAA TGTGCCTTCC TCTTCTCTCC CAGCACAGCC AAATAGAAAA 
CCAGGCATGT CGTCCACTGC ACGTCGATCC CGAGCAGCAT CTTCCCAGAG GGCAGAAGAA 
GAGGATGATG ATATCAAACA ATTGGCAGCT TGGGCTACCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689497.1
CDS	180..881
Translation	MSKLGKFFKGGGSSKSRAAPSPQEALVRLRETEEMLGKKQEYLENRIQREIALAKKHGTQNKRAALQALKRKKRFEKQLTQIDGTLSTIEFQREALENSHTNTEVLRNMGFAAKAMKSVHENMDLNKIDDLMQEITEQQDIAQEISEAFSQRVGFGDDFDEDELMAELEELEQEELNKKMTNIRLPNVPSSSLPAQPNRKPGMSSTARRSRAASSQRAEEEDDDIKQLAAWAT

Target ORF information:

RefSeq Version	NM_152284.4
Organism	Homo sapiens(human)
Definition	Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152284.4

ORF Insert Sequence:

ATGAGCAAGT TGGGCAAGTT CTTTAAAGGG GGCGGCTCTT CTAAGAGCCG AGCCGCTCCC 
AGTCCCCAGG AGGCCCTGGT CCGACTTCGG GAGACTGAGG AGATGCTGGG CAAGAAACAA 
GAGTACCTGG AAAATCGAAT CCAGAGAGAA ATCGCCCTGG CCAAGAAGCA CGGCACGCAG 
AATAAGCGAG CTGCATTACA GGCACTAAAG AGAAAGAAGA GGTTCGAGAA ACAGCTCACT 
CAGATTGATG GCACACTTTC TACCATTGAG TTCCAGAGAG AAGCCCTGGA GAACTCACAC 
ACCAACACTG AGGTGTTGAG GAACATGGGC TTTGCAGCAA AAGCGATGAA ATCTGTTCAT 
GAAAACATGG ATCTGAACAA AATAGATGAT TTGATGCAAG AGATCACAGA GCAACAGGAT 
ATCGCCCAAG AAATCTCAGA AGCATTTTCT CAACGGGTTG GCTTTGGTGA TGACTTTGAT 
GAGGATGAGT TGATGGCAGA ACTTGAAGAA TTGGAACAGG AGGAATTAAA TAAGAAGATG 
ACAAATATCC GCCTTCCAAA TGTGCCTTCC TCTTCTCTCC CAGCACAGCC AAATAGAAAA 
CCAGGCATGT CGTCCACTGC ACGTCGATCC CGAGCAGCAT CTTCCCAGAG GGCAGAAGAA 
GAGGATGATG ATATCAAACA ATTGGCAGCT TGGGCTACCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.
Open biology6(10)(2016 Oct)
Capalbo L,Mela I,Abad MA,Jeyaprakash AA,Edwardson JM,D'Avino PP

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CHMP4C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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