SLC25A46 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC25A46
Entrez Gene ID	91137
Full Name	solute carrier family 25 member 46
Synonyms	HMSN6B
General protein information	Preferred Names solute carrier family 25 member 46 Names solute carrier family 25 member 46
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q22.1
Summary	This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. [provided by RefSeq, Aug 2016].
Disorder MIM:	610826
Disorder Html:	Neuropathy, hereditary motor and sensory, type VIB, 616505 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303249.3	NP_001290178.1	solute carrier family 25 member 46 isoform 2
NM_138773.4	NP_620128.1	solute carrier family 25 member 46 isoform 1
NM_138773.3	NP_620128.1	solute carrier family 25 member 46 isoform 1
NM_001303249.2	NP_001290178.1	solute carrier family 25 member 46 isoform 2
NM_001303250.2	NP_001290179.1	solute carrier family 25 member 46 isoform 3
NM_001303250.3	NP_001290179.1	solute carrier family 25 member 46 isoform 3

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002704	XP_312224.5
Canis lupus familiaris (dog)	SLC25A46	XP_005618270.1
Bos taurus (cattle)	SLC25A46	XP_002689483.2
Mus musculus (house mouse)	Slc25a46	NP_080441.1
Rattus norvegicus (Norway rat)	Slc25a46	NP_001093985.1
Drosophila melanogaster (fruit fly)	CG5755	NP_609864.1
Gallus gallus (chicken)	SLC25A46	NP_001007831.1
Xenopus tropicalis (tropical clawed frog)	slc25a46	NP_001016130.1
Pan troglodytes (chimpanzee)	SLC25A46	XP_517867.2
Drosophila melanogaster (fruit fly)	CG8931	NP_573096.1
Homo sapiens (human)	SLC25A46	NP_620128.1
	SLC25A46	XP_001100405.1
Danio rerio (zebrafish)	slc25a46	NP_001002558.1
Caenorhabditis elegans (roundworm)	Y40B1B.8	NP_493364.1

Gene Ontology
Bibliography

Related articles in PubMed

Pontocerebellar hypoplasia with spinal muscular atrophy (PCH1): identification of SLC25A46 mutations in the original Dutch PCH1 family.
van Dijk T, Rudnik-Sch?neborn S, Senderek J, Hajmousa G, Mei H, Dusl M, Aronica E, Barth P, Baas F
Brain : a journal of neurology140(8)e46(2017 Aug)

Extension of the phenotype of biallelic loss-of-function mutations in SLC25A46 to the severe form of pontocerebellar hypoplasia type I.
Braunisch MC, Gallwitz H, Abicht A, Diebold I, Holinski-Feder E, Van Maldergem L, Lammens M, Kov?cs-Nagy R, Alhaddad B, Strom TM, Meitinger T, Senderek J, Rudnik-Sch?neborn S, Haack TB
Clinical genetics(2017 Jun)

Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.
Duchesne A, Vaiman A, Castille J, Beauvallet C, Gaignard P, Floriot S, Rodriguez S, Vilotte M, Boulanger L, Passet B, Albaric O, Guillaume F, Boukadiri A, Richard L, Bertaud M, Timsit E, Guatteo R, Jaffr?zic F, Calvel P, Helary L, Mahla R, Esquerr? D, P?choux C, Liuu S, Vallat JM, Boichard D, Slama A, Vilotte JL
PLoS genetics13(4)e1006597(2017 Apr)

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics13(4)e1006656(2017 Apr)

SLC25A46 Mutations Associated with Autosomal Recessive Cerebellar Ataxia in North African Families.
Hammer MB, Ding J, Mochel F, Eleuch-Fayache G, Charles P, Coutelier M, Gibbs JR, Arepalli SK, Chong SB, Hernandez DG, Majounie E, Clipman S, Bouhlal Y, Nehdi H, Brice A, Hentati F, Stevanin G, Amouri R, Durr A, Singleton AB
Neuro-degenerative diseases17(4-5)208-212(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we showed that the Slc25a46 disruption caused a fusion/fission imbalance and an abnormal mitochondrial architecture that disturbed mitochondrial metabolism. These data extended the range of phenotypes associated with Slc25a46 dysfunction. Moreover, this Slc25a46 knock-out mouse model should be useful to further elucidate the role of SLC25A46 in mitochondrial dynamics
Title: Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.

Our mutant mice provide a valid model for understanding the mechanistic basis of the complex SLC25A46-mediated pathologies, as well as for screening potential therapeutic interventions.
Title: Novel insights into SLC25A46-related pathologies in a genetic mouse model.

SLC25A46 is selectively degraded from the outer membrane independently of mitophagy and apoptosis, providing a framework for mechanistic studies in the proteolysis of outer membrane proteins
Title: Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.

This study identified of a homozygous missense mutation c.1022T>C and a homozygous genomic deletion involving exon 1 in SLC25A46 encoding a mitochondrial protein leading to lethal pontocerebellar hypoplasia with apnoea and profound weakness.
Title: Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.

These results show that SLC25A46 plays a role in a mitochondrial/endoplasmic reticulum pathway that facilitates lipid transfer, and link altered mitochondrial dynamics to early-onset neurodegenerative disease and cell fate decisions.
Title: SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.

The following SLC25A46 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC25A46 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu74306	NM_138773.4 Latest version!	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu39777	NM_001303250.3 Latest version!	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu74307	NM_001303249.3 Latest version!	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu74306	NM_138773.3	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu74307	NM_001303249.2	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu39777	NM_001303250.2	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC25A46 ( NM_138773.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_620128.1 Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu74306
Clone ID Related Accession (Same CDS sequence)	NM_138773.4 , NM_138773.3
Accession Version	NM_138773.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	solute carrier family 25 member 46 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA713164.1, AK290217.1, BC017169.1 and AC008650.8. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_138773.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.107181.1, SRR1660807.223771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000355943.8/ ENSP00000348211.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TGAGATAATT CGAGATAATA CTGGCATTTT GGAGTGTGTT 
AAAGAAGGAA TTGGAAGAGT GATAGGCATG GGAGTGCCTC ATAGCAAACG ACTTCTTCCG 
CTTCTTTCCT TGATCTTCCC TACGGTGCTT CATGGAGTTC TTCATTACAT CATCAGCTCA 
GTTATTCAGA AGTTTGTCCT ACTAATTCTA AAGAGAAAGA CTTACAATAG CCACCTAGCT 
GAGAGCACTA GCCCTGTGCA GAGTATGTTG GATGCTTATT TTCCAGAACT TATTGCTAAC 
TTTGCTGCCA GTCTTTGTTC TGACGTTATA CTTTACCCAT TGGAAACAGT TTTGCACCGC 
CTTCACATTC AAGGAACACG CACAATAATT GACAATACAG ACCTTGGCTA TGAAGTGCTT 
CCAATTAATA CACAATATGA GGGAATGAGA GACTGTATCA ATACCATAAG GCAGGAGGAA 
GGAGTGTTTG GTTTTTATAA AGGGTTTGGT GCTGTTATAA TACAGTACAC ACTGCATGCA 
GCTGTTTTAC AGATTACCAA AATTATTTAC TCTACACTTC TTCAAAATAA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620128.1
CDS	114..1370
Translation	MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Target ORF information:

RefSeq Version	NM_138773.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138773.4

ORF Insert Sequence:

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TGAGATAATT CGAGATAATA CTGGCATTTT GGAGTGTGTT 
AAAGAAGGAA TTGGAAGAGT GATAGGCATG GGAGTGCCTC ATAGCAAACG ACTTCTTCCG 
CTTCTTTCCT TGATCTTCCC TACGGTGCTT CATGGAGTTC TTCATTACAT CATCAGCTCA 
GTTATTCAGA AGTTTGTCCT ACTAATTCTA AAGAGAAAGA CTTACAATAG CCACCTAGCT 
GAGAGCACTA GCCCTGTGCA GAGTATGTTG GATGCTTATT TTCCAGAACT TATTGCTAAC 
TTTGCTGCCA GTCTTTGTTC TGACGTTATA CTTTACCCAT TGGAAACAGT TTTGCACCGC 
CTTCACATTC AAGGAACACG CACAATAATT GACAATACAG ACCTTGGCTA TGAAGTGCTT 
CCAATTAATA CACAATATGA GGGAATGAGA GACTGTATCA ATACCATAAG GCAGGAGGAA 
GGAGTGTTTG GTTTTTATAA AGGGTTTGGT GCTGTTATAA TACAGTACAC ACTGCATGCA 
GCTGTTTTAC AGATTACCAA AATTATTTAC TCTACACTTC TTCAAAATAA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A46 ( NM_001303250.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290179.1 Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu39777
Clone ID Related Accession (Same CDS sequence)	NM_001303250.2 , NM_001303250.3
Accession Version	NM_001303250.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-28
Organism	Homo sapiens(human)
Product	solute carrier family 25 member 46 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB051498.1, AK302326.1, BC017169.1 and AC008650.8. On Aug 6, 2016 this sequence version replaced NM_001303250.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302326.1, DC399490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAACAG AACAGCTGAA TAGATTTGCT GGATTTGGTA TTGGACTTGC AAGTCTCTTT 
ACAGAAAATG TATTGGCACA TCCTTGCATT GTTCTACGCC GCCAATGTCA GGTTAATTAC 
CATGCTCAGC ATTACCATCT CACTCCATTT ACAGTCATCA ATATTATGTA CAGTTTCAAC 
AAAACTCAGG GACCTAGAGC CCTGTGGAAA GGAATGGGAA GTACATTTAT TGTCCAGGGA 
GTCACACTTG GAGCAGAAGG CATAATTAGT GAATTTACAC CTTTGCCAAG GGAGGTTTTA 
CATAAATGGA GTCCTAAACA AATAGGAGAA CACCTTCTAC TGAAATCCCT AACTTACGTG 
GTGGCAATGC CTTTTTATTC AGCAAGTCTG ATTGAAACAG TGCAGAGTGA GATAATTCGA 
GATAATACTG GCATTTTGGA GTGTGTTAAA GAAGGAATTG GAAGAGTGAT AGGCATGGGA 
GTGCCTCATA GCAAACGACT TCTTCCGCTT CTTTCCTTGA TCTTCCCTAC GGTGCTTCAT 
GGAGTTCTTC ATTACATCAT CAGCTCAGTT ATTCAGAAGT TTGTCCTACT AATTCTAAAG 
AGAAAGACTT ACAATAGCCA CCTAGCTGAG AGCACTAGCC CTGTGCAGAG TATGTTGGAT 
GCTTATTTTC CAGAACTTAT TGCTAACTTT GCTGCCAGTC TTTGTTCTGA CGTTATACTT 
TACCCATTGG AAACAGTTTT GCACCGCCTT CACATTCAAG GAACACGCAC AATAATTGAC 
AATACAGACC TTGGCTATGA AGTGCTTCCA ATTAATACAC AATATGAGGG AATGAGAGAC 
TGTATCAATA CCATAAGGCA GGAGGAAGGA GTGTTTGGTT TTTATAAAGG GTTTGGTGCT 
GTTATAATAC AGTACACACT GCATGCAGCT GTTTTACAGA TTACCAAAAT TATTTACTCT 
ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290179.1
CDS	103..1086
Translation	MKTEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Target ORF information:

RefSeq Version	NM_001303250.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303250.2

ORF Insert Sequence:

ATGAAAACAG AACAGCTGAA TAGATTTGCT GGATTTGGTA TTGGACTTGC AAGTCTCTTT 
ACAGAAAATG TATTGGCACA TCCTTGCATT GTTCTACGCC GCCAATGTCA GGTTAATTAC 
CATGCTCAGC ATTACCATCT CACTCCATTT ACAGTCATCA ATATTATGTA CAGTTTCAAC 
AAAACTCAGG GACCTAGAGC CCTGTGGAAA GGAATGGGAA GTACATTTAT TGTCCAGGGA 
GTCACACTTG GAGCAGAAGG CATAATTAGT GAATTTACAC CTTTGCCAAG GGAGGTTTTA 
CATAAATGGA GTCCTAAACA AATAGGAGAA CACCTTCTAC TGAAATCCCT AACTTACGTG 
GTGGCAATGC CTTTTTATTC AGCAAGTCTG ATTGAAACAG TGCAGAGTGA GATAATTCGA 
GATAATACTG GCATTTTGGA GTGTGTTAAA GAAGGAATTG GAAGAGTGAT AGGCATGGGA 
GTGCCTCATA GCAAACGACT TCTTCCGCTT CTTTCCTTGA TCTTCCCTAC GGTGCTTCAT 
GGAGTTCTTC ATTACATCAT CAGCTCAGTT ATTCAGAAGT TTGTCCTACT AATTCTAAAG 
AGAAAGACTT ACAATAGCCA CCTAGCTGAG AGCACTAGCC CTGTGCAGAG TATGTTGGAT 
GCTTATTTTC CAGAACTTAT TGCTAACTTT GCTGCCAGTC TTTGTTCTGA CGTTATACTT 
TACCCATTGG AAACAGTTTT GCACCGCCTT CACATTCAAG GAACACGCAC AATAATTGAC 
AATACAGACC TTGGCTATGA AGTGCTTCCA ATTAATACAC AATATGAGGG AATGAGAGAC 
TGTATCAATA CCATAAGGCA GGAGGAAGGA GTGTTTGGTT TTTATAAAGG GTTTGGTGCT 
GTTATAATAC AGTACACACT GCATGCAGCT GTTTTACAGA TTACCAAAAT TATTTACTCT 
ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A46 ( NM_001303250.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290179.1 Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu39777
Clone ID Related Accession (Same CDS sequence)	NM_001303250.2 , NM_001303250.3
Accession Version	NM_001303250.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	solute carrier family 25 member 46 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB051498.1, AK302326.1, BC017169.1 and AC008650.8. On May 31, 2019 this sequence version replaced NM_001303250.2. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.122836.1, AK302326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAACAG AACAGCTGAA TAGATTTGCT GGATTTGGTA TTGGACTTGC AAGTCTCTTT 
ACAGAAAATG TATTGGCACA TCCTTGCATT GTTCTACGCC GCCAATGTCA GGTTAATTAC 
CATGCTCAGC ATTACCATCT CACTCCATTT ACAGTCATCA ATATTATGTA CAGTTTCAAC 
AAAACTCAGG GACCTAGAGC CCTGTGGAAA GGAATGGGAA GTACATTTAT TGTCCAGGGA 
GTCACACTTG GAGCAGAAGG CATAATTAGT GAATTTACAC CTTTGCCAAG GGAGGTTTTA 
CATAAATGGA GTCCTAAACA AATAGGAGAA CACCTTCTAC TGAAATCCCT AACTTACGTG 
GTGGCAATGC CTTTTTATTC AGCAAGTCTG ATTGAAACAG TGCAGAGTGA GATAATTCGA 
GATAATACTG GCATTTTGGA GTGTGTTAAA GAAGGAATTG GAAGAGTGAT AGGCATGGGA 
GTGCCTCATA GCAAACGACT TCTTCCGCTT CTTTCCTTGA TCTTCCCTAC GGTGCTTCAT 
GGAGTTCTTC ATTACATCAT CAGCTCAGTT ATTCAGAAGT TTGTCCTACT AATTCTAAAG 
AGAAAGACTT ACAATAGCCA CCTAGCTGAG AGCACTAGCC CTGTGCAGAG TATGTTGGAT 
GCTTATTTTC CAGAACTTAT TGCTAACTTT GCTGCCAGTC TTTGTTCTGA CGTTATACTT 
TACCCATTGG AAACAGTTTT GCACCGCCTT CACATTCAAG GAACACGCAC AATAATTGAC 
AATACAGACC TTGGCTATGA AGTGCTTCCA ATTAATACAC AATATGAGGG AATGAGAGAC 
TGTATCAATA CCATAAGGCA GGAGGAAGGA GTGTTTGGTT TTTATAAAGG GTTTGGTGCT 
GTTATAATAC AGTACACACT GCATGCAGCT GTTTTACAGA TTACCAAAAT TATTTACTCT 
ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290179.1
CDS	94..1077
Translation	MKTEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Target ORF information:

RefSeq Version	NM_001303250.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303250.3

ORF Insert Sequence:

ATGAAAACAG AACAGCTGAA TAGATTTGCT GGATTTGGTA TTGGACTTGC AAGTCTCTTT 
ACAGAAAATG TATTGGCACA TCCTTGCATT GTTCTACGCC GCCAATGTCA GGTTAATTAC 
CATGCTCAGC ATTACCATCT CACTCCATTT ACAGTCATCA ATATTATGTA CAGTTTCAAC 
AAAACTCAGG GACCTAGAGC CCTGTGGAAA GGAATGGGAA GTACATTTAT TGTCCAGGGA 
GTCACACTTG GAGCAGAAGG CATAATTAGT GAATTTACAC CTTTGCCAAG GGAGGTTTTA 
CATAAATGGA GTCCTAAACA AATAGGAGAA CACCTTCTAC TGAAATCCCT AACTTACGTG 
GTGGCAATGC CTTTTTATTC AGCAAGTCTG ATTGAAACAG TGCAGAGTGA GATAATTCGA 
GATAATACTG GCATTTTGGA GTGTGTTAAA GAAGGAATTG GAAGAGTGAT AGGCATGGGA 
GTGCCTCATA GCAAACGACT TCTTCCGCTT CTTTCCTTGA TCTTCCCTAC GGTGCTTCAT 
GGAGTTCTTC ATTACATCAT CAGCTCAGTT ATTCAGAAGT TTGTCCTACT AATTCTAAAG 
AGAAAGACTT ACAATAGCCA CCTAGCTGAG AGCACTAGCC CTGTGCAGAG TATGTTGGAT 
GCTTATTTTC CAGAACTTAT TGCTAACTTT GCTGCCAGTC TTTGTTCTGA CGTTATACTT 
TACCCATTGG AAACAGTTTT GCACCGCCTT CACATTCAAG GAACACGCAC AATAATTGAC 
AATACAGACC TTGGCTATGA AGTGCTTCCA ATTAATACAC AATATGAGGG AATGAGAGAC 
TGTATCAATA CCATAAGGCA GGAGGAAGGA GTGTTTGGTT TTTATAAAGG GTTTGGTGCT 
GTTATAATAC AGTACACACT GCATGCAGCT GTTTTACAGA TTACCAAAAT TATTTACTCT 
ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A46 ( NM_138773.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620128.1 Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu74306
Clone ID Related Accession (Same CDS sequence)	NM_138773.4 , NM_138773.3
Accession Version	NM_138773.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	solute carrier family 25 member 46 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008650.8, DA713164.1, AK290217.1 and BC017169.1. This sequence is a reference standard in the RefSeqGene project. On Aug 6, 2016 this sequence version replaced NM_138773.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.223771.1, SRR1660809.73003.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TGAGATAATT CGAGATAATA CTGGCATTTT GGAGTGTGTT 
AAAGAAGGAA TTGGAAGAGT GATAGGCATG GGAGTGCCTC ATAGCAAACG ACTTCTTCCG 
CTTCTTTCCT TGATCTTCCC TACGGTGCTT CATGGAGTTC TTCATTACAT CATCAGCTCA 
GTTATTCAGA AGTTTGTCCT ACTAATTCTA AAGAGAAAGA CTTACAATAG CCACCTAGCT 
GAGAGCACTA GCCCTGTGCA GAGTATGTTG GATGCTTATT TTCCAGAACT TATTGCTAAC 
TTTGCTGCCA GTCTTTGTTC TGACGTTATA CTTTACCCAT TGGAAACAGT TTTGCACCGC 
CTTCACATTC AAGGAACACG CACAATAATT GACAATACAG ACCTTGGCTA TGAAGTGCTT 
CCAATTAATA CACAATATGA GGGAATGAGA GACTGTATCA ATACCATAAG GCAGGAGGAA 
GGAGTGTTTG GTTTTTATAA AGGGTTTGGT GCTGTTATAA TACAGTACAC ACTGCATGCA 
GCTGTTTTAC AGATTACCAA AATTATTTAC TCTACACTTC TTCAAAATAA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620128.1
CDS	149..1405
Translation	MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Target ORF information:

RefSeq Version	NM_138773.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138773.3

ORF Insert Sequence:

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TGAGATAATT CGAGATAATA CTGGCATTTT GGAGTGTGTT 
AAAGAAGGAA TTGGAAGAGT GATAGGCATG GGAGTGCCTC ATAGCAAACG ACTTCTTCCG 
CTTCTTTCCT TGATCTTCCC TACGGTGCTT CATGGAGTTC TTCATTACAT CATCAGCTCA 
GTTATTCAGA AGTTTGTCCT ACTAATTCTA AAGAGAAAGA CTTACAATAG CCACCTAGCT 
GAGAGCACTA GCCCTGTGCA GAGTATGTTG GATGCTTATT TTCCAGAACT TATTGCTAAC 
TTTGCTGCCA GTCTTTGTTC TGACGTTATA CTTTACCCAT TGGAAACAGT TTTGCACCGC 
CTTCACATTC AAGGAACACG CACAATAATT GACAATACAG ACCTTGGCTA TGAAGTGCTT 
CCAATTAATA CACAATATGA GGGAATGAGA GACTGTATCA ATACCATAAG GCAGGAGGAA 
GGAGTGTTTG GTTTTTATAA AGGGTTTGGT GCTGTTATAA TACAGTACAC ACTGCATGCA 
GCTGTTTTAC AGATTACCAA AATTATTTAC TCTACACTTC TTCAAAATAA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A46 ( NM_001303249.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290178.1 Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu74307
Clone ID Related Accession (Same CDS sequence)	NM_001303249.3 , NM_001303249.2
Accession Version	NM_001303249.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	solute carrier family 25 member 46 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA713164.1, AK300123.1, BC017169.1 and AC008650.8. On Jun 1, 2019 this sequence version replaced NM_001303249.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300123.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TATGTTGGAT GCTTATTTTC CAGAACTTAT TGCTAACTTT 
GCTGCCAGTC TTTGTTCTGA CGTTATACTT TACCCATTGG AAACAGTTTT GCACCGCCTT 
CACATTCAAG GAACACGCAC AATAATTGAC AATACAGACC TTGGCTATGA AGTGCTTCCA 
ATTAATACAC AATATGAGGG AATGAGAGAC TGTATCAATA CCATAAGGCA GGAGGAAGGA 
GTGTTTGGTT TTTATAAAGG GTTTGGTGCT GTTATAATAC AGTACACACT GCATGCAGCT 
GTTTTACAGA TTACCAAAAT TATTTACTCT ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290178.1
CDS	114..1127
Translation	MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Target ORF information:

RefSeq Version	NM_001303249.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303249.3

ORF Insert Sequence:

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TATGTTGGAT GCTTATTTTC CAGAACTTAT TGCTAACTTT 
GCTGCCAGTC TTTGTTCTGA CGTTATACTT TACCCATTGG AAACAGTTTT GCACCGCCTT 
CACATTCAAG GAACACGCAC AATAATTGAC AATACAGACC TTGGCTATGA AGTGCTTCCA 
ATTAATACAC AATATGAGGG AATGAGAGAC TGTATCAATA CCATAAGGCA GGAGGAAGGA 
GTGTTTGGTT TTTATAAAGG GTTTGGTGCT GTTATAATAC AGTACACACT GCATGCAGCT 
GTTTTACAGA TTACCAAAAT TATTTACTCT ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A46 ( NM_001303249.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290178.1 Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu74307
Clone ID Related Accession (Same CDS sequence)	NM_001303249.3 , NM_001303249.2
Accession Version	NM_001303249.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-28
Organism	Homo sapiens(human)
Product	solute carrier family 25 member 46 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008650.8, DA713164.1, AK300123.1 and BC017169.1. On Aug 6, 2016 this sequence version replaced NM_001303249.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300123.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TATGTTGGAT GCTTATTTTC CAGAACTTAT TGCTAACTTT 
GCTGCCAGTC TTTGTTCTGA CGTTATACTT TACCCATTGG AAACAGTTTT GCACCGCCTT 
CACATTCAAG GAACACGCAC AATAATTGAC AATACAGACC TTGGCTATGA AGTGCTTCCA 
ATTAATACAC AATATGAGGG AATGAGAGAC TGTATCAATA CCATAAGGCA GGAGGAAGGA 
GTGTTTGGTT TTTATAAAGG GTTTGGTGCT GTTATAATAC AGTACACACT GCATGCAGCT 
GTTTTACAGA TTACCAAAAT TATTTACTCT ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290178.1
CDS	149..1162
Translation	MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Target ORF information:

RefSeq Version	NM_001303249.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 46 (SLC25A46), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303249.2

ORF Insert Sequence:

ATGCATCCGC GGCGCCCGGA CGGATTTGAT GGCTTGGGCT ACCGGGGTGG TGCCCGGGAC 
GAGCAGGGCT TTGGCGGCGC CTTCCCTGCA AGGTCCTTCA GCACCGGGTC GGACCTGGGC 
CACTGGGTGA CGACTCCCCC AGATATCCCC GGCAGCCGCA ACCTGCACTG GGGCGAGAAG 
AGCCCGCCCT ACGGCGTGCC CACCACCTCC ACCCCGTACG AAGGCCCCAC GGAGGAACCC 
TTTTCCAGTG GCGGCGGCGG CAGTGTGCAG GGGCAGAGCA GTGAACAGCT GAATAGATTT 
GCTGGATTTG GTATTGGACT TGCAAGTCTC TTTACAGAAA ATGTATTGGC ACATCCTTGC 
ATTGTTCTAC GCCGCCAATG TCAGGTTAAT TACCATGCTC AGCATTACCA TCTCACTCCA 
TTTACAGTCA TCAATATTAT GTACAGTTTC AACAAAACTC AGGGACCTAG AGCCCTGTGG 
AAAGGAATGG GAAGTACATT TATTGTCCAG GGAGTCACAC TTGGAGCAGA AGGCATAATT 
AGTGAATTTA CACCTTTGCC AAGGGAGGTT TTACATAAAT GGAGTCCTAA ACAAATAGGA 
GAACACCTTC TACTGAAATC CCTAACTTAC GTGGTGGCAA TGCCTTTTTA TTCAGCAAGT 
CTGATTGAAA CAGTGCAGAG TATGTTGGAT GCTTATTTTC CAGAACTTAT TGCTAACTTT 
GCTGCCAGTC TTTGTTCTGA CGTTATACTT TACCCATTGG AAACAGTTTT GCACCGCCTT 
CACATTCAAG GAACACGCAC AATAATTGAC AATACAGACC TTGGCTATGA AGTGCTTCCA 
ATTAATACAC AATATGAGGG AATGAGAGAC TGTATCAATA CCATAAGGCA GGAGGAAGGA 
GTGTTTGGTT TTTATAAAGG GTTTGGTGCT GTTATAATAC AGTACACACT GCATGCAGCT 
GTTTTACAGA TTACCAAAAT TATTTACTCT ACACTTCTTC AAAATAACAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pontocerebellar hypoplasia with spinal muscular atrophy (PCH1): identification of SLC25A46 mutations in the original Dutch PCH1 family.
Brain : a journal of neurology140(8)e46(2017 Aug)
van Dijk T,Rudnik-Sch?neborn S,Senderek J,Hajmousa G,Mei H,Dusl M,Aronica E,Barth P,Baas F

Extension of the phenotype of biallelic loss-of-function mutations in SLC25A46 to the severe form of pontocerebellar hypoplasia type I.
Clinical genetics(2017 Jun)
Braunisch MC,Gallwitz H,Abicht A,Diebold I,Holinski-Feder E,Van Maldergem L,Lammens M,Kov?cs-Nagy R,Alhaddad B,Strom TM,Meitinger T,Senderek J,Rudnik-Sch?neborn S,Haack TB

Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.
PLoS genetics13(4)e1006597(2017 Apr)
Duchesne A,Vaiman A,Castille J,Beauvallet C,Gaignard P,Floriot S,Rodriguez S,Vilotte M,Boulanger L,Passet B,Albaric O,Guillaume F,Boukadiri A,Richard L,Bertaud M,Timsit E,Guatteo R,Jaffr?zic F,Calvel P,Helary L,Mahla R,Esquerr? D,P?choux C,Liuu S,Vallat JM,Boichard D,Slama A,Vilotte JL

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
PLoS genetics13(4)e1006656(2017 Apr)
Terzenidou ME,Segklia A,Kano T,Papastefanaki F,Karakostas A,Charalambous M,Ioakeimidis F,Papadaki M,Kloukina I,Chrysanthou-Piterou M,Samiotaki M,Panayotou G,Matsas R,Douni E

SLC25A46 Mutations Associated with Autosomal Recessive Cerebellar Ataxia in North African Families.
Neuro-degenerative diseases17(4-5)208-212(2017)
Hammer MB,Ding J,Mochel F,Eleuch-Fayache G,Charles P,Coutelier M,Gibbs JR,Arepalli SK,Chong SB,Hernandez DG,Majounie E,Clipman S,Bouhlal Y,Nehdi H,Brice A,Hentati F,Stevanin G,Amouri R,Durr A,Singleton AB

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SLC25A46 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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