ACVR2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACVR2A
Entrez Gene ID	92
Full Name	activin A receptor type 2A
Synonyms	ACTRII,ACVR2
General protein information	Preferred Names activin A receptor type 2A Names activin receptor type-2A activin A receptor, type IIA
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q22.3-q23.1
Summary	This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013].
Disorder MIM:	102581

mRNA and Protein(s)

mRNA	Protein	Name
NM_001616.4	NP_001607.1	activin receptor type-2A isoform 1 precursor
NM_001278579.2	NP_001265508.1	activin receptor type-2A isoform 1 precursor
NM_001278579.1	NP_001265508.1	activin receptor type-2A isoform 1 precursor
NM_001616.5	NP_001607.1	activin receptor type-2A isoform 1 precursor
NM_001278580.1	NP_001265509.1	activin receptor type-2A isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACVR2A	NP_001265508.1
	ACVR2A	XP_001095960.2
Pan troglodytes (chimpanzee)	ACVR2A	XP_003949946.1
Canis lupus familiaris (dog)	ACVR2A	XP_005632022.1
Mus musculus (house mouse)	Acvr2a	NP_031422.3
Danio rerio (zebrafish)	acvr2aa	NP_001103748.1
Xenopus tropicalis (tropical clawed frog)	acvr2a	NP_001135613.1
Bos taurus (cattle)	ACVR2A	NP_776652.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000763	XP_311300.4
Rattus norvegicus (Norway rat)	Acvr2a	NP_113759.1
Gallus gallus (chicken)	ACVR2A	NP_990698.1
Drosophila melanogaster (fruit fly)	put	NP_001262574.1

Gene Ontology
Bibliography

Related articles in PubMed

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro.
Yong HEJ, Murthi P, Kalionis B, Keogh RJ, Brennecke SP
Pregnancy hypertension(2017 Nov)

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.
Kulminski AM, He L, Culminskaya I, Loika Y, Kernogitski Y, Arbeev KG, Loiko E, Arbeeva L, Bagley O, Duan M, Yashkin A, Fang F, Kovtun M, Ukraintseva SV, Wu D, Yashin AI
PLoS genetics12(11)e1006314(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
Title: TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.

This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.
Title: Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.

Data suggest ALK1 and ACVR2A/ACVR2B, acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
Title: Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains.

Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.
Title: Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.

Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B.
Title: Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

The following ACVR2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACVR2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00939	NM_001278579.2 Latest version!	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00939	NM_001616.5 Latest version!	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu01002	NM_001278580.1 Latest version!	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu00939	NM_001278579.1	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00939	NM_001616.4	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACVR2A ( NM_001616.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001607.1 Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00939
Clone ID Related Accession (Same CDS sequence)	NM_001616.4 , NM_001278579.2 , NM_001278579.1 , NM_001616.5
Accession Version	NM_001616.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	activin receptor type-2A isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D31770.1, X62381.1, BC067417.1, DA531622.1, BG616903.1, AW162986.1, BM503220.1, W03601.1, DN918410.1, T07746.1, BU676046.1 and AA125825.1. On Jun 30, 2013 this sequence version replaced NM_001616.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.268933.1, SRR1803616.12990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001607.1
CDS	159..1700
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	NM_001616.4
Organism	Homo sapiens(human)
Definition	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001616.4

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACVR2A ( NM_001278579.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265508.1 Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00939
Clone ID Related Accession (Same CDS sequence)	NM_001616.4 , NM_001278579.2 , NM_001278579.1 , NM_001616.5
Accession Version	NM_001278579.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	activin receptor type-2A isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301629.1, M93415.1, DA531622.1, BG616903.1, AW162986.1, BM503220.1, W03601.1, DN918410.1, T07746.1 and BU676046.1. On May 31, 2019 this sequence version replaced NM_001278579.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M93415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265508.1
CDS	270..1811
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	NM_001278579.2
Organism	Homo sapiens(human)
Definition	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278579.2

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACVR2A ( NM_001278579.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265508.1 Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00939
Clone ID Related Accession (Same CDS sequence)	NM_001616.4 , NM_001278579.2 , NM_001278579.1 , NM_001616.5
Accession Version	NM_001278579.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	activin receptor type-2A isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301629.1, M93415.1, DA531622.1, BG616903.1, AW162986.1, BM503220.1, W03601.1, DN918410.1, T07746.1, BU676046.1 and AA125825.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M93415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265508.1
CDS	270..1811
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	NM_001278579.1
Organism	Homo sapiens(human)
Definition	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278579.1

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACVR2A ( NM_001616.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001607.1 Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.

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CloneID	OHu00939
Clone ID Related Accession (Same CDS sequence)	NM_001616.4 , NM_001278579.2 , NM_001278579.1 , NM_001616.5
Accession Version	NM_001616.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	activin receptor type-2A isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X62381.1, BC067417.1, DA531622.1, BG616903.1, AW162986.1, BM503220.1, W03601.1, DN918410.1, T07746.1 and BU676046.1. On Nov 22, 2018 this sequence version replaced NM_001616.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.268933.1, SRR1803616.12990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000241416.12/ ENSP00000241416.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001607.1
CDS	125..1666
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	NM_001616.5
Organism	Homo sapiens(human)
Definition	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001616.5

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 
ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAAAGAC 
AGAACCAATC AAACTGGTGT TGAACCGTGT TATGGTGACA AAGATAAACG GCGGCATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTGTAGAAA AAAAAGACAG CCCTGAAGTA 
TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCCTG 
CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 
TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 
CCCCCACCTT CTCCATTACT AGGTTTGAAA CCACTGCAGT TATTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAACG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATACG AAGTCTACAG TTTGCCTGGA 
ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 
GTGGATCTTT GGCTGATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAACC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAATT TGAGGCTGGC AAGTCTGCAG GCGATACCCA TGGACAGGTT 
GGTACCCGGA GGTACATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 
GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAACT GGCTTCTCGC 
TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 
CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC CATTGAAGAA 
TGTTGGGATC ACGACGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACC 
CAGATGCAGA GACTAACAAA TATTATTACC ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACVR2A ( NM_001278580.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265509.1 Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 3, mRNA.

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CloneID	OHu01002
Clone ID Related Accession (Same CDS sequence)	NM_001278580.1
Accession Version	NM_001278580.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	activin receptor type-2A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301629.1, M93415.1, DA531622.1, BG616903.1, AW162986.1, BM503220.1, W03601.1, DN918410.1, T07746.1, BU676046.1 and AA125825.1. Transcript Variant: This variant (3) lacks an alternate exon and uses an alternate splice site in an internal exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301629.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTAATG AAAAGTTTTC TTATTTTCCG GAGATGGAAG TCACACAGCC CACTTCAAAT 
CCAGTTACAC CTAAGCCACC CTATTACAAC ATCCTGCTCT ATTCCTTGGT GCCACTTATG 
TTAATTGCGG GGATTGTCAT TTGTGCATTT TGGGTGTACA GGCATCACAA GATGGCCTAC 
CCTCCTGTAC TTGTTCCAAC TCAAGACCCA GGACCACCCC CACCTTCTCC ATTACTAGGT 
TTGAAACCAC TGCAGTTATT AGAAGTGAAA GCAAGGGGAA GATTTGGTTG TGTCTGGAAA 
GCCCAGTTGC TTAACGAATA TGTGGCTGTC AAAATATTTC CAATACAGGA CAAACAGTCA 
TGGCAAAATG AATACGAAGT CTACAGTTTG CCTGGAATGA AGCATGAGAA CATATTACAG 
TTCATTGGTG CAGAAAAACG AGGCACCAGT GTTGATGTGG ATCTTTGGCT GATCACAGCA 
TTTCATGAAA AGGGTTCACT ATCAGACTTT CTTAAGGCTA ATGTGGTCTC TTGGAATGAA 
CTGTGTCATA TTGCAGAAAC CATGGCTAGA GGATTGGCAT ATTTACATGA GGATATACCT 
GGCCTAAAAG ATGGCCACAA ACCTGCCATA TCTCACAGGG ACATCAAAAG TAAAAATGTG 
CTGTTGAAAA ACAACCTGAC AGCTTGCATT GCTGACTTTG GGTTGGCCTT AAAATTTGAG 
GCTGGCAAGT CTGCAGGCGA TACCCATGGA CAGGTTGGTA CCCGGAGGTA CATGGCTCCA 
GAGGTATTAG AGGGTGCTAT AAACTTCCAA AGGGATGCAT TTTTGAGGAT AGATATGTAT 
GCCATGGGAT TAGTCCTATG GGAACTGGCT TCTCGCTGTA CTGCTGCAGA TGGACCTGTA 
GATGAATACA TGTTGCCATT TGAGGAGGAA ATTGGCCAGC ATCCATCTCT TGAAGACATG 
CAGGAAGTTG TTGTGCATAA AAAAAAGAGG CCTGTTTTAA GAGATTATTG GCAGAAACAT 
GCTGGAATGG CAATGCTCTG TGAAACCATT GAAGAATGTT GGGATCACGA CGCAGAAGCC 
AGGTTATCAG CTGGATGTGT AGGTGAAAGA ATTACCCAGA TGCAGAGACT AACAAATATT 
ATTACCACAG AGGACATTGT AACAGTGGTC ACAATGGTGA CAAATGTTGA CTTTCCTCCC 
AAAGAATCTA GTCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265509.1
CDS	397..1614
Translation	MCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	NM_001278580.1
Organism	Homo sapiens(human)
Definition	Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278580.1

ORF Insert Sequence:

ATGTGTAATG AAAAGTTTTC TTATTTTCCG GAGATGGAAG TCACACAGCC CACTTCAAAT 
CCAGTTACAC CTAAGCCACC CTATTACAAC ATCCTGCTCT ATTCCTTGGT GCCACTTATG 
TTAATTGCGG GGATTGTCAT TTGTGCATTT TGGGTGTACA GGCATCACAA GATGGCCTAC 
CCTCCTGTAC TTGTTCCAAC TCAAGACCCA GGACCACCCC CACCTTCTCC ATTACTAGGT 
TTGAAACCAC TGCAGTTATT AGAAGTGAAA GCAAGGGGAA GATTTGGTTG TGTCTGGAAA 
GCCCAGTTGC TTAACGAATA TGTGGCTGTC AAAATATTTC CAATACAGGA CAAACAGTCA 
TGGCAAAATG AATACGAAGT CTACAGTTTG CCTGGAATGA AGCATGAGAA CATATTACAG 
TTCATTGGTG CAGAAAAACG AGGCACCAGT GTTGATGTGG ATCTTTGGCT GATCACAGCA 
TTTCATGAAA AGGGTTCACT ATCAGACTTT CTTAAGGCTA ATGTGGTCTC TTGGAATGAA 
CTGTGTCATA TTGCAGAAAC CATGGCTAGA GGATTGGCAT ATTTACATGA GGATATACCT 
GGCCTAAAAG ATGGCCACAA ACCTGCCATA TCTCACAGGG ACATCAAAAG TAAAAATGTG 
CTGTTGAAAA ACAACCTGAC AGCTTGCATT GCTGACTTTG GGTTGGCCTT AAAATTTGAG 
GCTGGCAAGT CTGCAGGCGA TACCCATGGA CAGGTTGGTA CCCGGAGGTA CATGGCTCCA 
GAGGTATTAG AGGGTGCTAT AAACTTCCAA AGGGATGCAT TTTTGAGGAT AGATATGTAT 
GCCATGGGAT TAGTCCTATG GGAACTGGCT TCTCGCTGTA CTGCTGCAGA TGGACCTGTA 
GATGAATACA TGTTGCCATT TGAGGAGGAA ATTGGCCAGC ATCCATCTCT TGAAGACATG 
CAGGAAGTTG TTGTGCATAA AAAAAAGAGG CCTGTTTTAA GAGATTATTG GCAGAAACAT 
GCTGGAATGG CAATGCTCTG TGAAACCATT GAAGAATGTT GGGATCACGA CGCAGAAGCC 
AGGTTATCAG CTGGATGTGT AGGTGAAAGA ATTACCCAGA TGCAGAGACT AACAAATATT 
ATTACCACAG AGGACATTGT AACAGTGGTC ACAATGGTGA CAAATGTTGA CTTTCCTCCC 
AAAGAATCTA GTCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro.
Pregnancy hypertension(2017 Nov)
Yong HEJ,Murthi P,Kalionis B,Keogh RJ,Brennecke SP

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.
PLoS genetics12(11)e1006314(2016 Nov)
Kulminski AM,He L,Culminskaya I,Loika Y,Kernogitski Y,Arbeev KG,Loiko E,Arbeeva L,Bagley O,Duan M,Yashkin A,Fang F,Kovtun M,Ukraintseva SV,Wu D,Yashin AI

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ACVR2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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