NOG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOG
Entrez Gene ID	9241
Full Name	noggin
Synonyms	SYM1,SYNS1,SYNS1A
General protein information	Preferred Names noggin Names noggin symphalangism 1 (proximal)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q22
Summary	The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
Disorder MIM:	602991
Disorder Html:	Symphalangism, proximal, 1A, 185800 (3); Multiple synostoses syndrome 1, 186500 (3); Tarsal-carpal coalition syndrome, 186570 (3); Stapes ankylosis with broad thumb and toes, 184460 (3); Brachydactyly, type B2, 611377 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005450.4	NP_005441.1	noggin precursor
NM_005450.5	NP_005441.1	noggin precursor
NM_005450.6	NP_005441.1	noggin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	NOG	NP_005441.1
Rattus norvegicus (Norway rat)	Nog	NP_037122.1
Danio rerio (zebrafish)	nog1	NP_571058.2
Gallus gallus (chicken)	NOG	NP_989454.1
Danio rerio (zebrafish)	nog3	NP_571057.1
Xenopus tropicalis (tropical clawed frog)	nog	NP_001165369.1
Pan troglodytes (chimpanzee)	NOG	XP_523802.2
	NOG	XP_001104355.1
Canis lupus familiaris (dog)	NOG	XP_005625045.1
Danio rerio (zebrafish)	LOC100333103	XP_002664025.1
Bos taurus (cattle)	NOG	XP_002695600.1
Mus musculus (house mouse)	Nog	NP_032737.1

Gene Ontology
Bibliography

Related articles in PubMed

Tarsal-carpal coalition syndrome: Report of a novel missense mutation in NOG gene and phenotypic delineation.
Das Bhowmik A, Salem Ramakumaran V, Dalal A
American journal of medical genetics. Part A176(1)219-224(2018 Jan)

The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells.
AlShaibi HF, Ahmed F, Buckle C, Fowles ACM, Awlia J, Cecchini MG, Eaton CL
Biotechnology and applied biochemistry(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we describe a Danish family suffering from SYNS1 due to a novel NOG gene mutation (C230Y). We provide detailed clinical description of the family members presenting rare phenotype of the shoulders shared by affected individuals but no hearing loss, further adding to the phenotypic variability of the syndrome.
Title: Further delineation of facioaudiosymphalangism syndrome: Description of a family with a novel NOG mutation and without hearing loss.

A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.
Title: A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.

An imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic differentiation of ankylosing spondylitis-mesenchymal stem cells.
Title: Imbalance Between Bone Morphogenetic Protein 2 and Noggin Induces Abnormal Osteogenic Differentiation of Mesenchymal Stem Cells in Ankylosing Spondylitis.

Novel p.W150C NOG mutation associated with proximal symphalangism and conductive hearing impairment was identified in a Chinese family.Impaired dimerization of mutant NOG is an important pathogenic mechanism for the NOG-related disorder.
Title: A Novel Missense Mutation of NOG Interferes With the Dimerization of NOG and Causes Proximal Symphalangism Syndrome in a Chinese Family.

early noggin exposure may play a specific role in the directed differentiation of DA cells from human embryonic stem cells.
Title: Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells.

The following NOG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19429	NM_005450.6 Latest version!	Homo sapiens noggin (NOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19429	NM_005450.4	Homo sapiens noggin (NOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu19429	NM_005450.5	Homo sapiens noggin (NOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOG ( NM_005450.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005441.1 Homo sapiens noggin (NOG), mRNA.

Price & Availability↑

CloneID	OHu19429
Clone ID Related Accession (Same CDS sequence)	NM_005450.4 , NM_005450.5 , NM_005450.6
Accession Version	NM_005450.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	noggin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015724.9. This sequence is a reference standard in the RefSeqGene project. On Jun 4, 2008 this sequence version replaced NM_005450.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC 
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT 
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC 
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC 
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC 
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG 
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG 
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT 
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC 
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC 
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005441.1
CDS	526..1224
Translation	MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC

Target ORF information:

RefSeq Version	NM_005450.4
Organism	Homo sapiens(human)
Definition	Homo sapiens noggin (NOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005450.4

ORF Insert Sequence:

ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC 
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT 
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC 
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC 
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC 
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG 
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG 
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT 
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC 
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC 
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOG ( NM_005450.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005441.1 Homo sapiens noggin (NOG), mRNA.

Price & Availability↑

CloneID	OHu19429
Clone ID Related Accession (Same CDS sequence)	NM_005450.4 , NM_005450.5 , NM_005450.6
Accession Version	NM_005450.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-16
Organism	Homo sapiens(human)
Product	noggin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015724.9. On May 17, 2019 this sequence version replaced NM_005450.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK314080.1, BC034027.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC 
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT 
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC 
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC 
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC 
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG 
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG 
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT 
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC 
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC 
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005441.1
CDS	526..1224
Translation	MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC

Target ORF information:

RefSeq Version	NM_005450.5
Organism	Homo sapiens(human)
Definition	Homo sapiens noggin (NOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005450.5

ORF Insert Sequence:

ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC 
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT 
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC 
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC 
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC 
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG 
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG 
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT 
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC 
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC 
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NOG ( NM_005450.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005441.1 Homo sapiens noggin (NOG), mRNA.

Price & Availability↑

CloneID	OHu19429
Clone ID Related Accession (Same CDS sequence)	NM_005450.4 , NM_005450.5 , NM_005450.6
Accession Version	NM_005450.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	noggin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015724.9. On Aug 31, 2019 this sequence version replaced NM_005450.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK314080.1, BC034027.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC 
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT 
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC 
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC 
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC 
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG 
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG 
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT 
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC 
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC 
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005441.1
CDS	526..1224
Translation	MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC

Target ORF information:

RefSeq Version	NM_005450.6
Organism	Homo sapiens(human)
Definition	Homo sapiens noggin (NOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005450.6

ORF Insert Sequence:

ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC 
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT 
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC 
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC 
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC 
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG 
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG 
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT 
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC 
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC 
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tarsal-carpal coalition syndrome: Report of a novel missense mutation in NOG gene and phenotypic delineation.
American journal of medical genetics. Part A176(1)219-224(2018 Jan)
Das Bhowmik A,Salem Ramakumaran V,Dalal A

The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells.
Biotechnology and applied biochemistry(2017 Oct)
AlShaibi HF,Ahmed F,Buckle C,Fowles ACM,Awlia J,Cecchini MG,Eaton CL

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NOG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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