WASL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WASL
Entrez Gene ID	8976
Full Name	Wiskott-Aldrich syndrome like
Synonyms	N-WASP,NWASP,WASPB
General protein information	Preferred Names Wiskott-Aldrich syndrome like Names neural Wiskott-Aldrich syndrome protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q31.32
Summary	This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013].
Disorder MIM:	605056

mRNA and Protein(s)

mRNA	Protein	Name
NM_003941.4	NP_003932.3	neural Wiskott-Aldrich syndrome protein
NM_003941.3	NP_003932.3	neural Wiskott-Aldrich syndrome protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	WASL	NP_003932.3
	WASL	XP_001085180.2
Pan troglodytes (chimpanzee)	WASL	XP_519342.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning.
Hebbrecht T, Van Audenhove I, Zwaenepoel O, Verhelle A, Gettemans J
PloS one12(9)e0185076(2017)

The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.
Palazzo A, Bluteau O, Messaoudi K, Marangoni F, Chang Y, Souquere S, Pierron G, Lapierre V, Zheng Y, Vainchenker W, Raslova H, Debili N
Journal of thrombosis and haemostasis : JTH14(12)2524-2535(2016 Dec)

Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
Watson JR, Fox HM, Nietlispach D, Gallop JL, Owen D, Mott HR
The Journal of biological chemistry291(26)13875-90(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

By using VCA nanobodiess, study shows the influence of N-WASps VCA domain in invadopodium formation and extracellular matrix degradation
Title: VCA nanobodies target N-WASp to reduce invadopodium formation and functioning.

N-WASP positively regulates demarcation membrane system development and proplatelet formation, and the Src family kinases in association with CDC42 regulate proplatelet formation through N-WASP
Title: The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.

Recruitment of Paxillin, Cdc42 and N-WASP is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells.
Title: Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.

This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.
Title: Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.

the Cdc42/Nwasp/stress fibers/YAP signal pathway may potentially play an important role in regulating podocyte apoptosis. Maintaining necessary Cdc42 would be one potent way to prevent proteinuria kidney diseases.
Title: Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.

The following WASL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WASL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03621	NM_003941.4 Latest version!	Homo sapiens WASP like actin nucleation promoting factor (WASL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu03621	NM_003941.3	Homo sapiens Wiskott-Aldrich syndrome like (WASL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WASL ( NM_003941.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003932.3 Homo sapiens WASP like actin nucleation promoting factor (WASL), mRNA.

Price & Availability↑

CloneID	OHu03621
Clone ID Related Accession (Same CDS sequence)	NM_003941.4 , NM_003941.3
Accession Version	NM_003941.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	neural Wiskott-Aldrich syndrome protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052955.1, BC028602.1 and DB380642.1. On Nov 22, 2018 this sequence version replaced NM_003941.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052955.1, SRR1660805.240690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000223023.5/ ENSP00000223023.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCCG TCCAGCAGCA GCCGCCGCCG CCGCGGAGGG TCACCAACGT GGGGTCCCTG 
TTGCTCACCC CGCAGGAGAA CGAGTCCCTC TTCACTTTCC TCGGCAAGAA ATGTGTGACT 
ATGTCTTCAG CAGTGGTGCA GTTATATGCA GCAGATCGGA ACTGTATGTG GTCAAAGAAG 
TGCAGTGGTG TTGCTTGTCT TGTTAAGGAC AATCCACAGA GATCTTATTT TTTAAGAATA 
TTTGACATTA AGGATGGGAA ACTATTGTGG GAACAAGAGC TATACAATAA CTTTGTATAT 
AATAGTCCTA GAGGATATTT TCATACCTTT GCTGGAGATA CTTGTCAAGT TGCTCTTAAT 
TTTGCCAATG AAGAAGAAGC AAAAAAATTT CGAAAAGCAG TTACAGACCT TTTGGGCCGT 
CGACAAAGGA AATCTGAGAA AAGACGAGAT CCCCCAAATG GTCCTAATCT ACCCATGGCT 
ACAGTTGATA TAAAAAATCC AGAAATCACA ACAAATAGAT TTTATGGTCC ACAAGTCAAC 
AACATCTCCC ATACCAAAGA AAAGAAGAAG GGAAAAGCTA AAAAGAAGAG ATTAACCAAG 
GCAGATATAG GAACACCAAG CAATTTCCAG CACATTGGAC ATGTTGGTTG GGATCCAAAT 
ACAGGCTTTG ATCTGAATAA TTTGGATCCA GAATTGAAGA ATCTTTTCGA TATGTGTGGA 
ATCTCAGAGG CACAACTTAA AGACAGAGAA ACATCAAAAG TTATATATGA CTTTATTGAA 
AAAACAGGAG GTGTTGAAGC TGTTAAAAAT GAACTGCGGA GGCAAGCACC ACCACCTCCA 
CCACCATCAA GGGGAGGGCC ACCTCCTCCT CCTCCCCCTC CACACAACTC AGGTCCTCCT 
CCTCCTCCTG CTAGGGGAAG AGGCGCTCCT CCCCCACCAC CTTCAAGAGC TCCCACAGCT 
GCACCTCCAC CACCGCCTCC TTCCAGGCCA AGTGTAGCAG TCCCTCCACC ACCGCCAAAT 
AGGATGTACC CTCCTCCACC TCCAGCCCTT CCCTCCTCAG CACCTTCAGG GCCTCCACCA 
CCACCTCCAT CTGTGTTGGG GGTAGGGCCA GTGGCACCAC CCCCACCGCC TCCACCTCCA 
CCTCCTCCTG GGCCACCGCC CCCGCCTGGC CTGCCTTCTG ATGGGGACCA TCAGGTTCCA 
ACTACTGCAG GAAACAAAGC AGCTCTTTTA GATCAAATTA GAGAGGGTGC TCAGCTAAAA 
AAAGTGGAGC AGAACAGTCG GCCAGTGTCC TGCTCTGGAC GAGATGCACT GTTAGACCAG 
ATACGACAGG GTATCCAACT AAAATCTGTG GCTGATGGCC AAGAGTCTAC ACCACCAACA 
CCTGCACCCA CTTCAGGAAT TGTGGGTGCA TTAATGGAAG TGATGCAGAA AAGGAGCAAA 
GCCATTCATT CTTCAGATGA AGATGAAGAT GAAGATGATG AAGAAGATTT TGAGGATGAT 
GATGAGTGGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003932.3
CDS	270..1787
Translation	MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED

Target ORF information:

RefSeq Version	NM_003941.4
Organism	Homo sapiens(human)
Definition	Homo sapiens WASP like actin nucleation promoting factor (WASL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003941.4

ORF Insert Sequence:

ATGAGCTCCG TCCAGCAGCA GCCGCCGCCG CCGCGGAGGG TCACCAACGT GGGGTCCCTG 
TTGCTCACCC CGCAGGAGAA CGAGTCCCTC TTCACTTTCC TCGGCAAGAA ATGTGTGACT 
ATGTCTTCAG CAGTGGTGCA GTTATATGCA GCAGATCGGA ACTGTATGTG GTCAAAGAAG 
TGCAGTGGTG TTGCTTGTCT TGTTAAGGAC AATCCACAGA GATCTTATTT TTTAAGAATA 
TTTGACATTA AGGATGGGAA ACTATTGTGG GAACAAGAGC TATACAATAA CTTTGTATAT 
AATAGTCCTA GAGGATATTT TCATACCTTT GCTGGAGATA CTTGTCAAGT TGCTCTTAAT 
TTTGCCAATG AAGAAGAAGC AAAAAAATTT CGAAAAGCAG TTACAGACCT TTTGGGCCGT 
CGACAAAGGA AATCTGAGAA AAGACGAGAT CCCCCAAATG GTCCTAATCT ACCCATGGCT 
ACAGTTGATA TAAAAAATCC AGAAATCACA ACAAATAGAT TTTATGGTCC ACAAGTCAAC 
AACATCTCCC ATACCAAAGA AAAGAAGAAG GGAAAAGCTA AAAAGAAGAG ATTAACCAAG 
GCAGATATAG GAACACCAAG CAATTTCCAG CACATTGGAC ATGTTGGTTG GGATCCAAAT 
ACAGGCTTTG ATCTGAATAA TTTGGATCCA GAATTGAAGA ATCTTTTCGA TATGTGTGGA 
ATCTCAGAGG CACAACTTAA AGACAGAGAA ACATCAAAAG TTATATATGA CTTTATTGAA 
AAAACAGGAG GTGTTGAAGC TGTTAAAAAT GAACTGCGGA GGCAAGCACC ACCACCTCCA 
CCACCATCAA GGGGAGGGCC ACCTCCTCCT CCTCCCCCTC CACACAACTC AGGTCCTCCT 
CCTCCTCCTG CTAGGGGAAG AGGCGCTCCT CCCCCACCAC CTTCAAGAGC TCCCACAGCT 
GCACCTCCAC CACCGCCTCC TTCCAGGCCA AGTGTAGCAG TCCCTCCACC ACCGCCAAAT 
AGGATGTACC CTCCTCCACC TCCAGCCCTT CCCTCCTCAG CACCTTCAGG GCCTCCACCA 
CCACCTCCAT CTGTGTTGGG GGTAGGGCCA GTGGCACCAC CCCCACCGCC TCCACCTCCA 
CCTCCTCCTG GGCCACCGCC CCCGCCTGGC CTGCCTTCTG ATGGGGACCA TCAGGTTCCA 
ACTACTGCAG GAAACAAAGC AGCTCTTTTA GATCAAATTA GAGAGGGTGC TCAGCTAAAA 
AAAGTGGAGC AGAACAGTCG GCCAGTGTCC TGCTCTGGAC GAGATGCACT GTTAGACCAG 
ATACGACAGG GTATCCAACT AAAATCTGTG GCTGATGGCC AAGAGTCTAC ACCACCAACA 
CCTGCACCCA CTTCAGGAAT TGTGGGTGCA TTAATGGAAG TGATGCAGAA AAGGAGCAAA 
GCCATTCATT CTTCAGATGA AGATGAAGAT GAAGATGATG AAGAAGATTT TGAGGATGAT 
GATGAGTGGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WASL ( NM_003941.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003932.3 Homo sapiens Wiskott-Aldrich syndrome like (WASL), mRNA.

Price & Availability↑

CloneID	OHu03621
Clone ID Related Accession (Same CDS sequence)	NM_003941.4 , NM_003941.3
Accession Version	NM_003941.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	neural Wiskott-Aldrich syndrome protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF593336.1, BC052955.1, BC028602.1 and DB380642.1. On Jul 12, 2013 this sequence version replaced NM_003941.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.196470.1, SRR1803617.110532.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTCCG TCCAGCAGCA GCCGCCGCCG CCGCGGAGGG TCACCAACGT GGGGTCCCTG 
TTGCTCACCC CGCAGGAGAA CGAGTCCCTC TTCACTTTCC TCGGCAAGAA ATGTGTGACT 
ATGTCTTCAG CAGTGGTGCA GTTATATGCA GCAGATCGGA ACTGTATGTG GTCAAAGAAG 
TGCAGTGGTG TTGCTTGTCT TGTTAAGGAC AATCCACAGA GATCTTATTT TTTAAGAATA 
TTTGACATTA AGGATGGGAA ACTATTGTGG GAACAAGAGC TATACAATAA CTTTGTATAT 
AATAGTCCTA GAGGATATTT TCATACCTTT GCTGGAGATA CTTGTCAAGT TGCTCTTAAT 
TTTGCCAATG AAGAAGAAGC AAAAAAATTT CGAAAAGCAG TTACAGACCT TTTGGGCCGT 
CGACAAAGGA AATCTGAGAA AAGACGAGAT CCCCCAAATG GTCCTAATCT ACCCATGGCT 
ACAGTTGATA TAAAAAATCC AGAAATCACA ACAAATAGAT TTTATGGTCC ACAAGTCAAC 
AACATCTCCC ATACCAAAGA AAAGAAGAAG GGAAAAGCTA AAAAGAAGAG ATTAACCAAG 
GCAGATATAG GAACACCAAG CAATTTCCAG CACATTGGAC ATGTTGGTTG GGATCCAAAT 
ACAGGCTTTG ATCTGAATAA TTTGGATCCA GAATTGAAGA ATCTTTTCGA TATGTGTGGA 
ATCTCAGAGG CACAACTTAA AGACAGAGAA ACATCAAAAG TTATATATGA CTTTATTGAA 
AAAACAGGAG GTGTTGAAGC TGTTAAAAAT GAACTGCGGA GGCAAGCACC ACCACCTCCA 
CCACCATCAA GGGGAGGGCC ACCTCCTCCT CCTCCCCCTC CACACAACTC AGGTCCTCCT 
CCTCCTCCTG CTAGGGGAAG AGGCGCTCCT CCCCCACCAC CTTCAAGAGC TCCCACAGCT 
GCACCTCCAC CACCGCCTCC TTCCAGGCCA AGTGTAGCAG TCCCTCCACC ACCGCCAAAT 
AGGATGTACC CTCCTCCACC TCCAGCCCTT CCCTCCTCAG CACCTTCAGG GCCTCCACCA 
CCACCTCCAT CTGTGTTGGG GGTAGGGCCA GTGGCACCAC CCCCACCGCC TCCACCTCCA 
CCTCCTCCTG GGCCACCGCC CCCGCCTGGC CTGCCTTCTG ATGGGGACCA TCAGGTTCCA 
ACTACTGCAG GAAACAAAGC AGCTCTTTTA GATCAAATTA GAGAGGGTGC TCAGCTAAAA 
AAAGTGGAGC AGAACAGTCG GCCAGTGTCC TGCTCTGGAC GAGATGCACT GTTAGACCAG 
ATACGACAGG GTATCCAACT AAAATCTGTG GCTGATGGCC AAGAGTCTAC ACCACCAACA 
CCTGCACCCA CTTCAGGAAT TGTGGGTGCA TTAATGGAAG TGATGCAGAA AAGGAGCAAA 
GCCATTCATT CTTCAGATGA AGATGAAGAT GAAGATGATG AAGAAGATTT TGAGGATGAT 
GATGAGTGGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003932.3
CDS	338..1855
Translation	MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED

Target ORF information:

RefSeq Version	NM_003941.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Wiskott-Aldrich syndrome like (WASL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003941.3

ORF Insert Sequence:

ATGAGCTCCG TCCAGCAGCA GCCGCCGCCG CCGCGGAGGG TCACCAACGT GGGGTCCCTG 
TTGCTCACCC CGCAGGAGAA CGAGTCCCTC TTCACTTTCC TCGGCAAGAA ATGTGTGACT 
ATGTCTTCAG CAGTGGTGCA GTTATATGCA GCAGATCGGA ACTGTATGTG GTCAAAGAAG 
TGCAGTGGTG TTGCTTGTCT TGTTAAGGAC AATCCACAGA GATCTTATTT TTTAAGAATA 
TTTGACATTA AGGATGGGAA ACTATTGTGG GAACAAGAGC TATACAATAA CTTTGTATAT 
AATAGTCCTA GAGGATATTT TCATACCTTT GCTGGAGATA CTTGTCAAGT TGCTCTTAAT 
TTTGCCAATG AAGAAGAAGC AAAAAAATTT CGAAAAGCAG TTACAGACCT TTTGGGCCGT 
CGACAAAGGA AATCTGAGAA AAGACGAGAT CCCCCAAATG GTCCTAATCT ACCCATGGCT 
ACAGTTGATA TAAAAAATCC AGAAATCACA ACAAATAGAT TTTATGGTCC ACAAGTCAAC 
AACATCTCCC ATACCAAAGA AAAGAAGAAG GGAAAAGCTA AAAAGAAGAG ATTAACCAAG 
GCAGATATAG GAACACCAAG CAATTTCCAG CACATTGGAC ATGTTGGTTG GGATCCAAAT 
ACAGGCTTTG ATCTGAATAA TTTGGATCCA GAATTGAAGA ATCTTTTCGA TATGTGTGGA 
ATCTCAGAGG CACAACTTAA AGACAGAGAA ACATCAAAAG TTATATATGA CTTTATTGAA 
AAAACAGGAG GTGTTGAAGC TGTTAAAAAT GAACTGCGGA GGCAAGCACC ACCACCTCCA 
CCACCATCAA GGGGAGGGCC ACCTCCTCCT CCTCCCCCTC CACACAACTC AGGTCCTCCT 
CCTCCTCCTG CTAGGGGAAG AGGCGCTCCT CCCCCACCAC CTTCAAGAGC TCCCACAGCT 
GCACCTCCAC CACCGCCTCC TTCCAGGCCA AGTGTAGCAG TCCCTCCACC ACCGCCAAAT 
AGGATGTACC CTCCTCCACC TCCAGCCCTT CCCTCCTCAG CACCTTCAGG GCCTCCACCA 
CCACCTCCAT CTGTGTTGGG GGTAGGGCCA GTGGCACCAC CCCCACCGCC TCCACCTCCA 
CCTCCTCCTG GGCCACCGCC CCCGCCTGGC CTGCCTTCTG ATGGGGACCA TCAGGTTCCA 
ACTACTGCAG GAAACAAAGC AGCTCTTTTA GATCAAATTA GAGAGGGTGC TCAGCTAAAA 
AAAGTGGAGC AGAACAGTCG GCCAGTGTCC TGCTCTGGAC GAGATGCACT GTTAGACCAG 
ATACGACAGG GTATCCAACT AAAATCTGTG GCTGATGGCC AAGAGTCTAC ACCACCAACA 
CCTGCACCCA CTTCAGGAAT TGTGGGTGCA TTAATGGAAG TGATGCAGAA AAGGAGCAAA 
GCCATTCATT CTTCAGATGA AGATGAAGAT GAAGATGATG AAGAAGATTT TGAGGATGAT 
GATGAGTGGG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning.
PloS one12(9)e0185076(2017)
Hebbrecht T,Van Audenhove I,Zwaenepoel O,Verhelle A,Gettemans J

The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.
Journal of thrombosis and haemostasis : JTH14(12)2524-2535(2016 Dec)
Palazzo A,Bluteau O,Messaoudi K,Marangoni F,Chang Y,Souquere S,Pierron G,Lapierre V,Zheng Y,Vainchenker W,Raslova H,Debili N

Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
The Journal of biological chemistry291(26)13875-90(2016 Jun)
Watson JR,Fox HM,Nietlispach D,Gallop JL,Owen D,Mott HR

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WASL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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