TBRG4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TBRG4
Entrez Gene ID	9238
Full Name	transforming growth factor beta regulator 4
Synonyms	CPR2,FASTKD4
General protein information	Preferred Names transforming growth factor beta regulator 4 Names protein TBRG4 FAST kinase domain-containing protein 4 FAST kinase domains 4 H_TD2522F11.8 cell cycle progression protein 2 cell cycle progression restoration protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p13
Disorder MIM:	611325

mRNA and Protein(s)

mRNA	Protein	Name
NM_004749.3	NP_004740.2	protein TBRG4 isoform 1
NM_001261834.1	NP_001248763.1	FAST kinase domain-containing protein 4 isoform 3
NM_004749.4	NP_004740.2	FAST kinase domain-containing protein 4 isoform 1
NM_030900.3	NP_112162.1	FAST kinase domain-containing protein 4 isoform 2
NM_199122.2	NP_954573.1	FAST kinase domain-containing protein 4 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Tbrg4	NP_001012154.1
Danio rerio (zebrafish)	tbrg4	XP_690863.4
Homo sapiens (human)	TBRG4	NP_001248763.1
	TBRG4	XP_001087107.2
Bos taurus (cattle)	TBRG4	NP_001070435.1
Xenopus tropicalis (tropical clawed frog)	tbrg4	NP_001004904.2
Pan troglodytes (chimpanzee)	TBRG4	XP_001150329.2
Canis lupus familiaris (dog)	LOC482691	XP_005642255.1
Mus musculus (house mouse)	Tbrg4	NP_001123929.1
Gallus gallus (chicken)	TBRG4	XP_418515.2

Gene Ontology
Bibliography

Related articles in PubMed

The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.
Jourdain AA, Popow J, de la Fuente MA, Martinou JC, Anderson P, Simarro M
Nucleic acids research45(19)10941-10947(2017 Nov)

FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain.
Boehm E, Zaganelli S, Maundrell K, Jourdain AA, Thore S, Martinou JC
Nucleic acids research45(10)6135-6146(2017 Jun)

SLERT Regulates DDX21 Rings Associated with Pol I Transcription.
Xing YH, Yao RW, Zhang Y, Guo CJ, Jiang S, Xu G, Dong R, Yang L, Chen LL
Cell169(4)664-678.e16(2017 May)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Despite the fact that proteins of the FASTK family FASTKD1-5 share the same domains, they exhibit various-sometimes opposing-functions in almost all steps of mitochondrial RNA metabolism.
Title: The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.

Disruption of FASTKD4 reduces the level of ND3 and of other mature mRNAs including ND5 and CYB, and causes accumulation of ND5-CYB precursor RNA. Disrupting FASTKD1 and FASTKD4 decreases ND3 mRNA like depleting FASTKD4 alone, indicating that FASTKD4 loss is epistatic. RAP domain of FASTKD4 has a nuclease fold with a conserved aspartate at the putative active site, mutation of which abolishes its function.
Title: FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain.

SLERT is 694 nucleotides & contains SNORA5A & SNORA5C at its ends; it is produced from the human TBRG4 locus via skipping of exons 4 and 5 that leads to both SNORA5A & SNORA5C embedded within one intron, thereby producing SLERT from this alternatively spliced intron; results reveal an important control of ribosome biogenesis by SLERT lncRNA & its regulatory role in DDX21 ring-shaped arrangements acting on Pol I complexes.
Title: SLERT Regulates DDX21 Rings Associated with Pol I Transcription.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following TBRG4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBRG4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04575	NM_004749.4 Latest version!	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu55997	NM_001261834.1 Latest version!	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu02761	NM_030900.3 Latest version!	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$300.30 $429.00
OHu02761	NM_199122.2 Latest version!	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$300.30 $429.00
View Old Accession Versions >>
OHu04575	NM_004749.3	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TBRG4 ( NM_004749.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004740.2 Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04575
Clone ID Related Accession (Same CDS sequence)	NM_004749.3 , NM_004749.4
Accession Version	NM_004749.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	protein TBRG4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA980367.1, BC017235.2 and BM150942.1. On May 18, 2012 this sequence version replaced NM_004749.2. Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. ##Evidence-Data-START## Transcript exon combination :: AL833840.1, SRR1803613.212836.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGTGCCT GGAGTTGGTG GAGCACTTTG GCCCCAATGA GCTGCGGAAG 
GTGCTGGTGA TGCTGGCAGC TCAGAGCCGG CGGTCCGTGC CCTTGCTGCG GGCCATCTCC 
TACCACCTGG TGCAGAAGCC CTTCTCTCTG ACGAAAGATG TGCTCTTGGA CGTGGCCTAT 
GCCTATGGCA AACTCAGCTT TCACCAGACC CAGGTGTCCC AGCGCCTGGC CACCGACCTG 
CTATCCCTCA TGCCCAGCCT GACTTCTGGT GAGGTGGCCC ACTGTGCCAA GTCCTTCGCC 
TTACTCAAGT GGCTCAGCCT GCCCCTGTTT GAGGCCTTTG CCCAGCACGT CCTGAACAGA 
GCGCAGGACA TCACCCTGCC CCACCTGTGC AGCGTACTTC TGGCTTTTGC GCGTCTGAAC 
TTCCATCCAG ACCAAGAGGA TCAGTTCTTC AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG 
CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG GACCTGGTGT GGGCCCTGTG TGTGCTGCAG 
CAGGCACGGG AAGCAGAGCT GCAAGCCGTC CTCCACCCTG AATTTCACAT CCAATTTCTA 
GGGGGCAAGT CTCAGAAGGA TCAGAACACC TTCCAGAAGC TGCTCCACAT CAACGCCACT 
GCCCTGCTGG AGTACCCCGA GTACTCGGGT CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT 
GGGCCCTCAG CCCTTGACAG GAAGGTGACC CCCCTGCAAA AGGAGCTGCA GGAGACGCTG 
AAGGGGCTGC TGGGGAGCGC CGACAAGGGC AGCCTCGAGG TGGCCACGCA GTATGGCTGG 
GTGCTGGATG CTGAGGTGCT GCTGGACAGT GACGGCGAGT TTCTGCCCGT AAGGGACTTT 
GTGGCACCTC ACCTTGCCCA GCCAACTGGG AGCCAGTCAC CACCTCCAGG GTCTAAGAGG 
CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC TTCAACAGCC GAAGCAAGGA CTTGCTGGGT 
CGCTTTGTTC TGGCCCGGCG ACACATAGTG GCTGCAGGCT TCCTGATAGT GGACGTCCCA 
TTCTATGAGT GGCTGGAACT CAAGTCTGAA TGGCAGAAAG GCGCCTACCT CAAGGACAAG 
ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004740.2
CDS	156..2051
Translation	MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK

Target ORF information:

RefSeq Version	NM_004749.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004749.3

ORF Insert Sequence:

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGTGCCT GGAGTTGGTG GAGCACTTTG GCCCCAATGA GCTGCGGAAG 
GTGCTGGTGA TGCTGGCAGC TCAGAGCCGG CGGTCCGTGC CCTTGCTGCG GGCCATCTCC 
TACCACCTGG TGCAGAAGCC CTTCTCTCTG ACGAAAGATG TGCTCTTGGA CGTGGCCTAT 
GCCTATGGCA AACTCAGCTT TCACCAGACC CAGGTGTCCC AGCGCCTGGC CACCGACCTG 
CTATCCCTCA TGCCCAGCCT GACTTCTGGT GAGGTGGCCC ACTGTGCCAA GTCCTTCGCC 
TTACTCAAGT GGCTCAGCCT GCCCCTGTTT GAGGCCTTTG CCCAGCACGT CCTGAACAGA 
GCGCAGGACA TCACCCTGCC CCACCTGTGC AGCGTACTTC TGGCTTTTGC GCGTCTGAAC 
TTCCATCCAG ACCAAGAGGA TCAGTTCTTC AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG 
CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG GACCTGGTGT GGGCCCTGTG TGTGCTGCAG 
CAGGCACGGG AAGCAGAGCT GCAAGCCGTC CTCCACCCTG AATTTCACAT CCAATTTCTA 
GGGGGCAAGT CTCAGAAGGA TCAGAACACC TTCCAGAAGC TGCTCCACAT CAACGCCACT 
GCCCTGCTGG AGTACCCCGA GTACTCGGGT CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT 
GGGCCCTCAG CCCTTGACAG GAAGGTGACC CCCCTGCAAA AGGAGCTGCA GGAGACGCTG 
AAGGGGCTGC TGGGGAGCGC CGACAAGGGC AGCCTCGAGG TGGCCACGCA GTATGGCTGG 
GTGCTGGATG CTGAGGTGCT GCTGGACAGT GACGGCGAGT TTCTGCCCGT AAGGGACTTT 
GTGGCACCTC ACCTTGCCCA GCCAACTGGG AGCCAGTCAC CACCTCCAGG GTCTAAGAGG 
CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC TTCAACAGCC GAAGCAAGGA CTTGCTGGGT 
CGCTTTGTTC TGGCCCGGCG ACACATAGTG GCTGCAGGCT TCCTGATAGT GGACGTCCCA 
TTCTATGAGT GGCTGGAACT CAAGTCTGAA TGGCAGAAAG GCGCCTACCT CAAGGACAAG 
ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBRG4 ( NM_004749.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004740.2 Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04575
Clone ID Related Accession (Same CDS sequence)	NM_004749.3 , NM_004749.4
Accession Version	NM_004749.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	FAST kinase domain-containing protein 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA980367.1, BC017235.2 and BM150942.1. On Nov 22, 2018 this sequence version replaced NM_004749.3. Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833840.1, SRR1803613.212836.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258770.8/ ENSP00000258770.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGTGCCT GGAGTTGGTG GAGCACTTTG GCCCCAATGA GCTGCGGAAG 
GTGCTGGTGA TGCTGGCAGC TCAGAGCCGG CGGTCCGTGC CCTTGCTGCG GGCCATCTCC 
TACCACCTGG TGCAGAAGCC CTTCTCTCTG ACGAAAGATG TGCTCTTGGA CGTGGCCTAT 
GCCTATGGCA AACTCAGCTT TCACCAGACC CAGGTGTCCC AGCGCCTGGC CACCGACCTG 
CTATCCCTCA TGCCCAGCCT GACTTCTGGT GAGGTGGCCC ACTGTGCCAA GTCCTTCGCC 
TTACTCAAGT GGCTCAGCCT GCCCCTGTTT GAGGCCTTTG CCCAGCACGT CCTGAACAGA 
GCGCAGGACA TCACCCTGCC CCACCTGTGC AGCGTACTTC TGGCTTTTGC GCGTCTGAAC 
TTCCATCCAG ACCAAGAGGA TCAGTTCTTC AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG 
CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG GACCTGGTGT GGGCCCTGTG TGTGCTGCAG 
CAGGCACGGG AAGCAGAGCT GCAAGCCGTC CTCCACCCTG AATTTCACAT CCAATTTCTA 
GGGGGCAAGT CTCAGAAGGA TCAGAACACC TTCCAGAAGC TGCTCCACAT CAACGCCACT 
GCCCTGCTGG AGTACCCCGA GTACTCGGGT CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT 
GGGCCCTCAG CCCTTGACAG GAAGGTGACC CCCCTGCAAA AGGAGCTGCA GGAGACGCTG 
AAGGGGCTGC TGGGGAGCGC CGACAAGGGC AGCCTCGAGG TGGCCACGCA GTATGGCTGG 
GTGCTGGATG CTGAGGTGCT GCTGGACAGT GACGGCGAGT TTCTGCCCGT AAGGGACTTT 
GTGGCACCTC ACCTTGCCCA GCCAACTGGG AGCCAGTCAC CACCTCCAGG GTCTAAGAGG 
CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC TTCAACAGCC GAAGCAAGGA CTTGCTGGGT 
CGCTTTGTTC TGGCCCGGCG ACACATAGTG GCTGCAGGCT TCCTGATAGT GGACGTCCCA 
TTCTATGAGT GGCTGGAACT CAAGTCTGAA TGGCAGAAAG GCGCCTACCT CAAGGACAAG 
ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004740.2
CDS	106..2001
Translation	MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK

Target ORF information:

RefSeq Version	NM_004749.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004749.4

ORF Insert Sequence:

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGTGCCT GGAGTTGGTG GAGCACTTTG GCCCCAATGA GCTGCGGAAG 
GTGCTGGTGA TGCTGGCAGC TCAGAGCCGG CGGTCCGTGC CCTTGCTGCG GGCCATCTCC 
TACCACCTGG TGCAGAAGCC CTTCTCTCTG ACGAAAGATG TGCTCTTGGA CGTGGCCTAT 
GCCTATGGCA AACTCAGCTT TCACCAGACC CAGGTGTCCC AGCGCCTGGC CACCGACCTG 
CTATCCCTCA TGCCCAGCCT GACTTCTGGT GAGGTGGCCC ACTGTGCCAA GTCCTTCGCC 
TTACTCAAGT GGCTCAGCCT GCCCCTGTTT GAGGCCTTTG CCCAGCACGT CCTGAACAGA 
GCGCAGGACA TCACCCTGCC CCACCTGTGC AGCGTACTTC TGGCTTTTGC GCGTCTGAAC 
TTCCATCCAG ACCAAGAGGA TCAGTTCTTC AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG 
CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG GACCTGGTGT GGGCCCTGTG TGTGCTGCAG 
CAGGCACGGG AAGCAGAGCT GCAAGCCGTC CTCCACCCTG AATTTCACAT CCAATTTCTA 
GGGGGCAAGT CTCAGAAGGA TCAGAACACC TTCCAGAAGC TGCTCCACAT CAACGCCACT 
GCCCTGCTGG AGTACCCCGA GTACTCGGGT CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT 
GGGCCCTCAG CCCTTGACAG GAAGGTGACC CCCCTGCAAA AGGAGCTGCA GGAGACGCTG 
AAGGGGCTGC TGGGGAGCGC CGACAAGGGC AGCCTCGAGG TGGCCACGCA GTATGGCTGG 
GTGCTGGATG CTGAGGTGCT GCTGGACAGT GACGGCGAGT TTCTGCCCGT AAGGGACTTT 
GTGGCACCTC ACCTTGCCCA GCCAACTGGG AGCCAGTCAC CACCTCCAGG GTCTAAGAGG 
CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC TTCAACAGCC GAAGCAAGGA CTTGCTGGGT 
CGCTTTGTTC TGGCCCGGCG ACACATAGTG GCTGCAGGCT TCCTGATAGT GGACGTCCCA 
TTCTATGAGT GGCTGGAACT CAAGTCTGAA TGGCAGAAAG GCGCCTACCT CAAGGACAAG 
ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBRG4 ( NM_001261834.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001248763.1 Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 4, mRNA.

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CloneID	OHu55997
Clone ID Related Accession (Same CDS sequence)	NM_001261834.1
Accession Version	NM_001261834.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	FAST kinase domain-containing protein 4 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA980367.1, AK300489.1, AK298155.1 and BM150942.1. Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.73562.1, AK300489.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGTCA GCGGTGGTGC TCGCTGCGAC ATCATGGCAG CTCACCTGGT AAAGCGATGC 
ACGTGCCTCC TGAGAGAAGC TGCTCGTCAG GCCCCTGCCA TGGCTCCAGT TGGCCGACTG 
AGACTTGCCT GGGTAGCCCA TAAGACTCTG ACTTCCTCAG CCACCTCACC CATTTCCCAC 
CTCCCAGGTT CCTTGATGGA GCCGGTGGAG AAGGAACGAG CATCTACTCC CTACATAGAG 
AAGCAGGTGG ACCACCTCAT CAAGAAGGCC ACAAGGCCAG AGGAGCTCCT GGAGCTACTT 
GGTGGCAGTC ACGACTTGGA CAGCAATCAA GCAGCAATGG TACTTATCCG GCTCTCTCAC 
TTGCTGTCTG AGAAGCCAGA AGATAAAGGC TTGCTCATAC AGGATGCCCA CTTTCATCAA 
CTTCTCTGTC TGCTCAACAG TCAGATTGCC TCGGTCTGGC ATGGTACCCT CTCGAAGCTG 
CTGGGAAGCC TGTATGCTCT GGGCATCCCC AAGGCCTCCA AGGAGCTGCA GTCGGTGGAG 
CAGGAGGTCC GCTGGCGCAT GCGGAAGCTC AAGTACAAGC ACCTGGCCTT CCTGGCAGAG 
TCCTGTGCCA CCCTCTCACA GGAGCAGCAC TCGCAGGAGC TGCTGGCTGA GCTGCTCACA 
CACCTGGAAA GGCGTTGGAC AGAAATTGAA GATTCCCACA CATTAGTGAC CGTCATGATG 
AAGGTGGGAC ACCTCTCGGA GCCACTAATG AACCGCCTGG AAGACAAGTG CCTGGAGTTG 
GTGGAGCACT TTGGCCCCAA TGAGCTGCGG AAGGTGCTGG TGATGCTGGC AGCTCAGAGC 
CGGCGGTCCG TGCCCTTGCT GCGGGCCATC TCCTACCACC TGGTGCAGAA GCCCTTCTCT 
CTGACGAAAG ATGTGCTCTT GGACGTGGCC TATGCCTATG GCAAACTCAG CTTTCACCAG 
ACCCAGGTGT CCCAGCGCCT GGCCACCGAC CTGCTATCCC TCATGCCCAG CCTGACTTCT 
GGTGAGGTGG CCCACTGTGC CAAGTCCTTC GCCTTACTCA AGTGGCTCAG CCTGCCCCTG 
TTTGAGGCCT TTGCCCAGCA CGTCCTGAAC AGAGCGCAGG ACATCACCCT GCCCCACCTG 
TGCAGCGTAC TTCTGGCTTT TGCGCGTCTG AACTTCCATC CAGACCAAGA GGATCAGTTC 
TTCAGCCTGG TACATGAGAA GCTGGGGTCA GAGCTGCCAG GCCTGGAGCC AGCCCTGCAG 
GTGGACCTGG TGTGGGCCCT GTGTGTGCTG CAGCAGGCAC GGGAAGCAGA GCTGCAAGCC 
GTCCTCCACC CTGAATTTCA CATCCAATTT CTAGGGGGCA AGTCTCAGAA GGATCAGAAC 
ACCTTCCAGA AGCTGCTCCA CATCAACGCC ACTGCCCTGC TGGAGTACCC CGAGTACTCG 
GGTCCCCTTC TGCCTGCCTC GGCTGTGGCC CCTGGGCCCT CAGCCCTTGA CAGGAAGGTG 
ACCCCCCTGC AAAAGGAGCT GCAGGAGACG CTGAAGGGGC TGCTGGGGAG CGCCGACAAG 
GGCAGCCTCG AGGTGGCCAC GCAGTATGGC TGGGTGCTGG ATGCTGAGGT GCTGCTGGAC 
AGTGACGGCG AGTTTCTGCC CGTAAGGGAC TTTGTGGCAC CTCACCTTGC CCAGCCAACT 
GGGAGCCAGT CACCACCTCC AGGGTCTAAG AGGCTAGCGT TCTTGCGGTG GGAGTTCCCC 
AACTTCAACA GCCGAAGCAA GGACTTGCTG GGTCGCTTTG TTCTGGCCCG GCGACACATA 
GTGGCTGCAG GCTTCCTGAT AGTGGACGTC CCATTCTATG AGTGGCTGGA ACTCAAGTCT 
GAATGGCAGA AAGGCGCCTA CCTCAAGGAC AAGATGCGCA AAGCGGTGGC TGAGGAGCTG 
GCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001248763.1
CDS	79..2007
Translation	MEVSGGARCDIMAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK

Target ORF information:

RefSeq Version	NM_001261834.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001261834.1

ORF Insert Sequence:

ATGGAGGTCA GCGGTGGTGC TCGCTGCGAC ATCATGGCAG CTCACCTGGT AAAGCGATGC 
ACGTGCCTCC TGAGAGAAGC TGCTCGTCAG GCCCCTGCCA TGGCTCCAGT TGGCCGACTG 
AGACTTGCCT GGGTAGCCCA TAAGACTCTG ACTTCCTCAG CCACCTCACC CATTTCCCAC 
CTCCCAGGTT CCTTGATGGA GCCGGTGGAG AAGGAACGAG CATCTACTCC CTACATAGAG 
AAGCAGGTGG ACCACCTCAT CAAGAAGGCC ACAAGGCCAG AGGAGCTCCT GGAGCTACTT 
GGTGGCAGTC ACGACTTGGA CAGCAATCAA GCAGCAATGG TACTTATCCG GCTCTCTCAC 
TTGCTGTCTG AGAAGCCAGA AGATAAAGGC TTGCTCATAC AGGATGCCCA CTTTCATCAA 
CTTCTCTGTC TGCTCAACAG TCAGATTGCC TCGGTCTGGC ATGGTACCCT CTCGAAGCTG 
CTGGGAAGCC TGTATGCTCT GGGCATCCCC AAGGCCTCCA AGGAGCTGCA GTCGGTGGAG 
CAGGAGGTCC GCTGGCGCAT GCGGAAGCTC AAGTACAAGC ACCTGGCCTT CCTGGCAGAG 
TCCTGTGCCA CCCTCTCACA GGAGCAGCAC TCGCAGGAGC TGCTGGCTGA GCTGCTCACA 
CACCTGGAAA GGCGTTGGAC AGAAATTGAA GATTCCCACA CATTAGTGAC CGTCATGATG 
AAGGTGGGAC ACCTCTCGGA GCCACTAATG AACCGCCTGG AAGACAAGTG CCTGGAGTTG 
GTGGAGCACT TTGGCCCCAA TGAGCTGCGG AAGGTGCTGG TGATGCTGGC AGCTCAGAGC 
CGGCGGTCCG TGCCCTTGCT GCGGGCCATC TCCTACCACC TGGTGCAGAA GCCCTTCTCT 
CTGACGAAAG ATGTGCTCTT GGACGTGGCC TATGCCTATG GCAAACTCAG CTTTCACCAG 
ACCCAGGTGT CCCAGCGCCT GGCCACCGAC CTGCTATCCC TCATGCCCAG CCTGACTTCT 
GGTGAGGTGG CCCACTGTGC CAAGTCCTTC GCCTTACTCA AGTGGCTCAG CCTGCCCCTG 
TTTGAGGCCT TTGCCCAGCA CGTCCTGAAC AGAGCGCAGG ACATCACCCT GCCCCACCTG 
TGCAGCGTAC TTCTGGCTTT TGCGCGTCTG AACTTCCATC CAGACCAAGA GGATCAGTTC 
TTCAGCCTGG TACATGAGAA GCTGGGGTCA GAGCTGCCAG GCCTGGAGCC AGCCCTGCAG 
GTGGACCTGG TGTGGGCCCT GTGTGTGCTG CAGCAGGCAC GGGAAGCAGA GCTGCAAGCC 
GTCCTCCACC CTGAATTTCA CATCCAATTT CTAGGGGGCA AGTCTCAGAA GGATCAGAAC 
ACCTTCCAGA AGCTGCTCCA CATCAACGCC ACTGCCCTGC TGGAGTACCC CGAGTACTCG 
GGTCCCCTTC TGCCTGCCTC GGCTGTGGCC CCTGGGCCCT CAGCCCTTGA CAGGAAGGTG 
ACCCCCCTGC AAAAGGAGCT GCAGGAGACG CTGAAGGGGC TGCTGGGGAG CGCCGACAAG 
GGCAGCCTCG AGGTGGCCAC GCAGTATGGC TGGGTGCTGG ATGCTGAGGT GCTGCTGGAC 
AGTGACGGCG AGTTTCTGCC CGTAAGGGAC TTTGTGGCAC CTCACCTTGC CCAGCCAACT 
GGGAGCCAGT CACCACCTCC AGGGTCTAAG AGGCTAGCGT TCTTGCGGTG GGAGTTCCCC 
AACTTCAACA GCCGAAGCAA GGACTTGCTG GGTCGCTTTG TTCTGGCCCG GCGACACATA 
GTGGCTGCAG GCTTCCTGAT AGTGGACGTC CCATTCTATG AGTGGCTGGA ACTCAAGTCT 
GAATGGCAGA AAGGCGCCTA CCTCAAGGAC AAGATGCGCA AAGCGGTGGC TGAGGAGCTG 
GCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBRG4 ( NM_030900.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112162.1 Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 2, mRNA.

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CloneID	OHu02761
Clone ID Related Accession (Same CDS sequence)	NM_030900.3 , NM_199122.2
Accession Version	NM_030900.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	FAST kinase domain-containing protein 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA980367.1, AK222943.1, AB023165.1 and BM150942.1. On May 18, 2012 this sequence version replaced NM_030900.2. Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222943.1, SRR1803616.152718.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGCACGT CCTGAACAGA GCGCAGGACA TCACCCTGCC CCACCTGTGC 
AGCGTACTTC TGGCTTTTGC GCGTCTGAAC TTCCATCCAG ACCAAGAGGA TCAGTTCTTC 
AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG 
GACCTGGTGT GGGCCCTGTG TGTGCTGCAG CAGGCACGGG AAGCAGAGCT GCAAGCCGTC 
CTCCACCCTG AATTTCACAT CCAATTTCTA GGGGGCAAGT CTCAGAAGGA TCAGAACACC 
TTCCAGAAGC TGCTCCACAT CAACGCCACT GCCCTGCTGG AGTACCCCGA GTACTCGGGT 
CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT GGGCCCTCAG CCCTTGACAG GAAGGTGACC 
CCCCTGCAAA AGGAGCTGCA GGAGACGCTG AAGGGGCTGC TGGGGAGCGC CGACAAGGGC 
AGCCTCGAGG TGGCCACGCA GTATGGCTGG GTGCTGGATG CTGAGGTGCT GCTGGACAGT 
GACGGCGAGT TTCTGCCCGT AAGGGACTTT GTGGCACCTC ACCTTGCCCA GCCAACTGGG 
AGCCAGTCAC CACCTCCAGG GTCTAAGAGG CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC 
TTCAACAGCC GAAGCAAGGA CTTGCTGGGT CGCTTTGTTC TGGCCCGGCG ACACATAGTG 
GCTGCAGGCT TCCTGATAGT GGACGTCCCA TTCTATGAGT GGCTGGAACT CAAGTCTGAA 
TGGCAGAAAG GCGCCTACCT CAAGGACAAG ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112162.1
CDS	156..1721
Translation	MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK

Target ORF information:

RefSeq Version	NM_030900.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030900.3

ORF Insert Sequence:

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGCACGT CCTGAACAGA GCGCAGGACA TCACCCTGCC CCACCTGTGC 
AGCGTACTTC TGGCTTTTGC GCGTCTGAAC TTCCATCCAG ACCAAGAGGA TCAGTTCTTC 
AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG 
GACCTGGTGT GGGCCCTGTG TGTGCTGCAG CAGGCACGGG AAGCAGAGCT GCAAGCCGTC 
CTCCACCCTG AATTTCACAT CCAATTTCTA GGGGGCAAGT CTCAGAAGGA TCAGAACACC 
TTCCAGAAGC TGCTCCACAT CAACGCCACT GCCCTGCTGG AGTACCCCGA GTACTCGGGT 
CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT GGGCCCTCAG CCCTTGACAG GAAGGTGACC 
CCCCTGCAAA AGGAGCTGCA GGAGACGCTG AAGGGGCTGC TGGGGAGCGC CGACAAGGGC 
AGCCTCGAGG TGGCCACGCA GTATGGCTGG GTGCTGGATG CTGAGGTGCT GCTGGACAGT 
GACGGCGAGT TTCTGCCCGT AAGGGACTTT GTGGCACCTC ACCTTGCCCA GCCAACTGGG 
AGCCAGTCAC CACCTCCAGG GTCTAAGAGG CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC 
TTCAACAGCC GAAGCAAGGA CTTGCTGGGT CGCTTTGTTC TGGCCCGGCG ACACATAGTG 
GCTGCAGGCT TCCTGATAGT GGACGTCCCA TTCTATGAGT GGCTGGAACT CAAGTCTGAA 
TGGCAGAAAG GCGCCTACCT CAAGGACAAG ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBRG4 ( NM_199122.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_954573.1 Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 3, mRNA.

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CloneID	OHu02761
Clone ID Related Accession (Same CDS sequence)	NM_030900.3 , NM_199122.2
Accession Version	NM_199122.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	FAST kinase domain-containing protein 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA980367.1, AK001281.1 and BM150942.1. On May 18, 2012 this sequence version replaced NM_199122.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK001281.1, SRR1803616.155935.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGCACGT CCTGAACAGA GCGCAGGACA TCACCCTGCC CCACCTGTGC 
AGCGTACTTC TGGCTTTTGC GCGTCTGAAC TTCCATCCAG ACCAAGAGGA TCAGTTCTTC 
AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG 
GACCTGGTGT GGGCCCTGTG TGTGCTGCAG CAGGCACGGG AAGCAGAGCT GCAAGCCGTC 
CTCCACCCTG AATTTCACAT CCAATTTCTA GGGGGCAAGT CTCAGAAGGA TCAGAACACC 
TTCCAGAAGC TGCTCCACAT CAACGCCACT GCCCTGCTGG AGTACCCCGA GTACTCGGGT 
CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT GGGCCCTCAG CCCTTGACAG GAAGGTGACC 
CCCCTGCAAA AGGAGCTGCA GGAGACGCTG AAGGGGCTGC TGGGGAGCGC CGACAAGGGC 
AGCCTCGAGG TGGCCACGCA GTATGGCTGG GTGCTGGATG CTGAGGTGCT GCTGGACAGT 
GACGGCGAGT TTCTGCCCGT AAGGGACTTT GTGGCACCTC ACCTTGCCCA GCCAACTGGG 
AGCCAGTCAC CACCTCCAGG GTCTAAGAGG CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC 
TTCAACAGCC GAAGCAAGGA CTTGCTGGGT CGCTTTGTTC TGGCCCGGCG ACACATAGTG 
GCTGCAGGCT TCCTGATAGT GGACGTCCCA TTCTATGAGT GGCTGGAACT CAAGTCTGAA 
TGGCAGAAAG GCGCCTACCT CAAGGACAAG ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954573.1
CDS	135..1700
Translation	MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK

Target ORF information:

RefSeq Version	NM_199122.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199122.2

ORF Insert Sequence:

ATGGCAGCTC ACCTGGTAAA GCGATGCACG TGCCTCCTGA GAGAAGCTGC TCGTCAGGCC 
CCTGCCATGG CTCCAGTTGG CCGACTGAGA CTTGCCTGGG TAGCCCATAA GACTCTGACT 
TCCTCAGCCA CCTCACCCAT TTCCCACCTC CCAGGTTCCT TGATGGAGCC GGTGGAGAAG 
GAACGAGCAT CTACTCCCTA CATAGAGAAG CAGGTGGACC ACCTCATCAA GAAGGCCACA 
AGGCCAGAGG AGCTCCTGGA GCTACTTGGT GGCAGTCACG ACTTGGACAG CAATCAAGCA 
GCAATGGTAC TTATCCGGCT CTCTCACTTG CTGTCTGAGA AGCCAGAAGA TAAAGGCTTG 
CTCATACAGG ATGCCCACTT TCATCAACTT CTCTGTCTGC TCAACAGTCA GATTGCCTCG 
GTCTGGCATG GTACCCTCTC GAAGCTGCTG GGAAGCCTGT ATGCTCTGGG CATCCCCAAG 
GCCTCCAAGG AGCTGCAGTC GGTGGAGCAG GAGGTCCGCT GGCGCATGCG GAAGCTCAAG 
TACAAGCACC TGGCCTTCCT GGCAGAGTCC TGTGCCACCC TCTCACAGGA GCAGCACTCG 
CAGGAGCTGC TGGCTGAGCT GCTCACACAC CTGGAAAGGC GTTGGACAGA AATTGAAGAT 
TCCCACACAT TAGTGACCGT CATGATGAAG GTGGGACACC TCTCGGAGCC ACTAATGAAC 
CGCCTGGAAG ACAAGCACGT CCTGAACAGA GCGCAGGACA TCACCCTGCC CCACCTGTGC 
AGCGTACTTC TGGCTTTTGC GCGTCTGAAC TTCCATCCAG ACCAAGAGGA TCAGTTCTTC 
AGCCTGGTAC ATGAGAAGCT GGGGTCAGAG CTGCCAGGCC TGGAGCCAGC CCTGCAGGTG 
GACCTGGTGT GGGCCCTGTG TGTGCTGCAG CAGGCACGGG AAGCAGAGCT GCAAGCCGTC 
CTCCACCCTG AATTTCACAT CCAATTTCTA GGGGGCAAGT CTCAGAAGGA TCAGAACACC 
TTCCAGAAGC TGCTCCACAT CAACGCCACT GCCCTGCTGG AGTACCCCGA GTACTCGGGT 
CCCCTTCTGC CTGCCTCGGC TGTGGCCCCT GGGCCCTCAG CCCTTGACAG GAAGGTGACC 
CCCCTGCAAA AGGAGCTGCA GGAGACGCTG AAGGGGCTGC TGGGGAGCGC CGACAAGGGC 
AGCCTCGAGG TGGCCACGCA GTATGGCTGG GTGCTGGATG CTGAGGTGCT GCTGGACAGT 
GACGGCGAGT TTCTGCCCGT AAGGGACTTT GTGGCACCTC ACCTTGCCCA GCCAACTGGG 
AGCCAGTCAC CACCTCCAGG GTCTAAGAGG CTAGCGTTCT TGCGGTGGGA GTTCCCCAAC 
TTCAACAGCC GAAGCAAGGA CTTGCTGGGT CGCTTTGTTC TGGCCCGGCG ACACATAGTG 
GCTGCAGGCT TCCTGATAGT GGACGTCCCA TTCTATGAGT GGCTGGAACT CAAGTCTGAA 
TGGCAGAAAG GCGCCTACCT CAAGGACAAG ATGCGCAAAG CGGTGGCTGA GGAGCTGGCC 
AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.
Nucleic acids research45(19)10941-10947(2017 Nov)
Jourdain AA,Popow J,de la Fuente MA,Martinou JC,Anderson P,Simarro M

FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain.
Nucleic acids research45(10)6135-6146(2017 Jun)
Boehm E,Zaganelli S,Maundrell K,Jourdain AA,Thore S,Martinou JC

SLERT Regulates DDX21 Rings Associated with Pol I Transcription.
Cell169(4)664-678.e16(2017 May)
Xing YH,Yao RW,Zhang Y,Guo CJ,Jiang S,Xu G,Dong R,Yang L,Chen LL

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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TBRG4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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