CLDN8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLDN8
Entrez Gene ID	9073
Full Name	claudin 8
Synonyms	HEL-S-79
General protein information	Preferred Names claudin 8 Names claudin-8 epididymis secretory protein Li 79
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.11
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010].
Disorder MIM:	611231

mRNA and Protein(s)

mRNA	Protein	Name
NM_199328.2	NP_955360.1	claudin-8
NM_199328.3	NP_955360.1	claudin-8

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLDN8	XP_531532.1
Rattus norvegicus (Norway rat)	Cldn8	NP_001032863.1
Danio rerio (zebrafish)	zgc:110333	NP_001017799.1
Homo sapiens (human)	CLDN8	NP_955360.1
	CLDN8	XP_001100214.1
Canis lupus familiaris (dog)	CLDN8	XP_005638865.1
Mus musculus (house mouse)	Cldn8	NP_061248.1
Gallus gallus (chicken)	CLDN8	XP_004938436.1
Danio rerio (zebrafish)	cldn8	NP_001003733.1
Danio rerio (zebrafish)	cldn17	NP_001104000.1
Bos taurus (cattle)	CLDN8	NP_001091565.1

Gene Ontology
Bibliography

Related articles in PubMed

CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration.
Ashikari D, Takayama KI, Obinata D, Takahashi S, Inoue S
Cancer science108(7)1386-1393(2017 Jul)

Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine.
Liu TH, Chung RH, Wang SC, Fang CP, Tsou HH, Shih CL, Kuo HW, Wang Y, Liu YL
PloS one12(11)e0187639(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer
Title: CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration.

data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine
Title: Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine.

SOX9 may promote cell growth by repressing the expression of CLDN8.
Title: Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression.

Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 pathway.
Title: Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease.

High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma.
Title: Claudin 8 Contributes to Malignant Proliferation in Human Osteosarcoma U2OS Cells.

The following CLDN8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32283	NM_199328.3 Latest version!	Homo sapiens claudin 8 (CLDN8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu32283	NM_199328.2	Homo sapiens claudin 8 (CLDN8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLDN8 ( NM_199328.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_955360.1 Homo sapiens claudin 8 (CLDN8), mRNA.

Price & Availability↑

CloneID	OHu32283
Clone ID Related Accession (Same CDS sequence)	NM_199328.2 , NM_199328.3
Accession Version	NM_199328.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	claudin-8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA629490.1, AY358707.1, AL049977.1 and AW235670.1. This sequence is a reference standard in the RefSeqGene project. On May 29, 2010 this sequence version replaced NM_199328.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCAACCC ATGCCTTAGA AATCGCTGGG CTGTTTCTTG GTGGTGTTGG AATGGTGGGC 
ACAGTGGCTG TCACTGTCAT GCCTCAGTGG AGAGTGTCGG CCTTCATTGA AAACAACATC 
GTGGTTTTTG AAAACTTCTG GGAAGGACTG TGGATGAATT GCGTGAGGCA GGCTAACATC 
AGGATGCAGT GCAAAATCTA TGATTCCCTG CTGGCTCTTT CTCCGGACCT ACAGGCAGCC 
AGAGGACTGA TGTGTGCTGC TTCCGTGATG TCCTTCTTGG CTTTCATGAT GGCCATCCTT 
GGCATGAAAT GCACCAGGTG CACGGGGGAC AATGAGAAGG TGAAGGCTCA CATTCTGCTG 
ACGGCTGGAA TCATCTTCAT CATCACGGGC ATGGTGGTGC TCATCCCTGT GAGCTGGGTT 
GCCAATGCCA TCATCAGAGA TTTCTATAAC TCAATAGTGA ATGTTGCCCA AAAACGTGAG 
CTTGGAGAAG CTCTCTACTT AGGATGGACC ACGGCACTGG TGCTGATTGT TGGAGGAGCT 
CTGTTCTGCT GCGTTTTTTG TTGCAACGAA AAGAGCAGTA GCTACAGATA CTCGATACCT 
TCCCATCGCA CAACCCAAAA AAGTTATCAC ACCGGAAAGA AGTCACCGAG CGTCTACTCC 
AGAAGTCAGT ATGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955360.1
CDS	227..904
Translation	MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEKSSSYRYSIPSHRTTQKSYHTGKKSPSVYSRSQYV

Target ORF information:

RefSeq Version	NM_199328.2
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 8 (CLDN8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199328.2

ORF Insert Sequence:

ATGGCAACCC ATGCCTTAGA AATCGCTGGG CTGTTTCTTG GTGGTGTTGG AATGGTGGGC 
ACAGTGGCTG TCACTGTCAT GCCTCAGTGG AGAGTGTCGG CCTTCATTGA AAACAACATC 
GTGGTTTTTG AAAACTTCTG GGAAGGACTG TGGATGAATT GCGTGAGGCA GGCTAACATC 
AGGATGCAGT GCAAAATCTA TGATTCCCTG CTGGCTCTTT CTCCGGACCT ACAGGCAGCC 
AGAGGACTGA TGTGTGCTGC TTCCGTGATG TCCTTCTTGG CTTTCATGAT GGCCATCCTT 
GGCATGAAAT GCACCAGGTG CACGGGGGAC AATGAGAAGG TGAAGGCTCA CATTCTGCTG 
ACGGCTGGAA TCATCTTCAT CATCACGGGC ATGGTGGTGC TCATCCCTGT GAGCTGGGTT 
GCCAATGCCA TCATCAGAGA TTTCTATAAC TCAATAGTGA ATGTTGCCCA AAAACGTGAG 
CTTGGAGAAG CTCTCTACTT AGGATGGACC ACGGCACTGG TGCTGATTGT TGGAGGAGCT 
CTGTTCTGCT GCGTTTTTTG TTGCAACGAA AAGAGCAGTA GCTACAGATA CTCGATACCT 
TCCCATCGCA CAACCCAAAA AAGTTATCAC ACCGGAAAGA AGTCACCGAG CGTCTACTCC 
AGAAGTCAGT ATGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN8 ( NM_199328.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_955360.1 Homo sapiens claudin 8 (CLDN8), mRNA.

Price & Availability↑

CloneID	OHu32283
Clone ID Related Accession (Same CDS sequence)	NM_199328.2 , NM_199328.3
Accession Version	NM_199328.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-07
Organism	Homo sapiens(human)
Product	claudin-8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA629490.1, AY358707.1, AL049977.1 and AW235670.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_199328.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY358707.1, BC058004.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000399899.2/ ENSP00000382783.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCAACCC ATGCCTTAGA AATCGCTGGG CTGTTTCTTG GTGGTGTTGG AATGGTGGGC 
ACAGTGGCTG TCACTGTCAT GCCTCAGTGG AGAGTGTCGG CCTTCATTGA AAACAACATC 
GTGGTTTTTG AAAACTTCTG GGAAGGACTG TGGATGAATT GCGTGAGGCA GGCTAACATC 
AGGATGCAGT GCAAAATCTA TGATTCCCTG CTGGCTCTTT CTCCGGACCT ACAGGCAGCC 
AGAGGACTGA TGTGTGCTGC TTCCGTGATG TCCTTCTTGG CTTTCATGAT GGCCATCCTT 
GGCATGAAAT GCACCAGGTG CACGGGGGAC AATGAGAAGG TGAAGGCTCA CATTCTGCTG 
ACGGCTGGAA TCATCTTCAT CATCACGGGC ATGGTGGTGC TCATCCCTGT GAGCTGGGTT 
GCCAATGCCA TCATCAGAGA TTTCTATAAC TCAATAGTGA ATGTTGCCCA AAAACGTGAG 
CTTGGAGAAG CTCTCTACTT AGGATGGACC ACGGCACTGG TGCTGATTGT TGGAGGAGCT 
CTGTTCTGCT GCGTTTTTTG TTGCAACGAA AAGAGCAGTA GCTACAGATA CTCGATACCT 
TCCCATCGCA CAACCCAAAA AAGTTATCAC ACCGGAAAGA AGTCACCGAG CGTCTACTCC 
AGAAGTCAGT ATGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955360.1
CDS	173..850
Translation	MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEKSSSYRYSIPSHRTTQKSYHTGKKSPSVYSRSQYV

Target ORF information:

RefSeq Version	NM_199328.3
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 8 (CLDN8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199328.3

ORF Insert Sequence:

ATGGCAACCC ATGCCTTAGA AATCGCTGGG CTGTTTCTTG GTGGTGTTGG AATGGTGGGC 
ACAGTGGCTG TCACTGTCAT GCCTCAGTGG AGAGTGTCGG CCTTCATTGA AAACAACATC 
GTGGTTTTTG AAAACTTCTG GGAAGGACTG TGGATGAATT GCGTGAGGCA GGCTAACATC 
AGGATGCAGT GCAAAATCTA TGATTCCCTG CTGGCTCTTT CTCCGGACCT ACAGGCAGCC 
AGAGGACTGA TGTGTGCTGC TTCCGTGATG TCCTTCTTGG CTTTCATGAT GGCCATCCTT 
GGCATGAAAT GCACCAGGTG CACGGGGGAC AATGAGAAGG TGAAGGCTCA CATTCTGCTG 
ACGGCTGGAA TCATCTTCAT CATCACGGGC ATGGTGGTGC TCATCCCTGT GAGCTGGGTT 
GCCAATGCCA TCATCAGAGA TTTCTATAAC TCAATAGTGA ATGTTGCCCA AAAACGTGAG 
CTTGGAGAAG CTCTCTACTT AGGATGGACC ACGGCACTGG TGCTGATTGT TGGAGGAGCT 
CTGTTCTGCT GCGTTTTTTG TTGCAACGAA AAGAGCAGTA GCTACAGATA CTCGATACCT 
TCCCATCGCA CAACCCAAAA AAGTTATCAC ACCGGAAAGA AGTCACCGAG CGTCTACTCC 
AGAAGTCAGT ATGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration.
Cancer science108(7)1386-1393(2017 Jul)
Ashikari D,Takayama KI,Obinata D,Takahashi S,Inoue S

Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine.
PloS one12(11)e0187639(2017)
Liu TH,Chung RH,Wang SC,Fang CP,Tsou HH,Shih CL,Kuo HW,Wang Y,Liu YL

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CLDN8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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