CD3G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD3G
Entrez Gene ID	917
Full Name	CD3g molecule
Synonyms	CD3-GAMMA,IMD17,T3G
General protein information	Preferred Names CD3g molecule Names T-cell surface glycoprotein CD3 gamma chain CD3g antigen, gamma polypeptide (TiT3 complex) CD3g molecule, epsilon (CD3-TCR complex) CD3g molecule, gamma (CD3-TCR complex) T-cell antigen receptor complex, gamma subunit of T3 T-cell receptor T3 gamma chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008].
Disorder MIM:	186740
Disorder Html:	Immunodeficiency 17, CD3 gamma deficient, 615607 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_006718941.2	XP_006719004.1	T-cell surface glycoprotein CD3 gamma chain isoform X2
NM_000073.2	NP_000064.1	T-cell surface glycoprotein CD3 gamma chain precursor
XM_005271724.4	XP_005271781.1	T-cell surface glycoprotein CD3 gamma chain isoform X1
NM_000073.3	NP_000064.1	T-cell surface glycoprotein CD3 gamma chain precursor
XM_005271724.3	XP_005271781.1	T-cell surface glycoprotein CD3 gamma chain isoform X1
XM_006718941.3	XP_006719004.1	T-cell surface glycoprotein CD3 gamma chain isoform X2

Pathways from BioSystems

Homologies

	CD3G	XP_001093643.2
Bos taurus (cattle)	CD3G	NP_001035562.2
Pan troglodytes (chimpanzee)	CD3G	XP_508790.2
Rattus norvegicus (Norway rat)	Cd3g	NP_001071114.1
Homo sapiens (human)	CD3G	NP_000064.1
Canis lupus familiaris (dog)	CD3G	XP_005619768.1
Mus musculus (house mouse)	Cd3g	NP_033980.1

Gene Ontology
Bibliography

Related articles in PubMed

T cells, mast cells and microvascular density in diffuse large B cell lymphoma.
Marinaccio C, Ingravallo G, Gaudio F, Perrone T, Ruggieri S, Opinto G, Nico B, Maiorano E, Specchia G, Ribatti D
Clinical and experimental medicine16(3)301-6(2016 Aug)

Fine-tuning of T-cell development by the CD3? di-leucine-based TCR-sorting motif.
Lauritsen JP, Boding L, Buus TB, Kongsbak M, Levring TB, Rode AK, Bonefeld CM, Geisler C
International immunology27(8)393-404(2015 Aug)

Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR.
He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, Yin Y, Workman CJ, Vignali KM, Vignali DA, Mariuzza RA, Orban J
The Journal of biological chemistry290(32)19796-805(2015 Aug)

Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.
Zhou Y, Gou LT, Guo ZH, Liu HR, Wang JM, Zhou SX, Yang JL, Li XA
Molecular medicine reports12(1)147-54(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD3 showed a positive correlation with tryptase and microvascular density, while multiple regression analysis efficaciously predicted microvascular density depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in Diffuse large B cell lymphoma patients.
Title: T cells, mast cells and microvascular density in diffuse large B cell lymphoma.

The study identifies an important role of the CD3gamma dileucine motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.
Title: Fine-tuning of T-cell development by the CD3? di-leucine-based TCR-sorting motif.

The docking site for CD3 subunits on the T Cell receptor beta chain has been identified by solution NMR.
Title: Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR.

HER2/CD3 BsAb efficiently inhibited the growth of breast cancer tissue by activating and inducing the proliferation of tumor tissue infiltrating lymphocytes.
Title: Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.

Low cord blood Foxp3/CD3gamma mRNA ratios are highly predictive for early allergy development.
Title: Low cord blood Foxp3/CD3? mRNA ratios: a marker of increased risk for allergy development.

The following CD3G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD3G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18079	NM_000073.3 Latest version!	Homo sapiens CD3g molecule (CD3G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18079	XM_006718941.3 Latest version!	Homo sapiens CD3g molecule (CD3G), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu45923	XM_005271724.4 Latest version!	Homo sapiens CD3g molecule (CD3G), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu18079	NM_000073.2	Homo sapiens CD3g molecule (CD3G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu45923	XM_005271724.3	Homo sapiens CD3g molecule (CD3G), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu18079	XM_006718941.2	Homo sapiens CD3g molecule (CD3G), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD3G ( NM_000073.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000064.1 Homo sapiens CD3g molecule (CD3G), mRNA.

Price & Availability↑

CloneID	OHu18079
Clone ID Related Accession (Same CDS sequence)	XM_006718941.2 , NM_000073.2 , NM_000073.3 , XM_006718941.3
Accession Version	NM_000073.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 gamma chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC378393.1, X04145.1, DB116263.1 and AK310622.1. This sequence is a reference standard in the RefSeqGene project. On Jan 31, 2008 this sequence version replaced NM_000073.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223314.1, X04145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 5' end.

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000064.1
CDS	81..629
Translation	MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN

Target ORF information:

RefSeq Version	NM_000073.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3g molecule (CD3G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000073.2

ORF Insert Sequence:

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3G ( NM_000073.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000064.1 Homo sapiens CD3g molecule (CD3G), mRNA.

Price & Availability↑

CloneID	OHu18079
Clone ID Related Accession (Same CDS sequence)	XM_006718941.2 , NM_000073.2 , NM_000073.3 , XM_006718941.3
Accession Version	NM_000073.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 gamma chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC378393.1, X04145.1, DB116263.1, AK310622.1 and AP001582.4. On Nov 22, 2019 this sequence version replaced NM_000073.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223314.1, X04145.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 5' end.

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000064.1
CDS	81..629
Translation	MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN

Target ORF information:

RefSeq Version	NM_000073.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3g molecule (CD3G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000073.3

ORF Insert Sequence:

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3G ( XM_006718941.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719004.1 Homo sapiens CD3g molecule (CD3G), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu18079
Clone ID Related Accession (Same CDS sequence)	XM_006718941.2 , NM_000073.2 , NM_000073.3 , XM_006718941.3
Accession Version	XM_006718941.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 gamma chain isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006718941.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719004.1
CDS	69..617
Translation	MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN

Target ORF information:

RefSeq Version	XM_006718941.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3g molecule (CD3G), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718941.2

ORF Insert Sequence:

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3G ( XM_006718941.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006719004.1 Homo sapiens CD3g molecule (CD3G), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu18079
Clone ID Related Accession (Same CDS sequence)	XM_006718941.2 , NM_000073.2 , NM_000073.3 , XM_006718941.3
Accession Version	XM_006718941.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 gamma chain isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006718941.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006719004.1
CDS	72..620
Translation	MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN

Target ORF information:

RefSeq Version	XM_006718941.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3g molecule (CD3G), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718941.3

ORF Insert Sequence:

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGC TTCAGACAAG CAGACTCTGT TGCCCAATGA CCAGCTCTAC 
CAGCCCCTCA AGGATCGAGA AGATGACCAG TACAGCCACC TTCAAGGAAA CCAGTTGAGG 
AGGAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3G ( XM_005271724.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005271781.1 Homo sapiens CD3g molecule (CD3G), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu45923
Clone ID Related Accession (Same CDS sequence)	XM_005271724.4 , XM_005271724.3
Accession Version	XM_005271724.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 gamma chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005271724.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGG TAAAAGAATG CTCTTAGATG AGAGATGGGA CCACCTGAGA 
CCCTCAGCTT TCCTCCTACC ATTATGTACC CAATGGAAGA GACTGAGTTG GTGCTTCTTG 
CTAGTGTGCA TAGTTGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005271781.1
CDS	72..632
Translation	MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRGKRMLLDERWDHLRPSAFLLPLCTQWKRLSWCFLLVCIVG

Target ORF information:

RefSeq Version	XM_005271724.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3g molecule (CD3G), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005271724.4

ORF Insert Sequence:

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGG TAAAAGAATG CTCTTAGATG AGAGATGGGA CCACCTGAGA 
CCCTCAGCTT TCCTCCTACC ATTATGTACC CAATGGAAGA GACTGAGTTG GTGCTTCTTG 
CTAGTGTGCA TAGTTGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD3G ( XM_005271724.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005271781.1 Homo sapiens CD3g molecule (CD3G), transcript variant X1, mRNA.

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CloneID	OHu45923
Clone ID Related Accession (Same CDS sequence)	XM_005271724.4 , XM_005271724.3
Accession Version	XM_005271724.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD3 gamma chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005271724.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGG TAAAAGAATG CTCTTAGATG AGAGATGGGA CCACCTGAGA 
CCCTCAGCTT TCCTCCTACC ATTATGTACC CAATGGAAGA GACTGAGTTG GTGCTTCTTG 
CTAGTGTGCA TAGTTGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005271781.1
CDS	118..678
Translation	MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRGKRMLLDERWDHLRPSAFLLPLCTQWKRLSWCFLLVCIVG

Target ORF information:

RefSeq Version	XM_005271724.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD3g molecule (CD3G), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005271724.3

ORF Insert Sequence:

ATGGAACAGG GGAAGGGCCT GGCTGTCCTC ATCCTGGCTA TCATTCTTCT TCAAGGTACT 
TTGGCCCAGT CAATCAAAGG AAACCACTTG GTTAAGGTGT ATGACTATCA AGAAGATGGT 
TCGGTACTTC TGACTTGTGA TGCAGAAGCC AAAAATATCA CATGGTTTAA AGATGGGAAG 
ATGATCGGCT TCCTAACTGA AGATAAAAAA AAATGGAATC TGGGAAGTAA TGCCAAGGAC 
CCTCGAGGGA TGTATCAGTG TAAAGGATCA CAGAACAAGT CAAAACCACT CCAAGTGTAT 
TACAGAATGT GTCAGAACTG CATTGAACTA AATGCAGCCA CCATATCTGG CTTTCTCTTT 
GCTGAAATCG TCAGCATTTT CGTCCTTGCT GTTGGGGTCT ACTTCATTGC TGGACAGGAT 
GGAGTTCGCC AGTCGAGAGG TAAAAGAATG CTCTTAGATG AGAGATGGGA CCACCTGAGA 
CCCTCAGCTT TCCTCCTACC ATTATGTACC CAATGGAAGA GACTGAGTTG GTGCTTCTTG 
CTAGTGTGCA TAGTTGGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

T cells, mast cells and microvascular density in diffuse large B cell lymphoma.
Clinical and experimental medicine16(3)301-6(2016 Aug)
Marinaccio C,Ingravallo G,Gaudio F,Perrone T,Ruggieri S,Opinto G,Nico B,Maiorano E,Specchia G,Ribatti D

Fine-tuning of T-cell development by the CD3? di-leucine-based TCR-sorting motif.
International immunology27(8)393-404(2015 Aug)
Lauritsen JP,Boding L,Buus TB,Kongsbak M,Levring TB,Rode AK,Bonefeld CM,Geisler C

Identification of the Docking Site for CD3 on the T Cell Receptor ? Chain by Solution NMR.
The Journal of biological chemistry290(32)19796-805(2015 Aug)
He Y,Rangarajan S,Kerzic M,Luo M,Chen Y,Wang Q,Yin Y,Workman CJ,Vignali KM,Vignali DA,Mariuzza RA,Orban J

Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.
Molecular medicine reports12(1)147-54(2015 Jul)
Zhou Y,Gou LT,Guo ZH,Liu HR,Wang JM,Zhou SX,Yang JL,Li XA

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CD3G cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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