UCN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UCN2
Entrez Gene ID	90226
Full Name	urocortin 2
Synonyms	SRP,UCN-II,UCNI,UR,URP
General protein information	Preferred Names urocortin 2 Names urocortin-2 prepro-urocortin 2 stresscopin-related peptide ucn II urocortin II urocortin-related peptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.31
Summary	This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008].
Disorder MIM:	605902

mRNA and Protein(s)

mRNA	Protein	Name
NM_033199.3	NP_149976.1	urocortin-2 preproprotein
NM_033199.4	NP_149976.1	urocortin-2 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ucn2	NP_659543.1
Rattus norvegicus (Norway rat)	Ucn2	NP_596876.2
Canis lupus familiaris (dog)	UCN2	XP_005632644.1
Bos taurus (cattle)	UCN2	XP_005223073.1
Homo sapiens (human)	UCN2	NP_149976.1

Gene Ontology
Bibliography

Related articles in PubMed

Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.
Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T
The Journal of experimental medicine214(7)1877-1888(2017 Jul)

Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.
Stirrat CG, Venkatasubramanian S, Pawade T, Mitchell AJ, Shah AS, Lang NN, Newby DE
British journal of clinical pharmacology82(4)974-82(2016 Oct)

TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children.
Priego T, S?nchez J, Pic? C, Ahrens W, De Henauw S, Kourides Y, Lissner L, Moln?r D, Moreno LA, Russo P, Siani A, Veidebaum T, Palou A,
The Journal of clinical endocrinology and metabolism100(9)3556-64(2015 Sep)

Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition.
Voltolini C, Battersby S, Novembri R, Torricelli M, Severi FM, Petraglia F, Norman JE
Endocrinology156(2)670-9(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure.
Title: Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.

examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure
Title: Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.

The transcripts of TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.
Title: TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children.

up-regulated in placenta, fetal membranes, and myometrium in labor
Title: Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition.

Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes.
Title: Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes and the differentiation of mouse 3T3L1 pre-adipocytes.

The following UCN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15989	NM_033199.4 Latest version!	Homo sapiens urocortin 2 (UCN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15989	NM_033199.3	Homo sapiens urocortin 2 (UCN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UCN2 ( NM_033199.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_149976.1 Homo sapiens urocortin 2 (UCN2), mRNA.

Price & Availability↑

CloneID	OHu15989
Clone ID Related Accession (Same CDS sequence)	NM_033199.3 , NM_033199.4
Accession Version	NM_033199.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	urocortin-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC002647.2. On May 5, 2005 this sequence version replaced NM_033199.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002647.2, BQ428279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2161920 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCAGGT GTGCTCTGCT GTTGCTGATG GTCCTGATGT TGGGCAGAGT CCTGGTTGTC 
CCAGTGACCC CTATCCCAAC CTTCCAGCTC CGCCCTCAGA ATTCTCCCCA GACCACTCCC 
CGACCTGCGG CCTCAGAGAG CCCCTCAGCT GCTCCCACAT GGCCGTGGGC TGCCCAGAGC 
CACTGCAGCC CCACCCGCCA CCCTGGCTCG CGCATTGTCC TATCGCTGGA TGTCCCCATC 
GGCCTCTTGC AGATCTTACT GGAGCAAGCC CGGGCCAGGG CTGCCAGGGA GCAGGCCACC 
ACCAACGCCC GCATCCTGGC CCGTGTCGGC CACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149976.1
CDS	79..417
Translation	MTRCALLLLMVLMLGRVLVVPVTPIPTFQLRPQNSPQTTPRPAASESPSAAPTWPWAAQSHCSPTRHPGSRIVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC

Target ORF information:

RefSeq Version	NM_033199.3
Organism	Homo sapiens(human)
Definition	Homo sapiens urocortin 2 (UCN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033199.3

ORF Insert Sequence:

ATGACCAGGT GTGCTCTGCT GTTGCTGATG GTCCTGATGT TGGGCAGAGT CCTGGTTGTC 
CCAGTGACCC CTATCCCAAC CTTCCAGCTC CGCCCTCAGA ATTCTCCCCA GACCACTCCC 
CGACCTGCGG CCTCAGAGAG CCCCTCAGCT GCTCCCACAT GGCCGTGGGC TGCCCAGAGC 
CACTGCAGCC CCACCCGCCA CCCTGGCTCG CGCATTGTCC TATCGCTGGA TGTCCCCATC 
GGCCTCTTGC AGATCTTACT GGAGCAAGCC CGGGCCAGGG CTGCCAGGGA GCAGGCCACC 
ACCAACGCCC GCATCCTGGC CCGTGTCGGC CACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCN2 ( NM_033199.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_149976.1 Homo sapiens urocortin 2 (UCN2), mRNA.

Price & Availability↑

CloneID	OHu15989
Clone ID Related Accession (Same CDS sequence)	NM_033199.3 , NM_033199.4
Accession Version	NM_033199.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	urocortin-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC121252.4 and BC002647.2. On Nov 22, 2018 this sequence version replaced NM_033199.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002647.2, BC022096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2161920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000273610.4/ ENSP00000273610.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCAGGT GTGCTCTGCT GTTGCTGATG GTCCTGATGT TGGGCAGAGT CCTGGTTGTC 
CCAGTGACCC CTATCCCAAC CTTCCAGCTC CGCCCTCAGA ATTCTCCCCA GACCACTCCC 
CGACCTGCGG CCTCAGAGAG CCCCTCAGCT GCTCCCACAT GGCCGTGGGC TGCCCAGAGC 
CACTGCAGCC CCACCCGCCA CCCTGGCTCG CGCATTGTCC TATCGCTGGA TGTCCCCATC 
GGCCTCTTGC AGATCTTACT GGAGCAAGCC CGGGCCAGGG CTGCCAGGGA GCAGGCCACC 
ACCAACGCCC GCATCCTGGC CCGTGTCGGC CACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149976.1
CDS	92..430
Translation	MTRCALLLLMVLMLGRVLVVPVTPIPTFQLRPQNSPQTTPRPAASESPSAAPTWPWAAQSHCSPTRHPGSRIVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC

Target ORF information:

RefSeq Version	NM_033199.4
Organism	Homo sapiens(human)
Definition	Homo sapiens urocortin 2 (UCN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033199.4

ORF Insert Sequence:

ATGACCAGGT GTGCTCTGCT GTTGCTGATG GTCCTGATGT TGGGCAGAGT CCTGGTTGTC 
CCAGTGACCC CTATCCCAAC CTTCCAGCTC CGCCCTCAGA ATTCTCCCCA GACCACTCCC 
CGACCTGCGG CCTCAGAGAG CCCCTCAGCT GCTCCCACAT GGCCGTGGGC TGCCCAGAGC 
CACTGCAGCC CCACCCGCCA CCCTGGCTCG CGCATTGTCC TATCGCTGGA TGTCCCCATC 
GGCCTCTTGC AGATCTTACT GGAGCAAGCC CGGGCCAGGG CTGCCAGGGA GCAGGCCACC 
ACCAACGCCC GCATCCTGGC CCGTGTCGGC CACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.
The Journal of experimental medicine214(7)1877-1888(2017 Jul)
Tsuda T,Takefuji M,Wettschureck N,Kotani K,Morimoto R,Okumura T,Kaur H,Eguchi S,Sakaguchi T,Ishihama S,Kikuchi R,Unno K,Matsushita K,Ishikawa S,Offermanns S,Murohara T

Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.
British journal of clinical pharmacology82(4)974-82(2016 Oct)
Stirrat CG,Venkatasubramanian S,Pawade T,Mitchell AJ,Shah AS,Lang NN,Newby DE

TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children.
The Journal of clinical endocrinology and metabolism100(9)3556-64(2015 Sep)
Priego T,S?nchez J,Pic? C,Ahrens W,De Henauw S,Kourides Y,Lissner L,Moln?r D,Moreno LA,Russo P,Siani A,Veidebaum T,Palou A,

Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition.
Endocrinology156(2)670-9(2015 Feb)
Voltolini C,Battersby S,Novembri R,Torricelli M,Severi FM,Petraglia F,Norman JE

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

UCN2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報