SMDT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMDT1
Entrez Gene ID	91689
Full Name	single-pass membrane protein with aspartate rich tail 1
Synonyms	C22orf32,DDDD,EMRE
General protein information	Preferred Names single-pass membrane protein with aspartate rich tail 1 Names essential MCU regulator, mitochondrial UPF0466 protein C22orf32, mitochondrial single-pass membrane protein with aspartate-rich tail 1, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2
Summary	This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017].
Disorder MIM:	615588

mRNA and Protein(s)

mRNA	Protein	Name
XM_011530509.1	XP_011528811.1	essential MCU regulator, mitochondrial isoform X1
XM_011547542.1	XP_011545844.1	essential MCU regulator, mitochondrial isoform X1
XM_011547754.1	XP_011546056.1	essential MCU regulator, mitochondrial isoform X1
NM_033318.4	NP_201575.3	essential MCU regulator, mitochondrial precursor
XM_011530509.2	XP_011528811.1	essential MCU regulator, mitochondrial isoform X1
XM_011547037.1	XP_011545339.1	essential MCU regulator, mitochondrial isoform X1
XM_011530509.3	XP_011528811.1	essential MCU regulator, mitochondrial isoform X1
NM_033318.5	NP_201575.3	essential MCU regulator, mitochondrial precursor

Pathways from BioSystems

Homologies

	C10H22orf32	XP_001106801.1
Rattus norvegicus (Norway rat)	Smdt1	XP_235517.6
Pan troglodytes (chimpanzee)	C22H22orf32	XP_003953947.1
Canis lupus familiaris (dog)	SMDT1	XP_852033.1
Bos taurus (cattle)	SMDT1	NP_001039402.1
Xenopus tropicalis (tropical clawed frog)	smdt1	NP_001107674.1
Homo sapiens (human)	SMDT1	NP_201575.3
Mus musculus (house mouse)	Smdt1	NP_081190.1
Gallus gallus (chicken)	C22ORF32	XP_001233649.1

Gene Ontology
Bibliography

Related articles in PubMed

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
K?nig T, Tr?der SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, M?hlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T
Molecular cell64(1)148-162(2016 Oct)

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Tomar D, Dong Z, Shanmughapriya S, Koch DA, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Ja?a F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M
Cell reports15(8)1673-85(2016 05)

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.
Tsai MF, Phillips CB, Ranaghan M, Tsai CW, Wu Y, Willliams C, Miller C
eLife5(2016 04)

EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.
Vais H, Mallilankaraman K, Mak DD, Hoff H, Payne R, Tanis JE, Foskett JK
Cell reports14(3)403-410(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, the authors determine the transmembrane orientation of EMRE, and show that its known MCU-activating function is mediated by the interaction of transmembrane helices from both proteins.
Title: Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.

Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells.
Title: Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).

EMRE (C22orf32) is an integral mitochondrial inner membrane protein and component of the mitochondrial uniporter complex (uniplex). It is essential for uniporter channel activity. In its absence, the pore does not interact with its regulators MICU1/2.
Title: EMRE is an essential component of the mitochondrial calcium uniporter complex.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following SMDT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMDT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01660	NM_033318.5 Latest version!	Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01660	XM_011530509.3 Latest version!	Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01660	XM_011547037.1 Latest version!	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01660	XM_011547542.1 Latest version!	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01660	XM_011547754.1 Latest version!	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01660	XM_011530509.1	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01660	XM_011530509.2	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01660	NM_033318.4	Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMDT1 ( NM_033318.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_201575.3 Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	NM_033318.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	essential MCU regulator, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI754670.1, Z82192.1, AL021878.4 and BC024237.2. On May 21, 2011 this sequence version replaced NM_033318.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC024237.2, SRR1660803.235619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_201575.3
CDS	79..402
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	NM_033318.4
Organism	Homo sapiens(human)
Definition	Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033318.4

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( NM_033318.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_201575.3 Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	NM_033318.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	essential MCU regulator, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI754670.1, Z82192.1, AL021878.4 and BC024237.2. On May 17, 2019 this sequence version replaced NM_033318.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.789904.1, BC024237.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331479.4/ ENSP00000327467.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_201575.3
CDS	70..393
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	NM_033318.5
Organism	Homo sapiens(human)
Definition	Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033318.5

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( XM_011530509.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011528811.1 Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	XM_011530509.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	essential MCU regulator, mitochondrial isoform X1
Comment

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011528811.1
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	XM_011530509.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530509.1

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( XM_011547542.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011545844.1 Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	XM_011547542.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	essential MCU regulator, mitochondrial isoform X1
Comment

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011545844.1
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	XM_011547542.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011547542.1

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( XM_011547754.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011546056.1 Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	XM_011547754.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	essential MCU regulator, mitochondrial isoform X1
Comment

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011546056.1
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	XM_011547754.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011547754.1

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( XM_011530509.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011528811.1 Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	XM_011530509.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	essential MCU regulator, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011530509.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011528811.1
CDS	83..406
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	XM_011530509.2
Organism	Homo sapiens(human)
Definition	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530509.2

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( XM_011547037.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011545339.1 Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	XM_011547037.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	essential MCU regulator, mitochondrial isoform X1
Comment

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011545339.1
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	XM_011547037.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens single-pass membrane protein with aspartate-rich tail 1 (SMDT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011547037.1

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMDT1 ( XM_011530509.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011528811.1 Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01660
Clone ID Related Accession (Same CDS sequence)	XM_011530509.1 , XM_011547542.1 , XM_011547754.1 , NM_033318.4 , XM_011530509.2 , XM_011547037.1 , XM_011530509.3 , NM_033318.5
Accession Version	XM_011530509.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	essential MCU regulator, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000022.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011530509.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011528811.1
CDS	70..393
Translation	MASGAARWLVLAPVRSGALRSGPSLRKDGDVSAAWSGSGRSLVPSRSVIVTRSGAILPKPVKMSFGLLRVFSIVIPFLYVGTLISKNFAALLEEHDIFVPEDDDDDD

Target ORF information:

RefSeq Version	XM_011530509.3
Organism	Homo sapiens(human)
Definition	Homo sapiens single-pass membrane protein with aspartate rich tail 1 (SMDT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530509.3

ORF Insert Sequence:

ATGGCGTCCG GAGCGGCTCG CTGGCTAGTA TTGGCACCCG TCAGGTCCGG GGCTCTCCGG 
AGCGGGCCTA GCTTGAGGAA AGATGGCGAT GTCTCCGCCG CATGGAGCGG CTCAGGCCGG 
AGCCTGGTAC CGTCGAGGTC AGTCATCGTT ACCCGCAGCG GCGCCATTTT GCCCAAACCG 
GTGAAAATGT CCTTCGGCCT TCTCCGTGTG TTCTCCATTG TGATCCCCTT TCTCTATGTC 
GGGACACTCA TTAGCAAGAA CTTTGCTGCT CTACTTGAGG AACATGACAT TTTTGTTCCA 
GAGGATGATG ATGATGATGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
Molecular cell64(1)148-162(2016 Oct)
K?nig T,Tr?der SE,Bakka K,Korwitz A,Richter-Dennerlein R,Lampe PA,Patron M,M?hlmeister M,Guerrero-Castillo S,Brandt U,Decker T,Lauria I,Paggio A,Rizzuto R,Rugarli EI,De Stefani D,Langer T

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Cell reports15(8)1673-85(2016 05)
Tomar D,Dong Z,Shanmughapriya S,Koch DA,Thomas T,Hoffman NE,Timbalia SA,Goldman SJ,Breves SL,Corbally DP,Nemani N,Fairweather JP,Cutri AR,Zhang X,Song J,Ja?a F,Huang J,Barrero C,Rabinowitz JE,Luongo TS,Schumacher SM,Rockman ME,Dietrich A,Merali S,Caplan J,Stathopulos P,Ahima RS,Cheung JY,Houser SR,Koch WJ,Patel V,Gohil VM,Elrod JW,Rajan S,Madesh M

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.
eLife5(2016 04)
Tsai MF,Phillips CB,Ranaghan M,Tsai CW,Wu Y,Willliams C,Miller C

EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.
Cell reports14(3)403-410(2016 Jan)
Vais H,Mallilankaraman K,Mak DD,Hoff H,Payne R,Tanis JE,Foskett JK

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

SMDT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報