WFDC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WFDC8
Entrez Gene ID	90199
Full Name	WAP four-disulfide core domain 8
Synonyms	C20orf170,HEL-S-292,WAP8,dJ461P17.1
General protein information	Preferred Names WAP four-disulfide core domain 8 Names WAP four-disulfide core domain protein 8 WAP motif protein 1 epididymis secretory protein Li 292 protease inhibitor WAP8 putative protease inhibitor WAP8 testicular secretory protein Li 68
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181510.3	NP_852611.2	WAP four-disulfide core domain protein 8 precursor
NM_130896.3	NP_570966.2	WAP four-disulfide core domain protein 8 precursor
NM_181510.2	NP_852611.2	WAP four-disulfide core domain protein 8 precursor
NM_130896.2	NP_570966.2	WAP four-disulfide core domain protein 8 precursor
XM_017028119.1	XP_016883608.1	WAP four-disulfide core domain protein 8 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	WFDC8	XP_001156135.1
Rattus norvegicus (Norway rat)	Wfdc8	XP_006235689.1
	WFDC8	XP_001107439.1
Bos taurus (cattle)	WFDC8	XP_002692387.2
Homo sapiens (human)	WFDC8	NP_570966.2
Canis lupus familiaris (dog)	LOC477245	XP_534437.2
Mus musculus (house mouse)	Wfdc8	NP_001074019.1

Gene Ontology
Bibliography

Related articles in PubMed

Reproduction and immunity-driven natural selection in the human WFDC locus.
Ferreira Z, Seixas S, Andr?s AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Swanson WJ, , Clark AG, Green ED, Hurle B
Molecular biology and evolution30(4)938-50(2013 Apr)

Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans.
Ferreira Z, Hurle B, Rocha J, Seixas S
Molecular biology and evolution28(10)2811-22(2011 Oct)

The evolution of a genetic locus encoding small serine proteinase inhibitors.
Clauss A, Lilja H, Lundwall A
Biochemical and biophysical research communications333(2)383-9(2005 Jul)

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
Clauss A, Lilja H, Lundwall A
The Biochemical journal368(Pt 1)233-42(2002 Nov)

The DNA sequence and comparative analysis of human chromosome 20.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
Nature414(6866)865-71(2001 Dec 20-27)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We propose that the evolution of WFDC8 and SPINT4 has been shaped by complex selective scenarios due to the interdependence of variant fitness and ecological variables.
Title: Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans.

The following WFDC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WFDC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05924	NM_130896.3 Latest version!	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu05924	NM_181510.3 Latest version!	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu93153	XM_017028119.1 Latest version!	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu05924	NM_181510.2	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu05924	NM_130896.2	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WFDC8 ( NM_181510.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_852611.2 Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu05924
Clone ID Related Accession (Same CDS sequence)	NM_181510.3 , NM_130896.3 , NM_181510.2 , NM_130896.2
Accession Version	NM_181510.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 8 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121778.12 and AL031663.2. On Jun 2, 2019 this sequence version replaced NM_181510.2. Transcript Variant: This variant (b) has an alternate 3' UTR and represents the longer transcript, as compared to variant a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: GQ472209.1, AF492016.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852611.2
CDS	38..763
Translation	MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTVKKGFCPRKPLLCTKIDKPKCLQDEECPLVEKCCSHCGLKCMDPRR

Target ORF information:

RefSeq Version	NM_181510.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181510.3

ORF Insert Sequence:

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC8 ( NM_130896.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_570966.2 Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu05924
Clone ID Related Accession (Same CDS sequence)	NM_181510.3 , NM_130896.3 , NM_181510.2 , NM_130896.2
Accession Version	NM_130896.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 8 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121778.12 and AL031663.2. On Jun 2, 2019 this sequence version replaced NM_130896.2. Transcript Variant: This variant (a) represents the shorter transcript. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HM005608.1, SRR5189667.371189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159931 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570966.2
CDS	38..763
Translation	MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTVKKGFCPRKPLLCTKIDKPKCLQDEECPLVEKCCSHCGLKCMDPRR

Target ORF information:

RefSeq Version	NM_130896.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130896.3

ORF Insert Sequence:

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC8 ( NM_181510.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_852611.2 Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu05924
Clone ID Related Accession (Same CDS sequence)	NM_181510.3 , NM_130896.3 , NM_181510.2 , NM_130896.2
Accession Version	NM_181510.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 8 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121778.12 and AL031663.2. On Jul 26, 2007 this sequence version replaced NM_181510.1. Transcript Variant: This variant (b) has an alternate 3' UTR and represents the longer transcript, as compared to variant a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF492016.1, GQ472209.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852611.2
CDS	80..805
Translation	MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTVKKGFCPRKPLLCTKIDKPKCLQDEECPLVEKCCSHCGLKCMDPRR

Target ORF information:

RefSeq Version	NM_181510.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181510.2

ORF Insert Sequence:

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC8 ( NM_130896.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_570966.2 Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu05924
Clone ID Related Accession (Same CDS sequence)	NM_181510.3 , NM_130896.3 , NM_181510.2 , NM_130896.2
Accession Version	NM_130896.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 8 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121778.12 and AL031663.2. On Jul 26, 2007 this sequence version replaced NM_130896.1. Transcript Variant: This variant (a) represents the shorter transcript. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HM005608.1, AF492015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159931 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570966.2
CDS	80..805
Translation	MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTVKKGFCPRKPLLCTKIDKPKCLQDEECPLVEKCCSHCGLKCMDPRR

Target ORF information:

RefSeq Version	NM_130896.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130896.2

ORF Insert Sequence:

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGTCAA AAAAGGTTTC 
TGCCCACGCA AGCCCTTGCT ATGTACCAAG ATTGATAAAC CCAAGTGCCT GCAGGATGAG 
GAGTGCCCAT TGGTGGAAAA GTGCTGCTCA CATTGTGGAC TGAAATGTAT GGACCCCAGA 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WFDC8 ( XM_017028119.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883608.1 Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant X1, mRNA.

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CloneID	OHu93153
Clone ID Related Accession (Same CDS sequence)	XM_017028119.1
Accession Version	XM_017028119.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	WAP four-disulfide core domain protein 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGGTAA GGATTGGGGA 
TATACCTCCC AAATCTATTG GGCATGTGCC AAGGATGTCA TGCTGTCTCC ATGGAGTGGG 
GGGTGTCTTG AACCTCAGAT GCTCCTTGGG CTCATCTTTG AGGATCTTTG GGAACCCCTT 
TTAATGCCCA ACAAGTTATA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883608.1
CDS	59..802
Translation	MWTVRTEGGHFPLHSPTFSWRNVAFLLLLSLALEWTSAMLTKKIKHKPGLCPKERLTCTTELPDSCNTDFDCKEYQKCCFFACQKKCMDPFQEPCMLPVRHGNCNHEAQRWHFDFKNYRCTPFKYRGCEGNANNFLNEDACRTACMLIVKDGQCPLFPFTERKECPPSCHSDIDCPQTDKCCESRCGFVCARAWTGKDWGYTSQIYWACAKDVMLSPWSGGCLEPQMLLGLIFEDLWEPLLMPNKLY

Target ORF information:

RefSeq Version	XM_017028119.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WAP four-disulfide core domain 8 (WFDC8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017028119.1

ORF Insert Sequence:

ATGTGGACTG TCCGAACTGA AGGAGGGCAC TTTCCTCTCC ATAGCCCCAC CTTCTCCTGG 
AGGAATGTAG CTTTCCTGCT GCTTCTCTCC CTTGCTTTGG AGTGGACTTC TGCAATGCTG 
ACCAAGAAGA TCAAACACAA ACCAGGGTTA TGTCCCAAAG AGAGGCTCAC CTGTACCACT 
GAACTTCCGG ACTCATGTAA CACAGATTTT GACTGCAAGG AATACCAGAA GTGCTGCTTT 
TTTGCCTGTC AGAAGAAGTG CATGGATCCC TTTCAAGAAC CCTGCATGCT ACCTGTGAGG 
CATGGAAACT GTAATCATGA GGCACAGCGC TGGCATTTTG ACTTTAAAAA TTACCGCTGC 
ACACCCTTCA AATACAGGGG CTGCGAAGGG AATGCCAACA ACTTCTTAAA TGAGGATGCC 
TGCAGAACGG CCTGCATGTT AATTGTTAAG GATGGACAAT GCCCACTCTT CCCTTTCACT 
GAACGTAAGG AGTGTCCACC TTCATGTCAC AGTGACATCG ATTGTCCCCA GACAGACAAA 
TGTTGTGAAT CCAGGTGTGG CTTTGTTTGT GCCAGGGCCT GGACAGGTAA GGATTGGGGA 
TATACCTCCC AAATCTATTG GGCATGTGCC AAGGATGTCA TGCTGTCTCC ATGGAGTGGG 
GGGTGTCTTG AACCTCAGAT GCTCCTTGGG CTCATCTTTG AGGATCTTTG GGAACCCCTT 
TTAATGCCCA ACAAGTTATA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reproduction and immunity-driven natural selection in the human WFDC locus.
Molecular biology and evolution30(4)938-50(2013 Apr)
Ferreira Z,Seixas S,Andr?s AM,Kretzschmar WW,Mullikin JC,Cherukuri PF,Cruz P,Swanson WJ,,Clark AG,Green ED,Hurle B

Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans.
Molecular biology and evolution28(10)2811-22(2011 Oct)
Ferreira Z,Hurle B,Rocha J,Seixas S

The evolution of a genetic locus encoding small serine proteinase inhibitors.
Biochemical and biophysical research communications333(2)383-9(2005 Jul)
Clauss A,Lilja H,Lundwall A

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.
The Biochemical journal368(Pt 1)233-42(2002 Nov)
Clauss A,Lilja H,Lundwall A

The DNA sequence and comparative analysis of human chromosome 20.
Nature414(6866)865-71(2001 Dec 20-27)
Deloukas P,Matthews LH,Ashurst J,Burton J,Gilbert JG,Jones M,Stavrides G,Almeida JP,Babbage AK,Bagguley CL,Bailey J,Barlow KF,Bates KN,Beard LM,Beare DM,Beasley OP,Bird CP,Blakey SE,Bridgeman AM,Brown AJ,Buck D,Burrill W,Butler AP,Carder C,Carter NP,Chapman JC,Clamp M,Clark G,Clark LN,Clark SY,Clee CM,Clegg S,Cobley VE,Collier RE,Connor R,Corby NR,Coulson A,Coville GJ,Deadman R,Dhami P,Dunn M,Ellington AG,Frankland JA,Fraser A,French L,Garner P,Grafham DV,Griffiths C,Griffiths MN,Gwilliam R,Hall RE,Hammond S,Harley JL,Heath PD,Ho S,Holden JL,Howden PJ,Huckle E,Hunt AR,Hunt SE,Jekosch K,Johnson CM,Johnson D,Kay MP,Kimberley AM,King A,Knights A,Laird GK,Lawlor S,Lehvaslaiho MH,Leversha M,Lloyd C,Lloyd DM,Lovell JD,Marsh VL,Martin SL,McConnachie LJ,McLay K,McMurray AA,Milne S,Mistry D,Moore MJ,Mullikin JC,Nickerson T,Oliver K,Parker A,Patel R,Pearce TA,Peck AI,Phillimore BJ,Prathalingam SR,Plumb RW,Ramsay H,Rice CM,Ross MT,Scott CE,Sehra HK,Shownkeen R,Sims S,Skuce CD,Smith ML,Soderlund C,Steward CA,Sulston JE,Swann M,Sycamore N,Taylor R,Tee L,Thomas DW,Thorpe A,Tracey A,Tromans AC,Vaudin M,Wall M,Wallis JM,Whitehead SL,Whittaker P,Willey DL,Williams L,Williams SA,Wilming L,Wray PW,Hubbard T,Durbin RM,Bentley DR,Beck S,Rogers J

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WFDC8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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