ZNF598 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZNF598
Entrez Gene ID	90850
Full Name	zinc finger protein 598
Synonyms	HEL2
General protein information	Preferred Names zinc finger protein 598 Names E3 ubiquitin-protein ligase ZNF598
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012].
Disorder MIM:	617508

mRNA and Protein(s)

mRNA	Protein	Name
NM_178167.4	NP_835461.2	E3 ubiquitin-protein ligase ZNF598
NM_178167.3	NP_835461.2	E3 ubiquitin-protein ligase ZNF598

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ZNF598	XP_003314963.2
Rattus norvegicus (Norway rat)	Zfp598	NP_001099240.1
	ZNF598	XP_001082834.2
Gallus gallus (chicken)	ZNF598	XP_414850.2
Xenopus tropicalis (tropical clawed frog)	znf598	NP_001119543.1
Homo sapiens (human)	ZNF598	NP_835461.2
Bos taurus (cattle)	ZNF598	XP_003587855.1
Mus musculus (house mouse)	Zfp598	NP_898972.1
Canis lupus familiaris (dog)	ZNF598	XP_005621769.1
Danio rerio (zebrafish)	znf598	NP_001028890.1

Gene Ontology
Bibliography

Related articles in PubMed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.
Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N
Nature communications816056(2017 Jul)

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ
Molecular cell65(4)751-760.e4(2017 Feb)

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.
Juszkiewicz S, Hegde RS
Molecular cell65(4)743-750.e4(2017 Feb)

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N
Molecular and cellular biology32(17)3585-93(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ZNF598, RACK1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosome-associated quality control pathways.
Title: ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.

The following ZNF598 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZNF598 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20969	NM_178167.4 Latest version!	Homo sapiens zinc finger protein 598 (ZNF598), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
View Old Accession Versions >>
OHu20969	NM_178167.3	Homo sapiens zinc finger protein 598 (ZNF598), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZNF598 ( NM_178167.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_835461.2 Homo sapiens zinc finger protein 598 (ZNF598), mRNA.

Price & Availability↑

CloneID	OHu20969
Clone ID Related Accession (Same CDS sequence)	NM_178167.4 , NM_178167.3
Accession Version	NM_178167.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2715bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase ZNF598
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005606.3, BC050477.1, BC041015.1 and CA309611.1. This sequence is a reference standard in the RefSeqGene project. On Nov 8, 2018 this sequence version replaced NM_178167.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC050477.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCGGCGG CGGGGGGCGC CGAGGGGCGG CGCGCGGCCC TGGAGGCGGC GGCGGCGGCA 
GCTCCTGAGC GGGGAGGCGG GAGCTGCGTG CTGTGCTGCG GAGACCTGGA GGCCACGGCG 
CTGGGCCGCT GCGACCACCC GGTGTGCTAC CGCTGCTCTA CCAAGATGCG GGTGCTCTGC 
GAGCAGCGCT ACTGCGCCGT GTGCCGCGAG GAGCTGCGCC AGGTGGTCTT TGGGAAGAAG 
CTTCCTGCCT TTGCCACCAT CCCCATCCAC CAGCTGCAGC ATGAGAAGAA ATATGATATC 
TACTTTGCAG ATGGAAAGGT GTACGCATTG TACAGGCAGC TGCTGCAGCA CGAGTGCCCG 
CGGTGCCCCG AGCTGCCACC TTTCAGCCTC TTCGGGGACC TGGAGCAGCA CATGCGGAGG 
CAGCATGAGC TCTTCTGCTG CCGTCTGTGC CTCCAGCACC TCCAGATCTT CACATATGAG 
CGCAAGTGGT ACTCGCGCAA GGACCTGGCC CGGCATCGCA TGCAGGGTGA CCCCGATGAC 
ACGTCGCACC GTGGGCACCC GCTCTGCAAG TTCTGTGACG AGCGCTACCT GGACAATGAT 
GAGCTGCTTA AGCACCTGCG CCGCGACCAC TACTTCTGCC ACTTCTGCGA CTCGGACGGG 
GCCCAGGACT ACTACAGCGA CTATGCCTAC CTGCGTGAGC ACTTCCGGGA GAAGCACTTT 
CTGTGTGAGG AAGGCCGCTG CAGCACGGAG CAGTTCACCC ACGCCTTCCG CACCGAGATC 
GACCTCAAGG CCCACAGGAC GGCCTGCCAC AGTCGCAGCC GCGCCGAGGC ACGCCAGAAC 
CGCCACATCG ACCTGCAGTT CAGCTACGCG CCACGGCACT CGCGCCGGAA CGAGGGGGTC 
GTTGGTGGCG AAGACTACGA GGAGGTGGAC AGGTACAGCC GCCAGGGCCG AGTGGCCCGG 
GCTGGCACTC GCGGAGCCCA GCAGAGCCGC CGAGGAAGCT GGAGGTACAA AAGGGAAGAA 
GAGGACCGAG AAGTAGCAGC TGCTGTCCGG GCCTCCGTGG CCGCACAGCA GCAGGAGGAG 
GCTCGCAGGA GTGAGGATCA GGAGGAAGGC GGTAGGCCCA AGAAGGAGGA GGCAGCGGCG 
CGGGGACCTG AGGATCCCCG TGGCCCCCGG CGCTCACCCC GGACTCAGGG CGAAGGCCCA 
GGCCCCAAGG AAACCTCGAC AAATGGTCCT GTAAGCCAAG AAGCCTTCTC GGTGACAGGC 
CCAGCCGCCC CAGGGTGTGT GGGGGTGCCA GGCGCCCTCC CACCACCCAG CCCGAAGCTC 
AAGGACGAAG ACTTCCCCAG CCTCTCTGCC TCCACTTCCT CCTCCTGCTC CACTGCAGCA 
ACCCCGGGCC CTGTGGGGTT GGCGCTGCCG TACGCCATCC CTGCCAGAGG CAGGAGTGCC 
TTCCAGGAGG AGGACTTCCC CGCCCTGGTG TCCTCGGTGC CCAAGCCTGG CACCGCCCCC 
ACCAGCCTTG TCTCTGCCTG GAACAGCAGC AGTAGCAGCA AGAAGGTAGC ACAGCCCCCA 
CTCTCGGCGC AGGCTACCGG CAGCGGCCAG CCCACCAGGA AGGCTGGGAA GGGGAGCAGG 
GGCGGCAGGA AGGGCGGCCC GCCCTTCACA CAGGAGGAGG AGGAGGACGG CGGCCCGGCC 
CTGCAGGAGC TTCTGAGCAC ACGCCCCACG GGCTCCGTCT CCTCCACACT GGGGCTGGCC 
TCCATCCAAC CCTCTAAAGT TGGGAAGAAG AAGAAAGTGG GCTCGGAGAA GCCAGGCACC 
ACATTGCCAC AGCCCCCGCC CGCTACCTGT CCCCCAGGGG CTTTGCAGGC CCCGGAAGCT 
CCTGCCAGCA GAGCCGAGGG GCCAGTTGCC GTCGTCGTTA ATGGACACAT GGAGGGCCCG 
GCCCCTGCTC GGAGTGCCCC CAAGGAACCC CCTGGGCTCC CAAGGCCCCT GGGGTCCTTC 
CCCTGCCCCA CGCCACAGGA GGACTTCCCA GCGCTCGGCG GCCCCTGCCC ACCCCGGATG 
CCGCCGCCCC CAGGCTTCAG CGCTGTGGTG CTCCTGAAGG GCACGCCTCC CCCACCCCCG 
CCGGGCCTGG TGCCCCCAAT CAGCAAGCCG CCCCCTGGCT TCTCTGGCCT TCTGCCTAGC 
CCCCACCCGG CCTGTGTCCC CAGCCCCGCC ACCACCACCA CCACAAAAGC ACCCAGGCTG 
CTGCCTGCCC CACGGGCGTA CCTAGTCCCC GAGAACTTCC GGGAGAGGAA CCTTCAGCTC 
ATCCAGTCCA TCAGGGACTT CCTGCAGAGC GACGAGGCCC GCTTCAGCGA GTTCAAGAGC 
CACTCAGGGG AGTTCAGACA GGGCCTGATC TCCGCAGCCC AGTATTACAA GAGTTGCCGG 
GACCTGCTGG GGGAGAATTT CCAGAAGGTC TTTAATGAGC TGCTGGTCCT GCTGCCCGAC 
ACGGCCAAGC AGCAGGAGCT CCTGTCTGCA CACACGGACT TCTGCAACCG CGAGAAGCCT 
CTGAGCACCA AGTCCAAGAA GAACAAGAAG AGCGCGTGGC AGGCCACCAC CCAGCAGGCG 
GGCCTGGACT GCCGTGTGTG CCCCACCTGC CAGCAGGTGC TCGCGCATGG CGATGCCAGC 
AGCCACCAGG CGCTGCATGC TGCCCGGGAC GACGACTTCC CCTCCCTGCA AGCCATCGCC 
AGGATCATCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835461.2
CDS	75..2789
Translation	MAAAGGAEGRRAALEAAAAAAPERGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLCEQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAEARQNRHIDLQFSYAPRHSRRNEGVVGGEDYEEVDRYSRQGRVARAGTRGAQQSRRGSWRYKREEEDREVAAAVRASVAAQQQEEARRSEDQEEGGRPKKEEAAARGPEDPRGPRRSPRTQGEGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPGALPPPSPKLKDEDFPSLSASTSSSCSTAATPGPVGLALPYAIPARGRSAFQEEDFPALVSSVPKPGTAPTSLVSAWNSSSSSKKVAQPPLSAQATGSGQPTRKAGKGSRGGRKGGPPFTQEEEEDGGPALQELLSTRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGTTLPQPPPATCPPGALQAPEAPASRAEGPVAVVVNGHMEGPAPARSAPKEPPGLPRPLGSFPCPTPQEDFPALGGPCPPRMPPPPGFSAVVLLKGTPPPPPPGLVPPISKPPPGFSGLLPSPHPACVPSPATTTTTKAPRLLPAPRAYLVPENFRERNLQLIQSIRDFLQSDEARFSEFKSHSGEFRQGLISAAQYYKSCRDLLGENFQKVFNELLVLLPDTAKQQELLSAHTDFCNREKPLSTKSKKNKKSAWQATTQQAGLDCRVCPTCQQVLAHGDASSHQALHAARDDDFPSLQAIARIIT

Target ORF information:

RefSeq Version	NM_178167.4
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger protein 598 (ZNF598), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178167.4

ORF Insert Sequence:

ATGGCGGCGG CGGGGGGCGC CGAGGGGCGG CGCGCGGCCC TGGAGGCGGC GGCGGCGGCA 
GCTCCTGAGC GGGGAGGCGG GAGCTGCGTG CTGTGCTGCG GAGACCTGGA GGCCACGGCG 
CTGGGCCGCT GCGACCACCC GGTGTGCTAC CGCTGCTCTA CCAAGATGCG GGTGCTCTGC 
GAGCAGCGCT ACTGCGCCGT GTGCCGCGAG GAGCTGCGCC AGGTGGTCTT TGGGAAGAAG 
CTTCCTGCCT TTGCCACCAT CCCCATCCAC CAGCTGCAGC ATGAGAAGAA ATATGATATC 
TACTTTGCAG ATGGAAAGGT GTACGCATTG TACAGGCAGC TGCTGCAGCA CGAGTGCCCG 
CGGTGCCCCG AGCTGCCACC TTTCAGCCTC TTCGGGGACC TGGAGCAGCA CATGCGGAGG 
CAGCATGAGC TCTTCTGCTG CCGTCTGTGC CTCCAGCACC TCCAGATCTT CACATATGAG 
CGCAAGTGGT ACTCGCGCAA GGACCTGGCC CGGCATCGCA TGCAGGGTGA CCCCGATGAC 
ACGTCGCACC GTGGGCACCC GCTCTGCAAG TTCTGTGACG AGCGCTACCT GGACAATGAT 
GAGCTGCTTA AGCACCTGCG CCGCGACCAC TACTTCTGCC ACTTCTGCGA CTCGGACGGG 
GCCCAGGACT ACTACAGCGA CTATGCCTAC CTGCGTGAGC ACTTCCGGGA GAAGCACTTT 
CTGTGTGAGG AAGGCCGCTG CAGCACGGAG CAGTTCACCC ACGCCTTCCG CACCGAGATC 
GACCTCAAGG CCCACAGGAC GGCCTGCCAC AGTCGCAGCC GCGCCGAGGC ACGCCAGAAC 
CGCCACATCG ACCTGCAGTT CAGCTACGCG CCACGGCACT CGCGCCGGAA CGAGGGGGTC 
GTTGGTGGCG AAGACTACGA GGAGGTGGAC AGGTACAGCC GCCAGGGCCG AGTGGCCCGG 
GCTGGCACTC GCGGAGCCCA GCAGAGCCGC CGAGGAAGCT GGAGGTACAA AAGGGAAGAA 
GAGGACCGAG AAGTAGCAGC TGCTGTCCGG GCCTCCGTGG CCGCACAGCA GCAGGAGGAG 
GCTCGCAGGA GTGAGGATCA GGAGGAAGGC GGTAGGCCCA AGAAGGAGGA GGCAGCGGCG 
CGGGGACCTG AGGATCCCCG TGGCCCCCGG CGCTCACCCC GGACTCAGGG CGAAGGCCCA 
GGCCCCAAGG AAACCTCGAC AAATGGTCCT GTAAGCCAAG AAGCCTTCTC GGTGACAGGC 
CCAGCCGCCC CAGGGTGTGT GGGGGTGCCA GGCGCCCTCC CACCACCCAG CCCGAAGCTC 
AAGGACGAAG ACTTCCCCAG CCTCTCTGCC TCCACTTCCT CCTCCTGCTC CACTGCAGCA 
ACCCCGGGCC CTGTGGGGTT GGCGCTGCCG TACGCCATCC CTGCCAGAGG CAGGAGTGCC 
TTCCAGGAGG AGGACTTCCC CGCCCTGGTG TCCTCGGTGC CCAAGCCTGG CACCGCCCCC 
ACCAGCCTTG TCTCTGCCTG GAACAGCAGC AGTAGCAGCA AGAAGGTAGC ACAGCCCCCA 
CTCTCGGCGC AGGCTACCGG CAGCGGCCAG CCCACCAGGA AGGCTGGGAA GGGGAGCAGG 
GGCGGCAGGA AGGGCGGCCC GCCCTTCACA CAGGAGGAGG AGGAGGACGG CGGCCCGGCC 
CTGCAGGAGC TTCTGAGCAC ACGCCCCACG GGCTCCGTCT CCTCCACACT GGGGCTGGCC 
TCCATCCAAC CCTCTAAAGT TGGGAAGAAG AAGAAAGTGG GCTCGGAGAA GCCAGGCACC 
ACATTGCCAC AGCCCCCGCC CGCTACCTGT CCCCCAGGGG CTTTGCAGGC CCCGGAAGCT 
CCTGCCAGCA GAGCCGAGGG GCCAGTTGCC GTCGTCGTTA ATGGACACAT GGAGGGCCCG 
GCCCCTGCTC GGAGTGCCCC CAAGGAACCC CCTGGGCTCC CAAGGCCCCT GGGGTCCTTC 
CCCTGCCCCA CGCCACAGGA GGACTTCCCA GCGCTCGGCG GCCCCTGCCC ACCCCGGATG 
CCGCCGCCCC CAGGCTTCAG CGCTGTGGTG CTCCTGAAGG GCACGCCTCC CCCACCCCCG 
CCGGGCCTGG TGCCCCCAAT CAGCAAGCCG CCCCCTGGCT TCTCTGGCCT TCTGCCTAGC 
CCCCACCCGG CCTGTGTCCC CAGCCCCGCC ACCACCACCA CCACAAAAGC ACCCAGGCTG 
CTGCCTGCCC CACGGGCGTA CCTAGTCCCC GAGAACTTCC GGGAGAGGAA CCTTCAGCTC 
ATCCAGTCCA TCAGGGACTT CCTGCAGAGC GACGAGGCCC GCTTCAGCGA GTTCAAGAGC 
CACTCAGGGG AGTTCAGACA GGGCCTGATC TCCGCAGCCC AGTATTACAA GAGTTGCCGG 
GACCTGCTGG GGGAGAATTT CCAGAAGGTC TTTAATGAGC TGCTGGTCCT GCTGCCCGAC 
ACGGCCAAGC AGCAGGAGCT CCTGTCTGCA CACACGGACT TCTGCAACCG CGAGAAGCCT 
CTGAGCACCA AGTCCAAGAA GAACAAGAAG AGCGCGTGGC AGGCCACCAC CCAGCAGGCG 
GGCCTGGACT GCCGTGTGTG CCCCACCTGC CAGCAGGTGC TCGCGCATGG CGATGCCAGC 
AGCCACCAGG CGCTGCATGC TGCCCGGGAC GACGACTTCC CCTCCCTGCA AGCCATCGCC 
AGGATCATCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNF598 ( NM_178167.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_835461.2 Homo sapiens zinc finger protein 598 (ZNF598), mRNA.

Price & Availability↑

CloneID	OHu20969
Clone ID Related Accession (Same CDS sequence)	NM_178167.4 , NM_178167.3
Accession Version	NM_178167.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2715bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase ZNF598
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005606.3, BC050477.1, BC041015.1 and CA309611.1. This sequence is a reference standard in the RefSeqGene project. On Oct 20, 2012 this sequence version replaced NM_178167.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC050477.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGG CGGGGGGCGC CGAGGGGCGG CGCGCGGCCC TGGAGGCGGC GGCGGCGGCA 
GCTCCTGAGC GGGGAGGCGG GAGCTGCGTG CTGTGCTGCG GAGACCTGGA GGCCACGGCG 
CTGGGCCGCT GCGACCACCC GGTGTGCTAC CGCTGCTCTA CCAAGATGCG GGTGCTCTGC 
GAGCAGCGCT ACTGCGCCGT GTGCCGCGAG GAGCTGCGCC AGGTGGTCTT TGGGAAGAAG 
CTTCCTGCCT TTGCCACCAT CCCCATCCAC CAGCTGCAGC ATGAGAAGAA ATATGATATC 
TACTTTGCAG ATGGAAAGGT GTACGCATTG TACAGGCAGC TGCTGCAGCA CGAGTGCCCG 
CGGTGCCCCG AGCTGCCACC TTTCAGCCTC TTCGGGGACC TGGAGCAGCA CATGCGGAGG 
CAGCATGAGC TCTTCTGCTG CCGTCTGTGC CTCCAGCACC TCCAGATCTT CACATATGAG 
CGCAAGTGGT ACTCGCGCAA GGACCTGGCC CGGCATCGCA TGCAGGGTGA CCCCGATGAC 
ACGTCGCACC GTGGGCACCC GCTCTGCAAG TTCTGTGACG AGCGCTACCT GGACAATGAT 
GAGCTGCTTA AGCACCTGCG CCGCGACCAC TACTTCTGCC ACTTCTGCGA CTCGGACGGG 
GCCCAGGACT ACTACAGCGA CTATGCCTAC CTGCGTGAGC ACTTCCGGGA GAAGCACTTT 
CTGTGTGAGG AAGGCCGCTG CAGCACGGAG CAGTTCACCC ACGCCTTCCG CACCGAGATC 
GACCTCAAGG CCCACAGGAC GGCCTGCCAC AGTCGCAGCC GCGCCGAGGC ACGCCAGAAC 
CGCCACATCG ACCTGCAGTT CAGCTACGCG CCACGGCACT CGCGCCGGAA CGAGGGGGTC 
GTTGGTGGCG AAGACTACGA GGAGGTGGAC AGGTACAGCC GCCAGGGCCG AGTGGCCCGG 
GCTGGCACTC GCGGAGCCCA GCAGAGCCGC CGAGGAAGCT GGAGGTACAA AAGGGAAGAA 
GAGGACCGAG AAGTAGCAGC TGCTGTCCGG GCCTCCGTGG CCGCACAGCA GCAGGAGGAG 
GCTCGCAGGA GTGAGGATCA GGAGGAAGGC GGTAGGCCCA AGAAGGAGGA GGCAGCGGCG 
CGGGGACCTG AGGATCCCCG TGGCCCCCGG CGCTCACCCC GGACTCAGGG CGAAGGCCCA 
GGCCCCAAGG AAACCTCGAC AAATGGTCCT GTAAGCCAAG AAGCCTTCTC GGTGACAGGC 
CCAGCCGCCC CAGGGTGTGT GGGGGTGCCA GGCGCCCTCC CACCACCCAG CCCGAAGCTC 
AAGGACGAAG ACTTCCCCAG CCTCTCTGCC TCCACTTCCT CCTCCTGCTC CACTGCAGCA 
ACCCCGGGCC CTGTGGGGTT GGCGCTGCCG TACGCCATCC CTGCCAGAGG CAGGAGTGCC 
TTCCAGGAGG AGGACTTCCC CGCCCTGGTG TCCTCGGTGC CCAAGCCTGG CACCGCCCCC 
ACCAGCCTTG TCTCTGCCTG GAACAGCAGC AGTAGCAGCA AGAAGGTAGC ACAGCCCCCA 
CTCTCGGCGC AGGCTACCGG CAGCGGCCAG CCCACCAGGA AGGCTGGGAA GGGGAGCAGG 
GGCGGCAGGA AGGGCGGCCC GCCCTTCACA CAGGAGGAGG AGGAGGACGG CGGCCCGGCC 
CTGCAGGAGC TTCTGAGCAC ACGCCCCACG GGCTCCGTCT CCTCCACACT GGGGCTGGCC 
TCCATCCAAC CCTCTAAAGT TGGGAAGAAG AAGAAAGTGG GCTCGGAGAA GCCAGGCACC 
ACATTGCCAC AGCCCCCGCC CGCTACCTGT CCCCCAGGGG CTTTGCAGGC CCCGGAAGCT 
CCTGCCAGCA GAGCCGAGGG GCCAGTTGCC GTCGTCGTTA ATGGACACAT GGAGGGCCCG 
GCCCCTGCTC GGAGTGCCCC CAAGGAACCC CCTGGGCTCC CAAGGCCCCT GGGGTCCTTC 
CCCTGCCCCA CGCCACAGGA GGACTTCCCA GCGCTCGGCG GCCCCTGCCC ACCCCGGATG 
CCGCCGCCCC CAGGCTTCAG CGCTGTGGTG CTCCTGAAGG GCACGCCTCC CCCACCCCCG 
CCGGGCCTGG TGCCCCCAAT CAGCAAGCCG CCCCCTGGCT TCTCTGGCCT TCTGCCTAGC 
CCCCACCCGG CCTGTGTCCC CAGCCCCGCC ACCACCACCA CCACAAAAGC ACCCAGGCTG 
CTGCCTGCCC CACGGGCGTA CCTAGTCCCC GAGAACTTCC GGGAGAGGAA CCTTCAGCTC 
ATCCAGTCCA TCAGGGACTT CCTGCAGAGC GACGAGGCCC GCTTCAGCGA GTTCAAGAGC 
CACTCAGGGG AGTTCAGACA GGGCCTGATC TCCGCAGCCC AGTATTACAA GAGTTGCCGG 
GACCTGCTGG GGGAGAATTT CCAGAAGGTC TTTAATGAGC TGCTGGTCCT GCTGCCCGAC 
ACGGCCAAGC AGCAGGAGCT CCTGTCTGCA CACACGGACT TCTGCAACCG CGAGAAGCCT 
CTGAGCACCA AGTCCAAGAA GAACAAGAAG AGCGCGTGGC AGGCCACCAC CCAGCAGGCG 
GGCCTGGACT GCCGTGTGTG CCCCACCTGC CAGCAGGTGC TCGCGCATGG CGATGCCAGC 
AGCCACCAGG CGCTGCATGC TGCCCGGGAC GACGACTTCC CCTCCCTGCA AGCCATCGCC 
AGGATCATCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835461.2
CDS	75..2789
Translation	MAAAGGAEGRRAALEAAAAAAPERGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLCEQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAEARQNRHIDLQFSYAPRHSRRNEGVVGGEDYEEVDRYSRQGRVARAGTRGAQQSRRGSWRYKREEEDREVAAAVRASVAAQQQEEARRSEDQEEGGRPKKEEAAARGPEDPRGPRRSPRTQGEGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPGALPPPSPKLKDEDFPSLSASTSSSCSTAATPGPVGLALPYAIPARGRSAFQEEDFPALVSSVPKPGTAPTSLVSAWNSSSSSKKVAQPPLSAQATGSGQPTRKAGKGSRGGRKGGPPFTQEEEEDGGPALQELLSTRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGTTLPQPPPATCPPGALQAPEAPASRAEGPVAVVVNGHMEGPAPARSAPKEPPGLPRPLGSFPCPTPQEDFPALGGPCPPRMPPPPGFSAVVLLKGTPPPPPPGLVPPISKPPPGFSGLLPSPHPACVPSPATTTTTKAPRLLPAPRAYLVPENFRERNLQLIQSIRDFLQSDEARFSEFKSHSGEFRQGLISAAQYYKSCRDLLGENFQKVFNELLVLLPDTAKQQELLSAHTDFCNREKPLSTKSKKNKKSAWQATTQQAGLDCRVCPTCQQVLAHGDASSHQALHAARDDDFPSLQAIARIIT

Target ORF information:

RefSeq Version	NM_178167.3
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger protein 598 (ZNF598), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178167.3

ORF Insert Sequence:

ATGGCGGCGG CGGGGGGCGC CGAGGGGCGG CGCGCGGCCC TGGAGGCGGC GGCGGCGGCA 
GCTCCTGAGC GGGGAGGCGG GAGCTGCGTG CTGTGCTGCG GAGACCTGGA GGCCACGGCG 
CTGGGCCGCT GCGACCACCC GGTGTGCTAC CGCTGCTCTA CCAAGATGCG GGTGCTCTGC 
GAGCAGCGCT ACTGCGCCGT GTGCCGCGAG GAGCTGCGCC AGGTGGTCTT TGGGAAGAAG 
CTTCCTGCCT TTGCCACCAT CCCCATCCAC CAGCTGCAGC ATGAGAAGAA ATATGATATC 
TACTTTGCAG ATGGAAAGGT GTACGCATTG TACAGGCAGC TGCTGCAGCA CGAGTGCCCG 
CGGTGCCCCG AGCTGCCACC TTTCAGCCTC TTCGGGGACC TGGAGCAGCA CATGCGGAGG 
CAGCATGAGC TCTTCTGCTG CCGTCTGTGC CTCCAGCACC TCCAGATCTT CACATATGAG 
CGCAAGTGGT ACTCGCGCAA GGACCTGGCC CGGCATCGCA TGCAGGGTGA CCCCGATGAC 
ACGTCGCACC GTGGGCACCC GCTCTGCAAG TTCTGTGACG AGCGCTACCT GGACAATGAT 
GAGCTGCTTA AGCACCTGCG CCGCGACCAC TACTTCTGCC ACTTCTGCGA CTCGGACGGG 
GCCCAGGACT ACTACAGCGA CTATGCCTAC CTGCGTGAGC ACTTCCGGGA GAAGCACTTT 
CTGTGTGAGG AAGGCCGCTG CAGCACGGAG CAGTTCACCC ACGCCTTCCG CACCGAGATC 
GACCTCAAGG CCCACAGGAC GGCCTGCCAC AGTCGCAGCC GCGCCGAGGC ACGCCAGAAC 
CGCCACATCG ACCTGCAGTT CAGCTACGCG CCACGGCACT CGCGCCGGAA CGAGGGGGTC 
GTTGGTGGCG AAGACTACGA GGAGGTGGAC AGGTACAGCC GCCAGGGCCG AGTGGCCCGG 
GCTGGCACTC GCGGAGCCCA GCAGAGCCGC CGAGGAAGCT GGAGGTACAA AAGGGAAGAA 
GAGGACCGAG AAGTAGCAGC TGCTGTCCGG GCCTCCGTGG CCGCACAGCA GCAGGAGGAG 
GCTCGCAGGA GTGAGGATCA GGAGGAAGGC GGTAGGCCCA AGAAGGAGGA GGCAGCGGCG 
CGGGGACCTG AGGATCCCCG TGGCCCCCGG CGCTCACCCC GGACTCAGGG CGAAGGCCCA 
GGCCCCAAGG AAACCTCGAC AAATGGTCCT GTAAGCCAAG AAGCCTTCTC GGTGACAGGC 
CCAGCCGCCC CAGGGTGTGT GGGGGTGCCA GGCGCCCTCC CACCACCCAG CCCGAAGCTC 
AAGGACGAAG ACTTCCCCAG CCTCTCTGCC TCCACTTCCT CCTCCTGCTC CACTGCAGCA 
ACCCCGGGCC CTGTGGGGTT GGCGCTGCCG TACGCCATCC CTGCCAGAGG CAGGAGTGCC 
TTCCAGGAGG AGGACTTCCC CGCCCTGGTG TCCTCGGTGC CCAAGCCTGG CACCGCCCCC 
ACCAGCCTTG TCTCTGCCTG GAACAGCAGC AGTAGCAGCA AGAAGGTAGC ACAGCCCCCA 
CTCTCGGCGC AGGCTACCGG CAGCGGCCAG CCCACCAGGA AGGCTGGGAA GGGGAGCAGG 
GGCGGCAGGA AGGGCGGCCC GCCCTTCACA CAGGAGGAGG AGGAGGACGG CGGCCCGGCC 
CTGCAGGAGC TTCTGAGCAC ACGCCCCACG GGCTCCGTCT CCTCCACACT GGGGCTGGCC 
TCCATCCAAC CCTCTAAAGT TGGGAAGAAG AAGAAAGTGG GCTCGGAGAA GCCAGGCACC 
ACATTGCCAC AGCCCCCGCC CGCTACCTGT CCCCCAGGGG CTTTGCAGGC CCCGGAAGCT 
CCTGCCAGCA GAGCCGAGGG GCCAGTTGCC GTCGTCGTTA ATGGACACAT GGAGGGCCCG 
GCCCCTGCTC GGAGTGCCCC CAAGGAACCC CCTGGGCTCC CAAGGCCCCT GGGGTCCTTC 
CCCTGCCCCA CGCCACAGGA GGACTTCCCA GCGCTCGGCG GCCCCTGCCC ACCCCGGATG 
CCGCCGCCCC CAGGCTTCAG CGCTGTGGTG CTCCTGAAGG GCACGCCTCC CCCACCCCCG 
CCGGGCCTGG TGCCCCCAAT CAGCAAGCCG CCCCCTGGCT TCTCTGGCCT TCTGCCTAGC 
CCCCACCCGG CCTGTGTCCC CAGCCCCGCC ACCACCACCA CCACAAAAGC ACCCAGGCTG 
CTGCCTGCCC CACGGGCGTA CCTAGTCCCC GAGAACTTCC GGGAGAGGAA CCTTCAGCTC 
ATCCAGTCCA TCAGGGACTT CCTGCAGAGC GACGAGGCCC GCTTCAGCGA GTTCAAGAGC 
CACTCAGGGG AGTTCAGACA GGGCCTGATC TCCGCAGCCC AGTATTACAA GAGTTGCCGG 
GACCTGCTGG GGGAGAATTT CCAGAAGGTC TTTAATGAGC TGCTGGTCCT GCTGCCCGAC 
ACGGCCAAGC AGCAGGAGCT CCTGTCTGCA CACACGGACT TCTGCAACCG CGAGAAGCCT 
CTGAGCACCA AGTCCAAGAA GAACAAGAAG AGCGCGTGGC AGGCCACCAC CCAGCAGGCG 
GGCCTGGACT GCCGTGTGTG CCCCACCTGC CAGCAGGTGC TCGCGCATGG CGATGCCAGC 
AGCCACCAGG CGCTGCATGC TGCCCGGGAC GACGACTTCC CCTCCCTGCA AGCCATCGCC 
AGGATCATCA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.
Nature communications816056(2017 Jul)
Garzia A,Jafarnejad SM,Meyer C,Chapat C,Gogakos T,Morozov P,Amiri M,Shapiro M,Molina H,Tuschl T,Sonenberg N

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.
Molecular cell65(4)751-760.e4(2017 Feb)
Sundaramoorthy E,Leonard M,Mak R,Liao J,Fulzele A,Bennett EJ

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.
Molecular cell65(4)743-750.e4(2017 Feb)
Juszkiewicz S,Hegde RS

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Molecular and cellular biology32(17)3585-93(2012 Sep)
Morita M,Ler LW,Fabian MR,Siddiqui N,Mullin M,Henderson VC,Alain T,Fonseca BD,Karashchuk G,Bennett CF,Kabuta T,Higashi S,Larsson O,Topisirovic I,Smith RJ,Gingras AC,Sonenberg N

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ZNF598 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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