Gene Symbol | SMC3 |
Entrez Gene ID | 9126 |
Full Name | structural maintenance of chromosomes 3 |
Synonyms | BAM,BMH,CDLS3,CSPG6,HCAP,SMC3L1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Cornelia de Lange syndrome 3, 610759 (3) |