KCNK17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNK17
Entrez Gene ID	89822
Full Name	potassium two pore domain channel subfamily K member 17
Synonyms	K2p17.1,TALK-2,TALK2,TASK-4,TASK4
General protein information	Preferred Names potassium two pore domain channel subfamily K member 17 Names potassium channel subfamily K member 17 2P domain potassium channel Talk-2 TWIK-related acid-sensitive K(+) channel 4 TWIK-related alkaline pH-activated K(+) channel 2 acid-sensitive potassium channel protein TASK-4 potassium channel, two pore domain subfamily K, member 17
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.2
Summary	The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Disorder MIM:	607370

mRNA and Protein(s)

mRNA	Protein	Name
NM_031460.3	NP_113648.2	potassium channel subfamily K member 17 isoform 1
NM_001135111.2	NP_001128583.1	potassium channel subfamily K member 17 isoform 2
NM_001135111.1	NP_001128583.1	potassium channel subfamily K member 17 isoform 2
NM_031460.4	NP_113648.2	potassium channel subfamily K member 17 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNK17	NP_113648.2
Pan troglodytes (chimpanzee)	KCNK17	XP_001173849.1
Bos taurus (cattle)	KCNK17	NP_776983.1
Xenopus tropicalis (tropical clawed frog)	kcnk17	XP_004919495.1
	KCNK17	XP_001117122.1
Canis lupus familiaris (dog)	KCNK17	XP_005627349.1
Gallus gallus (chicken)	KCNK17	XP_419477.2

Gene Ontology
Bibliography

Related articles in PubMed

Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems.
Suzuki Y, Tsutsumi K, Miyamoto T, Yamamura H, Imaizumi Y
PloS one12(10)e0186252(2017)

Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.
He L, Ma Q, Wang Y, Liu X, Yuan Y, Zhang Y, Ou W, Liu L, Tan X, Wang X
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association23(9)2322-7(2014 Oct)

Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
Friedrich C, Rinn? S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E, Decher N
EMBO molecular medicine6(7)937-51(2014 Jul)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
, , , , , Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J, Bell GI, Benediktsson R, Bergman RN, Boehm BO, Boerwinkle E, Bonnycastle LL, Burtt N, Cai Q, Campbell H, Carey J, Cauchi S, Caulfield M, Chan JC, Chang LC, Chang TJ, Chang YC, Charpentier G, Chen CH, Chen H, Chen YT, Chia KS, Chidambaram M, Chines PS, Cho NH, Cho YM, Chuang LM, Collins FS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Danesh J, Das D, de Faire U, Dedoussis G, Deloukas P, Dimas AS, Dina C, Doney AS, Donnelly PJ, Dorkhan M, van Duijn C, Dupuis J, Edkins S, Elliott P, Emilsson V, Erbel R, Eriksson JG, Escobedo J, Esko T, Eury E, Florez JC, Fontanillas P, Forouhi NG, Forsen T, Fox C, Fraser RM, Frayling TM, Froguel P, Frossard P, Gao Y, Gertow K, Gieger C, Gigante B, Grallert H, Grant GB, Grrop LC, Groves CJ, Grundberg E, Guiducci C, Hamsten A, Han BG, Hara K, Hassanali N, Hattersley AT, Hayward C, Hedman AK, Herder C, Hofman A, Holmen OL, Hovingh K, Hreidarsson AB, Hu C, Hu FB, Hui J, Humphries SE, Hunt SE, Hunter DJ, Hveem K, Hydrie ZI, Ikegami H, Illig T, Ingelsson E, Islam M, Isomaa B, Jackson AU, Jafar T, James A, Jia W, J?ckel KH, Jonsson A, Jowett JB, Kadowaki T, Kang HM, Kanoni S, Kao WH, Kathiresan S, Kato N, Katulanda P, Keinanen-Kiukaanniemi KM, Kelly AM, Khan H, Khaw KT, Khor CC, Kim HL, Kim S, Kim YJ, Kinnunen L, Klopp N, Kong A, Korpi-Hy?v?lti E, Kowlessur S, Kraft P, Kravic J, Kristensen MM, Krithika S, Kumar A, Kumate J, Kuusisto J, Kwak SH, Laakso M, Lagou V, Lakka TA, Langenberg C, Langford C, Lawrence R, Leander K, Lee JM, Lee NR, Li M, Li X, Li Y, Liang J, Liju S, Lim WY, Lind L, Lindgren CM, Lindholm E, Liu CT, Liu JJ, Lobbens S, Long J, Loos RJ, Lu W, Luan J, Lyssenko V, Ma RC, Maeda S, M?gi R, M?nnisto S, Matthews DR, Meigs JB, Melander O, Metspalu A, Meyer J, Mirza G, Mihailov E, Moebus S, Mohan V, Mohlke KL, Morris AD, M?hleisen TW, M?ller-Nurasyid M, Musk B, Nakamura J, Nakashima E, Navarro P, Ng PK, Nica AC, Nilsson PM, Nj?lstad I, N?then MM, Ohnaka K, Ong TH, Owen KR, Palmer CN, Pankow JS, Park KS, Parkin M, Pechlivanis S, Pedersen NL, Peltonen L, Perry JR, Peters A, Pinidiyapathirage JM, Platou CG, Potter S, Price JF, Qi L, Radha V, Rallidis L, Rasheed A, Rathman W, Rauramaa R, Raychaudhuri S, Rayner NW, Rees SD, Rehnberg E, Ripatti S, Robertson N, Roden M, Rossin EJ, Rudan I, Rybin D, Saaristo TE, Salomaa V, Saltevo J, Samuel M, Sanghera DK, Saramies J, Scott J, Scott LJ, Scott RA, Segr? AV, Sehmi J, Sennblad B, Shah N, Shah S, Shera AS, Shu XO, Shuldiner AR, Sigur?sson G, Sijbrands E, Silveira A, Sim X, Sivapalaratnam S, Small KS, So WY, Stan??kov? A, Stefansson K, Steinbach G, Steinthorsdottir V, Stirrups K, Strawbridge RJ, Stringham HM, Sun Q, Suo C, Syv?nen AC, Takayanagi R, Takeuchi F, Tay WT, Teslovich TM, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Trakalo J, Tremoli E, Trip MD, Tsai FJ, Tuomi T, Tuomilehto J, Uitterlinden AG, Valladares-Salgado A, Vedantam S, Veglia F, Voight BF, Wang C, Wareham NJ, Wennauer R, Wickremasinghe AR, Wilsgaard T, Wilson JF, Wiltshire S, Winckler W, Wong TY, Wood AR, Wu JY, Wu Y, Yamamoto K, Yamauchi T, Yang M, Yengo L, Yokota M, Young R, Zabaneh D, Zhang F, Zhang R, Zheng W, Zimmet PZ, Altshuler D, Bowden DW, Cho YS, Cox NJ, Cruz M, Hanis CL, Kooner J, Lee JY, Seielstad M, Teo YY, Boehnke M, Parra EJ, Chambers JC, Tai ES, McCarthy MI, Morris AP
Nature genetics46(3)234-44(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggested that heterodimerization of TASK1 and TALK2 provides cells with the ability to make multiple responses to a variety of physiological and pharmacological stimuli.
Title: Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems.

The T carrier of an single-nucleotide polymorphism is associated with reduced risk of cerebral hemorrhage in the Chinese population.
Title: Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.

This study demonstrates that Gly88 is a crucial residue for normal TASK-4 gating behavior and that the channel is strongly expressed in the cardiac conduction system.
Title: Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.

The rs10947803 SNP (A allele) in KCNK17 increases the risk of cerebral hemorrhage but not ischemic stroke in the Chinese population.
Title: The rs10947803 SNP of KCNK17 is associated with cerebral hemorrhage but not ischemic stroke in a Chinese population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.

The following KCNK17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNK17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24830	NM_031460.4 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu01384	NM_001135111.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu01384	NM_001135111.1	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu24830	NM_031460.3	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNK17 ( NM_031460.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_113648.2 Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24830
Clone ID Related Accession (Same CDS sequence)	NM_031460.3 , NM_031460.4
Accession Version	NM_031460.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 17 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP317866.1, AF358910.1 and BC025726.1. On Nov 22, 2018 this sequence version replaced NM_031460.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025726.1, AY358853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373231.9/ ENSP00000362328.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGGA ATGAACCCCT CCCAGAGGTA CCCACTGTGG 
TACAAGAACA TGGTGTCCCT GTGGATCCTC TTTGGGATGG CATGGCTGGC CTTGATCATC 
AAACTCATCC TCTCCCAGCT GGAGACGCCA GGGAGGGTAT GTTCCTGCTG CCACCACAGC 
TCTAAGGAAG ACTTCAAGTC CCAAAGCTGG AGACAGGGAC CTGACCGGGA GCCAGAGTCC 
CACTCCCCAC AGCAAGGATG CTATCCAGAG GGACCCATGG GAATCATACA GCATCTGGAA 
CCTTCTGCTC ACGCTGCAGG CTGTGGCAAG GACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113648.2
CDS	100..1098
Translation	MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS

Target ORF information:

RefSeq Version	NM_031460.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031460.4

ORF Insert Sequence:

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGGA ATGAACCCCT CCCAGAGGTA CCCACTGTGG 
TACAAGAACA TGGTGTCCCT GTGGATCCTC TTTGGGATGG CATGGCTGGC CTTGATCATC 
AAACTCATCC TCTCCCAGCT GGAGACGCCA GGGAGGGTAT GTTCCTGCTG CCACCACAGC 
TCTAAGGAAG ACTTCAAGTC CCAAAGCTGG AGACAGGGAC CTGACCGGGA GCCAGAGTCC 
CACTCCCCAC AGCAAGGATG CTATCCAGAG GGACCCATGG GAATCATACA GCATCTGGAA 
CCTTCTGCTC ACGCTGCAGG CTGTGGCAAG GACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK17 ( NM_001135111.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128583.1 Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01384
Clone ID Related Accession (Same CDS sequence)	NM_001135111.2 , NM_001135111.1
Accession Version	NM_001135111.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 17 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12 and BC025726.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_001135111.1. Transcript Variant: This variant (2) contains an additional exon at the 3' end compared to transcript variant 1. This results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA2142586 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGCA AGCTGCCTCA TTTCAGATAC GAGAAAACCA 
AACAGAGACT GGCAAACACT AGAGCGGACA TCGAAATCCT CTGGGGGCTT GTTAAAATAC 
AGATTTCTGG CCGGGCACGG TGGCTCACAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128583.1
CDS	100..915
Translation	MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIASCLISDTRKPNRDWQTLERTSKSSGGLLKYRFLAGHGGSHL

Target ORF information:

RefSeq Version	NM_001135111.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135111.2

ORF Insert Sequence:

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGCA AGCTGCCTCA TTTCAGATAC GAGAAAACCA 
AACAGAGACT GGCAAACACT AGAGCGGACA TCGAAATCCT CTGGGGGCTT GTTAAAATAC 
AGATTTCTGG CCGGGCACGG TGGCTCACAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK17 ( NM_001135111.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128583.1 Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01384
Clone ID Related Accession (Same CDS sequence)	NM_001135111.2 , NM_001135111.1
Accession Version	NM_001135111.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 17 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12 and BC025726.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) contains an additional exon at the 3' end compared to transcript variant 1. This results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BX346190.2 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA2142586 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGCA AGCTGCCTCA TTTCAGATAC GAGAAAACCA 
AACAGAGACT GGCAAACACT AGAGCGGACA TCGAAATCCT CTGGGGGCTT GTTAAAATAC 
AGATTTCTGG CCGGGCACGG TGGCTCACAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128583.1
CDS	142..957
Translation	MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIASCLISDTRKPNRDWQTLERTSKSSGGLLKYRFLAGHGGSHL

Target ORF information:

RefSeq Version	NM_001135111.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135111.1

ORF Insert Sequence:

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGCA AGCTGCCTCA TTTCAGATAC GAGAAAACCA 
AACAGAGACT GGCAAACACT AGAGCGGACA TCGAAATCCT CTGGGGGCTT GTTAAAATAC 
AGATTTCTGG CCGGGCACGG TGGCTCACAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK17 ( NM_031460.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_113648.2 Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA.

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CloneID	OHu24830
Clone ID Related Accession (Same CDS sequence)	NM_031460.3 , NM_031460.4
Accession Version	NM_031460.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 17 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP317866.1, AF358910.1 and BC025726.1. On Aug 16, 2006 this sequence version replaced NM_031460.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025726.1, AY358853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGGA ATGAACCCCT CCCAGAGGTA CCCACTGTGG 
TACAAGAACA TGGTGTCCCT GTGGATCCTC TTTGGGATGG CATGGCTGGC CTTGATCATC 
AAACTCATCC TCTCCCAGCT GGAGACGCCA GGGAGGGTAT GTTCCTGCTG CCACCACAGC 
TCTAAGGAAG ACTTCAAGTC CCAAAGCTGG AGACAGGGAC CTGACCGGGA GCCAGAGTCC 
CACTCCCCAC AGCAAGGATG CTATCCAGAG GGACCCATGG GAATCATACA GCATCTGGAA 
CCTTCTGCTC ACGCTGCAGG CTGTGGCAAG GACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113648.2
CDS	141..1139
Translation	MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS

Target ORF information:

RefSeq Version	NM_031460.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031460.3

ORF Insert Sequence:

ATGTACCGAC CGCGAGCCCG GGCGGCTCCC GAGGGCAGGG TCCGGGGCTG CGCGGTGCCC 
AGCACCGTGC TCCTGCTGCT CGCCTACCTG GCTTACCTGG CGCTGGGCAC CGGCGTGTTC 
TGGACGCTGG AGGGCCGCGC GGCGCAGGAC TCCAGCCGCA GCTTCCAGCG CGACAAGTGG 
GAGCTGTTGC AGAACTTCAC GTGTCTGGAC CGCCCGGCGC TGGACTCGCT GATCCGGGAT 
GTCGTCCAAG CATACAAAAA CGGAGCCAGC CTCCTCAGCA ACACCACCAG CATGGGGCGC 
TGGGAGCTCG TGGGCTCCTT CTTCTTTTCT GTGTCCACCA TCACCACCAT TGGCTATGGC 
AACCTGAGCC CCAACACGAT GGCTGCCCGC CTCTTCTGCA TCTTCTTTGC CCTTGTGGGG 
ATCCCACTCA ACCTCGTGGT GCTCAACCGA CTGGGGCATC TCATGCAGCA GGGAGTAAAC 
CACTGGGCCA GCAGGCTGGG GGGCACCTGG CAGGATCCTG ACAAGGCGCG GTGGCTGGCG 
GGCTCTGGCG CCCTCCTCTC GGGCCTCCTG CTCTTCCTGC TGCTGCCACC GCTGCTCTTC 
TCCCACATGG AGGGCTGGAG CTACACAGAG GGCTTCTACT TCGCCTTCAT CACCCTCAGC 
ACCGTGGGCT TCGGCGACTA CGTGATTGGA ATGAACCCCT CCCAGAGGTA CCCACTGTGG 
TACAAGAACA TGGTGTCCCT GTGGATCCTC TTTGGGATGG CATGGCTGGC CTTGATCATC 
AAACTCATCC TCTCCCAGCT GGAGACGCCA GGGAGGGTAT GTTCCTGCTG CCACCACAGC 
TCTAAGGAAG ACTTCAAGTC CCAAAGCTGG AGACAGGGAC CTGACCGGGA GCCAGAGTCC 
CACTCCCCAC AGCAAGGATG CTATCCAGAG GGACCCATGG GAATCATACA GCATCTGGAA 
CCTTCTGCTC ACGCTGCAGG CTGTGGCAAG GACAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems.
PloS one12(10)e0186252(2017)
Suzuki Y,Tsutsumi K,Miyamoto T,Yamamura H,Imaizumi Y

Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association23(9)2322-7(2014 Oct)
He L,Ma Q,Wang Y,Liu X,Yuan Y,Zhang Y,Ou W,Liu L,Tan X,Wang X

Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
EMBO molecular medicine6(7)937-51(2014 Jul)
Friedrich C,Rinn? S,Zumhagen S,Kiper AK,Silbernagel N,Netter MF,Stallmeyer B,Schulze-Bahr E,Decher N

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Nature genetics46(3)234-44(2014 Mar)
,,,,,Mahajan A,Go MJ,Zhang W,Below JE,Gaulton KJ,Ferreira T,Horikoshi M,Johnson AD,Ng MC,Prokopenko I,Saleheen D,Wang X,Zeggini E,Abecasis GR,Adair LS,Almgren P,Atalay M,Aung T,Baldassarre D,Balkau B,Bao Y,Barnett AH,Barroso I,Basit A,Been LF,Beilby J,Bell GI,Benediktsson R,Bergman RN,Boehm BO,Boerwinkle E,Bonnycastle LL,Burtt N,Cai Q,Campbell H,Carey J,Cauchi S,Caulfield M,Chan JC,Chang LC,Chang TJ,Chang YC,Charpentier G,Chen CH,Chen H,Chen YT,Chia KS,Chidambaram M,Chines PS,Cho NH,Cho YM,Chuang LM,Collins FS,Cornelis MC,Couper DJ,Crenshaw AT,van Dam RM,Danesh J,Das D,de Faire U,Dedoussis G,Deloukas P,Dimas AS,Dina C,Doney AS,Donnelly PJ,Dorkhan M,van Duijn C,Dupuis J,Edkins S,Elliott P,Emilsson V,Erbel R,Eriksson JG,Escobedo J,Esko T,Eury E,Florez JC,Fontanillas P,Forouhi NG,Forsen T,Fox C,Fraser RM,Frayling TM,Froguel P,Frossard P,Gao Y,Gertow K,Gieger C,Gigante B,Grallert H,Grant GB,Grrop LC,Groves CJ,Grundberg E,Guiducci C,Hamsten A,Han BG,Hara K,Hassanali N,Hattersley AT,Hayward C,Hedman AK,Herder C,Hofman A,Holmen OL,Hovingh K,Hreidarsson AB,Hu C,Hu FB,Hui J,Humphries SE,Hunt SE,Hunter DJ,Hveem K,Hydrie ZI,Ikegami H,Illig T,Ingelsson E,Islam M,Isomaa B,Jackson AU,Jafar T,James A,Jia W,J?ckel KH,Jonsson A,Jowett JB,Kadowaki T,Kang HM,Kanoni S,Kao WH,Kathiresan S,Kato N,Katulanda P,Keinanen-Kiukaanniemi KM,Kelly AM,Khan H,Khaw KT,Khor CC,Kim HL,Kim S,Kim YJ,Kinnunen L,Klopp N,Kong A,Korpi-Hy?v?lti E,Kowlessur S,Kraft P,Kravic J,Kristensen MM,Krithika S,Kumar A,Kumate J,Kuusisto J,Kwak SH,Laakso M,Lagou V,Lakka TA,Langenberg C,Langford C,Lawrence R,Leander K,Lee JM,Lee NR,Li M,Li X,Li Y,Liang J,Liju S,Lim WY,Lind L,Lindgren CM,Lindholm E,Liu CT,Liu JJ,Lobbens S,Long J,Loos RJ,Lu W,Luan J,Lyssenko V,Ma RC,Maeda S,M?gi R,M?nnisto S,Matthews DR,Meigs JB,Melander O,Metspalu A,Meyer J,Mirza G,Mihailov E,Moebus S,Mohan V,Mohlke KL,Morris AD,M?hleisen TW,M?ller-Nurasyid M,Musk B,Nakamura J,Nakashima E,Navarro P,Ng PK,Nica AC,Nilsson PM,Nj?lstad I,N?then MM,Ohnaka K,Ong TH,Owen KR,Palmer CN,Pankow JS,Park KS,Parkin M,Pechlivanis S,Pedersen NL,Peltonen L,Perry JR,Peters A,Pinidiyapathirage JM,Platou CG,Potter S,Price JF,Qi L,Radha V,Rallidis L,Rasheed A,Rathman W,Rauramaa R,Raychaudhuri S,Rayner NW,Rees SD,Rehnberg E,Ripatti S,Robertson N,Roden M,Rossin EJ,Rudan I,Rybin D,Saaristo TE,Salomaa V,Saltevo J,Samuel M,Sanghera DK,Saramies J,Scott J,Scott LJ,Scott RA,Segr? AV,Sehmi J,Sennblad B,Shah N,Shah S,Shera AS,Shu XO,Shuldiner AR,Sigur?sson G,Sijbrands E,Silveira A,Sim X,Sivapalaratnam S,Small KS,So WY,Stan??kov? A,Stefansson K,Steinbach G,Steinthorsdottir V,Stirrups K,Strawbridge RJ,Stringham HM,Sun Q,Suo C,Syv?nen AC,Takayanagi R,Takeuchi F,Tay WT,Teslovich TM,Thorand B,Thorleifsson G,Thorsteinsdottir U,Tikkanen E,Trakalo J,Tremoli E,Trip MD,Tsai FJ,Tuomi T,Tuomilehto J,Uitterlinden AG,Valladares-Salgado A,Vedantam S,Veglia F,Voight BF,Wang C,Wareham NJ,Wennauer R,Wickremasinghe AR,Wilsgaard T,Wilson JF,Wiltshire S,Winckler W,Wong TY,Wood AR,Wu JY,Wu Y,Yamamoto K,Yamauchi T,Yang M,Yengo L,Yokota M,Young R,Zabaneh D,Zhang F,Zhang R,Zheng W,Zimmet PZ,Altshuler D,Bowden DW,Cho YS,Cox NJ,Cruz M,Hanis CL,Kooner J,Lee JY,Seielstad M,Teo YY,Boehnke M,Parra EJ,Chambers JC,Tai ES,McCarthy MI,Morris AP

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KCNK17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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