VCY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VCY
Entrez Gene ID	9084
Full Name	variable charge, Y-linked
Synonyms	BPY1,VCY1,VCY1A
General protein information	Preferred Names variable charge, Y-linked Names testis-specific basic protein Y 1 basic charge, Y-linked 1 basic protein on Y chromosome, 1 testis-specific basic protein on Y, 1 variable charge, Y chromosome variably charged protein Y
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.221
Summary	The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Jul 2008].
Disorder MIM:	400012

mRNA and Protein(s)

mRNA	Protein	Name
NM_004679.2	NP_004670.1	testis-specific basic protein Y 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VCX2	XP_001140111.1
Homo sapiens (human)	VCY	NP_004670.1
Homo sapiens (human)	VCY1B	NP_870996.1
Pan troglodytes (chimpanzee)	LOC742075	XP_003319047.2
Homo sapiens (human)	VCX2	NP_057462.2

Gene Ontology
Bibliography

Related articles in PubMed

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.
Taguchi A, Taylor AD, Rodriguez J, Celikta? M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM
Cancer research74(17)4694-705(2014 Sep)

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
Hansen MA, Nielsen JE, Retelska D, Larsen N, Leffers H
Molecular reproduction and development75(2)219-29(2008 Feb)

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC
Nature423(6942)825-37(2003 Jun)

A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.
Lahn BT, Page DC
Human molecular genetics9(2)311-9(2000 Jan)

Functional coherence of the human Y chromosome.
Lahn BT, Page DC
Science (New York, N.Y.)278(5338)675-80(1997 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identified members of the VCX/Y gene family as novel CT antigens.
Title: A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.

Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor.
Title: A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.

The following VCY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VCY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18490	NM_004679.2 Latest version!	Homo sapiens variable charge Y-linked (VCY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VCY ( NM_004679.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004670.1 Homo sapiens variable charge Y-linked (VCY), mRNA.

Price & Availability↑

CloneID	OHu18490
Clone ID Related Accession (Same CDS sequence)	NM_004679.2
Accession Version	NM_004679.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	testis-specific basic protein Y 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF000979.1 and AI149997.1. This sequence is a reference standard in the RefSeqGene project. On Jun 28, 2004 this sequence version replaced NM_004679.1. ##Evidence-Data-START## Transcript exon combination :: AF000979.1, HY190743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158188, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCAAGGAGAC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGGC CCGAAGAAGA AGACTACCAA GGTGGCCGAG 
AAGGGAGAAG CAGTTCGTGG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTAAGGG GCGCCCATCT 
ACTCCCCTAT CTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004670.1
CDS	73..450
Translation	MSPKPRASGPPAKAKETGKRKSSSQPSPSGPKKKTTKVAEKGEAVRGGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSKGRPSTPLSP

Target ORF information:

RefSeq Version	NM_004679.2
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge Y-linked (VCY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004679.2

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCAAGGAGAC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGGC CCGAAGAAGA AGACTACCAA GGTGGCCGAG 
AAGGGAGAAG CAGTTCGTGG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGGG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GAGCGAGCTG GAGGAACCAC TGAGTAAGGG GCGCCCATCT 
ACTCCCCTAT CTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.
Cancer research74(17)4694-705(2014 Sep)
Taguchi A,Taylor AD,Rodriguez J,Celikta? M,Liu H,Ma X,Zhang Q,Wong CH,Chin A,Girard L,Behrens C,Lam WL,Lam S,Minna JD,Wistuba II,Gazdar AF,Hanash SM

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
Molecular reproduction and development75(2)219-29(2008 Feb)
Hansen MA,Nielsen JE,Retelska D,Larsen N,Leffers H

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Nature423(6942)825-37(2003 Jun)
Skaletsky H,Kuroda-Kawaguchi T,Minx PJ,Cordum HS,Hillier L,Brown LG,Repping S,Pyntikova T,Ali J,Bieri T,Chinwalla A,Delehaunty A,Delehaunty K,Du H,Fewell G,Fulton L,Fulton R,Graves T,Hou SF,Latrielle P,Leonard S,Mardis E,Maupin R,McPherson J,Miner T,Nash W,Nguyen C,Ozersky P,Pepin K,Rock S,Rohlfing T,Scott K,Schultz B,Strong C,Tin-Wollam A,Yang SP,Waterston RH,Wilson RK,Rozen S,Page DC

A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.
Human molecular genetics9(2)311-9(2000 Jan)
Lahn BT,Page DC

Functional coherence of the human Y chromosome.
Science (New York, N.Y.)278(5338)675-80(1997 Oct)
Lahn BT,Page DC

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VCY cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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