NAT8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NAT8
Entrez Gene ID	9027
Full Name	N-acetyltransferase 8 (putative)
Synonyms	ATase2,CCNAT,CML1,GLA,Hcml1,TSC501,TSC510
General protein information	Preferred Names N-acetyltransferase 8 (putative) Names N-acetyltransferase 8 N-acetyltransferase 8 (GCN5-related, putative) N-acetyltransferase 8 (camello like) acetyltransferase 2 camello-like protein 1 cysteinyl-conjugate N-acetyltransferase kidney- and liver-specific gene product probable N-acetyltransferase 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.1
Summary	This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008].
Disorder MIM:	606716

mRNA and Protein(s)

mRNA	Protein	Name
NM_003960.4	NP_003951.3	N-acetyltransferase 8
NM_003960.3	NP_003951.3	N-acetyltransferase 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	NAT8	NP_003951.3
Pan troglodytes (chimpanzee)	NAT8	XP_003949861.1
Rattus norvegicus (Norway rat)	Nat8	NP_072157.1
Mus musculus (house mouse)	Nat8	NP_075944.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of Increased n-acetylaspartate Levels in Cancer.
Zand B, Previs RA, Zacharias NM, Rupaimoole R, Mitamura T, Nagaraja AS, Guindani M, Dalton HJ, Yang L, Baddour J, Achreja A, Hu W, Pecot CV, Ivan C, Wu SY, McCullough CR, Gharpure KM, Shoshan E, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Wang Y, Nick AM, Davies MA, Armaiz-Pena G, Liu J, Lutgendorf SK, Baggerly KA, Eli MB, Lopez-Berestein G, Nagrath D, Bhattacharya PK, Sood AK
Journal of the National Cancer Institute108(6)djv426(2016 Jan)

The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides.
Ding Y, Dellisanti CD, Ko MH, Czajkowski C, Puglielli L
The Journal of biological chemistry289(46)32044-55(2014 Nov)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.
Mak AB, Pehar M, Nixon AM, Williams RA, Uetrecht AC, Puglielli L, Moffat J
Journal of molecular biology426(11)2175-82(2014 May)

Genetic determinants influencing human serum metabolome among African Americans.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh J, Boerwinkle E
PLoS genetics10(3)e1004212(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate that the NAA pathway has a prominent role in promoting tumor growth and represents a valuable target for anticancer therapy.
Title: Role of Increased n-acetylaspartate Levels in Cancer.

ATase1 and ATase2 are endoplasmic reticulum-based acetyltransferases that form homo- and heterodimers and associate with members of the oligosaccharyltransferase complex
Title: The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides.

Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation.
Title: Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ?-secretase (BACE1) levels and A? generation.

NAT8L is the NAA biosynthetic enzyme Asp-N-acetyltransferase and is highly specific for the acetylation of aspartate.
Title: Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.

NAT8 is the enzyme that acetylates cysteine S-conjugates to mercapturic acids
Title: Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids.

The following NAT8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NAT8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24209	NM_003960.4 Latest version!	Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24209	NM_003960.3	Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NAT8 ( NM_003960.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003951.3 Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.

Price & Availability↑

CloneID	OHu24209
Clone ID Related Accession (Same CDS sequence)	NM_003960.4 , NM_003960.3
Accession Version	NM_003960.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	N-acetyltransferase 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092653.3 and BG426653.1. On May 17, 2019 this sequence version replaced NM_003960.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012626.1, AF187813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000272425.4/ ENSP00000272425.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTT GTCACATCCG CAAATACCAG GAGAGCGACC GCCAGTGGGT TGTGGGCTTG 
CTCTCCCGGG GGATGGCCGA GCATGCCCCA GCCACCTTCC GGCAATTGCT GAAGCTGCCT 
CGAACCCTCA TACTCTTACT TGGGGGGCCC CTCGCCCTAC TCCTGGTCTC TGGATCCTGG 
CTTCTAGCCC TCGTGTTCAG CATCAGCCTC TTCCCTGCCC TGTGGTTCCT TGCCAAAAAA 
CCCTGGACGG AGTATGTGGA CATGACATTG TGCACAGACA TGTCTGACAT TACCAAATCC 
TACCTGAGTG AGCGTGGCTC CTGCTTCTGG GTGGCTGAGT CTGAAGAGAA GGTGGTGGGC 
ATGGTAGGAG CTCTGCCTGT TGATGATCCC ACCTTGAGGG AGAAGCGGTT GCAGCTGTTT 
CATCTCTTTG TGGACAGTGA GCACCGTCGT CAGGGGATAG CAAAAGCCCT GGTCAGGACT 
GTCCTCCAGT TTGCCCGGGA CCAGGGCTAC AGTGAAGTTA TCCTGGACAC CGGCACCATC 
CAGCTCTCTG CTATGGCCCT CTACCAGAGC ATGGGCTTCA AGAAGACGGG CCAGTCCTTC 
TTCTGTGTGT GGGCCAGGCT AGTGGCTCTT CATACAGTTC ATTTCATCTA CCACCTCCCT 
TCTTCTAAGG TAGGGAGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003951.3
CDS	180..863
Translation	MAPCHIRKYQESDRQWVVGLLSRGMAEHAPATFRQLLKLPRTLILLLGGPLALLLVSGSWLLALVFSISLFPALWFLAKKPWTEYVDMTLCTDMSDITKSYLSERGSCFWVAESEEKVVGMVGALPVDDPTLREKRLQLFHLFVDSEHRRQGIAKALVRTVLQFARDQGYSEVILDTGTIQLSAMALYQSMGFKKTGQSFFCVWARLVALHTVHFIYHLPSSKVGSL

Target ORF information:

RefSeq Version	NM_003960.4
Organism	Homo sapiens(human)
Definition	Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003960.4

ORF Insert Sequence:

ATGGCTCCTT GTCACATCCG CAAATACCAG GAGAGCGACC GCCAGTGGGT TGTGGGCTTG 
CTCTCCCGGG GGATGGCCGA GCATGCCCCA GCCACCTTCC GGCAATTGCT GAAGCTGCCT 
CGAACCCTCA TACTCTTACT TGGGGGGCCC CTCGCCCTAC TCCTGGTCTC TGGATCCTGG 
CTTCTAGCCC TCGTGTTCAG CATCAGCCTC TTCCCTGCCC TGTGGTTCCT TGCCAAAAAA 
CCCTGGACGG AGTATGTGGA CATGACATTG TGCACAGACA TGTCTGACAT TACCAAATCC 
TACCTGAGTG AGCGTGGCTC CTGCTTCTGG GTGGCTGAGT CTGAAGAGAA GGTGGTGGGC 
ATGGTAGGAG CTCTGCCTGT TGATGATCCC ACCTTGAGGG AGAAGCGGTT GCAGCTGTTT 
CATCTCTTTG TGGACAGTGA GCACCGTCGT CAGGGGATAG CAAAAGCCCT GGTCAGGACT 
GTCCTCCAGT TTGCCCGGGA CCAGGGCTAC AGTGAAGTTA TCCTGGACAC CGGCACCATC 
CAGCTCTCTG CTATGGCCCT CTACCAGAGC ATGGGCTTCA AGAAGACGGG CCAGTCCTTC 
TTCTGTGTGT GGGCCAGGCT AGTGGCTCTT CATACAGTTC ATTTCATCTA CCACCTCCCT 
TCTTCTAAGG TAGGGAGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAT8 ( NM_003960.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003951.3 Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.

Price & Availability↑

CloneID	OHu24209
Clone ID Related Accession (Same CDS sequence)	NM_003960.4 , NM_003960.3
Accession Version	NM_003960.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	N-acetyltransferase 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG426653.1 and AC092653.3. On Nov 1, 2006 this sequence version replaced NM_003960.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF187813.1, BC012626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTT GTCACATCCG CAAATACCAG GAGAGCGACC GCCAGTGGGT TGTGGGCTTG 
CTCTCCCGGG GGATGGCCGA GCATGCCCCA GCCACCTTCC GGCAATTGCT GAAGCTGCCT 
CGAACCCTCA TACTCTTACT TGGGGGGCCC CTCGCCCTAC TCCTGGTCTC TGGATCCTGG 
CTTCTAGCCC TCGTGTTCAG CATCAGCCTC TTCCCTGCCC TGTGGTTCCT TGCCAAAAAA 
CCCTGGACGG AGTATGTGGA CATGACATTG TGCACAGACA TGTCTGACAT TACCAAATCC 
TACCTGAGTG AGCGTGGCTC CTGCTTCTGG GTGGCTGAGT CTGAAGAGAA GGTGGTGGGC 
ATGGTAGGAG CTCTGCCTGT TGATGATCCC ACCTTGAGGG AGAAGCGGTT GCAGCTGTTT 
CATCTCTTTG TGGACAGTGA GCACCGTCGT CAGGGGATAG CAAAAGCCCT GGTCAGGACT 
GTCCTCCAGT TTGCCCGGGA CCAGGGCTAC AGTGAAGTTA TCCTGGACAC CGGCACCATC 
CAGCTCTCTG CTATGGCCCT CTACCAGAGC ATGGGCTTCA AGAAGACGGG CCAGTCCTTC 
TTCTGTGTGT GGGCCAGGCT AGTGGCTCTT CATACAGTTC ATTTCATCTA CCACCTCCCT 
TCTTCTAAGG TAGGGAGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003951.3
CDS	168..851
Translation	MAPCHIRKYQESDRQWVVGLLSRGMAEHAPATFRQLLKLPRTLILLLGGPLALLLVSGSWLLALVFSISLFPALWFLAKKPWTEYVDMTLCTDMSDITKSYLSERGSCFWVAESEEKVVGMVGALPVDDPTLREKRLQLFHLFVDSEHRRQGIAKALVRTVLQFARDQGYSEVILDTGTIQLSAMALYQSMGFKKTGQSFFCVWARLVALHTVHFIYHLPSSKVGSL

Target ORF information:

RefSeq Version	NM_003960.3
Organism	Homo sapiens(human)
Definition	Homo sapiens N-acetyltransferase 8 (putative) (NAT8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003960.3

ORF Insert Sequence:

ATGGCTCCTT GTCACATCCG CAAATACCAG GAGAGCGACC GCCAGTGGGT TGTGGGCTTG 
CTCTCCCGGG GGATGGCCGA GCATGCCCCA GCCACCTTCC GGCAATTGCT GAAGCTGCCT 
CGAACCCTCA TACTCTTACT TGGGGGGCCC CTCGCCCTAC TCCTGGTCTC TGGATCCTGG 
CTTCTAGCCC TCGTGTTCAG CATCAGCCTC TTCCCTGCCC TGTGGTTCCT TGCCAAAAAA 
CCCTGGACGG AGTATGTGGA CATGACATTG TGCACAGACA TGTCTGACAT TACCAAATCC 
TACCTGAGTG AGCGTGGCTC CTGCTTCTGG GTGGCTGAGT CTGAAGAGAA GGTGGTGGGC 
ATGGTAGGAG CTCTGCCTGT TGATGATCCC ACCTTGAGGG AGAAGCGGTT GCAGCTGTTT 
CATCTCTTTG TGGACAGTGA GCACCGTCGT CAGGGGATAG CAAAAGCCCT GGTCAGGACT 
GTCCTCCAGT TTGCCCGGGA CCAGGGCTAC AGTGAAGTTA TCCTGGACAC CGGCACCATC 
CAGCTCTCTG CTATGGCCCT CTACCAGAGC ATGGGCTTCA AGAAGACGGG CCAGTCCTTC 
TTCTGTGTGT GGGCCAGGCT AGTGGCTCTT CATACAGTTC ATTTCATCTA CCACCTCCCT 
TCTTCTAAGG TAGGGAGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of Increased n-acetylaspartate Levels in Cancer.
Journal of the National Cancer Institute108(6)djv426(2016 Jan)
Zand B,Previs RA,Zacharias NM,Rupaimoole R,Mitamura T,Nagaraja AS,Guindani M,Dalton HJ,Yang L,Baddour J,Achreja A,Hu W,Pecot CV,Ivan C,Wu SY,McCullough CR,Gharpure KM,Shoshan E,Pradeep S,Mangala LS,Rodriguez-Aguayo C,Wang Y,Nick AM,Davies MA,Armaiz-Pena G,Liu J,Lutgendorf SK,Baggerly KA,Eli MB,Lopez-Berestein G,Nagrath D,Bhattacharya PK,Sood AK

The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides.
The Journal of biological chemistry289(46)32044-55(2014 Nov)
Ding Y,Dellisanti CD,Ko MH,Czajkowski C,Puglielli L

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.
Journal of molecular biology426(11)2175-82(2014 May)
Mak AB,Pehar M,Nixon AM,Williams RA,Uetrecht AC,Puglielli L,Moffat J

Genetic determinants influencing human serum metabolome among African Americans.
PLoS genetics10(3)e1004212(2014 Mar)
Yu B,Zheng Y,Alexander D,Morrison AC,Coresh J,Boerwinkle E

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

NAT8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報