TM4SF5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TM4SF5
Entrez Gene ID	9032
Full Name	transmembrane 4 L six family member 5
General protein information	Preferred Names transmembrane 4 L six family member 5 Names transmembrane 4 L6 family member 5 tetraspan transmembrane protein L6H transmembrane 4 superfamily member 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.2
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	604657

mRNA and Protein(s)

mRNA	Protein	Name
NM_003963.2	NP_003954.2	transmembrane 4 L6 family member 5 precursor
NM_003963.3	NP_003954.2	transmembrane 4 L6 family member 5 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TM4SF5	XP_536611.1
Mus musculus (house mouse)	Tm4sf5	NP_083636.2
Bos taurus (cattle)	TM4SF5	NP_001039567.1
Danio rerio (zebrafish)	tm4sf5	NP_001002372.1
Homo sapiens (human)	TM4SF5	NP_003954.2
	LOC709844	XP_001095974.1
Pan troglodytes (chimpanzee)	TM4SF5	XP_523818.1
Rattus norvegicus (Norway rat)	Tm4sf5	NP_001100485.1
Xenopus tropicalis (tropical clawed frog)	LOC100490620	XP_004919013.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.
Cheong JG, Song DG, Song HE, Berditchevski F, Nam SH, Jung JW, Kim HJ, Kim JE, Kim S, Ryu J, Cho CY, Lee KM, Lee JW
Oncotarget8(8)13277-13292(2017 Feb)

TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes.
Ryu J, Lee JW
Mediators of inflammation20175108525(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels.
Title: Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.

promotes self-renewal and circulating tumor cell properties
Title: Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells.

TM4SF5-positive tumors exhibited locally-increased CD44 expression, suggesting tumor cell differentiation
Title: Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44.

TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer
Title: TM4SF5-CTD-2354A18.1-miR-4697-3P may play a key role in the pathogenesis of gastric cancer.

TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer.
Title: Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model.

The following TM4SF5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TM4SF5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31775	NM_003963.3 Latest version!	Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31775	NM_003963.2	Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TM4SF5 ( NM_003963.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003954.2 Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.

Price & Availability↑

CloneID	OHu31775
Clone ID Related Accession (Same CDS sequence)	NM_003963.2 , NM_003963.3
Accession Version	NM_003963.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	transmembrane 4 L6 family member 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091153.10 and AC233723.2. On Nov 25, 2018 this sequence version replaced NM_003963.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.117107.1, SRR5189664.21184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000270560.4/ ENSP00000270560.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGTACGG GAAAATGTGC CCGCTGTGTG GGGCTCTCCC TCATTACCCT CTGCCTCGTC 
TGCATTGTGG CCAACGCCCT CCTGCTGGTA CCTAATGGGG AGACCTCCTG GACCAACACC 
AACCATCTCA GCTTGCAAGT CTGGCTCATG GGCGGCTTCA TTGGCGGGGG CCTAATGGTA 
CTGTGTCCGG GGATTGCAGC CGTTCGGGCA GGGGGCAAGG GCTGCTGTGG TGCTGGGTGC 
TGTGGAAACC GCTGCAGGAT GCTGCGCTCG GTCTTCTCCT CGGCGTTCGG GGTGCTTGGT 
GCCATCTACT GCCTCTCGGT GTCTGGAGCT GGGCTCCGAA ATGGACCCAG ATGCTTAATG 
AACGGCGAGT GGGGCTACCA CTTCGAAGAC ACCGCGGGAG CTTACTTGCT CAACCGCACT 
CTATGGGATC GGTGCGAGGC GCCCCCTCGC GTGGTCCCCT GGAATGTGAC GCTCTTCTCG 
CTGCTGGTGG CCGCCTCCTG CCTGGAGATA GTACTGTGTG GGATCCAGCT GGTGAACGCG 
ACCATTGGTG TCTTCTGCGG CGATTGCAGG AAAAAACAGG ACACACCTCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003954.2
CDS	38..631
Translation	MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH

Target ORF information:

RefSeq Version	NM_003963.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003963.3

ORF Insert Sequence:

ATGTGTACGG GAAAATGTGC CCGCTGTGTG GGGCTCTCCC TCATTACCCT CTGCCTCGTC 
TGCATTGTGG CCAACGCCCT CCTGCTGGTA CCTAATGGGG AGACCTCCTG GACCAACACC 
AACCATCTCA GCTTGCAAGT CTGGCTCATG GGCGGCTTCA TTGGCGGGGG CCTAATGGTA 
CTGTGTCCGG GGATTGCAGC CGTTCGGGCA GGGGGCAAGG GCTGCTGTGG TGCTGGGTGC 
TGTGGAAACC GCTGCAGGAT GCTGCGCTCG GTCTTCTCCT CGGCGTTCGG GGTGCTTGGT 
GCCATCTACT GCCTCTCGGT GTCTGGAGCT GGGCTCCGAA ATGGACCCAG ATGCTTAATG 
AACGGCGAGT GGGGCTACCA CTTCGAAGAC ACCGCGGGAG CTTACTTGCT CAACCGCACT 
CTATGGGATC GGTGCGAGGC GCCCCCTCGC GTGGTCCCCT GGAATGTGAC GCTCTTCTCG 
CTGCTGGTGG CCGCCTCCTG CCTGGAGATA GTACTGTGTG GGATCCAGCT GGTGAACGCG 
ACCATTGGTG TCTTCTGCGG CGATTGCAGG AAAAAACAGG ACACACCTCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TM4SF5 ( NM_003963.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003954.2 Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.

Price & Availability↑

CloneID	OHu31775
Clone ID Related Accession (Same CDS sequence)	NM_003963.2 , NM_003963.3
Accession Version	NM_003963.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	transmembrane 4 L6 family member 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF027204.1. On May 30, 2002 this sequence version replaced NM_003963.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF027204.1, ERR279857.4201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTGTACGG GAAAATGTGC CCGCTGTGTG GGGCTCTCCC TCATTACCCT CTGCCTCGTC 
TGCATTGTGG CCAACGCCCT CCTGCTGGTA CCTAATGGGG AGACCTCCTG GACCAACACC 
AACCATCTCA GCTTGCAAGT CTGGCTCATG GGCGGCTTCA TTGGCGGGGG CCTAATGGTA 
CTGTGTCCGG GGATTGCAGC CGTTCGGGCA GGGGGCAAGG GCTGCTGTGG TGCTGGGTGC 
TGTGGAAACC GCTGCAGGAT GCTGCGCTCG GTCTTCTCCT CGGCGTTCGG GGTGCTTGGT 
GCCATCTACT GCCTCTCGGT GTCTGGAGCT GGGCTCCGAA ATGGACCCAG ATGCTTAATG 
AACGGCGAGT GGGGCTACCA CTTCGAAGAC ACCGCGGGAG CTTACTTGCT CAACCGCACT 
CTATGGGATC GGTGCGAGGC GCCCCCTCGC GTGGTCCCCT GGAATGTGAC GCTCTTCTCG 
CTGCTGGTGG CCGCCTCCTG CCTGGAGATA GTACTGTGTG GGATCCAGCT GGTGAACGCG 
ACCATTGGTG TCTTCTGCGG CGATTGCAGG AAAAAACAGG ACACACCTCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003954.2
CDS	32..625
Translation	MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH

Target ORF information:

RefSeq Version	NM_003963.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane 4 L six family member 5 (TM4SF5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003963.2

ORF Insert Sequence:

ATGTGTACGG GAAAATGTGC CCGCTGTGTG GGGCTCTCCC TCATTACCCT CTGCCTCGTC 
TGCATTGTGG CCAACGCCCT CCTGCTGGTA CCTAATGGGG AGACCTCCTG GACCAACACC 
AACCATCTCA GCTTGCAAGT CTGGCTCATG GGCGGCTTCA TTGGCGGGGG CCTAATGGTA 
CTGTGTCCGG GGATTGCAGC CGTTCGGGCA GGGGGCAAGG GCTGCTGTGG TGCTGGGTGC 
TGTGGAAACC GCTGCAGGAT GCTGCGCTCG GTCTTCTCCT CGGCGTTCGG GGTGCTTGGT 
GCCATCTACT GCCTCTCGGT GTCTGGAGCT GGGCTCCGAA ATGGACCCAG ATGCTTAATG 
AACGGCGAGT GGGGCTACCA CTTCGAAGAC ACCGCGGGAG CTTACTTGCT CAACCGCACT 
CTATGGGATC GGTGCGAGGC GCCCCCTCGC GTGGTCCCCT GGAATGTGAC GCTCTTCTCG 
CTGCTGGTGG CCGCCTCCTG CCTGGAGATA GTACTGTGTG GGATCCAGCT GGTGAACGCG 
ACCATTGGTG TCTTCTGCGG CGATTGCAGG AAAAAACAGG ACACACCTCA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.
Oncotarget8(8)13277-13292(2017 Feb)
Cheong JG,Song DG,Song HE,Berditchevski F,Nam SH,Jung JW,Kim HJ,Kim JE,Kim S,Ryu J,Cho CY,Lee KM,Lee JW

TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes.
Mediators of inflammation20175108525(2017)
Ryu J,Lee JW

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TM4SF5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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