DYRK1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DYRK1B
Entrez Gene ID	9149
Full Name	dual specificity tyrosine phosphorylation regulated kinase 1B
Synonyms	AOMS3,MIRK
General protein information	Preferred Names dual specificity tyrosine phosphorylation regulated kinase 1B Names dual specificity tyrosine-phosphorylation-regulated kinase 1B dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B minibrain-related kinase mirk protein kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Disorder MIM:	604556
Disorder Html:	Abdominal obesity-metabolic syndrome 3, 615812 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005259398.3	XP_005259455.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4
NM_006483.3	NP_006474.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65
NM_006484.2	NP_006475.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66
NM_004714.3	NP_004705.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
NM_006483.2	NP_006474.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65
NM_004714.2	NP_004705.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
XM_011548816.1	XP_011547118.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4
XM_005259398.4	XP_005259455.1	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dyrk1b	NP_001258299.1
Danio rerio (zebrafish)	dyrk1b	NP_001161737.1
	DYRK1B	XP_001089972.1
Bos taurus (cattle)	DYRK1B	NP_001074984.1
Rattus norvegicus (Norway rat)	Dyrk1b	NP_001100966.1
Xenopus tropicalis (tropical clawed frog)	dyrk1a.2	NP_001120373.1
Homo sapiens (human)	DYRK1B	NP_004705.1
Pan troglodytes (chimpanzee)	DYRK1B	XP_512657.2
Canis lupus familiaris (dog)	DYRK1B	XP_005616637.1

Gene Ontology
Bibliography

Related articles in PubMed

Dyrk1B overexpression is associated with breast cancer growth and a poor prognosis.
Chen Y, Wang S, He Z, Sun F, Huang Y, Ni Q, Wang H, Wang Y, Cheng C
Human pathology6648-58(2017 08)

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.
Abu Jhaisha S, Widowati EW, Kii I, Sonamoto R, Knapp S, Papadopoulos C, Becker W
Scientific reports7(1)6420(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dyrk1B was overexpressed in breast cancer tissues and cells and correlates with FoxO1 phosphorylation and cell proliferation.
Title: Dyrk1B overexpression is associated with breast cancer growth and a poor prognosis.

The study shows that DYRK1B is a novel ERK2 substrate, uncovering new links between two kinases involved in cell fate decisions.
Title: Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

High DYRK1B expression is associated with pancreatic and skin cancers.
Title: DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.

NKX3.1 and DYRK1B were shown to interact via the DYRK1B kinase domain. In vitro kinase assay showed that DYRK1B phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover.
Title: The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase.

Data reveal a novel role for miR-9 in regulation of the NFAT pathway by targeting KPNB1 and DYRK1B.
Title: miR-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B.

The following DYRK1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DYRK1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27885	NM_004714.3 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27885	XM_011548816.1 Latest version!	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27885	XM_005259398.4 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27842	NM_006483.3 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu27850	NM_006484.2 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu27842	NM_006483.2	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu27885	NM_004714.2	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27885	XM_005259398.3	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DYRK1B ( NM_004714.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004705.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27885
Clone ID Related Accession (Same CDS sequence)	XM_005259398.3 , NM_004714.3 , NM_004714.2 , XM_011548816.1 , XM_005259398.4
Accession Version	NM_004714.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y17999.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004714.2. Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018751.1, Y17999.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323039.10/ ENSP00000312789.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004705.1
CDS	242..2131
Translation	MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	NM_004714.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004714.3

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( NM_004714.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004705.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27885
Clone ID Related Accession (Same CDS sequence)	XM_005259398.3 , NM_004714.3 , NM_004714.2 , XM_011548816.1 , XM_005259398.4
Accession Version	NM_004714.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY024135.1, Y17999.1 and BQ446787.1. This sequence is a reference standard in the RefSeqGene project. On Jun 5, 2014 this sequence version replaced NM_004714.1. Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018751.1, Y17999.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004705.1
CDS	313..2202
Translation	MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	NM_004714.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004714.2

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( XM_005259398.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259455.1 Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X4, mRNA.

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CloneID	OHu27885
Clone ID Related Accession (Same CDS sequence)	XM_005259398.3 , NM_004714.3 , NM_004714.2 , XM_011548816.1 , XM_005259398.4
Accession Version	XM_005259398.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4
Comment

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005259455.1

Translation

MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	XM_005259398.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259398.3

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( XM_011548816.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011547118.1 Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X4, mRNA.

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CloneID	OHu27885
Clone ID Related Accession (Same CDS sequence)	XM_005259398.3 , NM_004714.3 , NM_004714.2 , XM_011548816.1 , XM_005259398.4
Accession Version	XM_011548816.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4
Comment

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011547118.1

Translation

MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	XM_011548816.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011548816.1

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( XM_005259398.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005259455.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant X1, mRNA.

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CloneID	OHu27885
Clone ID Related Accession (Same CDS sequence)	XM_005259398.3 , NM_004714.3 , NM_004714.2 , XM_011548816.1 , XM_005259398.4
Accession Version	XM_005259398.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005259398.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005259455.1
CDS	765..2654
Translation	MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	XM_005259398.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005259398.4

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( NM_006483.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006474.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 2, mRNA.

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CloneID	OHu27842
Clone ID Related Accession (Same CDS sequence)	NM_006483.3 , NM_006483.2
Accession Version	NM_006483.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y17999.1 and BI964831.1. On May 31, 2019 this sequence version replaced NM_006483.2. Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.654598.1, SRR3476690.20553.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006474.1
CDS	242..2011
Translation	MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	NM_006483.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006483.3

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( NM_006483.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006474.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 2, mRNA.

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CloneID	OHu27842
Clone ID Related Accession (Same CDS sequence)	NM_006483.3 , NM_006483.2
Accession Version	NM_006483.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY024135.1, Y17999.1, BI964831.1 and BQ446787.1. On Jun 5, 2014 this sequence version replaced NM_006483.1. Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.20553.1, SRR1660805.30690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006474.1
CDS	313..2082
Translation	MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	NM_006483.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006483.2

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 
AGCCCCCTGG GGGCTCTGCA GCACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCGC CCCTCGACAC CTGCCCCTCT 
TCCAGCACCG CCAGCTCCAT CTCCAGTTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 
CGGACCTACC GCTACAGCAA CCGATATTGT GGGGGCCCTG GGCCCCCTAT CACAGACTGT 
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GGCCCTGGGC AGGGGGTGAT 
GTGCCCCACA AGACACATCA AGCCCCTGCC TCTGCCTCGT CACTGCCTGG GACCGGGGCC 
CAGTTACCCC CCCAGCCCCG ATACCTTGGT CGTCCCCCAT CACCAACCTC ACCACCACCC 
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTGCTG ACTGCTCCCC ACCTCACCCA 
GCGCCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC TGGAGGTCGT 
CCACCCCTCC CGCCTCCTGA TGACCCTGCC ACTCTGGGGC CTCACCTGGG CCTCCGTGGT 
GTACCCCAGA GCACAGCAGC CAGCTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK1B ( NM_006484.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006475.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu27850
Clone ID Related Accession (Same CDS sequence)	NM_006484.2
Accession Version	NM_006484.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY024135.1, Y17999.1, BI964831.1 and BQ446787.1. On Jun 5, 2014 this sequence version replaced NM_006484.1. Transcript Variant: This variant (3, also known as 'c') lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (p66, also known as isoform c) is shorter than isoform p69. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGACCTGGTG 
CTGCGCATGC TGGAGTATGA GCCCGCCGCC CGCATCAGCC CCCTGGGGGC TCTGCAGCAC 
GGCTTCTTCC GCCGCACGGC CGACGAGGCC ACCAACACGG GCCCGGCAGG CAGCAGTGCC 
TCCACCTCGC CCGCGCCCCT CGACACCTGC CCCTCTTCCA GCACCGCCAG CTCCATCTCC 
AGTTCTGGAG GCTCCAGTGG CTCCTCCAGT GACAACCGGA CCTACCGCTA CAGCAACCGA 
TATTGTGGGG GCCCTGGGCC CCCTATCACA GACTGTGAGA TGAACAGCCC CCAGGTCCCA 
CCCTCCCAGC CGCTGCGGCC CTGGGCAGGG GGTGATGTGC CCCACAAGAC ACATCAAGCC 
CCTGCCTCTG CCTCGTCACT GCCTGGGACC GGGGCCCAGT TACCCCCCCA GCCCCGATAC 
CTTGGTCGTC CCCCATCACC AACCTCACCA CCACCCCCGG AGCTGATGGA TGTGAGCCTG 
GTGGGCGGCC CTGCTGACTG CTCCCCACCT CACCCAGCGC CTGCCCCCCA GCACCCGGCT 
GCCTCAGCCC TCCGGACTCG GATGACTGGA GGTCGTCCAC CCCTCCCGCC TCCTGATGAC 
CCTGCCACTC TGGGGCCTCA CCTGGGCCTC CGTGGTGTAC CCCAGAGCAC AGCAGCCAGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006475.1
CDS	313..2118
Translation	MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS

Target ORF information:

RefSeq Version	NM_006484.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006484.2

ORF Insert Sequence:

ATGGCCGTCC CACCGGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA GGAGCACACG 
CAGGTATTGC CTGATGTGCG GCTACTGCCT CGGAGGCTGC CCCTGGCCTT CCGGGATGCA 
ACCTCAGCCC CGCTGCGTAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAGCAGG CGCCACCCCA GGATTCGAGC 
AACAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTACATC 
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TACGAAATTG ACTCGCTCAT TGGCAAAGGC 
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CATCAGACCC AGGAGCTTGT GGCCATCAAG 
ATCATCAAGA ACAAAAAGGC TTTCCTGAAC CAGGCCCAGA TTGAGCTGCG GCTGCTGGAG 
CTGATGAACC AGCATGACAC GGAGATGAAG TACTATATAG TACACCTGAA GCGGCACTTC 
ATGTTCCGGA ACCACCTGTG CCTGGTATTT GAGCTGCTGT CCTACAACCT GTACGACCTC 
CTGCGCAACA CCCACTTCCG CGGCGTCTCG CTGAACCTGA CCCGGAAGCT GGCGCAGCAG 
CTCTGCACGG CACTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATTCA CTGCGACCTC 
AAGCCCGAAA ACATCTTGCT GTGCAACCCC AAGCGCAGCG CCATCAAGAT TGTGGACTTC 
GGCAGCTCCT GCCAGCTTGG CCAGAGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 
TCACCTGAGG TGCTCCTGGG CACACCCTAC GACCTGGCCA TTGACATGTG GTCCCTGGGC 
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCCAA TGAGGTCGAC 
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCGCCATGCT GGACCAGGCG 
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACG 
AAAGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGACCTGGTG 
CTGCGCATGC TGGAGTATGA GCCCGCCGCC CGCATCAGCC CCCTGGGGGC TCTGCAGCAC 
GGCTTCTTCC GCCGCACGGC CGACGAGGCC ACCAACACGG GCCCGGCAGG CAGCAGTGCC 
TCCACCTCGC CCGCGCCCCT CGACACCTGC CCCTCTTCCA GCACCGCCAG CTCCATCTCC 
AGTTCTGGAG GCTCCAGTGG CTCCTCCAGT GACAACCGGA CCTACCGCTA CAGCAACCGA 
TATTGTGGGG GCCCTGGGCC CCCTATCACA GACTGTGAGA TGAACAGCCC CCAGGTCCCA 
CCCTCCCAGC CGCTGCGGCC CTGGGCAGGG GGTGATGTGC CCCACAAGAC ACATCAAGCC 
CCTGCCTCTG CCTCGTCACT GCCTGGGACC GGGGCCCAGT TACCCCCCCA GCCCCGATAC 
CTTGGTCGTC CCCCATCACC AACCTCACCA CCACCCCCGG AGCTGATGGA TGTGAGCCTG 
GTGGGCGGCC CTGCTGACTG CTCCCCACCT CACCCAGCGC CTGCCCCCCA GCACCCGGCT 
GCCTCAGCCC TCCGGACTCG GATGACTGGA GGTCGTCCAC CCCTCCCGCC TCCTGATGAC 
CCTGCCACTC TGGGGCCTCA CCTGGGCCTC CGTGGTGTAC CCCAGAGCAC AGCAGCCAGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dyrk1B overexpression is associated with breast cancer growth and a poor prognosis.
Human pathology6648-58(2017 08)
Chen Y,Wang S,He Z,Sun F,Huang Y,Ni Q,Wang H,Wang Y,Cheng C

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.
Scientific reports7(1)6420(2017 Jul)
Abu Jhaisha S,Widowati EW,Kii I,Sonamoto R,Knapp S,Papadopoulos C,Becker W

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DYRK1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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