COX19 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX19
Entrez Gene ID	90639
Full Name	COX19, cytochrome c oxidase assembly factor
General protein information	Preferred Names COX19, cytochrome c oxidase assembly factor Names cytochrome c oxidase assembly protein COX19 COX19 cytochrome c oxidase assembly homolog cytochrome c oxidase assembly homolog 19 hCOX19
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p22.3
Summary	COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610429

mRNA and Protein(s)

mRNA	Protein	Name
NM_001031617.2	NP_001026788.1	cytochrome c oxidase assembly protein COX19
NM_001031617.3	NP_001026788.1	cytochrome c oxidase assembly protein COX19

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cox19	NP_932097.1
	COX19	XP_001084410.1
Danio rerio (zebrafish)	zgc:162175	NP_001104010.1
Homo sapiens (human)	COX19	NP_001026788.1
Pan troglodytes (chimpanzee)	COX19	XP_001144871.1
Bos taurus (cattle)	COX19	NP_001103436.1
Rattus norvegicus (Norway rat)	Cox19	NP_001100596.1
Xenopus tropicalis (tropical clawed frog)	cox19	NP_001120449.1
Gallus gallus (chicken)	COX19	NP_001243736.1

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
Wang H, St Julien KR, Stevenson DK, Hoffmann TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jelliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM
Pediatrics132(2)290-7(2013 Aug)

Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.
Fischer M, Horn S, Belkacemi A, Kojer K, Petrungaro C, Habich M, Ali M, K?ttner V, Bien M, Kauff F, Dengjel J, Herrmann JM, Riemer J
Molecular biology of the cell24(14)2160-70(2013 Jul)

COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.
Leary SC, Cobine PA, Nishimura T, Verdijk RM, de Krijger R, de Coo R, Tarnopolsky MA, Winge DR, Shoubridge EA
Molecular biology of the cell24(6)683-91(2013 Mar)

hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly.
Sacconi S, Trevisson E, Pistollato F, Baldoin MC, Rezzonico R, Bourget I, Desnuelle C, Tenconi R, Basso G, DiMauro S, Salviati L
Biochemical and biophysical research communications337(3)832-9(2005 Nov)

Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency.
Tay SK, Nesti C, Mancuso M, Schon EA, Shanske S, Bonilla E, Davidson MM, Dimauro S
Archives of neurology61(12)1935-7(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX19 is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A-mediated cellular copper efflux.
Title: COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.

Both hCox18p and hCox19p present significant amino acid identity with the corresponding yeast polypeptides and reveal highly conserved functional domains.
Title: hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly.

The following COX19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04417	NM_001031617.3 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX19 (COX19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04417	NM_001031617.2	Homo sapiens COX19, cytochrome c oxidase assembly factor (COX19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX19 ( NM_001031617.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001026788.1 Homo sapiens COX19, cytochrome c oxidase assembly factor (COX19), mRNA.

Price & Availability↑

CloneID	OHu04417
Clone ID Related Accession (Same CDS sequence)	NM_001031617.2 , NM_001031617.3
Accession Version	NM_001031617.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX19
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB077585.1, AY957566.1, AC073957.7 and AA437231.1. On Jul 14, 2006 this sequence version replaced NM_001031617.1. ##Evidence-Data-START## Transcript exon combination :: DB230605.1, SRR1660803.247765.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGACCG CCATGAATTT CGGGACCAAG AGCTTCCAGC CGCGGCCCCC GGACAAGGGC 
AGCTTCCCGC TGGATCACTT AGGTGAATGT AAAAGCTTTA AAGAGAAATT CATGAAGTGT 
CTTCATAACA ATAATTTTGA AAATGCTTTG TGCAGAAAGG AATCAAAAGA ATATTTAGAA 
TGCAGGATGG AGAGAAAATT GATGCTACAA GAACCATTGG AGAAACTGGG ATTTGGAGAC 
TTGACTAGTG GAAAATCAGA GGCAAAAAAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001026788.1
CDS	91..363
Translation	MSTAMNFGTKSFQPRPPDKGSFPLDHLGECKSFKEKFMKCLHNNNFENALCRKESKEYLECRMERKLMLQEPLEKLGFGDLTSGKSEAKK

Target ORF information:

RefSeq Version	NM_001031617.2
Organism	Homo sapiens(human)
Definition	Homo sapiens COX19, cytochrome c oxidase assembly factor (COX19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001031617.2

ORF Insert Sequence:

ATGTCGACCG CCATGAATTT CGGGACCAAG AGCTTCCAGC CGCGGCCCCC GGACAAGGGC 
AGCTTCCCGC TGGATCACTT AGGTGAATGT AAAAGCTTTA AAGAGAAATT CATGAAGTGT 
CTTCATAACA ATAATTTTGA AAATGCTTTG TGCAGAAAGG AATCAAAAGA ATATTTAGAA 
TGCAGGATGG AGAGAAAATT GATGCTACAA GAACCATTGG AGAAACTGGG ATTTGGAGAC 
TTGACTAGTG GAAAATCAGA GGCAAAAAAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX19 ( NM_001031617.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001026788.1 Homo sapiens cytochrome c oxidase assembly factor COX19 (COX19), mRNA.

Price & Availability↑

CloneID	OHu04417
Clone ID Related Accession (Same CDS sequence)	NM_001031617.2 , NM_001031617.3
Accession Version	NM_001031617.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX19
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY957566.1, AC073957.7 and AA437231.1. On Nov 22, 2018 this sequence version replaced NM_001031617.2. ##Evidence-Data-START## Transcript exon combination :: AY957566.1, SRR1660803.247765.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000344111.4/ ENSP00000342015.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGACCG CCATGAATTT CGGGACCAAG AGCTTCCAGC CGCGGCCCCC GGACAAGGGC 
AGCTTCCCGC TGGATCACTT AGGTGAATGT AAAAGCTTTA AAGAGAAATT CATGAAGTGT 
CTTCATAACA ATAATTTTGA AAATGCTTTG TGCAGAAAGG AATCAAAAGA ATATTTAGAA 
TGCAGGATGG AGAGAAAATT GATGCTACAA GAACCATTGG AGAAACTGGG ATTTGGAGAC 
TTGACTAGTG GAAAATCAGA GGCAAAAAAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001026788.1
CDS	41..313
Translation	MSTAMNFGTKSFQPRPPDKGSFPLDHLGECKSFKEKFMKCLHNNNFENALCRKESKEYLECRMERKLMLQEPLEKLGFGDLTSGKSEAKK

Target ORF information:

RefSeq Version	NM_001031617.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX19 (COX19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001031617.3

ORF Insert Sequence:

ATGTCGACCG CCATGAATTT CGGGACCAAG AGCTTCCAGC CGCGGCCCCC GGACAAGGGC 
AGCTTCCCGC TGGATCACTT AGGTGAATGT AAAAGCTTTA AAGAGAAATT CATGAAGTGT 
CTTCATAACA ATAATTTTGA AAATGCTTTG TGCAGAAAGG AATCAAAAGA ATATTTAGAA 
TGCAGGATGG AGAGAAAATT GATGCTACAA GAACCATTGG AGAAACTGGG ATTTGGAGAC 
TTGACTAGTG GAAAATCAGA GGCAAAAAAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
Pediatrics132(2)290-7(2013 Aug)
Wang H,St Julien KR,Stevenson DK,Hoffmann TJ,Witte JS,Lazzeroni LC,Krasnow MA,Quaintance CC,Oehlert JW,Jelliffe-Pawlowski LL,Gould JB,Shaw GM,O'Brodovich HM

Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.
Molecular biology of the cell24(14)2160-70(2013 Jul)
Fischer M,Horn S,Belkacemi A,Kojer K,Petrungaro C,Habich M,Ali M,K?ttner V,Bien M,Kauff F,Dengjel J,Herrmann JM,Riemer J

COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux.
Molecular biology of the cell24(6)683-91(2013 Mar)
Leary SC,Cobine PA,Nishimura T,Verdijk RM,de Krijger R,de Coo R,Tarnopolsky MA,Winge DR,Shoubridge EA

hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly.
Biochemical and biophysical research communications337(3)832-9(2005 Nov)
Sacconi S,Trevisson E,Pistollato F,Baldoin MC,Rezzonico R,Bourget I,Desnuelle C,Tenconi R,Basso G,DiMauro S,Salviati L

Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency.
Archives of neurology61(12)1935-7(2004 Dec)
Tay SK,Nesti C,Mancuso M,Schon EA,Shanske S,Bonilla E,Davidson MM,Dimauro S

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COX19 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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