CD1C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD1C
Entrez Gene ID	911
Full Name	CD1c molecule
Synonyms	BDCA1,CD1,CD1A,R7
General protein information	Preferred Names CD1c molecule Names T-cell surface glycoprotein CD1c CD1C antigen, c polypeptide cortical thymocyte antigen CD1C differentiation antigen CD1-alpha-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.1
Summary	This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008].
Disorder MIM:	188340

mRNA and Protein(s)

mRNA	Protein	Name
NM_001765.3	NP_001756.2	T-cell surface glycoprotein CD1c precursor
XM_005245579.4	XP_005245636.1	T-cell surface glycoprotein CD1c isoform X1
NM_001765.2	NP_001756.2	T-cell surface glycoprotein CD1c precursor
XM_005245579.5	XP_005245636.1	T-cell surface glycoprotein CD1c isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD1C	NP_001756.2
	CD1C	NP_001139005.1
Canis lupus familiaris (dog)	CD1C	NP_001122308.1
Pan troglodytes (chimpanzee)	CD1C	XP_513908.2

Gene Ontology
Bibliography

Related articles in PubMed

CD1c+ Blood Dendritic Cells in Atopic Dermatitis are Premature and Can Produce Disease-specific Chemokines.
Kapit?ny A, B?ke G, Nagy G, Doan-Xuan QM, Bacso Z, G?sp?r K, Boros G, Dajnoki Z, B?r? T, Rajnav?lgyi ?, Szegedi A
Acta dermato-venereologica97(3)325-331(2017 Mar)

Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.
Dyduch G, Tyrak KE, Glajcar A, Szpor J, Ulatowska-Bia?as M, Oko? K
BioMed research international20176803756(2017)

MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c.
Wen Q, Zhou C, Xiong W, Su J, He J, Zhang S, Du X, Liu S, Wang J, Ma L
Journal of immunology (Baltimore, Md. : 1950)197(2)580-9(2016 07)

Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected ? cells.
Schulte BM, Kers-Rebel ED, Bottino R, Piganelli JD, Galama JM, Engelse MA, de Koning EJ, Adema GJ
Clinical and experimental immunology184(3)293-307(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Circulating atopic dermatitis pre-dendritic CD1c+ cells are premature and bear atopic characteristics even without tissue-specific stimulation, suggesting that their development is not only influenced by the skin microenvironment, but also by the local milieu in the blood.
Title: CD1c+ Blood Dendritic Cells in Atopic Dermatitis are Premature and Can Produce Disease-specific Chemokines.

We found a significant difference in the density of intraepidermal CD1c+ cells between the examined lesions; the mean CD1c cell count was 7.00/mm(2) for invasive melanomas, 2.94 for in situ melanomas, and 13.35 for dysplastic nevi
Title: Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.

these results demonstrated the mechanism that suppression of CD1c by BCG infection is mediated by miR-381-3p
Title: MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c.

Stressed beta-cells have little effect on human BDCA1-expressed dendritic cells activation and function, while enterovirus-infected beta-cells impact these cells significantly.
Title: Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected ? cells.

human CD1c adopts different conformations dependent on ligand occupancy of its groove, with CE and ASG stabilizing CD1c conformations that provide a footprint for binding of CD1c self-reactive T-cell receptors
Title: Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

The following CD1C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD1C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03695	NM_001765.3 Latest version!	Homo sapiens CD1c molecule (CD1C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu34795	XM_005245579.5 Latest version!	Homo sapiens CD1c molecule (CD1C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu03695	NM_001765.2	Homo sapiens CD1c molecule (CD1C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu34795	XM_005245579.4	Homo sapiens CD1c molecule (CD1C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD1C ( NM_001765.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001756.2 Homo sapiens CD1c molecule (CD1C), mRNA.

Price & Availability↑

CloneID	OHu03695
Clone ID Related Accession (Same CDS sequence)	NM_001765.3 , NM_001765.2
Accession Version	NM_001765.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD1c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121986.12, M28827.1 and AA824381.1. On Nov 23, 2018 this sequence version replaced NM_001765.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.131085.1, SRR1163657.175873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368170.8/ ENSP00000357152.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGG ACACCACTTT 
TCCATGAATT GGATTGCCTT GGTAGTGATA GTGCCCTTGG TGATTCTAAT AGTCCTTGTG 
TTATGGTTTA AGAAGCACTG CTCATATCAG GACATCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001756.2
CDS	143..1144
Translation	MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPAGLSCRVRHSSLGGQDIILYWGHHFSMNWIALVVIVPLVILIVLVLWFKKHCSYQDIL

Target ORF information:

RefSeq Version	NM_001765.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD1c molecule (CD1C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001765.3

ORF Insert Sequence:

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGG ACACCACTTT 
TCCATGAATT GGATTGCCTT GGTAGTGATA GTGCCCTTGG TGATTCTAAT AGTCCTTGTG 
TTATGGTTTA AGAAGCACTG CTCATATCAG GACATCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD1C ( NM_001765.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001756.2 Homo sapiens CD1c molecule (CD1C), mRNA.

Price & Availability↑

CloneID	OHu03695
Clone ID Related Accession (Same CDS sequence)	NM_001765.3 , NM_001765.2
Accession Version	NM_001765.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD1c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121986.12, M28827.1 and AA824381.1. On Jul 21, 2006 this sequence version replaced NM_001765.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK226024.1, SRR1163657.258555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGG ACACCACTTT 
TCCATGAATT GGATTGCCTT GGTAGTGATA GTGCCCTTGG TGATTCTAAT AGTCCTTGTG 
TTATGGTTTA AGAAGCACTG CTCATATCAG GACATCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001756.2
CDS	293..1294
Translation	MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPAGLSCRVRHSSLGGQDIILYWGHHFSMNWIALVVIVPLVILIVLVLWFKKHCSYQDIL

Target ORF information:

RefSeq Version	NM_001765.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD1c molecule (CD1C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001765.2

ORF Insert Sequence:

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGG ACACCACTTT 
TCCATGAATT GGATTGCCTT GGTAGTGATA GTGCCCTTGG TGATTCTAAT AGTCCTTGTG 
TTATGGTTTA AGAAGCACTG CTCATATCAG GACATCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD1C ( XM_005245579.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005245636.1 Homo sapiens CD1c molecule (CD1C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu34795
Clone ID Related Accession (Same CDS sequence)	XM_005245579.4 , XM_005245579.5
Accession Version	XM_005245579.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD1c isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005245579.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGC TCATATCAGG 
ACATCCTGTG AGACTCTTCC CCCTGACTCC CCCATTGTGT TAAGAACCCA GCAACCCAGG 
AGCCTAGTAC AATATAGTGA TGCCATCCCG TCGACTCTCC ATTTAAATTG TTTCTCTTTC 
TGCATAATAA ACATTTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005245636.1
CDS	293..1333
Translation	MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPAGLSCRVRHSSLGGQDIILYWAHIRTSCETLPPDSPIVLRTQQPRSLVQYSDAIPSTLHLNCFSFCIINIC

Target ORF information:

RefSeq Version	XM_005245579.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD1c molecule (CD1C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005245579.4

ORF Insert Sequence:

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGC TCATATCAGG 
ACATCCTGTG AGACTCTTCC CCCTGACTCC CCCATTGTGT TAAGAACCCA GCAACCCAGG 
AGCCTAGTAC AATATAGTGA TGCCATCCCG TCGACTCTCC ATTTAAATTG TTTCTCTTTC 
TGCATAATAA ACATTTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD1C ( XM_005245579.5 ) cDNA ORF clone, Homo sapiens(human) -> XP_005245636.1 Homo sapiens CD1c molecule (CD1C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu34795
Clone ID Related Accession (Same CDS sequence)	XM_005245579.4 , XM_005245579.5
Accession Version	XM_005245579.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	T-cell surface glycoprotein CD1c isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005245579.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGC TCATATCAGG 
ACATCCTGTG AGACTCTTCC CCCTGACTCC CCCATTGTGT TAAGAACCCA GCAACCCAGG 
AGCCTAGTAC AATATAGTGA TGCCATCCCG TCGACTCTCC ATTTAAATTG TTTCTCTTTC 
TGCATAATAA ACATTTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005245636.1
CDS	179..1219
Translation	MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPAGLSCRVRHSSLGGQDIILYWAHIRTSCETLPPDSPIVLRTQQPRSLVQYSDAIPSTLHLNCFSFCIINIC

Target ORF information:

RefSeq Version	XM_005245579.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CD1c molecule (CD1C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005245579.5

ORF Insert Sequence:

ATGCTGTTTC TGCAGTTTCT GCTGCTAGCT CTTCTTCTCC CAGGTGGTGA CAATGCAGAC 
GCATCCCAGG AACACGTCTC CTTCCATGTC ATCCAGATCT TCTCATTTGT CAACCAATCC 
TGGGCACGAG GTCAGGGCTC AGGATGGCTG GACGAGTTGC AGACTCATGG CTGGGACAGT 
GAATCAGGCA CAATAATTTT CCTGCATAAC TGGTCCAAGG GCAACTTCAG CAATGAAGAG 
TTGTCAGACC TAGAGTTGTT ATTTCGTTTC TACCTCTTTG GATTAACTCG GGAGATTCAA 
GACCATGCAA GTCAAGATTA CTCGAAATAT CCCTTTGAAG TACAGGTGAA AGCGGGCTGT 
GAGCTGCATT CTGGAAAGAG CCCAGAAGGC TTCTTTCAGG TAGCTTTCAA CGGATTAGAT 
TTACTGAGTT TCCAGAATAC AACATGGGTG CCATCTCCAG GCTGTGGAAG TTTGGCCCAA 
AGTGTCTGTC ATCTACTCAA TCATCAGTAT GAAGGCGTCA CAGAAACAGT GTATAATCTC 
ATAAGAAGCA CTTGCCCCCG ATTTCTCTTG GGTCTCCTGG ATGCAGGGAA GATGTATGTA 
CACAGGCAAG TGAGGCCAGA AGCCTGGCTG TCCAGTCGCC CCAGCCTTGG GTCTGGCCAG 
CTGTTGCTGG TTTGTCATGC CTCCGGCTTC TACCCAAAGC CTGTTTGGGT GACATGGATG 
CGGAATGAAC AGGAGCAACT GGGCACTAAA CATGGTGATA TTCTTCCTAA TGCTGATGGG 
ACATGGTATC TTCAGGTGAT CCTGGAGGTG GCATCTGAGG AGCCTGCTGG CCTGTCTTGT 
CGAGTGAGAC ACAGCAGTCT AGGAGGCCAG GACATCATCC TCTACTGGGC TCATATCAGG 
ACATCCTGTG AGACTCTTCC CCCTGACTCC CCCATTGTGT TAAGAACCCA GCAACCCAGG 
AGCCTAGTAC AATATAGTGA TGCCATCCCG TCGACTCTCC ATTTAAATTG TTTCTCTTTC 
TGCATAATAA ACATTTGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD1c+ Blood Dendritic Cells in Atopic Dermatitis are Premature and Can Produce Disease-specific Chemokines.
Acta dermato-venereologica97(3)325-331(2017 Mar)
Kapit?ny A,B?ke G,Nagy G,Doan-Xuan QM,Bacso Z,G?sp?r K,Boros G,Dajnoki Z,B?r? T,Rajnav?lgyi ?,Szegedi A

Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.
BioMed research international20176803756(2017)
Dyduch G,Tyrak KE,Glajcar A,Szpor J,Ulatowska-Bia?as M,Oko? K

MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c.
Journal of immunology (Baltimore, Md. : 1950)197(2)580-9(2016 07)
Wen Q,Zhou C,Xiong W,Su J,He J,Zhang S,Du X,Liu S,Wang J,Ma L

Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected ? cells.
Clinical and experimental immunology184(3)293-307(2016 06)
Schulte BM,Kers-Rebel ED,Bottino R,Piganelli JD,Galama JM,Engelse MA,de Koning EJ,Adema GJ

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CD1C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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