CD247 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD247
Entrez Gene ID	919
Full Name	CD247 molecule
Synonyms	CD3-ZETA,CD3H,CD3Q,CD3Z,IMD25,T3Z,TCRZ
General protein information	Preferred Names CD247 molecule Names T-cell surface glycoprotein CD3 zeta chain CD247 antigen, zeta subunit CD3Z antigen, zeta polypeptide (TiT3 complex) CD3zeta chain T-cell antigen receptor complex, zeta subunit of CD3 T-cell receptor T3 zeta chain TCR zeta chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Summary	The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	186780
Disorder Html:	?Immunodeficiency 25, 610163 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000734.3	NP_000725.1	T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor
XM_017002801.1	XP_016858290.1	T-cell surface glycoprotein CD3 zeta chain isoform X2
NM_000734.4	NP_000725.1	T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor
XM_017002800.1	XP_016858289.1	T-cell surface glycoprotein CD3 zeta chain isoform X1
XM_011510145.1	XP_011508447.1	T-cell surface glycoprotein CD3 zeta chain isoform X4
XM_011510144.2	XP_011508446.1	T-cell surface glycoprotein CD3 zeta chain isoform X3
NM_198053.2	NP_932170.1	T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CD247	NP_996762.1
Pan troglodytes (chimpanzee)	CD247	XP_001174731.1
Bos taurus (cattle)	CD247	NP_776437.1
Rattus norvegicus (Norway rat)	Cd247	NP_740770.2
Xenopus tropicalis (tropical clawed frog)	cd247	XP_002936278.1
	CD247	NP_001070891.1
Homo sapiens (human)	CD247	NP_932170.1
Canis lupus familiaris (dog)	CD247	XP_005623027.1
Mus musculus (house mouse)	Cd247	NP_001106862.1

Gene Ontology
Bibliography

Related articles in PubMed

Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in ian Patients with Systemic Sclerosis.
Abbasi F, Mansouri R, Gharibdoost F, Aslani S, Mostafaei S, Kavosi H, Poursani S, Sobhani S, Mahmoudi M
Iranian journal of allergy, asthma, and immunology16(6)471-479(2017 Dec)

Analysis of the recovery of CD247 expression in a PID patient: insights into the spontaneous repair of defective genes.
Bl?zquez-Moreno A, P?rez-Portilla A, Ag?ndez-Llaca M, Dukovska D, Val?s-G?mez M, Aydogmus C, Ikinciogullari A, Regueiro JR, Reyburn HT
Blood130(10)1205-1208(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Multiple mutations were found in CD247 complementary DNAs (cDNAs) cloned from the patient as well as in cDNA and genomic DNA from other individuals, suggesting that genetic variation in this gene is frequent.
Title: Analysis of the recovery of CD247 expression in a PID patient: insights into the spontaneous repair of defective genes.

CD274 up-regulation in new-onset type 1 diabetes mellitusis correlated with disease pathogenesis.
Title: Genome-wide gene expression profiling reveals that CD274 is up-regulated new-onset type 1 diabetes mellitus.

CD3/28-activated T cells expanded in IL-7 and IL-15 produced greater expansion of memory stem T cells and central memory T cell-derived T cells compared with IL-2. Our strategy provides a powerful tool to elucidate the characteristics of CAR-modified T cells, regardless of the protocol used for expansion, reveals the functional properties of each expanded T cell subset.
Title: Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.

CD3Z hypermethylation was significantly correlated with SLE. CD3Z hypermethylation is an SLE risk factor that can be modified by environmental factors and is associated with more severe SLE clinical manifestations, which are related to deranged T cell function by downregulating the CD3zeta-chain.
Title: CD3Z hypermethylation is associated with severe clinical manifestations in systemic lupus erythematosus and reduces CD3?-chain expression in T cells.

Linkage and association studies revealed a chromosomal region in which a novel type 1 diabetes (T1D)/autoimmune thyroid disease (AITD) susceptibility gene, CD247, is located and showed association between T1D/AITD and several variants in this gene. These results suggests that common susceptibility genes act in concert with variants of CD247 to generate genetic risk for T1D/AITD in this population.
Title: Association of CD247 (CD3?) gene polymorphisms with T1D and AITD in the population of northern Sweden.

The following CD247 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD247 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13596	NM_000734.4 Latest version!	Homo sapiens CD247 molecule (CD247), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu19310	NM_198053.2 Latest version!	Homo sapiens CD247 molecule (CD247), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu56701	XM_011510144.2 Latest version!	Homo sapiens CD247 molecule (CD247), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu56702	XM_011510145.1 Latest version!	Homo sapiens CD247 molecule (CD247), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu90801	XM_017002800.1 Latest version!	Homo sapiens CD247 molecule (CD247), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu90802	XM_017002801.1 Latest version!	Homo sapiens CD247 molecule (CD247), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu13596	NM_000734.3	Homo sapiens CD247 molecule (CD247), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD247 ( NM_000734.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000725.1 Homo sapiens CD247 molecule (CD247), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13596
Clone ID Related Accession (Same CDS sequence)	NM_000734.3 , NM_000734.4
Accession Version	NM_000734.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL557555.3, AK313946.1, AK223325.1, BC025703.1 and AI420774.1. On Jan 31, 2008 this sequence version replaced NM_000734.2. Transcript Variant: This variant (2) uses an alternate splice site in the mid-coding region, which results in a missing in-frame codon, as compared to variant 1. The encoded isoform (2) is thus missing an internal amino acid, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL557555.3, AK223325.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGAG 
GCACAGAGCT TTGGCCTGCT GGATCCCAAA CTCTGCTACC TGCTGGATGG AATCCTCTTC 
ATCTATGGTG TCATTCTCAC TGCCTTGTTC CTGAGAGTGA AGTTCAGCAG GAGCGCAGAC 
GCCCCCGCGT ACCAGCAGGG CCAGAACCAG CTCTATAACG AGCTCAATCT AGGACGAAGA 
GAGGAGTACG ATGTTTTGGA CAAGAGACGT GGCCGGGACC CTGAGATGGG GGGAAAGCCG 
AGAAGGAAGA ACCCTCAGGA AGGCCTGTAC AATGAACTGC AGAAAGATAA GATGGCGGAG 
GCCTACAGTG AGATTGGGAT GAAAGGCGAG CGCCGGAGGG GCAAGGGGCA CGATGGCCTT 
TACCAGGGTC TCAGTACAGC CACCAAGGAC ACCTACGACG CCCTTCACAT GCAGGCCCTG 
CCCCCTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000725.1
CDS	146..637
Translation	MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	NM_000734.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000734.3

ORF Insert Sequence:

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGAG 
GCACAGAGCT TTGGCCTGCT GGATCCCAAA CTCTGCTACC TGCTGGATGG AATCCTCTTC 
ATCTATGGTG TCATTCTCAC TGCCTTGTTC CTGAGAGTGA AGTTCAGCAG GAGCGCAGAC 
GCCCCCGCGT ACCAGCAGGG CCAGAACCAG CTCTATAACG AGCTCAATCT AGGACGAAGA 
GAGGAGTACG ATGTTTTGGA CAAGAGACGT GGCCGGGACC CTGAGATGGG GGGAAAGCCG 
AGAAGGAAGA ACCCTCAGGA AGGCCTGTAC AATGAACTGC AGAAAGATAA GATGGCGGAG 
GCCTACAGTG AGATTGGGAT GAAAGGCGAG CGCCGGAGGG GCAAGGGGCA CGATGGCCTT 
TACCAGGGTC TCAGTACAGC CACCAAGGAC ACCTACGACG CCCTTCACAT GCAGGCCCTG 
CCCCCTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD247 ( NM_000734.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000725.1 Homo sapiens CD247 molecule (CD247), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13596
Clone ID Related Accession (Same CDS sequence)	NM_000734.3 , NM_000734.4
Accession Version	NM_000734.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031733.3 and AL359962.15. On Jun 2, 2019 this sequence version replaced NM_000734.3. Transcript Variant: This variant (2) uses an alternate splice site in the mid-coding region, which results in a missing in-frame codon, as compared to variant 1. The encoded isoform (2) is thus missing an internal amino acid, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138524.1051563.1, AK223325.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGAG 
GCACAGAGCT TTGGCCTGCT GGATCCCAAA CTCTGCTACC TGCTGGATGG AATCCTCTTC 
ATCTATGGTG TCATTCTCAC TGCCTTGTTC CTGAGAGTGA AGTTCAGCAG GAGCGCAGAC 
GCCCCCGCGT ACCAGCAGGG CCAGAACCAG CTCTATAACG AGCTCAATCT AGGACGAAGA 
GAGGAGTACG ATGTTTTGGA CAAGAGACGT GGCCGGGACC CTGAGATGGG GGGAAAGCCG 
AGAAGGAAGA ACCCTCAGGA AGGCCTGTAC AATGAACTGC AGAAAGATAA GATGGCGGAG 
GCCTACAGTG AGATTGGGAT GAAAGGCGAG CGCCGGAGGG GCAAGGGGCA CGATGGCCTT 
TACCAGGGTC TCAGTACAGC CACCAAGGAC ACCTACGACG CCCTTCACAT GCAGGCCCTG 
CCCCCTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000725.1
CDS	65..556
Translation	MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	NM_000734.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000734.4

ORF Insert Sequence:

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGAG 
GCACAGAGCT TTGGCCTGCT GGATCCCAAA CTCTGCTACC TGCTGGATGG AATCCTCTTC 
ATCTATGGTG TCATTCTCAC TGCCTTGTTC CTGAGAGTGA AGTTCAGCAG GAGCGCAGAC 
GCCCCCGCGT ACCAGCAGGG CCAGAACCAG CTCTATAACG AGCTCAATCT AGGACGAAGA 
GAGGAGTACG ATGTTTTGGA CAAGAGACGT GGCCGGGACC CTGAGATGGG GGGAAAGCCG 
AGAAGGAAGA ACCCTCAGGA AGGCCTGTAC AATGAACTGC AGAAAGATAA GATGGCGGAG 
GCCTACAGTG AGATTGGGAT GAAAGGCGAG CGCCGGAGGG GCAAGGGGCA CGATGGCCTT 
TACCAGGGTC TCAGTACAGC CACCAAGGAC ACCTACGACG CCCTTCACAT GCAGGCCCTG 
CCCCCTCGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD247 ( NM_198053.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_932170.1 Homo sapiens CD247 molecule (CD247), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19310
Clone ID Related Accession (Same CDS sequence)	NM_198053.2
Accession Version	NM_198053.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL557555.3, BC025703.1, AK223325.1 and AI420774.1. This sequence is a reference standard in the RefSeqGene project. On Jan 31, 2008 this sequence version replaced NM_198053.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025703.1, AL554350.3 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGAG 
GCACAGAGCT TTGGCCTGCT GGATCCCAAA CTCTGCTACC TGCTGGATGG AATCCTCTTC 
ATCTATGGTG TCATTCTCAC TGCCTTGTTC CTGAGAGTGA AGTTCAGCAG GAGCGCAGAC 
GCCCCCGCGT ACCAGCAGGG CCAGAACCAG CTCTATAACG AGCTCAATCT AGGACGAAGA 
GAGGAGTACG ATGTTTTGGA CAAGAGACGT GGCCGGGACC CTGAGATGGG GGGAAAGCCG 
CAGAGAAGGA AGAACCCTCA GGAAGGCCTG TACAATGAAC TGCAGAAAGA TAAGATGGCG 
GAGGCCTACA GTGAGATTGG GATGAAAGGC GAGCGCCGGA GGGGCAAGGG GCACGATGGC 
CTTTACCAGG GTCTCAGTAC AGCCACCAAG GACACCTACG ACGCCCTTCA CATGCAGGCC 
CTGCCCCCTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932170.1
CDS	146..640
Translation	MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	NM_198053.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198053.2

ORF Insert Sequence:

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGAG 
GCACAGAGCT TTGGCCTGCT GGATCCCAAA CTCTGCTACC TGCTGGATGG AATCCTCTTC 
ATCTATGGTG TCATTCTCAC TGCCTTGTTC CTGAGAGTGA AGTTCAGCAG GAGCGCAGAC 
GCCCCCGCGT ACCAGCAGGG CCAGAACCAG CTCTATAACG AGCTCAATCT AGGACGAAGA 
GAGGAGTACG ATGTTTTGGA CAAGAGACGT GGCCGGGACC CTGAGATGGG GGGAAAGCCG 
CAGAGAAGGA AGAACCCTCA GGAAGGCCTG TACAATGAAC TGCAGAAAGA TAAGATGGCG 
GAGGCCTACA GTGAGATTGG GATGAAAGGC GAGCGCCGGA GGGGCAAGGG GCACGATGGC 
CTTTACCAGG GTCTCAGTAC AGCCACCAAG GACACCTACG ACGCCCTTCA CATGCAGGCC 
CTGCCCCCTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD247 ( XM_011510144.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508446.1 Homo sapiens CD247 molecule (CD247), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu56701
Clone ID Related Accession (Same CDS sequence)	XM_011510144.2
Accession Version	XM_011510144.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510144.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTCGAT CCTGGGAGAA GGGACTCCAC AGCCTGGTGA GGACCCCTCT CACCACCTCT 
GAGGATCAGC AAGTCTTTGA AGAGGCACAG AGCTTTGGCC TGCTGGATCC CAAACTCTGC 
TACCTGCTGG ATGGAATCCT CTTCATCTAT GGTGTCATTC TCACTGCCTT GTTCCTGAGA 
GTGAAGTTCA GCAGGAGCGC AGACGCCCCC GCGTACCAGC AGGGCCAGAA CCAGCTCTAT 
AACGAGCTCA ATCTAGGACG AAGAGAGGAG TACGATGTTT TGGACAAGAG ACGTGGCCGG 
GACCCTGAGA TGGGGGGAAA GCCGCAGAGA AGGAAGAACC CTCAGGAAGG CCTGTACAAT 
GAACTGCAGA AAGATAAGAT GGCGGAGGCC TACAGTGAGA TTGGGATGAA AGGCGAGCGC 
CGGAGGGGCA AGGGGCACGA TGGCCTTTAC CAGGGTCTCA GTACAGCCAC CAAGGACACC 
TACGACGCCC TTCACATGCA GGCCCTGCCC CCTCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508446.1
CDS	190..708
Translation	MVRSWEKGLHSLVRTPLTTSEDQQVFEEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	XM_011510144.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510144.2

ORF Insert Sequence:

ATGGTTCGAT CCTGGGAGAA GGGACTCCAC AGCCTGGTGA GGACCCCTCT CACCACCTCT 
GAGGATCAGC AAGTCTTTGA AGAGGCACAG AGCTTTGGCC TGCTGGATCC CAAACTCTGC 
TACCTGCTGG ATGGAATCCT CTTCATCTAT GGTGTCATTC TCACTGCCTT GTTCCTGAGA 
GTGAAGTTCA GCAGGAGCGC AGACGCCCCC GCGTACCAGC AGGGCCAGAA CCAGCTCTAT 
AACGAGCTCA ATCTAGGACG AAGAGAGGAG TACGATGTTT TGGACAAGAG ACGTGGCCGG 
GACCCTGAGA TGGGGGGAAA GCCGCAGAGA AGGAAGAACC CTCAGGAAGG CCTGTACAAT 
GAACTGCAGA AAGATAAGAT GGCGGAGGCC TACAGTGAGA TTGGGATGAA AGGCGAGCGC 
CGGAGGGGCA AGGGGCACGA TGGCCTTTAC CAGGGTCTCA GTACAGCCAC CAAGGACACC 
TACGACGCCC TTCACATGCA GGCCCTGCCC CCTCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD247 ( XM_011510145.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508447.1 Homo sapiens CD247 molecule (CD247), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu56702
Clone ID Related Accession (Same CDS sequence)	XM_011510145.1
Accession Version	XM_011510145.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTCGAT CCTGGGAGAA GGGACTCCAC AGCCTGGTGA GGACCCCTCT CACCACCTCT 
GAGGATCAGC AAGTCTTTGA AGAGGCACAG AGCTTTGGCC TGCTGGATCC CAAACTCTGC 
TACCTGCTGG ATGGAATCCT CTTCATCTAT GGTGTCATTC TCACTGCCTT GTTCCTGAGA 
GTGAAGTTCA GCAGGAGCGC AGACGCCCCC GCGTACCAGC AGGGCCAGAA CCAGCTCTAT 
AACGAGCTCA ATCTAGGACG AAGAGAGGAG TACGATGTTT TGGACAAGAG ACGTGGCCGG 
GACCCTGAGA TGGGGGGAAA GCCGAGAAGG AAGAACCCTC AGGAAGGCCT GTACAATGAA 
CTGCAGAAAG ATAAGATGGC GGAGGCCTAC AGTGAGATTG GGATGAAAGG CGAGCGCCGG 
AGGGGCAAGG GGCACGATGG CCTTTACCAG GGTCTCAGTA CAGCCACCAA GGACACCTAC 
GACGCCCTTC ACATGCAGGC CCTGCCCCCT CGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508447.1
CDS	199..714
Translation	MVRSWEKGLHSLVRTPLTTSEDQQVFEEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	XM_011510145.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510145.1

ORF Insert Sequence:

ATGGTTCGAT CCTGGGAGAA GGGACTCCAC AGCCTGGTGA GGACCCCTCT CACCACCTCT 
GAGGATCAGC AAGTCTTTGA AGAGGCACAG AGCTTTGGCC TGCTGGATCC CAAACTCTGC 
TACCTGCTGG ATGGAATCCT CTTCATCTAT GGTGTCATTC TCACTGCCTT GTTCCTGAGA 
GTGAAGTTCA GCAGGAGCGC AGACGCCCCC GCGTACCAGC AGGGCCAGAA CCAGCTCTAT 
AACGAGCTCA ATCTAGGACG AAGAGAGGAG TACGATGTTT TGGACAAGAG ACGTGGCCGG 
GACCCTGAGA TGGGGGGAAA GCCGAGAAGG AAGAACCCTC AGGAAGGCCT GTACAATGAA 
CTGCAGAAAG ATAAGATGGC GGAGGCCTAC AGTGAGATTG GGATGAAAGG CGAGCGCCGG 
AGGGGCAAGG GGCACGATGG CCTTTACCAG GGTCTCAGTA CAGCCACCAA GGACACCTAC 
GACGCCCTTC ACATGCAGGC CCTGCCCCCT CGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD247 ( XM_017002800.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858289.1 Homo sapiens CD247 molecule (CD247), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu90801
Clone ID Related Accession (Same CDS sequence)	XM_017002800.1
Accession Version	XM_017002800.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGCC 
TCCAGCCTCC CCCACCCAAC TCAGCAGAGC CCTGAGAAGA AAGTCCTGGG TCCCGGAGGC 
TGCACCTGCA GACACAACAG ATTCTGCAAT GAGGCACAGA GCTTTGGCCT GCTGGATCCC 
AAACTCTGCT ACCTGCTGGA TGGAATCCTC TTCATCTATG GTGTCATTCT CACTGCCTTG 
TTCCTGAGAG TGAAGTTCAG CAGGAGCGCA GACGCCCCCG CGTACCAGCA GGGCCAGAAC 
CAGCTCTATA ACGAGCTCAA TCTAGGACGA AGAGAGGAGT ACGATGTTTT GGACAAGAGA 
CGTGGCCGGG ACCCTGAGAT GGGGGGAAAG CCGCAGAGAA GGAAGAACCC TCAGGAAGGC 
CTGTACAATG AACTGCAGAA AGATAAGATG GCGGAGGCCT ACAGTGAGAT TGGGATGAAA 
GGCGAGCGCC GGAGGGGCAA GGGGCACGAT GGCCTTTACC AGGGTCTCAG TACAGCCACC 
AAGGACACCT ACGACGCCCT TCACATGCAG GCCCTGCCCC CTCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858289.1
CDS	112..699
Translation	MKWKALFTAAILQAQLPITASSLPHPTQQSPEKKVLGPGGCTCRHNRFCNEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	XM_017002800.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002800.1

ORF Insert Sequence:

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGCC 
TCCAGCCTCC CCCACCCAAC TCAGCAGAGC CCTGAGAAGA AAGTCCTGGG TCCCGGAGGC 
TGCACCTGCA GACACAACAG ATTCTGCAAT GAGGCACAGA GCTTTGGCCT GCTGGATCCC 
AAACTCTGCT ACCTGCTGGA TGGAATCCTC TTCATCTATG GTGTCATTCT CACTGCCTTG 
TTCCTGAGAG TGAAGTTCAG CAGGAGCGCA GACGCCCCCG CGTACCAGCA GGGCCAGAAC 
CAGCTCTATA ACGAGCTCAA TCTAGGACGA AGAGAGGAGT ACGATGTTTT GGACAAGAGA 
CGTGGCCGGG ACCCTGAGAT GGGGGGAAAG CCGCAGAGAA GGAAGAACCC TCAGGAAGGC 
CTGTACAATG AACTGCAGAA AGATAAGATG GCGGAGGCCT ACAGTGAGAT TGGGATGAAA 
GGCGAGCGCC GGAGGGGCAA GGGGCACGAT GGCCTTTACC AGGGTCTCAG TACAGCCACC 
AAGGACACCT ACGACGCCCT TCACATGCAG GCCCTGCCCC CTCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD247 ( XM_017002801.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858290.1 Homo sapiens CD247 molecule (CD247), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu90802
Clone ID Related Accession (Same CDS sequence)	XM_017002801.1
Accession Version	XM_017002801.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 zeta chain isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGCC 
TCCAGCCTCC CCCACCCAAC TCAGCAGAGC CCTGAGAAGA AAGTCCTGGG TCCCGGAGGC 
TGCACCTGCA GACACAACAG ATTCTGCAAT GAGGCACAGA GCTTTGGCCT GCTGGATCCC 
AAACTCTGCT ACCTGCTGGA TGGAATCCTC TTCATCTATG GTGTCATTCT CACTGCCTTG 
TTCCTGAGAG TGAAGTTCAG CAGGAGCGCA GACGCCCCCG CGTACCAGCA GGGCCAGAAC 
CAGCTCTATA ACGAGCTCAA TCTAGGACGA AGAGAGGAGT ACGATGTTTT GGACAAGAGA 
CGTGGCCGGG ACCCTGAGAT GGGGGGAAAG CCGAGAAGGA AGAACCCTCA GGAAGGCCTG 
TACAATGAAC TGCAGAAAGA TAAGATGGCG GAGGCCTACA GTGAGATTGG GATGAAAGGC 
GAGCGCCGGA GGGGCAAGGG GCACGATGGC CTTTACCAGG GTCTCAGTAC AGCCACCAAG 
GACACCTACG ACGCCCTTCA CATGCAGGCC CTGCCCCCTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858290.1
CDS	110..694
Translation	MKWKALFTAAILQAQLPITASSLPHPTQQSPEKKVLGPGGCTCRHNRFCNEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR

Target ORF information:

RefSeq Version	XM_017002801.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD247 molecule (CD247), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002801.1

ORF Insert Sequence:

ATGAAGTGGA AGGCGCTTTT CACCGCGGCC ATCCTGCAGG CACAGTTGCC GATTACAGCC 
TCCAGCCTCC CCCACCCAAC TCAGCAGAGC CCTGAGAAGA AAGTCCTGGG TCCCGGAGGC 
TGCACCTGCA GACACAACAG ATTCTGCAAT GAGGCACAGA GCTTTGGCCT GCTGGATCCC 
AAACTCTGCT ACCTGCTGGA TGGAATCCTC TTCATCTATG GTGTCATTCT CACTGCCTTG 
TTCCTGAGAG TGAAGTTCAG CAGGAGCGCA GACGCCCCCG CGTACCAGCA GGGCCAGAAC 
CAGCTCTATA ACGAGCTCAA TCTAGGACGA AGAGAGGAGT ACGATGTTTT GGACAAGAGA 
CGTGGCCGGG ACCCTGAGAT GGGGGGAAAG CCGAGAAGGA AGAACCCTCA GGAAGGCCTG 
TACAATGAAC TGCAGAAAGA TAAGATGGCG GAGGCCTACA GTGAGATTGG GATGAAAGGC 
GAGCGCCGGA GGGGCAAGGG GCACGATGGC CTTTACCAGG GTCTCAGTAC AGCCACCAAG 
GACACCTACG ACGCCCTTCA CATGCAGGCC CTGCCCCCTC GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis.
ian journal of allergy, asthma, and immunology16(6)471-479(2017 Dec)
Abbasi F,Mansouri R,Gharibdoost F,Aslani S,Mostafaei S,Kavosi H,Poursani S,Sobhani S,Mahmoudi M

Analysis of the recovery of CD247 expression in a PID patient: insights into the spontaneous repair of defective genes.
Blood130(10)1205-1208(2017 09)
Bl?zquez-Moreno A,P?rez-Portilla A,Ag?ndez-Llaca M,Dukovska D,Val?s-G?mez M,Aydogmus C,Ikinciogullari A,Regueiro JR,Reyburn HT

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CD247 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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