MSC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSC
Entrez Gene ID	9242
Full Name	musculin
Synonyms	ABF-1,ABF1,MYOR,bHLHa22
General protein information	Preferred Names musculin Names musculin activated B-cell factor 1, homolog of mouse musculin activated B-cell factor-1 class A basic helix-loop-helix protein 22
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q13.3
Summary	The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008].
Disorder MIM:	603628

mRNA and Protein(s)

mRNA	Protein	Name
NM_005098.3	NP_005089.2	musculin

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MSC	XP_528162.3
Canis lupus familiaris (dog)	MSC	XP_544121.2
	MSC	XP_001082936.1
Mus musculus (house mouse)	Msc	NP_034957.1
Danio rerio (zebrafish)	LOC556396	XP_684279.3
Homo sapiens (human)	MSC	NP_005089.2
Xenopus tropicalis (tropical clawed frog)	msc	NP_001096235.1
Bos taurus (cattle)	MSC	NP_001179075.1
Rattus norvegicus (Norway rat)	Msc	NP_001178683.1
Gallus gallus (chicken)	MSC	XP_418293.4

Gene Ontology
Bibliography

Related articles in PubMed

Musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity.
Santarlasci V, Mazzoni A, Capone M, Rossi MC, Maggi L, Montaini G, Rossettini B, Cimaz R, Ramazzotti M, Barra G, De Palma R, Maggi E, Liotta F, Cosmi L, Romagnani S, Annunziato F
European journal of immunology47(9)1427-1442(2017 09)

Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.
Chiu YK, Lin IY, Su ST, Wang KH, Yang SY, Tsai DY, Hsieh YT, Lin KI
Journal of immunology (Baltimore, Md. : 1950)193(5)2207-17(2014 Sep)

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PloS one5(7)e11493(2010 Jul)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.
Ushmorov A, Leith?user F, Ritz O, Barth TF, M?ller P, Wirth T
Leukemia22(10)1942-4(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity
Title: Musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity.

results demonstrate that ABF-1 facilitates formation of memory B cells but prevents plasma cell differentiation.
Title: Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.
Title: ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.

role in repressing lymphotoxin alpha
Title: Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.

The following MSC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu04791	NM_005098.3 Latest version!	Homo sapiens musculin (MSC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSC ( NM_005098.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005089.2 Homo sapiens musculin (MSC), mRNA.

Price & Availability↑

CloneID	OHu04791
Clone ID Related Accession (Same CDS sequence)	NM_005098.3
Accession Version	NM_005098.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	musculin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB257094.1, BC067827.1 and BM685164.1. On Oct 27, 2006 this sequence version replaced NM_005098.2. ##Evidence-Data-START## Transcript exon combination :: BC067827.1, SRR1163655.528617.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCACGG GCTCGGTGAG TGATCCGGAG GAGATGGAGC TTCGGGGGCT GCAGCGGGAG 
TACCCGGTCC CCGCCTCCAA GAGGCCGCCC CTCCGCGGCG TAGAGCGCAG CTACGCCTCG 
CCCAGTGACA ACTCGTCGGC AGAGGAGGAG GACCCCGACG GCGAGGAGGA GCGCTGCGCT 
CTGGGCACAG CCGGCAGCGC GGAAGGCTGC AAGAGGAAGC GGCCCCGTGT GGCTGGGGGC 
GGCGGCGCAG GTGGTAGCGC GGGCGGTGGT GGCAAGAAGC CCCTCCCGGC CAAGGGCTCA 
GCCGCAGAGT GCAAGCAGTC GCAGCGGAAC GCGGCCAACG CCCGTGAGCG TGCCCGGATG 
CGCGTGCTGA GCAAAGCCTT CTCCAGGCTC AAGACCAGCC TGCCCTGGGT GCCCCCCGAC 
ACTAAGCTCT CCAAGCTGGA CACGCTCCGG CTGGCTTCCA GTTACATCGC TCACCTGCGG 
CAGCTGTTGC AGGAGGACCG CTATGAGAAC GGCTACGTGC ACCCAGTGAA CCTGACATGG 
CCATTCGTGG TCTCGGGAAG ACCGGACTCT GACACCAAAG AAGTTTCCGC AGCCAACAGA 
CTATGTGGAA CCACCGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005089.2
CDS	319..939
Translation	MSTGSVSDPEEMELRGLQREYPVPASKRPPLRGVERSYASPSDNSSAEEEDPDGEEERCALGTAGSAEGCKRKRPRVAGGGGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENGYVHPVNLTWPFVVSGRPDSDTKEVSAANRLCGTTA

Target ORF information:

RefSeq Version	NM_005098.3
Organism	Homo sapiens(human)
Definition	Homo sapiens musculin (MSC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005098.3

ORF Insert Sequence:

ATGTCCACGG GCTCGGTGAG TGATCCGGAG GAGATGGAGC TTCGGGGGCT GCAGCGGGAG 
TACCCGGTCC CCGCCTCCAA GAGGCCGCCC CTCCGCGGCG TAGAGCGCAG CTACGCCTCG 
CCCAGTGACA ACTCGTCGGC AGAGGAGGAG GACCCCGACG GCGAGGAGGA GCGCTGCGCT 
CTGGGCACAG CCGGCAGCGC GGAAGGCTGC AAGAGGAAGC GGCCCCGTGT GGCTGGGGGC 
GGCGGCGCAG GTGGTAGCGC GGGCGGTGGT GGCAAGAAGC CCCTCCCGGC CAAGGGCTCA 
GCCGCAGAGT GCAAGCAGTC GCAGCGGAAC GCGGCCAACG CCCGTGAGCG TGCCCGGATG 
CGCGTGCTGA GCAAAGCCTT CTCCAGGCTC AAGACCAGCC TGCCCTGGGT GCCCCCCGAC 
ACTAAGCTCT CCAAGCTGGA CACGCTCCGG CTGGCTTCCA GTTACATCGC TCACCTGCGG 
CAGCTGTTGC AGGAGGACCG CTATGAGAAC GGCTACGTGC ACCCAGTGAA CCTGACATGG 
CCATTCGTGG TCTCGGGAAG ACCGGACTCT GACACCAAAG AAGTTTCCGC AGCCAACAGA 
CTATGTGGAA CCACCGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity.
European journal of immunology47(9)1427-1442(2017 09)
Santarlasci V,Mazzoni A,Capone M,Rossi MC,Maggi L,Montaini G,Rossettini B,Cimaz R,Ramazzotti M,Barra G,De Palma R,Maggi E,Liotta F,Cosmi L,Romagnani S,Annunziato F

Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.
Journal of immunology (Baltimore, Md. : 1950)193(5)2207-17(2014 Sep)
Chiu YK,Lin IY,Su ST,Wang KH,Yang SY,Tsai DY,Hsieh YT,Lin KI

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
PloS one5(7)e11493(2010 Jul)
Jugessur A,Shi M,Gjessing HK,Lie RT,Wilcox AJ,Weinberg CR,Christensen K,Boyles AL,Daack-Hirsch S,Nguyen TT,Christiansen L,Lidral AC,Murray JC

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.
Leukemia22(10)1942-4(2008 Oct)
Ushmorov A,Leith?user F,Ritz O,Barth TF,M?ller P,Wirth T

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MSC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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