PAPSS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAPSS2
Entrez Gene ID	9060
Full Name	3'-phosphoadenosine 5'-phosphosulfate synthase 2
Synonyms	ATPSK2,BCYM4,SK2
General protein information	Preferred Names 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Names bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2 ATP sulfurylase/APS kinase 2 ATP sulfurylase/adenosine 5'-phosphosulfate kinase PAPS synthase 2 PAPS synthetase 2 SK 2 adenosine 5'-phosphosulfate kinase adenylyl-sulfate kinase bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 sulfate adenylyltransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.2-q23.31
Summary	Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	603005
Disorder Html:	Brachyolmia 4 with mild epiphyseal and metaphyseal changes, 612847 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001015880.1	NP_001015880.1	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b
NM_004670.3	NP_004661.2	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform a
NM_004670.4	NP_004661.2	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform a
NM_001015880.2	NP_001015880.1	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Papss2	NP_035994.2
Danio rerio (zebrafish)	papss2b	NP_997727.1
Caenorhabditis elegans (roundworm)	pps-1	NP_501857.1
Arabidopsis thaliana (thale cress)	APS3	NP_193204.1
Oryza sativa (rice)	Os03g0743900	NP_001051234.1
Xenopus tropicalis (tropical clawed frog)	papss2	XP_002935477.2
	PAPSS2	XP_001101994.1
Eremothecium gossypii	AGOS_ABR001W	NP_982947.1
Arabidopsis thaliana (thale cress)	APS1	NP_188929.1
Pan troglodytes (chimpanzee)	PAPSS2	XP_003312796.1
Rattus norvegicus (Norway rat)	Papss2	NP_001099845.2
Gallus gallus (chicken)	PAPSS2	XP_004942047.1
Danio rerio (zebrafish)	papss2a	NP_001071235.1
Arabidopsis thaliana (thale cress)	APS2	NP_564099.1
Arabidopsis thaliana (thale cress)	APS4	NP_199191.1
Homo sapiens (human)	PAPSS2	NP_001015880.1
Canis lupus familiaris (dog)	PAPSS2	XP_005636722.1
Bos taurus (cattle)	PAPSS2	NP_001069543.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.
Yerges-Armstrong LM, Chai S, O'Connell JR, Curran JE, Blangero J, Mitchell BD, Shuldiner AR, Damcott CM
The journals of gerontology. Series A, Biological sciences and medical sciences71(10)1295-9(2016 Oct)

Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.
Hashimoto K, Zaitseva IN, Bonala R, Attaluri S, Ozga K, Iden CR, Johnson F, Moriya M, Grollman AP, Sidorenko VS
Carcinogenesis37(7)647-655(2016 Jul)

Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children.
Chang X, Glessner J, Tin A, Li J, Guo Y, Wei Z, Liu Y, Mentch FD, Hou C, Zhao Y, Wang T, Qiu H, Kim C, Sleiman PM, Hakonarson H
Scientific reports518792(2015 Dec)

Exploring prostate cancer genome reveals simultaneous losses of PTEN, FAS and PAPSS2 in patients with PSA recurrence after radical prostatectomy.
Ibeawuchi C, Schmidt H, Voss R, Titze U, Abbas M, Neumann J, Eltze E, Hoogland AM, Jenster G, Brandt B, Semjonow A
International journal of molecular sciences16(2)3856-69(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates.
Title: Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.

Silencing of SULT1A1 and PAPSS2 led to a significant decrease in aristolactam-DNA levels in both cell lines following exposure to AA-I, indicating the critical role for sulfonation in the activation of AA-I in vivo Since HK-2 cells proved relatively resistant to knockdown with siRNAs
Title: Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.

Our results indicate that FGFR2 and PAPSS2 may play an important role in the regulation of magnesium homeostasis in children of European-American ancestry.
Title: Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children.

Direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation.
Title: PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation--in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.

Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy.
Title: Exploring prostate cancer genome reveals simultaneous losses of PTEN, FAS and PAPSS2 in patients with PSA recurrence after radical prostatectomy.

The following PAPSS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAPSS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04532	NM_004670.4 Latest version!	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17983	NM_001015880.2 Latest version!	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu04532	NM_004670.3	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17983	NM_001015880.1	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAPSS2 ( NM_004670.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004661.2 Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04532
Clone ID Related Accession (Same CDS sequence)	NM_004670.3 , NM_004670.4
Accession Version	NM_004670.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ221395.1, BC009894.2, BQ888954.1 and BQ772647.1. On Apr 27, 2005 this sequence version replaced NM_004670.2. Transcript Variant: This variant (1) represents the more frequently occurring transcript. It encodes isoform a, which has also been named PAPS synthase 2a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.98195.1, SRR1660803.43643.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGATGGC GTGATCAACA TGAGCATCCC CATTGTACTG 
CCCGTCTCTG CAGAGGATAA GACACGGCTG GAAGGGTGCA GCAAGTTTGT CCTGGCACAT 
GGTGGACGGA GGGTAGCTAT CTTACGAGAC GCTGAATTCT ATGAACACAG AAAAGAGGAA 
CGCTGTTCCC GTGTTTGGGG GACAACATGT ACAAAACACC CCCATATCAA AATGGTGATG 
GAAAGTGGGG ACTGGCTGGT TGGTGGAGAC CTTCAGGTGC TGGAGAAAAT AAGATGGAAT 
GATGGGCTGG ACCAATACCG TCTGACACCT CTGGAGCTCA AACAGAAATG TAAAGAAATG 
AATGCTGATG CGGTGTTTGC ATTCCAGTTG CGCAATCCTG TCCACAATGG CCATGCCCTG 
TTGATGCAGG ACACTCGCCG CAGGCTCCTA GAGAGGGGCT ACAAGCACCC GGTCCTCCTA 
CTACACCCTC TGGGCGGCTG GACCAAGGAT GACGATGTGC CTCTAGACTG GCGGATGAAG 
CAGCACGCGG CTGTGCTCGA GGAAGGGGTC CTGGATCCCA AGTCAACCAT TGTTGCCATC 
TTTCCGTCTC CCATGTTATA TGCTGGCCCC ACAGAGGTCC AGTGGCACTG CAGGTCCCGG 
ATGATTGCGG GTGCCAATTT CTACATTGTG GGGAGGGACC CTGCAGGAAT GCCCCATCCT 
GAAACCAAGA AGGATCTGTA TGAACCCACT CATGGGGGCA AGGTCTTGAG CATGGCCCCT 
GGCCTCACCT CTGTGGAAAT CATTCCATTC CGAGTGGCTG CCTACAACAA AGCCAAAAAA 
GCCATGGACT TCTATGATCC AGCAAGGCAC AATGAGTTTG ACTTCATCTC AGGAACTCGA 
ATGAGGAAGC TCGCCCGGGA AGGAGAGAAT CCCCCAGATG GCTTCATGGC CCCCAAAGCA 
TGGAAGGTCC TGACAGATTA TTACAGGTCC CTGGAGAAGA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004661.2
CDS	264..2108
Translation	MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN

Target ORF information:

RefSeq Version	NM_004670.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004670.3

ORF Insert Sequence:

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGATGGC GTGATCAACA TGAGCATCCC CATTGTACTG 
CCCGTCTCTG CAGAGGATAA GACACGGCTG GAAGGGTGCA GCAAGTTTGT CCTGGCACAT 
GGTGGACGGA GGGTAGCTAT CTTACGAGAC GCTGAATTCT ATGAACACAG AAAAGAGGAA 
CGCTGTTCCC GTGTTTGGGG GACAACATGT ACAAAACACC CCCATATCAA AATGGTGATG 
GAAAGTGGGG ACTGGCTGGT TGGTGGAGAC CTTCAGGTGC TGGAGAAAAT AAGATGGAAT 
GATGGGCTGG ACCAATACCG TCTGACACCT CTGGAGCTCA AACAGAAATG TAAAGAAATG 
AATGCTGATG CGGTGTTTGC ATTCCAGTTG CGCAATCCTG TCCACAATGG CCATGCCCTG 
TTGATGCAGG ACACTCGCCG CAGGCTCCTA GAGAGGGGCT ACAAGCACCC GGTCCTCCTA 
CTACACCCTC TGGGCGGCTG GACCAAGGAT GACGATGTGC CTCTAGACTG GCGGATGAAG 
CAGCACGCGG CTGTGCTCGA GGAAGGGGTC CTGGATCCCA AGTCAACCAT TGTTGCCATC 
TTTCCGTCTC CCATGTTATA TGCTGGCCCC ACAGAGGTCC AGTGGCACTG CAGGTCCCGG 
ATGATTGCGG GTGCCAATTT CTACATTGTG GGGAGGGACC CTGCAGGAAT GCCCCATCCT 
GAAACCAAGA AGGATCTGTA TGAACCCACT CATGGGGGCA AGGTCTTGAG CATGGCCCCT 
GGCCTCACCT CTGTGGAAAT CATTCCATTC CGAGTGGCTG CCTACAACAA AGCCAAAAAA 
GCCATGGACT TCTATGATCC AGCAAGGCAC AATGAGTTTG ACTTCATCTC AGGAACTCGA 
ATGAGGAAGC TCGCCCGGGA AGGAGAGAAT CCCCCAGATG GCTTCATGGC CCCCAAAGCA 
TGGAAGGTCC TGACAGATTA TTACAGGTCC CTGGAGAAGA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAPSS2 ( NM_004670.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004661.2 Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04532
Clone ID Related Accession (Same CDS sequence)	NM_004670.3 , NM_004670.4
Accession Version	NM_004670.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC009894.2, BQ888954.1 and BQ772647.1. On May 31, 2019 this sequence version replaced NM_004670.3. Transcript Variant: This variant (1) represents the more frequently occurring transcript. It encodes isoform a, which has also been named PAPS synthase 2a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.98195.1, SRR1803611.209561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGATGGC GTGATCAACA TGAGCATCCC CATTGTACTG 
CCCGTCTCTG CAGAGGATAA GACACGGCTG GAAGGGTGCA GCAAGTTTGT CCTGGCACAT 
GGTGGACGGA GGGTAGCTAT CTTACGAGAC GCTGAATTCT ATGAACACAG AAAAGAGGAA 
CGCTGTTCCC GTGTTTGGGG GACAACATGT ACAAAACACC CCCATATCAA AATGGTGATG 
GAAAGTGGGG ACTGGCTGGT TGGTGGAGAC CTTCAGGTGC TGGAGAAAAT AAGATGGAAT 
GATGGGCTGG ACCAATACCG TCTGACACCT CTGGAGCTCA AACAGAAATG TAAAGAAATG 
AATGCTGATG CGGTGTTTGC ATTCCAGTTG CGCAATCCTG TCCACAATGG CCATGCCCTG 
TTGATGCAGG ACACTCGCCG CAGGCTCCTA GAGAGGGGCT ACAAGCACCC GGTCCTCCTA 
CTACACCCTC TGGGCGGCTG GACCAAGGAT GACGATGTGC CTCTAGACTG GCGGATGAAG 
CAGCACGCGG CTGTGCTCGA GGAAGGGGTC CTGGATCCCA AGTCAACCAT TGTTGCCATC 
TTTCCGTCTC CCATGTTATA TGCTGGCCCC ACAGAGGTCC AGTGGCACTG CAGGTCCCGG 
ATGATTGCGG GTGCCAATTT CTACATTGTG GGGAGGGACC CTGCAGGAAT GCCCCATCCT 
GAAACCAAGA AGGATCTGTA TGAACCCACT CATGGGGGCA AGGTCTTGAG CATGGCCCCT 
GGCCTCACCT CTGTGGAAAT CATTCCATTC CGAGTGGCTG CCTACAACAA AGCCAAAAAA 
GCCATGGACT TCTATGATCC AGCAAGGCAC AATGAGTTTG ACTTCATCTC AGGAACTCGA 
ATGAGGAAGC TCGCCCGGGA AGGAGAGAAT CCCCCAGATG GCTTCATGGC CCCCAAAGCA 
TGGAAGGTCC TGACAGATTA TTACAGGTCC CTGGAGAAGA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004661.2
CDS	105..1949
Translation	MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN

Target ORF information:

RefSeq Version	NM_004670.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004670.4

ORF Insert Sequence:

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGATGGC GTGATCAACA TGAGCATCCC CATTGTACTG 
CCCGTCTCTG CAGAGGATAA GACACGGCTG GAAGGGTGCA GCAAGTTTGT CCTGGCACAT 
GGTGGACGGA GGGTAGCTAT CTTACGAGAC GCTGAATTCT ATGAACACAG AAAAGAGGAA 
CGCTGTTCCC GTGTTTGGGG GACAACATGT ACAAAACACC CCCATATCAA AATGGTGATG 
GAAAGTGGGG ACTGGCTGGT TGGTGGAGAC CTTCAGGTGC TGGAGAAAAT AAGATGGAAT 
GATGGGCTGG ACCAATACCG TCTGACACCT CTGGAGCTCA AACAGAAATG TAAAGAAATG 
AATGCTGATG CGGTGTTTGC ATTCCAGTTG CGCAATCCTG TCCACAATGG CCATGCCCTG 
TTGATGCAGG ACACTCGCCG CAGGCTCCTA GAGAGGGGCT ACAAGCACCC GGTCCTCCTA 
CTACACCCTC TGGGCGGCTG GACCAAGGAT GACGATGTGC CTCTAGACTG GCGGATGAAG 
CAGCACGCGG CTGTGCTCGA GGAAGGGGTC CTGGATCCCA AGTCAACCAT TGTTGCCATC 
TTTCCGTCTC CCATGTTATA TGCTGGCCCC ACAGAGGTCC AGTGGCACTG CAGGTCCCGG 
ATGATTGCGG GTGCCAATTT CTACATTGTG GGGAGGGACC CTGCAGGAAT GCCCCATCCT 
GAAACCAAGA AGGATCTGTA TGAACCCACT CATGGGGGCA AGGTCTTGAG CATGGCCCCT 
GGCCTCACCT CTGTGGAAAT CATTCCATTC CGAGTGGCTG CCTACAACAA AGCCAAAAAA 
GCCATGGACT TCTATGATCC AGCAAGGCAC AATGAGTTTG ACTTCATCTC AGGAACTCGA 
ATGAGGAAGC TCGCCCGGGA AGGAGAGAAT CCCCCAGATG GCTTCATGGC CCCCAAAGCA 
TGGAAGGTCC TGACAGATTA TTACAGGTCC CTGGAGAAGA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAPSS2 ( NM_001015880.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001015880.1 Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 2, mRNA.

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CloneID	OHu17983
Clone ID Related Accession (Same CDS sequence)	NM_001015880.1 , NM_001015880.2
Accession Version	NM_001015880.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ221395.1, CB960618.1, AF150754.2, BC009894.2, BQ888954.1 and BQ772647.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001015880.1. Transcript Variant: This variant (2) includes an alternate in-frame segment, compared to variant 1, resulting in a longer protein (isoform 2), compared to isoform 1. Isoform 2 has also been named PAPS synthase 2b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF150754.2, AF173365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000456849.2/ ENSP00000406157.1 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGGCATG GCCCTTCCTG ATGGCGTGAT CAACATGAGC 
ATCCCCATTG TACTGCCCGT CTCTGCAGAG GATAAGACAC GGCTGGAAGG GTGCAGCAAG 
TTTGTCCTGG CACATGGTGG ACGGAGGGTA GCTATCTTAC GAGACGCTGA ATTCTATGAA 
CACAGAAAAG AGGAACGCTG TTCCCGTGTT TGGGGGACAA CATGTACAAA ACACCCCCAT 
ATCAAAATGG TGATGGAAAG TGGGGACTGG CTGGTTGGTG GAGACCTTCA GGTGCTGGAG 
AAAATAAGAT GGAATGATGG GCTGGACCAA TACCGTCTGA CACCTCTGGA GCTCAAACAG 
AAATGTAAAG AAATGAATGC TGATGCGGTG TTTGCATTCC AGTTGCGCAA TCCTGTCCAC 
AATGGCCATG CCCTGTTGAT GCAGGACACT CGCCGCAGGC TCCTAGAGAG GGGCTACAAG 
CACCCGGTCC TCCTACTACA CCCTCTGGGC GGCTGGACCA AGGATGACGA TGTGCCTCTA 
GACTGGCGGA TGAAGCAGCA CGCGGCTGTG CTCGAGGAAG GGGTCCTGGA TCCCAAGTCA 
ACCATTGTTG CCATCTTTCC GTCTCCCATG TTATATGCTG GCCCCACAGA GGTCCAGTGG 
CACTGCAGGT CCCGGATGAT TGCGGGTGCC AATTTCTACA TTGTGGGGAG GGACCCTGCA 
GGAATGCCCC ATCCTGAAAC CAAGAAGGAT CTGTATGAAC CCACTCATGG GGGCAAGGTC 
TTGAGCATGG CCCCTGGCCT CACCTCTGTG GAAATCATTC CATTCCGAGT GGCTGCCTAC 
AACAAAGCCA AAAAAGCCAT GGACTTCTAT GATCCAGCAA GGCACAATGA GTTTGACTTC 
ATCTCAGGAA CTCGAATGAG GAAGCTCGCC CGGGAAGGAG AGAATCCCCC AGATGGCTTC 
ATGGCCCCCA AAGCATGGAA GGTCCTGACA GATTATTACA GGTCCCTGGA GAAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015880.1
CDS	105..1964
Translation	MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDGMALPDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN

Target ORF information:

RefSeq Version	NM_001015880.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015880.2

ORF Insert Sequence:

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGGCATG GCCCTTCCTG ATGGCGTGAT CAACATGAGC 
ATCCCCATTG TACTGCCCGT CTCTGCAGAG GATAAGACAC GGCTGGAAGG GTGCAGCAAG 
TTTGTCCTGG CACATGGTGG ACGGAGGGTA GCTATCTTAC GAGACGCTGA ATTCTATGAA 
CACAGAAAAG AGGAACGCTG TTCCCGTGTT TGGGGGACAA CATGTACAAA ACACCCCCAT 
ATCAAAATGG TGATGGAAAG TGGGGACTGG CTGGTTGGTG GAGACCTTCA GGTGCTGGAG 
AAAATAAGAT GGAATGATGG GCTGGACCAA TACCGTCTGA CACCTCTGGA GCTCAAACAG 
AAATGTAAAG AAATGAATGC TGATGCGGTG TTTGCATTCC AGTTGCGCAA TCCTGTCCAC 
AATGGCCATG CCCTGTTGAT GCAGGACACT CGCCGCAGGC TCCTAGAGAG GGGCTACAAG 
CACCCGGTCC TCCTACTACA CCCTCTGGGC GGCTGGACCA AGGATGACGA TGTGCCTCTA 
GACTGGCGGA TGAAGCAGCA CGCGGCTGTG CTCGAGGAAG GGGTCCTGGA TCCCAAGTCA 
ACCATTGTTG CCATCTTTCC GTCTCCCATG TTATATGCTG GCCCCACAGA GGTCCAGTGG 
CACTGCAGGT CCCGGATGAT TGCGGGTGCC AATTTCTACA TTGTGGGGAG GGACCCTGCA 
GGAATGCCCC ATCCTGAAAC CAAGAAGGAT CTGTATGAAC CCACTCATGG GGGCAAGGTC 
TTGAGCATGG CCCCTGGCCT CACCTCTGTG GAAATCATTC CATTCCGAGT GGCTGCCTAC 
AACAAAGCCA AAAAAGCCAT GGACTTCTAT GATCCAGCAA GGCACAATGA GTTTGACTTC 
ATCTCAGGAA CTCGAATGAG GAAGCTCGCC CGGGAAGGAG AGAATCCCCC AGATGGCTTC 
ATGGCCCCCA AAGCATGGAA GGTCCTGACA GATTATTACA GGTCCCTGGA GAAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAPSS2 ( NM_001015880.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001015880.1 Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17983
Clone ID Related Accession (Same CDS sequence)	NM_001015880.1 , NM_001015880.2
Accession Version	NM_001015880.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-28
Organism	Homo sapiens(human)
Product	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ221395.1, CB960618.1, AF150754.2, BC009894.2, BQ888954.1 and BQ772647.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) includes an alternate in-frame segment, compared to variant 1, resulting in a longer protein (isoform 2), compared to isoform 1. Isoform 2 has also been named PAPS synthase 2b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF150754.2, AF173365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGGCATG GCCCTTCCTG ATGGCGTGAT CAACATGAGC 
ATCCCCATTG TACTGCCCGT CTCTGCAGAG GATAAGACAC GGCTGGAAGG GTGCAGCAAG 
TTTGTCCTGG CACATGGTGG ACGGAGGGTA GCTATCTTAC GAGACGCTGA ATTCTATGAA 
CACAGAAAAG AGGAACGCTG TTCCCGTGTT TGGGGGACAA CATGTACAAA ACACCCCCAT 
ATCAAAATGG TGATGGAAAG TGGGGACTGG CTGGTTGGTG GAGACCTTCA GGTGCTGGAG 
AAAATAAGAT GGAATGATGG GCTGGACCAA TACCGTCTGA CACCTCTGGA GCTCAAACAG 
AAATGTAAAG AAATGAATGC TGATGCGGTG TTTGCATTCC AGTTGCGCAA TCCTGTCCAC 
AATGGCCATG CCCTGTTGAT GCAGGACACT CGCCGCAGGC TCCTAGAGAG GGGCTACAAG 
CACCCGGTCC TCCTACTACA CCCTCTGGGC GGCTGGACCA AGGATGACGA TGTGCCTCTA 
GACTGGCGGA TGAAGCAGCA CGCGGCTGTG CTCGAGGAAG GGGTCCTGGA TCCCAAGTCA 
ACCATTGTTG CCATCTTTCC GTCTCCCATG TTATATGCTG GCCCCACAGA GGTCCAGTGG 
CACTGCAGGT CCCGGATGAT TGCGGGTGCC AATTTCTACA TTGTGGGGAG GGACCCTGCA 
GGAATGCCCC ATCCTGAAAC CAAGAAGGAT CTGTATGAAC CCACTCATGG GGGCAAGGTC 
TTGAGCATGG CCCCTGGCCT CACCTCTGTG GAAATCATTC CATTCCGAGT GGCTGCCTAC 
AACAAAGCCA AAAAAGCCAT GGACTTCTAT GATCCAGCAA GGCACAATGA GTTTGACTTC 
ATCTCAGGAA CTCGAATGAG GAAGCTCGCC CGGGAAGGAG AGAATCCCCC AGATGGCTTC 
ATGGCCCCCA AAGCATGGAA GGTCCTGACA GATTATTACA GGTCCCTGGA GAAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015880.1
CDS	264..2123
Translation	MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDGMALPDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN

Target ORF information:

RefSeq Version	NM_001015880.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015880.1

ORF Insert Sequence:

ATGTCGGGGA TCAAGAAGCA AAAGACGGAG AACCAGCAGA AATCCACCAA TGTAGTCTAT 
CAGGCCCACC ATGTGAGCAG GAATAAGAGA GGGCAAGTGG TTGGAACAAG GGGTGGGTTC 
CGAGGATGTA CCGTGTGGCT AACAGGTCTC TCTGGTGCTG GAAAAACAAC GATAAGTTTT 
GCCCTGGAGG AGTACCTTGT CTCCCATGCC ATCCCTTGTT ACTCCCTGGA TGGGGACAAT 
GTCCGTCATG GCCTTAACAG AAATCTCGGA TTCTCTCCTG GGGACAGAGA GGAAAATATC 
CGCCGGATTG CTGAGGTGGC TAAGCTGTTT GCTGATGCTG GTCTGGTCTG CATTACCAGC 
TTTATTTCTC CATTCGCAAA GGATCGTGAG AATGCCCGCA AAATACATGA ATCAGCAGGG 
CTGCCATTCT TTGAAATATT TGTAGATGCA CCTCTAAATA TTTGTGAAAG CAGAGACGTA 
AAAGGCCTCT ATAAAAGGGC CAGAGCTGGG GAGATTAAAG GATTTACAGG TATTGATTCT 
GATTATGAGA AACCTGAAAC TCCTGAGCGT GTGCTTAAAA CCAATTTGTC CACAGTGAGT 
GACTGTGTCC ACCAGGTAGT GGAACTTCTG CAAGAGCAGA ACATTGTACC CTATACTATA 
ATCAAAGATA TCCACGAACT CTTTGTGCCG GAAAACAAAC TTGACCACGT CCGAGCTGAG 
GCTGAAACTC TCCCTTCATT ATCAATTACT AAGCTGGATC TCCAGTGGGT CCAGGTTTTG 
AGCGAAGGCT GGGCCACTCC CCTCAAAGGT TTCATGCGGG AGAAGGAGTA CTTACAGGTT 
ATGCACTTTG ACACCCTGCT AGATGGCATG GCCCTTCCTG ATGGCGTGAT CAACATGAGC 
ATCCCCATTG TACTGCCCGT CTCTGCAGAG GATAAGACAC GGCTGGAAGG GTGCAGCAAG 
TTTGTCCTGG CACATGGTGG ACGGAGGGTA GCTATCTTAC GAGACGCTGA ATTCTATGAA 
CACAGAAAAG AGGAACGCTG TTCCCGTGTT TGGGGGACAA CATGTACAAA ACACCCCCAT 
ATCAAAATGG TGATGGAAAG TGGGGACTGG CTGGTTGGTG GAGACCTTCA GGTGCTGGAG 
AAAATAAGAT GGAATGATGG GCTGGACCAA TACCGTCTGA CACCTCTGGA GCTCAAACAG 
AAATGTAAAG AAATGAATGC TGATGCGGTG TTTGCATTCC AGTTGCGCAA TCCTGTCCAC 
AATGGCCATG CCCTGTTGAT GCAGGACACT CGCCGCAGGC TCCTAGAGAG GGGCTACAAG 
CACCCGGTCC TCCTACTACA CCCTCTGGGC GGCTGGACCA AGGATGACGA TGTGCCTCTA 
GACTGGCGGA TGAAGCAGCA CGCGGCTGTG CTCGAGGAAG GGGTCCTGGA TCCCAAGTCA 
ACCATTGTTG CCATCTTTCC GTCTCCCATG TTATATGCTG GCCCCACAGA GGTCCAGTGG 
CACTGCAGGT CCCGGATGAT TGCGGGTGCC AATTTCTACA TTGTGGGGAG GGACCCTGCA 
GGAATGCCCC ATCCTGAAAC CAAGAAGGAT CTGTATGAAC CCACTCATGG GGGCAAGGTC 
TTGAGCATGG CCCCTGGCCT CACCTCTGTG GAAATCATTC CATTCCGAGT GGCTGCCTAC 
AACAAAGCCA AAAAAGCCAT GGACTTCTAT GATCCAGCAA GGCACAATGA GTTTGACTTC 
ATCTCAGGAA CTCGAATGAG GAAGCTCGCC CGGGAAGGAG AGAATCCCCC AGATGGCTTC 
ATGGCCCCCA AAGCATGGAA GGTCCTGACA GATTATTACA GGTCCCTGGA GAAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.
The journals of gerontology. Series A, Biological sciences and medical sciences71(10)1295-9(2016 Oct)
Yerges-Armstrong LM,Chai S,O'Connell JR,Curran JE,Blangero J,Mitchell BD,Shuldiner AR,Damcott CM

Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.
Carcinogenesis37(7)647-655(2016 Jul)
Hashimoto K,Zaitseva IN,Bonala R,Attaluri S,Ozga K,Iden CR,Johnson F,Moriya M,Grollman AP,Sidorenko VS

Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children.
Scientific reports518792(2015 Dec)
Chang X,Glessner J,Tin A,Li J,Guo Y,Wei Z,Liu Y,Mentch FD,Hou C,Zhao Y,Wang T,Qiu H,Kim C,Sleiman PM,Hakonarson H

Exploring prostate cancer genome reveals simultaneous losses of PTEN, FAS and PAPSS2 in patients with PSA recurrence after radical prostatectomy.
International journal of molecular sciences16(2)3856-69(2015 Feb)
Ibeawuchi C,Schmidt H,Voss R,Titze U,Abbas M,Neumann J,Eltze E,Hoogland AM,Jenster G,Brandt B,Semjonow A

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PAPSS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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