ARTN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARTN
Entrez Gene ID	9048
Full Name	artemin
Synonyms	ART,ENOVIN,EVN,NBN
General protein information	Preferred Names artemin Names artemin neublastin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.1
Summary	This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016].
Disorder MIM:	603886

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136215.2	NP_001129687.1	artemin isoform 3
NM_001136215.1	NP_001129687.1	artemin isoform 3
NM_057091.3	NP_476432.2	artemin isoform 1 preproprotein
NM_057090.2	NP_476431.2	artemin isoform 3
NM_057091.2	NP_476432.2	artemin isoform 1 preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ARTN	XP_002686562.1
Homo sapiens (human)	ARTN	NP_476431.2
Mus musculus (house mouse)	Artn	NP_033841.1
Pan troglodytes (chimpanzee)	ARTN	XP_001173961.1
	ARTN	XP_002801557.1
Rattus norvegicus (Norway rat)	Artn	NP_445849.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and clinical significance of ARTN and MMP-9 in endometrial carcinoma.
Wang XH, Liu YN, Tian K, Yao CX, Li LM, Zheng YQ, Shi ZM
Journal of biological regulators and homeostatic agents31(4)879-887(2017 Oct-Dec)

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.
Hidaka T, Ogawa E, Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Fujimura T, Aiba S, Nakayama K, Okuyama R, Yamamoto M
Nature immunology18(1)64-73(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AhR activation and ARTN expression were positively correlated in the epidermis of patients with atopic dermatitis.
Title: The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.

Report the activity, pharmacokinetics, conformational dynamics and biophysical properties of different glycoforms of ART.
Title: Investigating the Role of Artemin Glycosylation.

High ARTN increased xenograft tumor size and metastasis in hepatocellular carcinoma.
Title: Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma.

mRNA expression of Artemin (Artn) in the tongue mucosa of patients with burning mouth syndrome was significantly higher than that of control subjects.
Title: Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome.

Artemin expression promotes invasiveness and neurotrophic function of pancreatic adenocarcinoma cells in vivo and in vitro
Title: Neurotrophic Factor Artemin Promotes Invasiveness and Neurotrophic Function of Pancreatic Adenocarcinoma In Vivo and In Vitro.

The following ARTN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARTN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05677	NM_057091.3 Latest version!	Homo sapiens artemin (ARTN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu07413	NM_001136215.2 Latest version!	Homo sapiens artemin (ARTN), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu07413	NM_057090.2 Latest version!	Homo sapiens artemin (ARTN), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu07413	NM_001136215.1	Homo sapiens artemin (ARTN), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu05677	NM_057091.2	Homo sapiens artemin (ARTN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARTN ( NM_057091.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_476432.2 Homo sapiens artemin (ARTN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05677
Clone ID Related Accession (Same CDS sequence)	NM_057091.3 , NM_057091.2
Accession Version	NM_057091.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	artemin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF120274.1 and BC062375.1. On Nov 22, 2018 this sequence version replaced NM_057091.2. Transcript Variant: This variant (2) encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF120274.1, AI829054.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372359.10/ ENSP00000361434.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
CCTGCCCTGT GGCCCACCCT GGCCGCTCTG GCTCTGCTGA GCAGCGTCGC AGAGGCCTCC 
CTGGGCTCCG CGCCCCGCAG CCCTGCCCCC CGCGAAGGCC CCCCGCCTGT CCTGGCGTCC 
CCCGCCGGCC ACCTGCCGGG GGGACGCACG GCCCGCTGGT GCAGTGGAAG AGCCCGGCGG 
CCGCCGCCGC AGCCTTCTCG GCCCGCGCCC CCGCCGCCTG CACCCCCATC TGCTCTTCCC 
CGCGGGGGCC GCGCGGCGCG GGCTGGGGGC CCGGGCAGCC GCGCTCGGGC AGCGGGGGCG 
CGGGGCTGCC GCCTGCGCTC GCAGCTGGTG CCGGTGCGCG CGCTCGGCCT GGGCCACCGC 
TCCGACGAGC TGGTGCGTTT CCGCTTCTGC AGCGGCTCCT GCCGCCGCGC GCGCTCTCCA 
CACGACCTCA GCCTGGCCAG CCTACTGGGC GCCGGGGCCC TGCGACCGCC CCCGGGCTCC 
CGGCCCGTCA GCCAGCCCTG CTGCCGACCC ACGCGCTACG AAGCGGTCTC CTTCATGGAC 
GTCAACAGCA CCTGGAGAAC CGTGGACCGC CTCTCCGCCA CCGCCTGCGG CTGCCTGGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476432.2
CDS	302..964
Translation	MELGLGGLSTLSHCPWPRQQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG

Target ORF information:

RefSeq Version	NM_057091.3
Organism	Homo sapiens(human)
Definition	Homo sapiens artemin (ARTN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057091.3

ORF Insert Sequence:

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
CCTGCCCTGT GGCCCACCCT GGCCGCTCTG GCTCTGCTGA GCAGCGTCGC AGAGGCCTCC 
CTGGGCTCCG CGCCCCGCAG CCCTGCCCCC CGCGAAGGCC CCCCGCCTGT CCTGGCGTCC 
CCCGCCGGCC ACCTGCCGGG GGGACGCACG GCCCGCTGGT GCAGTGGAAG AGCCCGGCGG 
CCGCCGCCGC AGCCTTCTCG GCCCGCGCCC CCGCCGCCTG CACCCCCATC TGCTCTTCCC 
CGCGGGGGCC GCGCGGCGCG GGCTGGGGGC CCGGGCAGCC GCGCTCGGGC AGCGGGGGCG 
CGGGGCTGCC GCCTGCGCTC GCAGCTGGTG CCGGTGCGCG CGCTCGGCCT GGGCCACCGC 
TCCGACGAGC TGGTGCGTTT CCGCTTCTGC AGCGGCTCCT GCCGCCGCGC GCGCTCTCCA 
CACGACCTCA GCCTGGCCAG CCTACTGGGC GCCGGGGCCC TGCGACCGCC CCCGGGCTCC 
CGGCCCGTCA GCCAGCCCTG CTGCCGACCC ACGCGCTACG AAGCGGTCTC CTTCATGGAC 
GTCAACAGCA CCTGGAGAAC CGTGGACCGC CTCTCCGCCA CCGCCTGCGG CTGCCTGGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARTN ( NM_057091.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_476432.2 Homo sapiens artemin (ARTN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05677
Clone ID Related Accession (Same CDS sequence)	NM_057091.3 , NM_057091.2
Accession Version	NM_057091.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	artemin isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF120274.1, AL357079.24 and BC062375.1. On Oct 24, 2008 this sequence version replaced NM_057091.1. Transcript Variant: This variant (2) encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF120274.1, AI829054.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
CCTGCCCTGT GGCCCACCCT GGCCGCTCTG GCTCTGCTGA GCAGCGTCGC AGAGGCCTCC 
CTGGGCTCCG CGCCCCGCAG CCCTGCCCCC CGCGAAGGCC CCCCGCCTGT CCTGGCGTCC 
CCCGCCGGCC ACCTGCCGGG GGGACGCACG GCCCGCTGGT GCAGTGGAAG AGCCCGGCGG 
CCGCCGCCGC AGCCTTCTCG GCCCGCGCCC CCGCCGCCTG CACCCCCATC TGCTCTTCCC 
CGCGGGGGCC GCGCGGCGCG GGCTGGGGGC CCGGGCAGCC GCGCTCGGGC AGCGGGGGCG 
CGGGGCTGCC GCCTGCGCTC GCAGCTGGTG CCGGTGCGCG CGCTCGGCCT GGGCCACCGC 
TCCGACGAGC TGGTGCGTTT CCGCTTCTGC AGCGGCTCCT GCCGCCGCGC GCGCTCTCCA 
CACGACCTCA GCCTGGCCAG CCTACTGGGC GCCGGGGCCC TGCGACCGCC CCCGGGCTCC 
CGGCCCGTCA GCCAGCCCTG CTGCCGACCC ACGCGCTACG AAGCGGTCTC CTTCATGGAC 
GTCAACAGCA CCTGGAGAAC CGTGGACCGC CTCTCCGCCA CCGCCTGCGG CTGCCTGGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476432.2
CDS	783..1445
Translation	MELGLGGLSTLSHCPWPRQQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG

Target ORF information:

RefSeq Version	NM_057091.2
Organism	Homo sapiens(human)
Definition	Homo sapiens artemin (ARTN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057091.2

ORF Insert Sequence:

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
CCTGCCCTGT GGCCCACCCT GGCCGCTCTG GCTCTGCTGA GCAGCGTCGC AGAGGCCTCC 
CTGGGCTCCG CGCCCCGCAG CCCTGCCCCC CGCGAAGGCC CCCCGCCTGT CCTGGCGTCC 
CCCGCCGGCC ACCTGCCGGG GGGACGCACG GCCCGCTGGT GCAGTGGAAG AGCCCGGCGG 
CCGCCGCCGC AGCCTTCTCG GCCCGCGCCC CCGCCGCCTG CACCCCCATC TGCTCTTCCC 
CGCGGGGGCC GCGCGGCGCG GGCTGGGGGC CCGGGCAGCC GCGCTCGGGC AGCGGGGGCG 
CGGGGCTGCC GCCTGCGCTC GCAGCTGGTG CCGGTGCGCG CGCTCGGCCT GGGCCACCGC 
TCCGACGAGC TGGTGCGTTT CCGCTTCTGC AGCGGCTCCT GCCGCCGCGC GCGCTCTCCA 
CACGACCTCA GCCTGGCCAG CCTACTGGGC GCCGGGGCCC TGCGACCGCC CCCGGGCTCC 
CGGCCCGTCA GCCAGCCCTG CTGCCGACCC ACGCGCTACG AAGCGGTCTC CTTCATGGAC 
GTCAACAGCA CCTGGAGAAC CGTGGACCGC CTCTCCGCCA CCGCCTGCGG CTGCCTGGGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARTN ( NM_001136215.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129687.1 Homo sapiens artemin (ARTN), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu07413
Clone ID Related Accession (Same CDS sequence)	NM_001136215.2 , NM_001136215.1 , NM_057090.2
Accession Version	NM_001136215.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	artemin isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF120274.1 and BC062375.1. On Jun 1, 2019 this sequence version replaced NM_001136215.1. Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 2. The encoded isoform (3) is longer and lacks a predicted signal peptide compared to isoform 1. Both variants 4 and 5 encode the same isoform (3). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062375.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
GCTCCACTTG GTCTCTCCGC GCAGCCTGCC CTGTGGCCCA CCCTGGCCGC TCTGGCTCTG 
CTGAGCAGCG TCGCAGAGGC CTCCCTGGGC TCCGCGCCCC GCAGCCCTGC CCCCCGCGAA 
GGCCCCCCGC CTGTCCTGGC GTCCCCCGCC GGCCACCTGC CGGGGGGACG CACGGCCCGC 
TGGTGCAGTG GAAGAGCCCG GCGGCCGCCG CCGCAGCCTT CTCGGCCCGC GCCCCCGCCG 
CCTGCACCCC CATCTGCTCT TCCCCGCGGG GGCCGCGCGG CGCGGGCTGG GGGCCCGGGC 
AGCCGCGCTC GGGCAGCGGG GGCGCGGGGC TGCCGCCTGC GCTCGCAGCT GGTGCCGGTG 
CGCGCGCTCG GCCTGGGCCA CCGCTCCGAC GAGCTGGTGC GTTTCCGCTT CTGCAGCGGC 
TCCTGCCGCC GCGCGCGCTC TCCACACGAC CTCAGCCTGG CCAGCCTACT GGGCGCCGGG 
GCCCTGCGAC CGCCCCCGGG CTCCCGGCCC GTCAGCCAGC CCTGCTGCCG ACCCACGCGC 
TACGAAGCGG TCTCCTTCAT GGACGTCAAC AGCACCTGGA GAACCGTGGA CCGCCTCTCC 
GCCACCGCCT GCGGCTGCCT GGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129687.1
CDS	153..839
Translation	MELGLGGLSTLSHCPWPRQQAPLGLSAQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG

Target ORF information:

RefSeq Version	NM_001136215.2
Organism	Homo sapiens(human)
Definition	Homo sapiens artemin (ARTN), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136215.2

ORF Insert Sequence:

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
GCTCCACTTG GTCTCTCCGC GCAGCCTGCC CTGTGGCCCA CCCTGGCCGC TCTGGCTCTG 
CTGAGCAGCG TCGCAGAGGC CTCCCTGGGC TCCGCGCCCC GCAGCCCTGC CCCCCGCGAA 
GGCCCCCCGC CTGTCCTGGC GTCCCCCGCC GGCCACCTGC CGGGGGGACG CACGGCCCGC 
TGGTGCAGTG GAAGAGCCCG GCGGCCGCCG CCGCAGCCTT CTCGGCCCGC GCCCCCGCCG 
CCTGCACCCC CATCTGCTCT TCCCCGCGGG GGCCGCGCGG CGCGGGCTGG GGGCCCGGGC 
AGCCGCGCTC GGGCAGCGGG GGCGCGGGGC TGCCGCCTGC GCTCGCAGCT GGTGCCGGTG 
CGCGCGCTCG GCCTGGGCCA CCGCTCCGAC GAGCTGGTGC GTTTCCGCTT CTGCAGCGGC 
TCCTGCCGCC GCGCGCGCTC TCCACACGAC CTCAGCCTGG CCAGCCTACT GGGCGCCGGG 
GCCCTGCGAC CGCCCCCGGG CTCCCGGCCC GTCAGCCAGC CCTGCTGCCG ACCCACGCGC 
TACGAAGCGG TCTCCTTCAT GGACGTCAAC AGCACCTGGA GAACCGTGGA CCGCCTCTCC 
GCCACCGCCT GCGGCTGCCT GGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARTN ( NM_001136215.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129687.1 Homo sapiens artemin (ARTN), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu07413
Clone ID Related Accession (Same CDS sequence)	NM_001136215.2 , NM_001136215.1 , NM_057090.2
Accession Version	NM_001136215.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-05
Organism	Homo sapiens(human)
Product	artemin isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF120274.1, AL357079.24 and BC062375.1. Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 2. The encoded isoform (3) is longer and lacks a predicted signal peptide compared to isoform 1. Both variants 4 and 5 encode the same isoform (3). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062375.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
GCTCCACTTG GTCTCTCCGC GCAGCCTGCC CTGTGGCCCA CCCTGGCCGC TCTGGCTCTG 
CTGAGCAGCG TCGCAGAGGC CTCCCTGGGC TCCGCGCCCC GCAGCCCTGC CCCCCGCGAA 
GGCCCCCCGC CTGTCCTGGC GTCCCCCGCC GGCCACCTGC CGGGGGGACG CACGGCCCGC 
TGGTGCAGTG GAAGAGCCCG GCGGCCGCCG CCGCAGCCTT CTCGGCCCGC GCCCCCGCCG 
CCTGCACCCC CATCTGCTCT TCCCCGCGGG GGCCGCGCGG CGCGGGCTGG GGGCCCGGGC 
AGCCGCGCTC GGGCAGCGGG GGCGCGGGGC TGCCGCCTGC GCTCGCAGCT GGTGCCGGTG 
CGCGCGCTCG GCCTGGGCCA CCGCTCCGAC GAGCTGGTGC GTTTCCGCTT CTGCAGCGGC 
TCCTGCCGCC GCGCGCGCTC TCCACACGAC CTCAGCCTGG CCAGCCTACT GGGCGCCGGG 
GCCCTGCGAC CGCCCCCGGG CTCCCGGCCC GTCAGCCAGC CCTGCTGCCG ACCCACGCGC 
TACGAAGCGG TCTCCTTCAT GGACGTCAAC AGCACCTGGA GAACCGTGGA CCGCCTCTCC 
GCCACCGCCT GCGGCTGCCT GGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129687.1
CDS	634..1320
Translation	MELGLGGLSTLSHCPWPRQQAPLGLSAQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG

Target ORF information:

RefSeq Version	NM_001136215.1
Organism	Homo sapiens(human)
Definition	Homo sapiens artemin (ARTN), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136215.1

ORF Insert Sequence:

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
GCTCCACTTG GTCTCTCCGC GCAGCCTGCC CTGTGGCCCA CCCTGGCCGC TCTGGCTCTG 
CTGAGCAGCG TCGCAGAGGC CTCCCTGGGC TCCGCGCCCC GCAGCCCTGC CCCCCGCGAA 
GGCCCCCCGC CTGTCCTGGC GTCCCCCGCC GGCCACCTGC CGGGGGGACG CACGGCCCGC 
TGGTGCAGTG GAAGAGCCCG GCGGCCGCCG CCGCAGCCTT CTCGGCCCGC GCCCCCGCCG 
CCTGCACCCC CATCTGCTCT TCCCCGCGGG GGCCGCGCGG CGCGGGCTGG GGGCCCGGGC 
AGCCGCGCTC GGGCAGCGGG GGCGCGGGGC TGCCGCCTGC GCTCGCAGCT GGTGCCGGTG 
CGCGCGCTCG GCCTGGGCCA CCGCTCCGAC GAGCTGGTGC GTTTCCGCTT CTGCAGCGGC 
TCCTGCCGCC GCGCGCGCTC TCCACACGAC CTCAGCCTGG CCAGCCTACT GGGCGCCGGG 
GCCCTGCGAC CGCCCCCGGG CTCCCGGCCC GTCAGCCAGC CCTGCTGCCG ACCCACGCGC 
TACGAAGCGG TCTCCTTCAT GGACGTCAAC AGCACCTGGA GAACCGTGGA CCGCCTCTCC 
GCCACCGCCT GCGGCTGCCT GGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARTN ( NM_057090.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_476431.2 Homo sapiens artemin (ARTN), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu07413
Clone ID Related Accession (Same CDS sequence)	NM_001136215.2 , NM_001136215.1 , NM_057090.2
Accession Version	NM_057090.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	artemin isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF120274.1, AL357079.24 and BC062375.1. On Oct 24, 2008 this sequence version replaced NM_057090.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 2. The encoded isoform (3) is longer and lacks a predicted signal peptide compared to isoform 1. Both variants 4 and 5 encode the same isoform (3). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI935302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
GCTCCACTTG GTCTCTCCGC GCAGCCTGCC CTGTGGCCCA CCCTGGCCGC TCTGGCTCTG 
CTGAGCAGCG TCGCAGAGGC CTCCCTGGGC TCCGCGCCCC GCAGCCCTGC CCCCCGCGAA 
GGCCCCCCGC CTGTCCTGGC GTCCCCCGCC GGCCACCTGC CGGGGGGACG CACGGCCCGC 
TGGTGCAGTG GAAGAGCCCG GCGGCCGCCG CCGCAGCCTT CTCGGCCCGC GCCCCCGCCG 
CCTGCACCCC CATCTGCTCT TCCCCGCGGG GGCCGCGCGG CGCGGGCTGG GGGCCCGGGC 
AGCCGCGCTC GGGCAGCGGG GGCGCGGGGC TGCCGCCTGC GCTCGCAGCT GGTGCCGGTG 
CGCGCGCTCG GCCTGGGCCA CCGCTCCGAC GAGCTGGTGC GTTTCCGCTT CTGCAGCGGC 
TCCTGCCGCC GCGCGCGCTC TCCACACGAC CTCAGCCTGG CCAGCCTACT GGGCGCCGGG 
GCCCTGCGAC CGCCCCCGGG CTCCCGGCCC GTCAGCCAGC CCTGCTGCCG ACCCACGCGC 
TACGAAGCGG TCTCCTTCAT GGACGTCAAC AGCACCTGGA GAACCGTGGA CCGCCTCTCC 
GCCACCGCCT GCGGCTGCCT GGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476431.2
CDS	783..1469
Translation	MELGLGGLSTLSHCPWPRQQAPLGLSAQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG

Target ORF information:

RefSeq Version	NM_057090.2
Organism	Homo sapiens(human)
Definition	Homo sapiens artemin (ARTN), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057090.2

ORF Insert Sequence:

ATGGAACTTG GACTTGGAGG CCTCTCCACG CTGTCCCACT GCCCCTGGCC TAGGCAGCAG 
GCTCCACTTG GTCTCTCCGC GCAGCCTGCC CTGTGGCCCA CCCTGGCCGC TCTGGCTCTG 
CTGAGCAGCG TCGCAGAGGC CTCCCTGGGC TCCGCGCCCC GCAGCCCTGC CCCCCGCGAA 
GGCCCCCCGC CTGTCCTGGC GTCCCCCGCC GGCCACCTGC CGGGGGGACG CACGGCCCGC 
TGGTGCAGTG GAAGAGCCCG GCGGCCGCCG CCGCAGCCTT CTCGGCCCGC GCCCCCGCCG 
CCTGCACCCC CATCTGCTCT TCCCCGCGGG GGCCGCGCGG CGCGGGCTGG GGGCCCGGGC 
AGCCGCGCTC GGGCAGCGGG GGCGCGGGGC TGCCGCCTGC GCTCGCAGCT GGTGCCGGTG 
CGCGCGCTCG GCCTGGGCCA CCGCTCCGAC GAGCTGGTGC GTTTCCGCTT CTGCAGCGGC 
TCCTGCCGCC GCGCGCGCTC TCCACACGAC CTCAGCCTGG CCAGCCTACT GGGCGCCGGG 
GCCCTGCGAC CGCCCCCGGG CTCCCGGCCC GTCAGCCAGC CCTGCTGCCG ACCCACGCGC 
TACGAAGCGG TCTCCTTCAT GGACGTCAAC AGCACCTGGA GAACCGTGGA CCGCCTCTCC 
GCCACCGCCT GCGGCTGCCT GGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and clinical significance of ARTN and MMP-9 in endometrial carcinoma.
Journal of biological regulators and homeostatic agents31(4)879-887(2017 Oct-Dec)
Wang XH,Liu YN,Tian K,Yao CX,Li LM,Zheng YQ,Shi ZM

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.
Nature immunology18(1)64-73(2017 Jan)
Hidaka T,Ogawa E,Kobayashi EH,Suzuki T,Funayama R,Nagashima T,Fujimura T,Aiba S,Nakayama K,Okuyama R,Yamamoto M

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ARTN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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