EIF1AY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF1AY
Entrez Gene ID	9086
Full Name	eukaryotic translation initiation factor 1A, Y-linked
Synonyms	eIF-4C
General protein information	Preferred Names eukaryotic translation initiation factor 1A, Y-linked Names eukaryotic translation initiation factor 1A, Y-chromosomal eIF-1A Y isoform eukaryotic translation initiation factor 1A, Y chromosome eukaryotic translation initiation factor 4C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.223
Summary	This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder MIM:	400014

mRNA and Protein(s)

mRNA	Protein	Name
NM_001278612.1	NP_001265541.1	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2
NM_004681.3	NP_004672.2	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1
NM_004681.4	NP_004672.2	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Eif1ax	NP_001100433.1
Danio rerio (zebrafish)	eif1axa	NP_001006082.1
Caenorhabditis elegans (roundworm)	eif-1.A	NP_500650.1
Homo sapiens (human)	EIF1AY	NP_004672.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003119	XP_312806.2
Pan troglodytes (chimpanzee)	EIF1AY	NP_001008977.1
Drosophila melanogaster (fruit fly)	eIF-1A	NP_524728.2
	EIF1AY	NP_001138524.1
Mus musculus (house mouse)	Eif1ax	NP_079713.2
Gallus gallus (chicken)	EIF1AY	NP_001025975.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.
Luna RE, Arthanari H, Hiraishi H, Akabayov B, Tang L, Cox C, Markus MA, Luna LE, Ikeda Y, Watanabe R, Bedoya E, Yu C, Alikhan S, Wagner G, Asano K
Biochemistry52(52)9510-8(2013 Dec)

Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls.
Tian Y, Stamova B, Jickling GC, Xu H, Liu D, Ander BP, Bushnell C, Zhan X, Turner RJ, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR
Gender medicine9(2)68-75.e3(2012 Apr)

HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation.
Kichine E, Roz? V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, L?vy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ
Human reproduction (Oxford, England)27(2)615-24(2012 Feb)

H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births.
Nielsen HS, Wu F, Aghai Z, Steffensen R, van Halteren AG, Spierings E, Christiansen OB, Miklos D, Goulmy E
Human reproduction (Oxford, England)25(11)2745-52(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The N-terminal tail of eIF1A mediates the interaction with eIF5 and eIF1.
Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of Y chromosome haplotypes with autism.

The following EIF1AY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF1AY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12123	NM_004681.4 Latest version!	Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11708	NM_001278612.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu12123	NM_004681.3	Homo sapiens eukaryotic translation initiation factor 1A, Y-linked (EIF1AY), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF1AY ( NM_004681.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004672.2 Homo sapiens eukaryotic translation initiation factor 1A, Y-linked (EIF1AY), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12123
Clone ID Related Accession (Same CDS sequence)	NM_004681.3 , NM_004681.4
Accession Version	NM_004681.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP331805.1, BG499107.1, BC005248.1, AF000987.1 and AC007678.3. On Jul 2, 2013 this sequence version replaced NM_004681.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF000987.1, SRR1660807.43701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAGA ATAAAGGTAA AGGAGGTAAA AACAGGCGCA GGGGTAAAAA TGAGAATGAA 
TCTGAAAAAA GAGAGTTGGT GTTTAAAGAG GATGGACAAG AGTATGCTCA GGTAATCAAA 
ATGTTGGGAA ATGGACGATT GGAAGCATTG TGTTTTGATG GTGTAAAGAG GTTATGCCAT 
ATCAGAGGGA AATTGAGAAA AAAGGTTTGG ATAAATACAT CAGACATTAT ATTGGTTGGT 
CTACGGGACT ATCAGGATAA CAAAGCTGAT GTAATTTTAA AGTACAATGC AGATGAAGCT 
AGAAGCCTGA AGGCATATGG CGAGCTTCCA GAACATGCTA AAATCAATGA AACAGACACA 
TTTGGTCCTG GAGATGATGA TGAAATCCAG TTTGACGATA TTGGAGATGA TGATGAAGAC 
ATTGATGATA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004672.2
CDS	162..596
Translation	MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI

Target ORF information:

RefSeq Version	NM_004681.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 1A, Y-linked (EIF1AY), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004681.3

ORF Insert Sequence:

ATGCCCAAGA ATAAAGGTAA AGGAGGTAAA AACAGGCGCA GGGGTAAAAA TGAGAATGAA 
TCTGAAAAAA GAGAGTTGGT GTTTAAAGAG GATGGACAAG AGTATGCTCA GGTAATCAAA 
ATGTTGGGAA ATGGACGATT GGAAGCATTG TGTTTTGATG GTGTAAAGAG GTTATGCCAT 
ATCAGAGGGA AATTGAGAAA AAAGGTTTGG ATAAATACAT CAGACATTAT ATTGGTTGGT 
CTACGGGACT ATCAGGATAA CAAAGCTGAT GTAATTTTAA AGTACAATGC AGATGAAGCT 
AGAAGCCTGA AGGCATATGG CGAGCTTCCA GAACATGCTA AAATCAATGA AACAGACACA 
TTTGGTCCTG GAGATGATGA TGAAATCCAG TTTGACGATA TTGGAGATGA TGATGAAGAC 
ATTGATGATA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF1AY ( NM_004681.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004672.2 Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12123
Clone ID Related Accession (Same CDS sequence)	NM_004681.3 , NM_004681.4
Accession Version	NM_004681.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG499107.1, BC005248.1, AF000987.1 and AC007678.3. On Nov 22, 2018 this sequence version replaced NM_004681.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF000987.1, SRR5189655.181521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361365.7/ ENSP00000354722.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAAGA ATAAAGGTAA AGGAGGTAAA AACAGGCGCA GGGGTAAAAA TGAGAATGAA 
TCTGAAAAAA GAGAGTTGGT GTTTAAAGAG GATGGACAAG AGTATGCTCA GGTAATCAAA 
ATGTTGGGAA ATGGACGATT GGAAGCATTG TGTTTTGATG GTGTAAAGAG GTTATGCCAT 
ATCAGAGGGA AATTGAGAAA AAAGGTTTGG ATAAATACAT CAGACATTAT ATTGGTTGGT 
CTACGGGACT ATCAGGATAA CAAAGCTGAT GTAATTTTAA AGTACAATGC AGATGAAGCT 
AGAAGCCTGA AGGCATATGG CGAGCTTCCA GAACATGCTA AAATCAATGA AACAGACACA 
TTTGGTCCTG GAGATGATGA TGAAATCCAG TTTGACGATA TTGGAGATGA TGATGAAGAC 
ATTGATGATA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004672.2
CDS	97..531
Translation	MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI

Target ORF information:

RefSeq Version	NM_004681.4
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004681.4

ORF Insert Sequence:

ATGCCCAAGA ATAAAGGTAA AGGAGGTAAA AACAGGCGCA GGGGTAAAAA TGAGAATGAA 
TCTGAAAAAA GAGAGTTGGT GTTTAAAGAG GATGGACAAG AGTATGCTCA GGTAATCAAA 
ATGTTGGGAA ATGGACGATT GGAAGCATTG TGTTTTGATG GTGTAAAGAG GTTATGCCAT 
ATCAGAGGGA AATTGAGAAA AAAGGTTTGG ATAAATACAT CAGACATTAT ATTGGTTGGT 
CTACGGGACT ATCAGGATAA CAAAGCTGAT GTAATTTTAA AGTACAATGC AGATGAAGCT 
AGAAGCCTGA AGGCATATGG CGAGCTTCCA GAACATGCTA AAATCAATGA AACAGACACA 
TTTGGTCCTG GAGATGATGA TGAAATCCAG TTTGACGATA TTGGAGATGA TGATGAAGAC 
ATTGATGATA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF1AY ( NM_001278612.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265541.1 Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11708
Clone ID Related Accession (Same CDS sequence)	NM_001278612.1
Accession Version	NM_001278612.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP331805.1, BG499107.1, DQ786267.1, AF000987.1 and AC007678.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.190441.1, SRR1163657.199479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAAGA ATAAAGGTAA AGGAGGTAAA AACAGGCGCA GGGGTAAAAA TGAGAATGAA 
TCTGAAAAAA GAGAGTTGGT GTTTAAAGAG GATGGACAAG AGTATGCTCA GGTAATCAAA 
ATGTTGGGAA ATGGACGATT GGAAGCATTG TGTTTTGATG GTGTAAAGAG GTTATGCCAT 
ATCAGAGGGA AATTGAGAAA AAAGGATAAC AAAGCTGATG TAATTTTAAA GTACAATGCA 
GATGAAGCTA GAAGCCTGAA GGCATATGGC GAGCTTCCAG AACATGCTAA AATCAATGAA 
ACAGACACAT TTGGTCCTGG AGATGATGAT GAAATCCAGT TTGACGATAT TGGAGATGAT 
GATGAAGACA TTGATGATAT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265541.1
CDS	162..545
Translation	MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI

Target ORF information:

RefSeq Version	NM_001278612.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 1A Y-linked (EIF1AY), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278612.1

ORF Insert Sequence:

ATGCCCAAGA ATAAAGGTAA AGGAGGTAAA AACAGGCGCA GGGGTAAAAA TGAGAATGAA 
TCTGAAAAAA GAGAGTTGGT GTTTAAAGAG GATGGACAAG AGTATGCTCA GGTAATCAAA 
ATGTTGGGAA ATGGACGATT GGAAGCATTG TGTTTTGATG GTGTAAAGAG GTTATGCCAT 
ATCAGAGGGA AATTGAGAAA AAAGGATAAC AAAGCTGATG TAATTTTAAA GTACAATGCA 
GATGAAGCTA GAAGCCTGAA GGCATATGGC GAGCTTCCAG AACATGCTAA AATCAATGAA 
ACAGACACAT TTGGTCCTGG AGATGATGAT GAAATCCAGT TTGACGATAT TGGAGATGAT 
GATGAAGACA TTGATGATAT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.
Biochemistry52(52)9510-8(2013 Dec)
Luna RE,Arthanari H,Hiraishi H,Akabayov B,Tang L,Cox C,Markus MA,Luna LE,Ikeda Y,Watanabe R,Bedoya E,Yu C,Alikhan S,Wagner G,Asano K

Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls.
Gender medicine9(2)68-75.e3(2012 Apr)
Tian Y,Stamova B,Jickling GC,Xu H,Liu D,Ander BP,Bushnell C,Zhan X,Turner RJ,Davis RR,Verro P,Pevec WC,Hedayati N,Dawson DL,Khoury J,Jauch EC,Pancioli A,Broderick JP,Sharp FR

HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation.
Human reproduction (Oxford, England)27(2)615-24(2012 Feb)
Kichine E,Roz? V,Di Cristofaro J,Taulier D,Navarro A,Streichemberger E,Decarpentrie F,Metzler-Guillemain C,L?vy N,Chiaroni J,Paquis-Flucklinger V,Fellmann F,Mitchell MJ

H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births.
Human reproduction (Oxford, England)25(11)2745-52(2010 Nov)
Nielsen HS,Wu F,Aghai Z,Steffensen R,van Halteren AG,Spierings E,Christiansen OB,Miklos D,Goulmy E

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EIF1AY cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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