MYLK3 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYLK3
Entrez Gene ID	91807
Full Name	myosin light chain kinase 3
Synonyms	MLCK,MLCK2,caMLCK
General protein information	Preferred Names myosin light chain kinase 3 Names myosin light chain kinase 3 MLC kinase cardiac-MLCK cardiac-MyBP-C associated Ca/CaM kinase putative myosin light chain kinase 3
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 16 Map Location: 16q11.2
Summary	Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008].
Disorder MIM:	612147

mRNA and Protein(s)

mRNA	Protein	Name
XM_006721334.4	XP_006721397.1	myosin light chain kinase 3 isoform X1
NM_001308301.1	NP_001295230.1	myosin light chain kinase 3 isoform 2
NM_182493.2	NP_872299.2	myosin light chain kinase 3 isoform 1
XM_006721334.3	XP_006721397.1	myosin light chain kinase 3 isoform X1
NM_182493.3	NP_872299.2	myosin light chain kinase 3 isoform 1
XM_006721334.2	XP_006721397.1	myosin light chain kinase 3 isoform X4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MYLK3	XP_003315132.1
	MYLK3	XP_001113601.1
Canis lupus familiaris (dog)	MYLK3	XP_532569.4
Bos taurus (cattle)	MYLK3	XP_005218847.1
Mus musculus (house mouse)	Mylk3	NP_780650.2
Homo sapiens (human)	MYLK3	NP_872299.2
Rattus norvegicus (Norway rat)	Mylk3	NP_001104280.1
Gallus gallus (chicken)	MYLK3	XP_004944251.1
Xenopus tropicalis (tropical clawed frog)	mylk3	XP_002931740.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of MYLK3 mutations in familial dilated cardiomyopathy.
Tobita T, Nomura S, Morita H, Ko T, Fujita T, Toko H, Uto K, Hagiwara N, Aburatani H, Komuro I
Scientific reports7(1)17495(2017 Dec)

Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism.
Samak G, Gangwar R, Crosby LM, Desai LP, Wilhelm K, Waters CM, Rao R
American journal of physiology. Gastrointestinal and liver physiology306(11)G947-58(2014 Jun)

Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis.
Kuo CY, Chou TY, Chen CM, Tsai YF, Hwang GY, Hwang TL
Virus research175(1)20-9(2013 Jul)

Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.
Tsukamoto O, Kitakaze M
Circulation journal : official journal of the Japanese Circulation Society77(9)2218-25(2013)

Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability.
Al-Sadi R, Ye D, Dokladny K, Ma TY
Journal of immunology (Baltimore, Md. : 1950)180(8)5653-61(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism.
Title: Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism.

These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway.
Title: Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis.

Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.
Title: Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.

data indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK expression and activity and by an NF-kappaB-dependent increase in MLCK gene transcription
Title: Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability.

Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (cardiac-MLCK), which acts on MLC2v.
Title: A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.

The following MYLK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYLK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15966	NM_182493.3 Latest version!	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu49577	NM_001308301.1 Latest version!	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu49577	XM_006721334.4 Latest version!	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu49577	XM_006721334.3	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu15966	NM_182493.2	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu49577	XM_006721334.2	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYLK3 ( NM_182493.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_872299.2 Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15966
Clone ID Related Accession (Same CDS sequence)	NM_182493.2 , NM_182493.3
Accession Version	NM_182493.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2460bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myosin light chain kinase 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007225.2, AJ247087.1, DA561361.1, CR739116.1 and AL691746.1. On Nov 22, 2018 this sequence version replaced NM_182493.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AJ247087.1, BC109096.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394809.9/ ENSP00000378288.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAGGAA CCTCCAAGGA GAGTCTGGGG CATGGGGGGC TGCCAGGGTT GGGCAAGACC 
TGCTTAACAA CCATGGACAC AAAGCTGAAC ATGCTGAACG AGAAGGTGGA CCAGCTCCTG 
CACTTCCAAG AAGATGTCAC AGAGAAGTTG CAGAGCATGT GCCGAGACAT GGGCCACCTG 
GAGCGGGGCC TGCACAGGCT GGAGGCCTCC CGGGCACCGG GCCCGGGCGG GGCTGATGGG 
GTTCCCCACA TTGACACCCA GGCTGGGTGG CCCGAGGTCC TGGAGCTGGT GAGGGCCATG 
CAGCAGGATG CGGCCCAGCA CGGTGCCAGG CTGGAGGCCC TCTTCAGGAT GGTGGCTGCG 
GTGGACAGGG CCATCGCTTT GGTGGGGGCC ACGTTCCAGA AATCAAAGGT GGCGGATTTC 
CTCATGCAGG GGCGTGTGCC CTGGAGGAGA GGCAGCCCAG GTGACAGCCC TGAGGAGAAT 
AAAGAGCGAG TGGAAGAAGA GGGAGGAAAA CCAAAGCATG TGCTGAGCAC CAGTGGGGTG 
CAGTCTGATG CCAGGGAGCC TGGGGAAGAG AGCCAGAAGG CGGACGTGCT GGAGGGGACA 
GCGGAGAGGC TGCCCCCCAT CAGAGCGTCA GGGCTGGGAG CTGACCCCGC CCAGGCAGTG 
GTCTCACCGG GCCAGGGAGA TGGTGTTCCT GGCCCAGCCC AGGCATTCCC TGGCCACCTG 
CCCCTGCCCA CAAAGGTGGA AGCCAAGGCT CCTGAGACAC CCAGCGAGAA CCTCAGGACT 
GGCCTGGAAT TGGCTCCAGC ACCCGGCAGG GTCAATGTGG TCTCCCCGAG CCTGGAGGTT 
GCACCAGGTG CAGGACAAGG AGCATCGTCC AGCAGGCCTG ACCCTGAGCC CTTAGAGGAA 
GGCACGAGGC TGACTCCAGG GCCTGGCCCT CAGTGCCCAG GGCCTCCAGG GCTGCCAGCC 
CAGGCCAGGG CAACCCACAG TGGTGGAGAA ACACCTCCAA GGATCTCCAT CCACATACAA 
GAGATGGATA CTCCTGGGGA GATGCTGATG ACAGGCAGGG GCAGCCTTGG ACCCACCCTC 
ACCACAGAGG CTCCAGCAGC TGCCCAGCCA GGCAAGCAGG GCCCACCTGG GACCGGGCGC 
TGCCTCCAAG CCCCTGGGAC TGAGCCCGGA GAACAGACCC CTGAAGGAGC CAGAGAGCTC 
TCCCCGCTGC AGGAGAGCAG CAGCCCCGGG GGAGTGAAGG CAGAGGAGGA GCAAAGGGCT 
GGGGCCGAGC CTGGCACGAG ACCAAGCTTG GCCAGGAGTG ACGACAATGA CCACGAGGTT 
GGGGCCCTGG GCCTGCAGCA GGGCAAAAGC CCAGGGGCGG GAAACCCTGA GCCTGAGCAG 
GACTGTGCAG CCAGGGCTCC GGTGAGAGCT GAAGCAGTAA GGAGGATGCC CCCAGGCGCC 
GAGGCTGGCA GCGTGGTTCT GGATGACAGT CCGGCCCCAC CAGCTCCTTT TGAACACCGG 
GTAGTGAGCG TCAAGGAGAC CTCCATCTCT GCGGGTTACG AGGTGTGCCA GCACGAAGTC 
TTGGGAGGGG GTCGGTTTGG CCAGGTCCAC AGGTGCACAG AGAAGTCCAC AGGCCTCCCA 
CTGGCTGCCA AGATCATCAA AGTGAAGAGC GCCAAGGACC GGGAGGACGT GAAGAACGAG 
ATCAACATCA TGAACCAGCT CAGCCACGTG AACCTGATCC AGCTCTATGA CGCCTTCGAG 
AGCAAGCACA GCTGCACCCT TGTCATGGAG TACGTGGACG GGGGTGAGCT CTTCGACCGG 
ATCACAGATG AGAAGTACCA CCTGACTGAG CTGGATGTGG TCCTGTTCAC CAGGCAGATC 
TGTGAGGGTG TGCATTACCT GCACCAGCAC TACATCCTGC ACCTGGACCT CAAGCCGGAG 
AACATATTGT GCGTCAATCA GACAGGACAT CAAATTAAGA TCATTGACTT TGGGCTGGCC 
AGAAGGTACA AGCCTCGAGA GAAGCTGAAG GTGAACTTCG GCACTCCTGA GTTCCTGGCC 
CCAGAAGTCG TCAATTATGA GTTTGTCTCA TTCCCCACAG ACATGTGGAG TGTGGGAGTC 
ATCACCTACA TGCTACTCAG TGGCTTGTCC CCATTTCTAG GGGAAACAGA TGCAGAGACC 
ATGAATTTCA TTGTAAACTG TAGCTGGGAT TTTGATGCTG ACACCTTTGA AGGGCTCTCG 
GAGGAGGCCA AGGACTTTGT TTCCCGGTTG CTGGTCAAAG AGAAGAGCTG CAGAATGAGT 
GCCACACAGT GCCTGAAACA CGAGTGGCTG AATAATTTGC CTGCCAAAGC TTCAAGATCC 
AAAACTCGTC TCAAATCCCA ACTACTGCTG CAGAAATACA TAGCTCAAAG AAAATGGAAG 
AAACATTTCT ATGTGGTGAC TGCTGCCAAC AGGTTAAGGA AATTTCCAAC TTCTCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_872299.2
CDS	152..2611
Translation	MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Target ORF information:

RefSeq Version	NM_182493.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182493.3

ORF Insert Sequence:

ATGTCAGGAA CCTCCAAGGA GAGTCTGGGG CATGGGGGGC TGCCAGGGTT GGGCAAGACC 
TGCTTAACAA CCATGGACAC AAAGCTGAAC ATGCTGAACG AGAAGGTGGA CCAGCTCCTG 
CACTTCCAAG AAGATGTCAC AGAGAAGTTG CAGAGCATGT GCCGAGACAT GGGCCACCTG 
GAGCGGGGCC TGCACAGGCT GGAGGCCTCC CGGGCACCGG GCCCGGGCGG GGCTGATGGG 
GTTCCCCACA TTGACACCCA GGCTGGGTGG CCCGAGGTCC TGGAGCTGGT GAGGGCCATG 
CAGCAGGATG CGGCCCAGCA CGGTGCCAGG CTGGAGGCCC TCTTCAGGAT GGTGGCTGCG 
GTGGACAGGG CCATCGCTTT GGTGGGGGCC ACGTTCCAGA AATCAAAGGT GGCGGATTTC 
CTCATGCAGG GGCGTGTGCC CTGGAGGAGA GGCAGCCCAG GTGACAGCCC TGAGGAGAAT 
AAAGAGCGAG TGGAAGAAGA GGGAGGAAAA CCAAAGCATG TGCTGAGCAC CAGTGGGGTG 
CAGTCTGATG CCAGGGAGCC TGGGGAAGAG AGCCAGAAGG CGGACGTGCT GGAGGGGACA 
GCGGAGAGGC TGCCCCCCAT CAGAGCGTCA GGGCTGGGAG CTGACCCCGC CCAGGCAGTG 
GTCTCACCGG GCCAGGGAGA TGGTGTTCCT GGCCCAGCCC AGGCATTCCC TGGCCACCTG 
CCCCTGCCCA CAAAGGTGGA AGCCAAGGCT CCTGAGACAC CCAGCGAGAA CCTCAGGACT 
GGCCTGGAAT TGGCTCCAGC ACCCGGCAGG GTCAATGTGG TCTCCCCGAG CCTGGAGGTT 
GCACCAGGTG CAGGACAAGG AGCATCGTCC AGCAGGCCTG ACCCTGAGCC CTTAGAGGAA 
GGCACGAGGC TGACTCCAGG GCCTGGCCCT CAGTGCCCAG GGCCTCCAGG GCTGCCAGCC 
CAGGCCAGGG CAACCCACAG TGGTGGAGAA ACACCTCCAA GGATCTCCAT CCACATACAA 
GAGATGGATA CTCCTGGGGA GATGCTGATG ACAGGCAGGG GCAGCCTTGG ACCCACCCTC 
ACCACAGAGG CTCCAGCAGC TGCCCAGCCA GGCAAGCAGG GCCCACCTGG GACCGGGCGC 
TGCCTCCAAG CCCCTGGGAC TGAGCCCGGA GAACAGACCC CTGAAGGAGC CAGAGAGCTC 
TCCCCGCTGC AGGAGAGCAG CAGCCCCGGG GGAGTGAAGG CAGAGGAGGA GCAAAGGGCT 
GGGGCCGAGC CTGGCACGAG ACCAAGCTTG GCCAGGAGTG ACGACAATGA CCACGAGGTT 
GGGGCCCTGG GCCTGCAGCA GGGCAAAAGC CCAGGGGCGG GAAACCCTGA GCCTGAGCAG 
GACTGTGCAG CCAGGGCTCC GGTGAGAGCT GAAGCAGTAA GGAGGATGCC CCCAGGCGCC 
GAGGCTGGCA GCGTGGTTCT GGATGACAGT CCGGCCCCAC CAGCTCCTTT TGAACACCGG 
GTAGTGAGCG TCAAGGAGAC CTCCATCTCT GCGGGTTACG AGGTGTGCCA GCACGAAGTC 
TTGGGAGGGG GTCGGTTTGG CCAGGTCCAC AGGTGCACAG AGAAGTCCAC AGGCCTCCCA 
CTGGCTGCCA AGATCATCAA AGTGAAGAGC GCCAAGGACC GGGAGGACGT GAAGAACGAG 
ATCAACATCA TGAACCAGCT CAGCCACGTG AACCTGATCC AGCTCTATGA CGCCTTCGAG 
AGCAAGCACA GCTGCACCCT TGTCATGGAG TACGTGGACG GGGGTGAGCT CTTCGACCGG 
ATCACAGATG AGAAGTACCA CCTGACTGAG CTGGATGTGG TCCTGTTCAC CAGGCAGATC 
TGTGAGGGTG TGCATTACCT GCACCAGCAC TACATCCTGC ACCTGGACCT CAAGCCGGAG 
AACATATTGT GCGTCAATCA GACAGGACAT CAAATTAAGA TCATTGACTT TGGGCTGGCC 
AGAAGGTACA AGCCTCGAGA GAAGCTGAAG GTGAACTTCG GCACTCCTGA GTTCCTGGCC 
CCAGAAGTCG TCAATTATGA GTTTGTCTCA TTCCCCACAG ACATGTGGAG TGTGGGAGTC 
ATCACCTACA TGCTACTCAG TGGCTTGTCC CCATTTCTAG GGGAAACAGA TGCAGAGACC 
ATGAATTTCA TTGTAAACTG TAGCTGGGAT TTTGATGCTG ACACCTTTGA AGGGCTCTCG 
GAGGAGGCCA AGGACTTTGT TTCCCGGTTG CTGGTCAAAG AGAAGAGCTG CAGAATGAGT 
GCCACACAGT GCCTGAAACA CGAGTGGCTG AATAATTTGC CTGCCAAAGC TTCAAGATCC 
AAAACTCGTC TCAAATCCCA ACTACTGCTG CAGAAATACA TAGCTCAAAG AAAATGGAAG 
AAACATTTCT ATGTGGTGAC TGCTGCCAAC AGGTTAAGGA AATTTCCAAC TTCTCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLK3 ( NM_001308301.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001295230.1 Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu49577
Clone ID Related Accession (Same CDS sequence)	XM_006721334.4 , NM_001308301.1 , XM_006721334.3 , XM_006721334.2
Accession Version	NM_001308301.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	myosin light chain kinase 3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK299443.1 and AC007225.2. On Apr 29, 2015 this sequence version replaced XM_005256235.3. Transcript Variant: This variant (2) uses an alternate 5' most exon which results in a different 5' UTR and use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK299443.1, SRR1660803.19587.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295230.1
CDS	321..1757
Translation	MDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Target ORF information:

RefSeq Version	NM_001308301.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308301.1

ORF Insert Sequence:

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLK3 ( XM_006721334.4 ) cDNA ORF clone, Homo sapiens(Human) -> XP_006721397.1 Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA.

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CloneID	OHu49577
Clone ID Related Accession (Same CDS sequence)	XM_006721334.4 , NM_001308301.1 , XM_006721334.3 , XM_006721334.2
Accession Version	XM_006721334.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	myosin light chain kinase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006721334.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006721397.1
CDS	608..2044
Translation	MDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Target ORF information:

RefSeq Version	XM_006721334.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006721334.4

ORF Insert Sequence:

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLK3 ( XM_006721334.3 ) cDNA ORF clone, Homo sapiens(Human) -> XP_006721397.1 Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA.

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CloneID	OHu49577
Clone ID Related Accession (Same CDS sequence)	XM_006721334.4 , NM_001308301.1 , XM_006721334.3 , XM_006721334.2
Accession Version	XM_006721334.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	myosin light chain kinase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006721334.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006721397.1
CDS	608..2044
Translation	MDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Target ORF information:

RefSeq Version	XM_006721334.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006721334.3

ORF Insert Sequence:

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLK3 ( XM_006721334.2 ) cDNA ORF clone, Homo sapiens(Human) -> XP_006721397.1 Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu49577
Clone ID Related Accession (Same CDS sequence)	XM_006721334.4 , NM_001308301.1 , XM_006721334.3 , XM_006721334.2
Accession Version	XM_006721334.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	myosin light chain kinase 3 isoform X4
Comment

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_006721397.1

Translation

MDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Target ORF information:

RefSeq Version	XM_006721334.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006721334.2

ORF Insert Sequence:

ATGGATACTC CTGGGGAGAT GCTGATGACA GGCAGGGGCA GCCTTGGACC CACCCTCACC 
ACAGAGGCTC CAGCAGCTGC CCAGCCAGGC AAGCAGGGCC CACCTGGGAC CGGGCGCTGC 
CTCCAAGCCC CTGGGACTGA GCCCGGAGAA CAGACCCCTG AAGGAGCCAG AGAGCTCTCC 
CCGCTGCAGG AGAGCAGCAG CCCCGGGGGA GTGAAGGCAG AGGAGGAGCA AAGGGCTGGG 
GCCGAGCCTG GCACGAGACC AAGCTTGGCC AGGAGTGACG ACAATGACCA CGAGGTTGGG 
GCCCTGGGCC TGCAGCAGGG CAAAAGCCCA GGGGCGGGAA ACCCTGAGCC TGAGCAGGAC 
TGTGCAGCCA GGGCTCCGGT GAGAGCTGAA GCAGTAAGGA GGATGCCCCC AGGCGCCGAG 
GCTGGCAGCG TGGTTCTGGA TGACAGTCCG GCCCCACCAG CTCCTTTTGA ACACCGGGTA 
GTGAGCGTCA AGGAGACCTC CATCTCTGCG GGTTACGAGG TGTGCCAGCA CGAAGTCTTG 
GGAGGGGGTC GGTTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACAGG CCTCCCACTG 
GCTGCCAAGA TCATCAAAGT GAAGAGCGCC AAGGACCGGG AGGACGTGAA GAACGAGATC 
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTATGACGC CTTCGAGAGC 
AAGCACAGCT GCACCCTTGT CATGGAGTAC GTGGACGGGG GTGAGCTCTT CGACCGGATC 
ACAGATGAGA AGTACCACCT GACTGAGCTG GATGTGGTCC TGTTCACCAG GCAGATCTGT 
GAGGGTGTGC ATTACCTGCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCGGAGAAC 
ATATTGTGCG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG GCTGGCCAGA 
AGGTACAAGC CTCGAGAGAA GCTGAAGGTG AACTTCGGCA CTCCTGAGTT CCTGGCCCCA 
GAAGTCGTCA ATTATGAGTT TGTCTCATTC CCCACAGACA TGTGGAGTGT GGGAGTCATC 
ACCTACATGC TACTCAGTGG CTTGTCCCCA TTTCTAGGGG AAACAGATGC AGAGACCATG 
AATTTCATTG TAAACTGTAG CTGGGATTTT GATGCTGACA CCTTTGAAGG GCTCTCGGAG 
GAGGCCAAGG ACTTTGTTTC CCGGTTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 
ACACAGTGCC TGAAACACGA GTGGCTGAAT AATTTGCCTG CCAAAGCTTC AAGATCCAAA 
ACTCGTCTCA AATCCCAACT ACTGCTGCAG AAATACATAG CTCAAAGAAA ATGGAAGAAA 
CATTTCTATG TGGTGACTGC TGCCAACAGG TTAAGGAAAT TTCCAACTTC TCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLK3 ( NM_182493.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_872299.2 Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 1, mRNA.

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CloneID	OHu15966
Clone ID Related Accession (Same CDS sequence)	NM_182493.2 , NM_182493.3
Accession Version	NM_182493.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2460bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	myosin light chain kinase 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ247087.1, DA561361.1, CR739116.1, AC007225.2 and AL691746.1. On May 3, 2007 this sequence version replaced NM_182493.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AJ247087.1, BC109096.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGGAA CCTCCAAGGA GAGTCTGGGG CATGGGGGGC TGCCAGGGTT GGGCAAGACC 
TGCTTAACAA CCATGGACAC AAAGCTGAAC ATGCTGAACG AGAAGGTGGA CCAGCTCCTG 
CACTTCCAAG AAGATGTCAC AGAGAAGTTG CAGAGCATGT GCCGAGACAT GGGCCACCTG 
GAGCGGGGCC TGCACAGGCT GGAGGCCTCC CGGGCACCGG GCCCGGGCGG GGCTGATGGG 
GTTCCCCACA TTGACACCCA GGCTGGGTGG CCCGAGGTCC TGGAGCTGGT GAGGGCCATG 
CAGCAGGATG CGGCCCAGCA CGGTGCCAGG CTGGAGGCCC TCTTCAGGAT GGTGGCTGCG 
GTGGACAGGG CCATCGCTTT GGTGGGGGCC ACGTTCCAGA AATCAAAGGT GGCGGATTTC 
CTCATGCAGG GGCGTGTGCC CTGGAGGAGA GGCAGCCCAG GTGACAGCCC TGAGGAGAAT 
AAAGAGCGAG TGGAAGAAGA GGGAGGAAAA CCAAAGCATG TGCTGAGCAC CAGTGGGGTG 
CAGTCTGATG CCAGGGAGCC TGGGGAAGAG AGCCAGAAGG CGGACGTGCT GGAGGGGACA 
GCGGAGAGGC TGCCCCCCAT CAGAGCGTCA GGGCTGGGAG CTGACCCCGC CCAGGCAGTG 
GTCTCACCGG GCCAGGGAGA TGGTGTTCCT GGCCCAGCCC AGGCATTCCC TGGCCACCTG 
CCCCTGCCCA CAAAGGTGGA AGCCAAGGCT CCTGAGACAC CCAGCGAGAA CCTCAGGACT 
GGCCTGGAAT TGGCTCCAGC ACCCGGCAGG GTCAATGTGG TCTCCCCGAG CCTGGAGGTT 
GCACCAGGTG CAGGACAAGG AGCATCGTCC AGCAGGCCTG ACCCTGAGCC CTTAGAGGAA 
GGCACGAGGC TGACTCCAGG GCCTGGCCCT CAGTGCCCAG GGCCTCCAGG GCTGCCAGCC 
CAGGCCAGGG CAACCCACAG TGGTGGAGAA ACACCTCCAA GGATCTCCAT CCACATACAA 
GAGATGGATA CTCCTGGGGA GATGCTGATG ACAGGCAGGG GCAGCCTTGG ACCCACCCTC 
ACCACAGAGG CTCCAGCAGC TGCCCAGCCA GGCAAGCAGG GCCCACCTGG GACCGGGCGC 
TGCCTCCAAG CCCCTGGGAC TGAGCCCGGA GAACAGACCC CTGAAGGAGC CAGAGAGCTC 
TCCCCGCTGC AGGAGAGCAG CAGCCCCGGG GGAGTGAAGG CAGAGGAGGA GCAAAGGGCT 
GGGGCCGAGC CTGGCACGAG ACCAAGCTTG GCCAGGAGTG ACGACAATGA CCACGAGGTT 
GGGGCCCTGG GCCTGCAGCA GGGCAAAAGC CCAGGGGCGG GAAACCCTGA GCCTGAGCAG 
GACTGTGCAG CCAGGGCTCC GGTGAGAGCT GAAGCAGTAA GGAGGATGCC CCCAGGCGCC 
GAGGCTGGCA GCGTGGTTCT GGATGACAGT CCGGCCCCAC CAGCTCCTTT TGAACACCGG 
GTAGTGAGCG TCAAGGAGAC CTCCATCTCT GCGGGTTACG AGGTGTGCCA GCACGAAGTC 
TTGGGAGGGG GTCGGTTTGG CCAGGTCCAC AGGTGCACAG AGAAGTCCAC AGGCCTCCCA 
CTGGCTGCCA AGATCATCAA AGTGAAGAGC GCCAAGGACC GGGAGGACGT GAAGAACGAG 
ATCAACATCA TGAACCAGCT CAGCCACGTG AACCTGATCC AGCTCTATGA CGCCTTCGAG 
AGCAAGCACA GCTGCACCCT TGTCATGGAG TACGTGGACG GGGGTGAGCT CTTCGACCGG 
ATCACAGATG AGAAGTACCA CCTGACTGAG CTGGATGTGG TCCTGTTCAC CAGGCAGATC 
TGTGAGGGTG TGCATTACCT GCACCAGCAC TACATCCTGC ACCTGGACCT CAAGCCGGAG 
AACATATTGT GCGTCAATCA GACAGGACAT CAAATTAAGA TCATTGACTT TGGGCTGGCC 
AGAAGGTACA AGCCTCGAGA GAAGCTGAAG GTGAACTTCG GCACTCCTGA GTTCCTGGCC 
CCAGAAGTCG TCAATTATGA GTTTGTCTCA TTCCCCACAG ACATGTGGAG TGTGGGAGTC 
ATCACCTACA TGCTACTCAG TGGCTTGTCC CCATTTCTAG GGGAAACAGA TGCAGAGACC 
ATGAATTTCA TTGTAAACTG TAGCTGGGAT TTTGATGCTG ACACCTTTGA AGGGCTCTCG 
GAGGAGGCCA AGGACTTTGT TTCCCGGTTG CTGGTCAAAG AGAAGAGCTG CAGAATGAGT 
GCCACACAGT GCCTGAAACA CGAGTGGCTG AATAATTTGC CTGCCAAAGC TTCAAGATCC 
AAAACTCGTC TCAAATCCCA ACTACTGCTG CAGAAATACA TAGCTCAAAG AAAATGGAAG 
AAACATTTCT ATGTGGTGAC TGCTGCCAAC AGGTTAAGGA AATTTCCAAC TTCTCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_872299.2
CDS	117..2576
Translation	MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP

Target ORF information:

RefSeq Version	NM_182493.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin light chain kinase 3 (MYLK3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182493.2

ORF Insert Sequence:

ATGTCAGGAA CCTCCAAGGA GAGTCTGGGG CATGGGGGGC TGCCAGGGTT GGGCAAGACC 
TGCTTAACAA CCATGGACAC AAAGCTGAAC ATGCTGAACG AGAAGGTGGA CCAGCTCCTG 
CACTTCCAAG AAGATGTCAC AGAGAAGTTG CAGAGCATGT GCCGAGACAT GGGCCACCTG 
GAGCGGGGCC TGCACAGGCT GGAGGCCTCC CGGGCACCGG GCCCGGGCGG GGCTGATGGG 
GTTCCCCACA TTGACACCCA GGCTGGGTGG CCCGAGGTCC TGGAGCTGGT GAGGGCCATG 
CAGCAGGATG CGGCCCAGCA CGGTGCCAGG CTGGAGGCCC TCTTCAGGAT GGTGGCTGCG 
GTGGACAGGG CCATCGCTTT GGTGGGGGCC ACGTTCCAGA AATCAAAGGT GGCGGATTTC 
CTCATGCAGG GGCGTGTGCC CTGGAGGAGA GGCAGCCCAG GTGACAGCCC TGAGGAGAAT 
AAAGAGCGAG TGGAAGAAGA GGGAGGAAAA CCAAAGCATG TGCTGAGCAC CAGTGGGGTG 
CAGTCTGATG CCAGGGAGCC TGGGGAAGAG AGCCAGAAGG CGGACGTGCT GGAGGGGACA 
GCGGAGAGGC TGCCCCCCAT CAGAGCGTCA GGGCTGGGAG CTGACCCCGC CCAGGCAGTG 
GTCTCACCGG GCCAGGGAGA TGGTGTTCCT GGCCCAGCCC AGGCATTCCC TGGCCACCTG 
CCCCTGCCCA CAAAGGTGGA AGCCAAGGCT CCTGAGACAC CCAGCGAGAA CCTCAGGACT 
GGCCTGGAAT TGGCTCCAGC ACCCGGCAGG GTCAATGTGG TCTCCCCGAG CCTGGAGGTT 
GCACCAGGTG CAGGACAAGG AGCATCGTCC AGCAGGCCTG ACCCTGAGCC CTTAGAGGAA 
GGCACGAGGC TGACTCCAGG GCCTGGCCCT CAGTGCCCAG GGCCTCCAGG GCTGCCAGCC 
CAGGCCAGGG CAACCCACAG TGGTGGAGAA ACACCTCCAA GGATCTCCAT CCACATACAA 
GAGATGGATA CTCCTGGGGA GATGCTGATG ACAGGCAGGG GCAGCCTTGG ACCCACCCTC 
ACCACAGAGG CTCCAGCAGC TGCCCAGCCA GGCAAGCAGG GCCCACCTGG GACCGGGCGC 
TGCCTCCAAG CCCCTGGGAC TGAGCCCGGA GAACAGACCC CTGAAGGAGC CAGAGAGCTC 
TCCCCGCTGC AGGAGAGCAG CAGCCCCGGG GGAGTGAAGG CAGAGGAGGA GCAAAGGGCT 
GGGGCCGAGC CTGGCACGAG ACCAAGCTTG GCCAGGAGTG ACGACAATGA CCACGAGGTT 
GGGGCCCTGG GCCTGCAGCA GGGCAAAAGC CCAGGGGCGG GAAACCCTGA GCCTGAGCAG 
GACTGTGCAG CCAGGGCTCC GGTGAGAGCT GAAGCAGTAA GGAGGATGCC CCCAGGCGCC 
GAGGCTGGCA GCGTGGTTCT GGATGACAGT CCGGCCCCAC CAGCTCCTTT TGAACACCGG 
GTAGTGAGCG TCAAGGAGAC CTCCATCTCT GCGGGTTACG AGGTGTGCCA GCACGAAGTC 
TTGGGAGGGG GTCGGTTTGG CCAGGTCCAC AGGTGCACAG AGAAGTCCAC AGGCCTCCCA 
CTGGCTGCCA AGATCATCAA AGTGAAGAGC GCCAAGGACC GGGAGGACGT GAAGAACGAG 
ATCAACATCA TGAACCAGCT CAGCCACGTG AACCTGATCC AGCTCTATGA CGCCTTCGAG 
AGCAAGCACA GCTGCACCCT TGTCATGGAG TACGTGGACG GGGGTGAGCT CTTCGACCGG 
ATCACAGATG AGAAGTACCA CCTGACTGAG CTGGATGTGG TCCTGTTCAC CAGGCAGATC 
TGTGAGGGTG TGCATTACCT GCACCAGCAC TACATCCTGC ACCTGGACCT CAAGCCGGAG 
AACATATTGT GCGTCAATCA GACAGGACAT CAAATTAAGA TCATTGACTT TGGGCTGGCC 
AGAAGGTACA AGCCTCGAGA GAAGCTGAAG GTGAACTTCG GCACTCCTGA GTTCCTGGCC 
CCAGAAGTCG TCAATTATGA GTTTGTCTCA TTCCCCACAG ACATGTGGAG TGTGGGAGTC 
ATCACCTACA TGCTACTCAG TGGCTTGTCC CCATTTCTAG GGGAAACAGA TGCAGAGACC 
ATGAATTTCA TTGTAAACTG TAGCTGGGAT TTTGATGCTG ACACCTTTGA AGGGCTCTCG 
GAGGAGGCCA AGGACTTTGT TTCCCGGTTG CTGGTCAAAG AGAAGAGCTG CAGAATGAGT 
GCCACACAGT GCCTGAAACA CGAGTGGCTG AATAATTTGC CTGCCAAAGC TTCAAGATCC 
AAAACTCGTC TCAAATCCCA ACTACTGCTG CAGAAATACA TAGCTCAAAG AAAATGGAAG 
AAACATTTCT ATGTGGTGAC TGCTGCCAAC AGGTTAAGGA AATTTCCAAC TTCTCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of MYLK3 mutations in familial dilated cardiomyopathy.
Scientific reports7(1)17495(2017 Dec)
Tobita T,Nomura S,Morita H,Ko T,Fujita T,Toko H,Uto K,Hagiwara N,Aburatani H,Komuro I

Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism.
American journal of physiology. Gastrointestinal and liver physiology306(11)G947-58(2014 Jun)
Samak G,Gangwar R,Crosby LM,Desai LP,Wilhelm K,Waters CM,Rao R

Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis.
Virus research175(1)20-9(2013 Jul)
Kuo CY,Chou TY,Chen CM,Tsai YF,Hwang GY,Hwang TL

Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.
Circulation journal : official journal of the Japanese Circulation Society77(9)2218-25(2013)
Tsukamoto O,Kitakaze M

Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability.
Journal of immunology (Baltimore, Md. : 1950)180(8)5653-61(2008 Apr)
Al-Sadi R,Ye D,Dokladny K,Ma TY

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MYLK3 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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