IDI2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IDI2
Entrez Gene ID	91734
Full Name	isopentenyl-diphosphate delta isomerase 2
Synonyms	IPPI2
General protein information	Preferred Names isopentenyl-diphosphate delta isomerase 2 Names isopentenyl-diphosphate delta-isomerase 2 IPP isomerase 2 diphosphate dimethylallyl diphosphate isomerase 2 isopentenyl pyrophosphate isomerase 2 isopentenyl-diphosphate Delta-isomerase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p15.3
Summary	The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016].
Disorder MIM:	615389

mRNA and Protein(s)

mRNA	Protein	Name
NM_033261.2	NP_150286.1	isopentenyl-diphosphate delta-isomerase 2
NM_033261.3	NP_150286.1	isopentenyl-diphosphate delta-isomerase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	RGD1564347	XP_344623.3
Rattus norvegicus (Norway rat)	LOC102550988	XP_006254186.1
Pan troglodytes (chimpanzee)	IDI2	XP_507621.2
Rattus norvegicus (Norway rat)	RGD1564999	XP_001072335.3
Homo sapiens (human)	IDI2	NP_150286.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.
Nakamura K, Mori F, Tanji K, Miki Y, Yamada M, Kakita A, Takahashi H, Utsumi J, Sasaki H, Wakabayashi K
Neuropathology : official journal of the Japanese Society of Neuropathology35(5)432-40(2015 Oct)

Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.
Kato T, Emi M, Sato H, Arawaka S, Wada M, Kawanami T, Katagiri T, Tsuburaya K, Toyoshima I, Tanaka F, Sobue G, Matsubara K
Biochemical and biophysical research communications402(2)438-42(2010 Nov)

IDI2, a second isopentenyl diphosphate isomerase in mammals.
Clizbe DB, Owens ML, Masuda KR, Shackelford JE, Krisans SK
The Journal of biological chemistry282(9)6668-76(2007 Mar)

Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.
Breitling R, Laubner D, Clizbe D, Adamski J, Krisans SK
Journal of molecular evolution57(3)282-91(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of Lewy body formation.
Title: Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.

Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients.
Title: Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.

Enzyme kinetic analysis; both isozymes IDI1 and IDI2 are localized to the peroxisome by a PTS1-dependent pathway; data suggest that IDI2 is regulated independently from IDI1, by a mechanism that may involve PPARalpha
Title: IDI2, a second isopentenyl diphosphate isomerase in mammals.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

IDI2 is expressed at high levels only in skeletal muscle, where it may be involved in the specialized production of isoprenyl diphosphates for the posttranslational modification of proteins.
Title: Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.

The following IDI2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IDI2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05375	NM_033261.3 Latest version!	Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05375	NM_033261.2	Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IDI2 ( NM_033261.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_150286.1 Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA.

Price & Availability↑

CloneID	OHu05375
Clone ID Related Accession (Same CDS sequence)	NM_033261.2 , NM_033261.3
Accession Version	NM_033261.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	isopentenyl-diphosphate delta-isomerase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK056950.1. On Jun 10, 2002 this sequence version replaced NM_033261.1. ##Evidence-Data-START## Transcript exon combination :: AK056950.1, BC017778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGACA TAAATCTTGA CTGGGTTGAC AGGCGTCAGT TGCAGCGCTT GGAGGAAATG 
CTGATTGTTG TGGATGAGAA TGATAAGGTT ATTGGTGCCG ACACCAAGAG GAATTGCCAT 
CTGAACGAAA ACATTGAGAA AGGGCTGCTG CACCGAGCCT TCAGCGTTGT CTTGTTTAAC 
ACCAAGAATC GAATCCTGAT ACAGCAGAGG TCGGACACGA AAGTCACGTT TCCTGGGTAT 
TTTACCGACT CCTGTAGTAG CCACCCATTA TACAACCCAG CAGAACTGGA AGAAAAGGAT 
GCCATCGGAG TGAGGAGGGC AGCCCAGAGG CGTCTGCAAG CAGAGCTGGG AATTCCTGGG 
GAGCAGATTT CTCCAGAGGA CATTGTGTTC ATGACAATCT ATCACCACAA GGCAAAATCA 
GACAGAATTT GGGGAGAGCA TGAAATTTGT TACCTTCTGC TTGTGAGGAA AAACGTCACT 
CTGAACCCGG ATCCCAGTGA AACGAAAAGC ATCCTCTACC TGTCCCAGGA GGAGCTGTGG 
GAGCTGCTGG AGAGGGAGGC GAGGGGTGAA GTCAAAGTCA CCCCCTGGCT AAGAACCATT 
GCCGAGAGGT TTCTGTACCG GTGGTGGCCT CACCTGGATG ACGTGACCCC GTTTGTGGAG 
CTTCACAAAA TACACAGAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150286.1
CDS	66..749
Translation	MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFNTKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV

Target ORF information:

RefSeq Version	NM_033261.2
Organism	Homo sapiens(human)
Definition	Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033261.2

ORF Insert Sequence:

ATGTCTGACA TAAATCTTGA CTGGGTTGAC AGGCGTCAGT TGCAGCGCTT GGAGGAAATG 
CTGATTGTTG TGGATGAGAA TGATAAGGTT ATTGGTGCCG ACACCAAGAG GAATTGCCAT 
CTGAACGAAA ACATTGAGAA AGGGCTGCTG CACCGAGCCT TCAGCGTTGT CTTGTTTAAC 
ACCAAGAATC GAATCCTGAT ACAGCAGAGG TCGGACACGA AAGTCACGTT TCCTGGGTAT 
TTTACCGACT CCTGTAGTAG CCACCCATTA TACAACCCAG CAGAACTGGA AGAAAAGGAT 
GCCATCGGAG TGAGGAGGGC AGCCCAGAGG CGTCTGCAAG CAGAGCTGGG AATTCCTGGG 
GAGCAGATTT CTCCAGAGGA CATTGTGTTC ATGACAATCT ATCACCACAA GGCAAAATCA 
GACAGAATTT GGGGAGAGCA TGAAATTTGT TACCTTCTGC TTGTGAGGAA AAACGTCACT 
CTGAACCCGG ATCCCAGTGA AACGAAAAGC ATCCTCTACC TGTCCCAGGA GGAGCTGTGG 
GAGCTGCTGG AGAGGGAGGC GAGGGGTGAA GTCAAAGTCA CCCCCTGGCT AAGAACCATT 
GCCGAGAGGT TTCTGTACCG GTGGTGGCCT CACCTGGATG ACGTGACCCC GTTTGTGGAG 
CTTCACAAAA TACACAGAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IDI2 ( NM_033261.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_150286.1 Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA.

Price & Availability↑

CloneID	OHu05375
Clone ID Related Accession (Same CDS sequence)	NM_033261.2 , NM_033261.3
Accession Version	NM_033261.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	isopentenyl-diphosphate delta-isomerase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC022536.13. On Nov 23, 2018 this sequence version replaced NM_033261.2. ##Evidence-Data-START## Transcript exon combination :: AK056950.1, BC017778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000277517.2/ ENSP00000277517.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTGACA TAAATCTTGA CTGGGTTGAC AGGCGTCAGT TGCAGCGCTT GGAGGAAATG 
CTGATTGTTG TGGATGAGAA TGATAAGGTT ATTGGTGCCG ACACCAAGAG GAATTGCCAT 
CTGAACGAAA ACATTGAGAA AGGGCTGCTG CACCGAGCCT TCAGCGTTGT CTTGTTTAAC 
ACCAAGAATC GAATCCTGAT ACAGCAGAGG TCGGACACGA AAGTCACGTT TCCTGGGTAT 
TTTACCGACT CCTGTAGTAG CCACCCATTA TACAACCCAG CAGAACTGGA AGAAAAGGAT 
GCCATCGGAG TGAGGAGGGC AGCCCAGAGG CGTCTGCAAG CAGAGCTGGG AATTCCTGGG 
GAGCAGATTT CTCCAGAGGA CATTGTGTTC ATGACAATCT ATCACCACAA GGCAAAATCA 
GACAGAATTT GGGGAGAGCA TGAAATTTGT TACCTTCTGC TTGTGAGGAA AAACGTCACT 
CTGAACCCGG ATCCCAGTGA AACGAAAAGC ATCCTCTACC TGTCCCAGGA GGAGCTGTGG 
GAGCTGCTGG AGAGGGAGGC GAGGGGTGAA GTCAAAGTCA CCCCCTGGCT AAGAACCATT 
GCCGAGAGGT TTCTGTACCG GTGGTGGCCT CACCTGGATG ACGTGACCCC GTTTGTGGAG 
CTTCACAAAA TACACAGAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150286.1
CDS	66..749
Translation	MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFNTKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV

Target ORF information:

RefSeq Version	NM_033261.3
Organism	Homo sapiens(human)
Definition	Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033261.3

ORF Insert Sequence:

ATGTCTGACA TAAATCTTGA CTGGGTTGAC AGGCGTCAGT TGCAGCGCTT GGAGGAAATG 
CTGATTGTTG TGGATGAGAA TGATAAGGTT ATTGGTGCCG ACACCAAGAG GAATTGCCAT 
CTGAACGAAA ACATTGAGAA AGGGCTGCTG CACCGAGCCT TCAGCGTTGT CTTGTTTAAC 
ACCAAGAATC GAATCCTGAT ACAGCAGAGG TCGGACACGA AAGTCACGTT TCCTGGGTAT 
TTTACCGACT CCTGTAGTAG CCACCCATTA TACAACCCAG CAGAACTGGA AGAAAAGGAT 
GCCATCGGAG TGAGGAGGGC AGCCCAGAGG CGTCTGCAAG CAGAGCTGGG AATTCCTGGG 
GAGCAGATTT CTCCAGAGGA CATTGTGTTC ATGACAATCT ATCACCACAA GGCAAAATCA 
GACAGAATTT GGGGAGAGCA TGAAATTTGT TACCTTCTGC TTGTGAGGAA AAACGTCACT 
CTGAACCCGG ATCCCAGTGA AACGAAAAGC ATCCTCTACC TGTCCCAGGA GGAGCTGTGG 
GAGCTGCTGG AGAGGGAGGC GAGGGGTGAA GTCAAAGTCA CCCCCTGGCT AAGAACCATT 
GCCGAGAGGT TTCTGTACCG GTGGTGGCCT CACCTGGATG ACGTGACCCC GTTTGTGGAG 
CTTCACAAAA TACACAGAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.
Neuropathology : official journal of the Japanese Society of Neuropathology35(5)432-40(2015 Oct)
Nakamura K,Mori F,Tanji K,Miki Y,Yamada M,Kakita A,Takahashi H,Utsumi J,Sasaki H,Wakabayashi K

Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.
Biochemical and biophysical research communications402(2)438-42(2010 Nov)
Kato T,Emi M,Sato H,Arawaka S,Wada M,Kawanami T,Katagiri T,Tsuburaya K,Toyoshima I,Tanaka F,Sobue G,Matsubara K

IDI2, a second isopentenyl diphosphate isomerase in mammals.
The Journal of biological chemistry282(9)6668-76(2007 Mar)
Clizbe DB,Owens ML,Masuda KR,Shackelford JE,Krisans SK

Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.
Journal of molecular evolution57(3)282-91(2003 Sep)
Breitling R,Laubner D,Clizbe D,Adamski J,Krisans SK

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IDI2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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