ISX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ISX
Entrez Gene ID	91464
Full Name	intestine specific homeobox
Synonyms	Pix-1,RAXLX
General protein information	Preferred Names intestine specific homeobox Names intestine-specific homeobox RAX-like homeobox pancreas-intestine homeodomain transcription factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.3
Summary	Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008].
Disorder MIM:	612019

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303508.1	NP_001290437.1	intestine-specific homeobox
NM_001303508.2	NP_001290437.1	intestine-specific homeobox

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ISX	XP_001154843.1
Canis lupus familiaris (dog)	ISX	XP_853196.2
Homo sapiens (human)	ISX	NP_001008494.1
Mus musculus (house mouse)	Isx	NP_082113.2
Rattus norvegicus (Norway rat)	Isx	XP_006255209.1
Gallus gallus (chicken)	ISX	XP_004937856.1
	ISX	XP_001113063.1
Bos taurus (cattle)	ISX	XP_003586145.1

Gene Ontology
Bibliography

Related articles in PubMed

Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression.
Hsu SH, Wang LT, Chai CY, Wu CC, Hsi E, Chiou SS, Wang SN
Molecular carcinogenesis56(10)2167-2177(2017 Oct)

Intestine-Specific Homeobox Gene
Wang LT, Chiou SS, Chai CY, Hsi E, Yokoyama KK, Wang SN, Huang SK, Hsu SH
Cancer research77(15)4065-4077(2017 Aug)

Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.
Sue S, Shibata W, Kameta E, Sato T, Ishii Y, Kaneko H, Miwa H, Sasaki T, Tamura T, Kondo M, Maeda S
Journal of gastroenterology51(10)949-60(2016 Oct)

Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC.
Wang SN, Wang LT, Sun DP, Chai CY, Hsi E, Kuo HT, Yokoyama KK, Hsu SH
Oncotarget7(24)36924-36939(2016 Jun)

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.
Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J
The Journal of biological chemistry288(13)9017-27(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that ISX expression mediated AHR-induced tumorigenesis in hepatocellular carcinoma.
Title: Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression.

Overall, our results identified a feed-forward mechanism of immune suppression in hepatocellular carcinoma organized by ISX, which involves kynurenine-AHR signaling and PD-L1, offering insights into immune escape by hepatocellular carcinoma
Title: Intestine-Specific Homeobox Gene

ISX expression induced by H. pylori infection may lead to intestinal metaplasia and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis.
Title: Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.

our results indicate that E2F1 is an important downstream gene of ISX in hepatoma progression.
Title: Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC.

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX
Title: Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.

The following ISX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ISX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30776	NM_001303508.2 Latest version!	Homo sapiens intestine specific homeobox (ISX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu30776	NM_001303508.1	Homo sapiens intestine specific homeobox (ISX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ISX ( NM_001303508.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290437.1 Homo sapiens intestine specific homeobox (ISX), mRNA.

Price & Availability↑

CloneID	OHu30776
Clone ID Related Accession (Same CDS sequence)	NM_001303508.1 , NM_001303508.2
Accession Version	NM_001303508.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	intestine-specific homeobox
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR749372.1, Z83853.2, AL024494.1 and AK025181.1. ##Evidence-Data-START## Transcript exon combination :: CR749372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGCTG AGGTGGGCCC TGCTCTCTGC AGGGGTATGG AGAGAAATAG CTTGGGGTGC 
TGTGAGGCCC CGAAGAAGCT GAGCCTGTCC TTCTCCATTG AGGCGATCCT AAAGAGGCCT 
GCCAGGAGGA GTGATATGGA CAGACCAGAA GGGCCAGGTG AAGAGGGCCC CGGAGAAGCT 
GCGGCCTCAG GCTCTGGGCT AGAAAAGCCT CCAAAGGACC AGCCCCAGGA AGGAAGGAAG 
AGCAAGCGGA GGGTTCGTAC CACCTTCACC ACTGAGCAGC TGCATGAGCT GGAGAAGATC 
TTCCACTTTA CCCACTACCC AGACGTTCAC ATCCGCAGCC AGCTGGCAGC CAGGATCAAC 
CTCCCAGAAG CTCGGGTGCA GATCTGGTTC CAGAATCAGC GAGCCAAGTG GCGGAAGCAG 
GAGAAGATTG GCAACCTGGG GGCTCCACAG CAGCTGAGTG AAGCCAGTGT GGCCCTGCCC 
ACAAATCTGG ATGTGGCTGG GCCCACGTGG ACATCCACTG CTCTGCGCAG GCTGGCTCCT 
CCCACGAGCT GTTGTCCATC GGCTCAAGAT CAGCTGGCCT CTGCCTGGTT CCCTGCCTGG 
ATCACCCTCC TCCCAGCGCA CCCATGGGAA ACACAGCCTG TCCCAGGTCT TCCCATCCAT 
CAAACTTGCA TCCCTGTGCT ATGCATCCTT CCACCTCCAC ACCCCAAATG GGGCAGCATC 
TGTGCTACTT CAACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290437.1
CDS	664..1401
Translation	MCAEVGPALCRGMERNSLGCCEAPKKLSLSFSIEAILKRPARRSDMDRPEGPGEEGPGEAAASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAGPTWTSTALRRLAPPTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVPGLPIHQTCIPVLCILPPPHPKWGSICATST

Target ORF information:

RefSeq Version	NM_001303508.1
Organism	Homo sapiens(human)
Definition	Homo sapiens intestine specific homeobox (ISX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303508.1

ORF Insert Sequence:

ATGTGTGCTG AGGTGGGCCC TGCTCTCTGC AGGGGTATGG AGAGAAATAG CTTGGGGTGC 
TGTGAGGCCC CGAAGAAGCT GAGCCTGTCC TTCTCCATTG AGGCGATCCT AAAGAGGCCT 
GCCAGGAGGA GTGATATGGA CAGACCAGAA GGGCCAGGTG AAGAGGGCCC CGGAGAAGCT 
GCGGCCTCAG GCTCTGGGCT AGAAAAGCCT CCAAAGGACC AGCCCCAGGA AGGAAGGAAG 
AGCAAGCGGA GGGTTCGTAC CACCTTCACC ACTGAGCAGC TGCATGAGCT GGAGAAGATC 
TTCCACTTTA CCCACTACCC AGACGTTCAC ATCCGCAGCC AGCTGGCAGC CAGGATCAAC 
CTCCCAGAAG CTCGGGTGCA GATCTGGTTC CAGAATCAGC GAGCCAAGTG GCGGAAGCAG 
GAGAAGATTG GCAACCTGGG GGCTCCACAG CAGCTGAGTG AAGCCAGTGT GGCCCTGCCC 
ACAAATCTGG ATGTGGCTGG GCCCACGTGG ACATCCACTG CTCTGCGCAG GCTGGCTCCT 
CCCACGAGCT GTTGTCCATC GGCTCAAGAT CAGCTGGCCT CTGCCTGGTT CCCTGCCTGG 
ATCACCCTCC TCCCAGCGCA CCCATGGGAA ACACAGCCTG TCCCAGGTCT TCCCATCCAT 
CAAACTTGCA TCCCTGTGCT ATGCATCCTT CCACCTCCAC ACCCCAAATG GGGCAGCATC 
TGTGCTACTT CAACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ISX ( NM_001303508.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290437.1 Homo sapiens intestine specific homeobox (ISX), mRNA.

Price & Availability↑

CloneID	OHu30776
Clone ID Related Accession (Same CDS sequence)	NM_001303508.1 , NM_001303508.2
Accession Version	NM_001303508.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	intestine-specific homeobox
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR749372.1, Z83853.2, AL024494.1 and AK025181.1. On May 17, 2019 this sequence version replaced NM_001303508.1. ##Evidence-Data-START## Transcript exon combination :: CR749372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000404699.7/ ENSP00000386037.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGTGCTG AGGTGGGCCC TGCTCTCTGC AGGGGTATGG AGAGAAATAG CTTGGGGTGC 
TGTGAGGCCC CGAAGAAGCT GAGCCTGTCC TTCTCCATTG AGGCGATCCT AAAGAGGCCT 
GCCAGGAGGA GTGATATGGA CAGACCAGAA GGGCCAGGTG AAGAGGGCCC CGGAGAAGCT 
GCGGCCTCAG GCTCTGGGCT AGAAAAGCCT CCAAAGGACC AGCCCCAGGA AGGAAGGAAG 
AGCAAGCGGA GGGTTCGTAC CACCTTCACC ACTGAGCAGC TGCATGAGCT GGAGAAGATC 
TTCCACTTTA CCCACTACCC AGACGTTCAC ATCCGCAGCC AGCTGGCAGC CAGGATCAAC 
CTCCCAGAAG CTCGGGTGCA GATCTGGTTC CAGAATCAGC GAGCCAAGTG GCGGAAGCAG 
GAGAAGATTG GCAACCTGGG GGCTCCACAG CAGCTGAGTG AAGCCAGTGT GGCCCTGCCC 
ACAAATCTGG ATGTGGCTGG GCCCACGTGG ACATCCACTG CTCTGCGCAG GCTGGCTCCT 
CCCACGAGCT GTTGTCCATC GGCTCAAGAT CAGCTGGCCT CTGCCTGGTT CCCTGCCTGG 
ATCACCCTCC TCCCAGCGCA CCCATGGGAA ACACAGCCTG TCCCAGGTCT TCCCATCCAT 
CAAACTTGCA TCCCTGTGCT ATGCATCCTT CCACCTCCAC ACCCCAAATG GGGCAGCATC 
TGTGCTACTT CAACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290437.1
CDS	642..1379
Translation	MCAEVGPALCRGMERNSLGCCEAPKKLSLSFSIEAILKRPARRSDMDRPEGPGEEGPGEAAASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAGPTWTSTALRRLAPPTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVPGLPIHQTCIPVLCILPPPHPKWGSICATST

Target ORF information:

RefSeq Version	NM_001303508.2
Organism	Homo sapiens(human)
Definition	Homo sapiens intestine specific homeobox (ISX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303508.2

ORF Insert Sequence:

ATGTGTGCTG AGGTGGGCCC TGCTCTCTGC AGGGGTATGG AGAGAAATAG CTTGGGGTGC 
TGTGAGGCCC CGAAGAAGCT GAGCCTGTCC TTCTCCATTG AGGCGATCCT AAAGAGGCCT 
GCCAGGAGGA GTGATATGGA CAGACCAGAA GGGCCAGGTG AAGAGGGCCC CGGAGAAGCT 
GCGGCCTCAG GCTCTGGGCT AGAAAAGCCT CCAAAGGACC AGCCCCAGGA AGGAAGGAAG 
AGCAAGCGGA GGGTTCGTAC CACCTTCACC ACTGAGCAGC TGCATGAGCT GGAGAAGATC 
TTCCACTTTA CCCACTACCC AGACGTTCAC ATCCGCAGCC AGCTGGCAGC CAGGATCAAC 
CTCCCAGAAG CTCGGGTGCA GATCTGGTTC CAGAATCAGC GAGCCAAGTG GCGGAAGCAG 
GAGAAGATTG GCAACCTGGG GGCTCCACAG CAGCTGAGTG AAGCCAGTGT GGCCCTGCCC 
ACAAATCTGG ATGTGGCTGG GCCCACGTGG ACATCCACTG CTCTGCGCAG GCTGGCTCCT 
CCCACGAGCT GTTGTCCATC GGCTCAAGAT CAGCTGGCCT CTGCCTGGTT CCCTGCCTGG 
ATCACCCTCC TCCCAGCGCA CCCATGGGAA ACACAGCCTG TCCCAGGTCT TCCCATCCAT 
CAAACTTGCA TCCCTGTGCT ATGCATCCTT CCACCTCCAC ACCCCAAATG GGGCAGCATC 
TGTGCTACTT CAACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression.
Molecular carcinogenesis56(10)2167-2177(2017 Oct)
Hsu SH,Wang LT,Chai CY,Wu CC,Hsi E,Chiou SS,Wang SN

Intestine-Specific Homeobox Gene
Cancer research77(15)4065-4077(2017 Aug)
Wang LT,Chiou SS,Chai CY,Hsi E,Yokoyama KK,Wang SN,Huang SK,Hsu SH

Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.
Journal of gastroenterology51(10)949-60(2016 Oct)
Sue S,Shibata W,Kameta E,Sato T,Ishii Y,Kaneko H,Miwa H,Sasaki T,Tamura T,Kondo M,Maeda S

Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC.
Oncotarget7(24)36924-36939(2016 Jun)
Wang SN,Wang LT,Sun DP,Chai CY,Hsi E,Kuo HT,Yokoyama KK,Hsu SH

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.
The Journal of biological chemistry288(13)9017-27(2013 Mar)
Lobo GP,Amengual J,Baus D,Shivdasani RA,Taylor D,von Lintig J

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ISX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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