KRT75 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KRT75
Entrez Gene ID	9119
Full Name	keratin 75
Synonyms	K6HF,KB18,PFB
General protein information	Preferred Names keratin 75 Names keratin, type II cytoskeletal 75 CK-75 K75 cytokeratin type II cytokeratin-75 hK6hf keratin 75, type II keratin-6 hair follicle type II keratin-18 type II keratin-K6hf type-II keratin Kb18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008].
Disorder MIM:	609025
Disorder Html:	{Pseudofolliculitis barbae, susceptibility to}, 612318 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004693.2	NP_004684.2	keratin, type II cytoskeletal 75
NM_004693.3	NP_004684.2	keratin, type II cytoskeletal 75

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Krt75	NP_579935.1
	LOC699682	XP_001098580.2
Rattus norvegicus (Norway rat)	Krt75	NP_001008828.1
Gallus gallus (chicken)	KRT6A	NP_001001313.1
Homo sapiens (human)	KRT75	NP_004684.2
Bos taurus (cattle)	KRT75	NP_001070385.1
Gallus gallus (chicken)	KRT75	NP_001001314.1
Pan troglodytes (chimpanzee)	KRT75	XP_522391.3
Canis lupus familiaris (dog)	KRT75	XP_003433551.2

Gene Ontology
Bibliography

Related articles in PubMed

Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes.
Handra-Luca A, Dragoescu E
Annals of diagnostic pathology2358-61(2016 Aug)

Keratins as components of the enamel organic matrix.
Duverger O, Beniash E, Morasso MI
Matrix biology : journal of the International Society for Matrix Biology52-54260-265(2016 May-Jul)

Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant basal-HER2 subtype of breast cancer.
Martin-Castillo B, Lopez-Bonet E, Bux? M, Dorca J, Tuca-Rodr?guez F, Ruano MA, Colomer R, Menendez JA
Oncotarget6(9)7104-22(2015 Mar)

Hair keratin mutations in tooth enamel increase dental decay risk.
Duverger O, Ohara T, Shaffer JR, Donahue D, Zerfas P, Dullnig A, Crecelius C, Beniash E, Marazita ML, Morasso MI
The Journal of clinical investigation124(12)5219-24(2014 Dec)

Analysis of clinical characteristics and differential diagnosis of the lung biopsy specimens in 99 adenocarcinoma cases and 111 squamous cell carcinoma cases: utility of an immunohistochemical panel containing CK5/6, CK34?E12, p63, CK7 and TTF-1.
Xu XY, Yang GY, Yang JH, Li J
Pathology, research and practice210(10)680-5(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of CK5/6 and of P63 suggests a squamous differentiation including in the basaloid thyroid lymphoepithelial complexes
Title: Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes.

Studies show that mutation in epithelial hair keratin KRT75 leads to a skin condition called pseudofollicularis barbae. Carriers of this mutation have an altered enamel structure and mechanical properties leading to much higher prevalence of caries. [review]
Title: Keratins as components of the enamel organic matrix.

CK5/6 have roles in biologically aggressive tumors likely to display resistance to trastuzumab ab initio in women diagnosed with HER2+ cancer
Title: Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant basal-HER2 subtype of breast cancer.

Analysis of teeth from individuals carrying the KRT75(A161T) variant revealed an altered enamel structure and a marked reduction of enamel hardness, suggesting that a functional keratin network is required for the mechanical stability of tooth enamel.
Title: Hair keratin mutations in tooth enamel increase dental decay risk.

There were differences between CK5/6, p63,CK34betaE12 and TTF-1 expression with tumor differentiation in squamous cell carcinoma or adenocarcinomas
Title: Analysis of clinical characteristics and differential diagnosis of the lung biopsy specimens in 99 adenocarcinoma cases and 111 squamous cell carcinoma cases: utility of an immunohistochemical panel containing CK5/6, CK34?E12, p63, CK7 and TTF-1.

The following KRT75 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT75 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19371	NM_004693.3 Latest version!	Homo sapiens keratin 75 (KRT75), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
View Old Accession Versions >>
OHu19371	NM_004693.2	Homo sapiens keratin 75 (KRT75), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$229.50-$321.30 $459.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KRT75 ( NM_004693.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004684.2 Homo sapiens keratin 75 (KRT75), mRNA.

Price & Availability↑

CloneID	OHu19371
Clone ID Related Accession (Same CDS sequence)	NM_004693.2 , NM_004693.3
Accession Version	NM_004693.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 75
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK225962.1 and Y17282.1. This sequence is a reference standard in the RefSeqGene project. On Jul 25, 2007 this sequence version replaced NM_004693.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y17282.1, AK298960.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2144335, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END##

ATGTCTCGGC AGTCCTCCAT CACCTTCCAG TCTGGCAGCC GCAGGGGCTT CAGCACCACC 
TCGGCCATCA CCCCGGCAGC TGGCCGCTCC CGCTTCAGCT CTGTCTCTGT GGCCCGCTCT 
GCAGCAGGGA GTGGGGGCCT GGGAAGGATC AGCAGTGCTG GGGCCAGCTT TGGAAGCCGC 
AGCCTCTACA ACCTGGGGGG TGCCAAGCGG GTCTCCATCA ATGGGTGTGG CAGCAGCTGC 
CGAAGTGGCT TTGGTGGCAG GGCCAGCAAC AGGTTTGGAG TCAACAGTGG ATTTGGCTAT 
GGGGGTGGAG TTGGAGGAGG CTTCAGTGGC CCCAGCTTCC CCGTGTGTCC CCCTGGAGGC 
ATCCAAGAGG TCACTGTCAA CCAGAGTCTC CTGACTCCTC TTCACCTGCA AATCGACCCC 
ACCATCCAGC GGGTGCGGGC CGAGGAGCGC GAGCAGATCA AGACCCTCAA CAATAAGTTC 
GCCTCCTTCA TCGACAAGGT GAGGTTCTTG GAGCAGCAGA ACAAGGTCCT GGAGACCAAG 
TGGGCCCTCC TGCAGGAGCA GGGCTCCAGG ACTGTGAGGC AGAACCTAGA GCCCCTCTTT 
GATTCCTATA CCAGTGAGCT CCGACGGCAG CTGGAAAGCA TCACCACCGA GAGGGGCAGG 
CTTGAAGCTG AACTGAGGAA CATGCAGGAT GTTGTGGAAG ATTTCAAAGT CAGGTACGAA 
GATGAAATTA ACAAGCGCAC AGCTGCTGAG AATGAATTTG TAGCCCTGAA AAAGGACGTA 
GATGCTGCCT ATATGAACAA GGTGGAGCTG GAAGCCAAGG TCAAATCTCT GCCCGAGGAG 
ATCAACTTCA TCCACTCAGT CTTTGATGCA GAGCTGTCCC AGTTGCAGAC CCAGGTCGGT 
GACACATCCG TGGTGCTGTC CATGGACAAC AACCGCAACC TGGACCTGGA TAGTATCATC 
GCCGAGGTCA AAGCACAATA CGAGGACATT GCCAACCGCA GCCGGGCCGA GGCTGAGTCC 
TGGTACCAGA CCAAGTACGA GGAGCTGCAG GTCACCGCAG GCAGACATGG GGATGACCTT 
CGAAACACCA AACAAGAGAT CTCTGAAATG AACCGCATGA TCCAGAGGCT GAGAGCTGAG 
ATTGACAGCG TCAAGAAGCA GTGTTCCAGC TTGCAAACGG CCATTGCTGA TGCAGAGCAG 
CGGGGAGAAC TGGCTCTCAA GGATGCACGG GCCAAGCTGG TGGACCTTGA GGAGGCCCTG 
CAGAAGGCCA AGCAGGACAT GGCTCGGCTC CTGCGTGAGT ACCAGGAGCT GATGAACATC 
AAGCTGGCCC TGGACGTGGA GATCGCCACC TACCGCAAGC TGCTGGAAGG CGAGGAGTGC 
AGGTTGAGTG GAGAGGGAGT TTCTCCAGTT AACATTTCTG TGGTCACCTC TACTCTTTCC 
AGTGGCTATG GAAGCGGCAG CAGCATTGGA GGTGGAAACC TGGGCCTCGG TGGGGGCAGC 
GGCTACTCCT TCACCACCAG TGGTGGGCAT AGCCTGGGTG CAGGCCTGGG AGGTTCTGGA 
TTCAGTGCCA CCAGCAACCG GGGCTTAGGG GGCAGTGGTT CTAGCGTCAA GTTTGTCTCC 
ACCACATCCT CCAGCCAGAA GAGCTACACG CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004684.2
CDS	23..1678
Translation	MSRQSSITFQSGSRRGFSTTSAITPAAGRSRFSSVSVARSAAGSGGLGRISSAGASFGSRSLYNLGGAKRVSINGCGSSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLGGGSGYSFTTSGGHSLGAGLGGSGFSATSNRGLGGSGSSVKFVSTTSSSQKSYTH

Target ORF information:

RefSeq Version	NM_004693.2
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 75 (KRT75), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004693.2

ORF Insert Sequence:

ATGTCTCGGC AGTCCTCCAT CACCTTCCAG TCTGGCAGCC GCAGGGGCTT CAGCACCACC 
TCGGCCATCA CCCCGGCAGC TGGCCGCTCC CGCTTCAGCT CTGTCTCTGT GGCCCGCTCT 
GCAGCAGGGA GTGGGGGCCT GGGAAGGATC AGCAGTGCTG GGGCCAGCTT TGGAAGCCGC 
AGCCTCTACA ACCTGGGGGG TGCCAAGCGG GTCTCCATCA ATGGGTGTGG CAGCAGCTGC 
CGAAGTGGCT TTGGTGGCAG GGCCAGCAAC AGGTTTGGAG TCAACAGTGG ATTTGGCTAT 
GGGGGTGGAG TTGGAGGAGG CTTCAGTGGC CCCAGCTTCC CCGTGTGTCC CCCTGGAGGC 
ATCCAAGAGG TCACTGTCAA CCAGAGTCTC CTGACTCCTC TTCACCTGCA AATCGACCCC 
ACCATCCAGC GGGTGCGGGC CGAGGAGCGC GAGCAGATCA AGACCCTCAA CAATAAGTTC 
GCCTCCTTCA TCGACAAGGT GAGGTTCTTG GAGCAGCAGA ACAAGGTCCT GGAGACCAAG 
TGGGCCCTCC TGCAGGAGCA GGGCTCCAGG ACTGTGAGGC AGAACCTAGA GCCCCTCTTT 
GATTCCTATA CCAGTGAGCT CCGACGGCAG CTGGAAAGCA TCACCACCGA GAGGGGCAGG 
CTTGAAGCTG AACTGAGGAA CATGCAGGAT GTTGTGGAAG ATTTCAAAGT CAGGTACGAA 
GATGAAATTA ACAAGCGCAC AGCTGCTGAG AATGAATTTG TAGCCCTGAA AAAGGACGTA 
GATGCTGCCT ATATGAACAA GGTGGAGCTG GAAGCCAAGG TCAAATCTCT GCCCGAGGAG 
ATCAACTTCA TCCACTCAGT CTTTGATGCA GAGCTGTCCC AGTTGCAGAC CCAGGTCGGT 
GACACATCCG TGGTGCTGTC CATGGACAAC AACCGCAACC TGGACCTGGA TAGTATCATC 
GCCGAGGTCA AAGCACAATA CGAGGACATT GCCAACCGCA GCCGGGCCGA GGCTGAGTCC 
TGGTACCAGA CCAAGTACGA GGAGCTGCAG GTCACCGCAG GCAGACATGG GGATGACCTT 
CGAAACACCA AACAAGAGAT CTCTGAAATG AACCGCATGA TCCAGAGGCT GAGAGCTGAG 
ATTGACAGCG TCAAGAAGCA GTGTTCCAGC TTGCAAACGG CCATTGCTGA TGCAGAGCAG 
CGGGGAGAAC TGGCTCTCAA GGATGCACGG GCCAAGCTGG TGGACCTTGA GGAGGCCCTG 
CAGAAGGCCA AGCAGGACAT GGCTCGGCTC CTGCGTGAGT ACCAGGAGCT GATGAACATC 
AAGCTGGCCC TGGACGTGGA GATCGCCACC TACCGCAAGC TGCTGGAAGG CGAGGAGTGC 
AGGTTGAGTG GAGAGGGAGT TTCTCCAGTT AACATTTCTG TGGTCACCTC TACTCTTTCC 
AGTGGCTATG GAAGCGGCAG CAGCATTGGA GGTGGAAACC TGGGCCTCGG TGGGGGCAGC 
GGCTACTCCT TCACCACCAG TGGTGGGCAT AGCCTGGGTG CAGGCCTGGG AGGTTCTGGA 
TTCAGTGCCA CCAGCAACCG GGGCTTAGGG GGCAGTGGTT CTAGCGTCAA GTTTGTCTCC 
ACCACATCCT CCAGCCAGAA GAGCTACACG CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KRT75 ( NM_004693.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004684.2 Homo sapiens keratin 75 (KRT75), mRNA.

Price & Availability↑

CloneID	OHu19371
Clone ID Related Accession (Same CDS sequence)	NM_004693.2 , NM_004693.3
Accession Version	NM_004693.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	keratin, type II cytoskeletal 75
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC055736.20, AK225962.1 and Y17282.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004693.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y17282.1, AK298960.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2144335, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252245.6/ ENSP00000252245.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTCGGC AGTCCTCCAT CACCTTCCAG TCTGGCAGCC GCAGGGGCTT CAGCACCACC 
TCGGCCATCA CCCCGGCAGC TGGCCGCTCC CGCTTCAGCT CTGTCTCTGT GGCCCGCTCT 
GCAGCAGGGA GTGGGGGCCT GGGAAGGATC AGCAGTGCTG GGGCCAGCTT TGGAAGCCGC 
AGCCTCTACA ACCTGGGGGG TGCCAAGCGG GTCTCCATCA ATGGGTGTGG CAGCAGCTGC 
CGAAGTGGCT TTGGTGGCAG GGCCAGCAAC AGGTTTGGAG TCAACAGTGG ATTTGGCTAT 
GGGGGTGGAG TTGGAGGAGG CTTCAGTGGC CCCAGCTTCC CCGTGTGTCC CCCTGGAGGC 
ATCCAAGAGG TCACTGTCAA CCAGAGTCTC CTGACTCCTC TTCACCTGCA AATCGACCCC 
ACCATCCAGC GGGTGCGGGC CGAGGAGCGC GAGCAGATCA AGACCCTCAA CAATAAGTTC 
GCCTCCTTCA TCGACAAGGT GAGGTTCTTG GAGCAGCAGA ACAAGGTCCT GGAGACCAAG 
TGGGCCCTCC TGCAGGAGCA GGGCTCCAGG ACTGTGAGGC AGAACCTAGA GCCCCTCTTT 
GATTCCTATA CCAGTGAGCT CCGACGGCAG CTGGAAAGCA TCACCACCGA GAGGGGCAGG 
CTTGAAGCTG AACTGAGGAA CATGCAGGAT GTTGTGGAAG ATTTCAAAGT CAGGTACGAA 
GATGAAATTA ACAAGCGCAC AGCTGCTGAG AATGAATTTG TAGCCCTGAA AAAGGACGTA 
GATGCTGCCT ATATGAACAA GGTGGAGCTG GAAGCCAAGG TCAAATCTCT GCCCGAGGAG 
ATCAACTTCA TCCACTCAGT CTTTGATGCA GAGCTGTCCC AGTTGCAGAC CCAGGTCGGT 
GACACATCCG TGGTGCTGTC CATGGACAAC AACCGCAACC TGGACCTGGA TAGTATCATC 
GCCGAGGTCA AAGCACAATA CGAGGACATT GCCAACCGCA GCCGGGCCGA GGCTGAGTCC 
TGGTACCAGA CCAAGTACGA GGAGCTGCAG GTCACCGCAG GCAGACATGG GGATGACCTT 
CGAAACACCA AACAAGAGAT CTCTGAAATG AACCGCATGA TCCAGAGGCT GAGAGCTGAG 
ATTGACAGCG TCAAGAAGCA GTGTTCCAGC TTGCAAACGG CCATTGCTGA TGCAGAGCAG 
CGGGGAGAAC TGGCTCTCAA GGATGCACGG GCCAAGCTGG TGGACCTTGA GGAGGCCCTG 
CAGAAGGCCA AGCAGGACAT GGCTCGGCTC CTGCGTGAGT ACCAGGAGCT GATGAACATC 
AAGCTGGCCC TGGACGTGGA GATCGCCACC TACCGCAAGC TGCTGGAAGG CGAGGAGTGC 
AGGTTGAGTG GAGAGGGAGT TTCTCCAGTT AACATTTCTG TGGTCACCTC TACTCTTTCC 
AGTGGCTATG GAAGCGGCAG CAGCATTGGA GGTGGAAACC TGGGCCTCGG TGGGGGCAGC 
GGCTACTCCT TCACCACCAG TGGTGGGCAT AGCCTGGGTG CAGGCCTGGG AGGTTCTGGA 
TTCAGTGCCA CCAGCAACCG GGGCTTAGGG GGCAGTGGTT CTAGCGTCAA GTTTGTCTCC 
ACCACATCCT CCAGCCAGAA GAGCTACACG CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004684.2
CDS	68..1723
Translation	MSRQSSITFQSGSRRGFSTTSAITPAAGRSRFSSVSVARSAAGSGGLGRISSAGASFGSRSLYNLGGAKRVSINGCGSSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLGGGSGYSFTTSGGHSLGAGLGGSGFSATSNRGLGGSGSSVKFVSTTSSSQKSYTH

Target ORF information:

RefSeq Version	NM_004693.3
Organism	Homo sapiens(human)
Definition	Homo sapiens keratin 75 (KRT75), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004693.3

ORF Insert Sequence:

ATGTCTCGGC AGTCCTCCAT CACCTTCCAG TCTGGCAGCC GCAGGGGCTT CAGCACCACC 
TCGGCCATCA CCCCGGCAGC TGGCCGCTCC CGCTTCAGCT CTGTCTCTGT GGCCCGCTCT 
GCAGCAGGGA GTGGGGGCCT GGGAAGGATC AGCAGTGCTG GGGCCAGCTT TGGAAGCCGC 
AGCCTCTACA ACCTGGGGGG TGCCAAGCGG GTCTCCATCA ATGGGTGTGG CAGCAGCTGC 
CGAAGTGGCT TTGGTGGCAG GGCCAGCAAC AGGTTTGGAG TCAACAGTGG ATTTGGCTAT 
GGGGGTGGAG TTGGAGGAGG CTTCAGTGGC CCCAGCTTCC CCGTGTGTCC CCCTGGAGGC 
ATCCAAGAGG TCACTGTCAA CCAGAGTCTC CTGACTCCTC TTCACCTGCA AATCGACCCC 
ACCATCCAGC GGGTGCGGGC CGAGGAGCGC GAGCAGATCA AGACCCTCAA CAATAAGTTC 
GCCTCCTTCA TCGACAAGGT GAGGTTCTTG GAGCAGCAGA ACAAGGTCCT GGAGACCAAG 
TGGGCCCTCC TGCAGGAGCA GGGCTCCAGG ACTGTGAGGC AGAACCTAGA GCCCCTCTTT 
GATTCCTATA CCAGTGAGCT CCGACGGCAG CTGGAAAGCA TCACCACCGA GAGGGGCAGG 
CTTGAAGCTG AACTGAGGAA CATGCAGGAT GTTGTGGAAG ATTTCAAAGT CAGGTACGAA 
GATGAAATTA ACAAGCGCAC AGCTGCTGAG AATGAATTTG TAGCCCTGAA AAAGGACGTA 
GATGCTGCCT ATATGAACAA GGTGGAGCTG GAAGCCAAGG TCAAATCTCT GCCCGAGGAG 
ATCAACTTCA TCCACTCAGT CTTTGATGCA GAGCTGTCCC AGTTGCAGAC CCAGGTCGGT 
GACACATCCG TGGTGCTGTC CATGGACAAC AACCGCAACC TGGACCTGGA TAGTATCATC 
GCCGAGGTCA AAGCACAATA CGAGGACATT GCCAACCGCA GCCGGGCCGA GGCTGAGTCC 
TGGTACCAGA CCAAGTACGA GGAGCTGCAG GTCACCGCAG GCAGACATGG GGATGACCTT 
CGAAACACCA AACAAGAGAT CTCTGAAATG AACCGCATGA TCCAGAGGCT GAGAGCTGAG 
ATTGACAGCG TCAAGAAGCA GTGTTCCAGC TTGCAAACGG CCATTGCTGA TGCAGAGCAG 
CGGGGAGAAC TGGCTCTCAA GGATGCACGG GCCAAGCTGG TGGACCTTGA GGAGGCCCTG 
CAGAAGGCCA AGCAGGACAT GGCTCGGCTC CTGCGTGAGT ACCAGGAGCT GATGAACATC 
AAGCTGGCCC TGGACGTGGA GATCGCCACC TACCGCAAGC TGCTGGAAGG CGAGGAGTGC 
AGGTTGAGTG GAGAGGGAGT TTCTCCAGTT AACATTTCTG TGGTCACCTC TACTCTTTCC 
AGTGGCTATG GAAGCGGCAG CAGCATTGGA GGTGGAAACC TGGGCCTCGG TGGGGGCAGC 
GGCTACTCCT TCACCACCAG TGGTGGGCAT AGCCTGGGTG CAGGCCTGGG AGGTTCTGGA 
TTCAGTGCCA CCAGCAACCG GGGCTTAGGG GGCAGTGGTT CTAGCGTCAA GTTTGTCTCC 
ACCACATCCT CCAGCCAGAA GAGCTACACG CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes.
Annals of diagnostic pathology2358-61(2016 Aug)
Handra-Luca A,Dragoescu E

Keratins as components of the enamel organic matrix.
Matrix biology : journal of the International Society for Matrix Biology52-54260-265(2016 May-Jul)
Duverger O,Beniash E,Morasso MI

Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant basal-HER2 subtype of breast cancer.
Oncotarget6(9)7104-22(2015 Mar)
Martin-Castillo B,Lopez-Bonet E,Bux? M,Dorca J,Tuca-Rodr?guez F,Ruano MA,Colomer R,Menendez JA

Hair keratin mutations in tooth enamel increase dental decay risk.
The Journal of clinical investigation124(12)5219-24(2014 Dec)
Duverger O,Ohara T,Shaffer JR,Donahue D,Zerfas P,Dullnig A,Crecelius C,Beniash E,Marazita ML,Morasso MI

Analysis of clinical characteristics and differential diagnosis of the lung biopsy specimens in 99 adenocarcinoma cases and 111 squamous cell carcinoma cases: utility of an immunohistochemical panel containing CK5/6, CK34?E12, p63, CK7 and TTF-1.
Pathology, research and practice210(10)680-5(2014 Oct)
Xu XY,Yang GY,Yang JH,Li J

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KRT75 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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