CHRNA6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHRNA6
Entrez Gene ID	8973
Full Name	cholinergic receptor nicotinic alpha 6 subunit
Synonyms	CHNRA6
General protein information	Preferred Names cholinergic receptor nicotinic alpha 6 subunit Names neuronal acetylcholine receptor subunit alpha-6 acetylcholine receptor, nicotinic, alpha 6 (neuronal) cholinergic receptor, nicotinic alpha 6 cholinergic receptor, nicotinic, alpha 6 (neuronal) cholinergic receptor, nicotinic, alpha polypeptide 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.21
Summary	This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010].
Disorder MIM:	606888

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199279.1	NP_001186208.1	neuronal acetylcholine receptor subunit alpha-6 isoform 2 precursor
NM_004198.3	NP_004189.1	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CHRNA6	NP_001029266.1
Drosophila melanogaster (fruit fly)	nAcRalpha-7E	NP_525079.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000329	XP_310786.3
Homo sapiens (human)	CHRNA6	NP_004189.1
Bos taurus (cattle)	CHRNA6	XP_002698774.2
Gallus gallus (chicken)	CHRNA6	NP_990695.1
	CHRNA6	XP_001099152.1
Rattus norvegicus (Norway rat)	Chrna6	NP_476532.1
Caenorhabditis elegans (roundworm)	unc-38	NP_491472.1
Xenopus tropicalis (tropical clawed frog)	LOC100495287	XP_002942944.2
Canis lupus familiaris (dog)	CHRNA6	XP_539951.2
Mus musculus (house mouse)	Chrna6	NP_067344.2
Danio rerio (zebrafish)	chrna6	NP_001036149.1

Gene Ontology
Bibliography

Related articles in PubMed

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.
Wen L, Han H, Liu Q, Su K, Yang Z, Cui W, Yuan W, Ma Y, Fan R, Chen J, Jiang K, Jiang X, Payne TJ, Wang J, Li MD
Scientific reports7(1)9745(2017 Aug)

Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.
Kamens HM, Corley RP, Richmond PA, Darlington TM, Dowell R, Hopfer CJ, Stallings MC, Hewitt JK, Brown SA, Ehringer MA
Behavior genetics46(5)693-704(2016 Sep)

Functional interaction between Lypd6 and nicotinic acetylcholine receptors.
Arvaniti M, Jensen MM, Soni N, Wang H, Klein AB, Thiriet N, Pinborg LH, Muldoon PP, Wienecke J, Imad Damaj M, Kohlmeier KA, Gondr?-Lewis MC, Mikkelsen JD, Thomsen MS
Journal of neurochemistry138(6)806-20(2016 09)

Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.
Wen L, Yang Z, Cui W, Li MD
Translational psychiatry6(6)e843(2016 06)

The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.
Zeiger JS, Haberstick BC, Schlaepfer I, Collins AC, Corley RP, Crowley TJ, Hewitt JK, Hopfer CJ, Lessem J, McQueen MB, Rhee SH, Ehringer MA
Human molecular genetics17(5)724-34(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

More low frequency variants in the CHRNA6/CHRNB3 gene region were observed in cases compared to controls.
Title: Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.

To gain a better understanding of the pathological processes underlying ND and ND-related behaviors and to promote the development of effective smoking cessation therapies, we here present the most recent studies concerning the genetic effects of the CHRNB3-CHRNA6 gene cluster in ND.
Title: Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.

Polymorphism in CHRNA6 gene is associated with esophageal adenocarcinoma.
Title: A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations.

N-terminal alpha-helix (Asp57); complementary face/inner beta-fold (Arg87 or Asp92) and principal face/outer beta-fold (Ser156 or Asn171) residues in the halpha6 subunit are crucial for functional expression.
Title: Analysis of rare variations reveals roles of amino acid residues in the N-terminal extracellular domain of nicotinic acetylcholine receptor (nAChR) alpha6 subunit in the functional expression of human alpha6*-nAChRs.

Data show efficient expression of (alpha6beta2)2beta3 nicotinic acetylcholine receptors (AChRs) in Xenopus oocytes using free subunits with only small changes in alpha6 subunits, while not altering AChR pharmacology or channel structure.
Title: Efficient expression of functional (?6?2)2?3 AChRs in Xenopus oocytes from free subunits using slightly modified ?6 subunits.

The following CHRNA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHRNA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13892	NM_004198.3 Latest version!	Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13957	NM_001199279.1 Latest version!	Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHRNA6 ( NM_004198.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004189.1 Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13892
Clone ID Related Accession (Same CDS sequence)	NM_004198.3
Accession Version	NM_004198.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-6 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC307404.1 and BC014456.1. On Dec 3, 2010 this sequence version replaced NM_004198.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014456.1, SRR1803616.215210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 5' end.

ATGCTGACCA GCAAGGGGCA GGGATTCCTT CATGGGGGCT TGTGTCTCTG GCTGTGTGTG 
TTCACACCTT TCTTTAAAGG CTGTGTGGGC TGTGCAACTG AGGAGAGGCT CTTCCACAAA 
CTGTTTTCTC ATTACAACCA GTTCATCAGG CCTGTGGAAA ACGTTTCCGA CCCTGTCACG 
GTACACTTTG AAGTGGCCAT CACCCAGCTG GCCAACGTGG ATGAAGTAAA CCAGATCATG 
GAAACCAATT TGTGGCTGCG TCACATCTGG AATGATTATA AATTGCGCTG GGATCCAATG 
GAATATGATG GCATTGAGAC TCTTCGCGTT CCTGCAGATA AGATTTGGAA GCCCGACATT 
GTTCTCTATA ACAATGCTGT TGGTGACTTC CAAGTAGAAG GCAAAACAAA AGCTCTTCTT 
AAATACAATG GCATGATAAC CTGGACTCCA CCAGCTATTT TTAAGAGTTC CTGCCCTATG 
GATATCACCT TTTTCCCTTT TGATCATCAA AACTGTTCCC TAAAATTTGG TTCCTGGACG 
TATGACAAAG CTGAAATTGA TCTTCTAATC ATTGGATCAA AAGTGGATAT GAATGATTTT 
TGGGAAAACA GTGAATGGGA AATCATTGAT GCCTCTGGCT ACAAACATGA CATCAAATAC 
AACTGTTGTG AAGAGATATA CACAGATATA ACCTATTCTT TCTACATTAG AAGATTGCCG 
ATGTTTTACA CGATTAATCT GATCATCCCT TGTCTCTTTA TTTCATTTCT AACCGTGTTG 
GTCTTTTACC TTCCTTCGGA CTGTGGTGAA AAAGTGACGC TTTGTATTTC AGTCCTGCTT 
TCTCTGACTG TGTTTTTGCT GGTCATCACA GAAACCATCC CATCCACATC TCTGGTGGTC 
CCACTGGTGG GTGAGTACCT GCTGTTCACC ATGATCTTTG TCACACTGTC CATCGTGGTG 
ACTGTGTTTG TGTTGAACAT ACACTACCGC ACCCCAACCA CGCACACAAT GCCCAGGTGG 
GTGAAGACAG TTTTCCTGAA GCTGCTGCCC CAGGTCCTGC TGATGAGGTG GCCTCTGGAC 
AAGACAAGGG GCACAGGCTC TGATGCAGTG CCCAGAGGCC TTGCCAGGAG GCCTGCCAAA 
GGCAAGCTTG CAAGCCATGG GGAACCCAGA CATCTTAAAG AATGCTTCCA TTGTCACAAA 
TCAAATGAGC TTGCCACAAG CAAGAGAAGA TTAAGTCATC AGCCATTACA GTGGGTGGTG 
GAAAATTCGG AGCACTCGCC TGAAGTTGAA GATGTGATTA ACAGTGTTCA GTTCATAGCA 
GAAAACATGA AGAGCCACAA TGAAACCAAG GAGGTAGAAG ATGACTGGAA ATACGTGGCC 
ATGGTGGTGG ACAGAGTATT TCTTTGGGTA TTTATAATTG TCTGTGTATT TGGAACTGCA 
GGGCTATTTC TACAGCCACT ACTTGGGAAC ACAGGAAAAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004189.1
CDS	357..1841
Translation	MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGNTGKS

Target ORF information:

RefSeq Version	NM_004198.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004198.3

ORF Insert Sequence:

ATGCTGACCA GCAAGGGGCA GGGATTCCTT CATGGGGGCT TGTGTCTCTG GCTGTGTGTG 
TTCACACCTT TCTTTAAAGG CTGTGTGGGC TGTGCAACTG AGGAGAGGCT CTTCCACAAA 
CTGTTTTCTC ATTACAACCA GTTCATCAGG CCTGTGGAAA ACGTTTCCGA CCCTGTCACG 
GTACACTTTG AAGTGGCCAT CACCCAGCTG GCCAACGTGG ATGAAGTAAA CCAGATCATG 
GAAACCAATT TGTGGCTGCG TCACATCTGG AATGATTATA AATTGCGCTG GGATCCAATG 
GAATATGATG GCATTGAGAC TCTTCGCGTT CCTGCAGATA AGATTTGGAA GCCCGACATT 
GTTCTCTATA ACAATGCTGT TGGTGACTTC CAAGTAGAAG GCAAAACAAA AGCTCTTCTT 
AAATACAATG GCATGATAAC CTGGACTCCA CCAGCTATTT TTAAGAGTTC CTGCCCTATG 
GATATCACCT TTTTCCCTTT TGATCATCAA AACTGTTCCC TAAAATTTGG TTCCTGGACG 
TATGACAAAG CTGAAATTGA TCTTCTAATC ATTGGATCAA AAGTGGATAT GAATGATTTT 
TGGGAAAACA GTGAATGGGA AATCATTGAT GCCTCTGGCT ACAAACATGA CATCAAATAC 
AACTGTTGTG AAGAGATATA CACAGATATA ACCTATTCTT TCTACATTAG AAGATTGCCG 
ATGTTTTACA CGATTAATCT GATCATCCCT TGTCTCTTTA TTTCATTTCT AACCGTGTTG 
GTCTTTTACC TTCCTTCGGA CTGTGGTGAA AAAGTGACGC TTTGTATTTC AGTCCTGCTT 
TCTCTGACTG TGTTTTTGCT GGTCATCACA GAAACCATCC CATCCACATC TCTGGTGGTC 
CCACTGGTGG GTGAGTACCT GCTGTTCACC ATGATCTTTG TCACACTGTC CATCGTGGTG 
ACTGTGTTTG TGTTGAACAT ACACTACCGC ACCCCAACCA CGCACACAAT GCCCAGGTGG 
GTGAAGACAG TTTTCCTGAA GCTGCTGCCC CAGGTCCTGC TGATGAGGTG GCCTCTGGAC 
AAGACAAGGG GCACAGGCTC TGATGCAGTG CCCAGAGGCC TTGCCAGGAG GCCTGCCAAA 
GGCAAGCTTG CAAGCCATGG GGAACCCAGA CATCTTAAAG AATGCTTCCA TTGTCACAAA 
TCAAATGAGC TTGCCACAAG CAAGAGAAGA TTAAGTCATC AGCCATTACA GTGGGTGGTG 
GAAAATTCGG AGCACTCGCC TGAAGTTGAA GATGTGATTA ACAGTGTTCA GTTCATAGCA 
GAAAACATGA AGAGCCACAA TGAAACCAAG GAGGTAGAAG ATGACTGGAA ATACGTGGCC 
ATGGTGGTGG ACAGAGTATT TCTTTGGGTA TTTATAATTG TCTGTGTATT TGGAACTGCA 
GGGCTATTTC TACAGCCACT ACTTGGGAAC ACAGGAAAAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRNA6 ( NM_001199279.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186208.1 Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13957
Clone ID Related Accession (Same CDS sequence)	NM_001199279.1
Accession Version	NM_001199279.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	neuronal acetylcholine receptor subunit alpha-6 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC307404.1, AK298798.1 and BC014456.1. Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298798.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

ATGCTGACCA GCAAGGGGCA GGGATTCCTT CATGGGGGCT TGTGTCTCTG GCTGTGTGTG 
TTCACACCTT TCTTTAAAGG CTGTGTGGGC TGTGCAACTG AGGAGAGGCT CTTCCACAAA 
CTGTTTTCTC ATTACAACCA GTTCATCAGG CCTGTGGAAA ACGTTTCCGA CCCTGTCACG 
GTACACTTTG AAGTGGCCAT CACCCAGCTG GCCAACGTGA TCTGGAATGA TTATAAATTG 
CGCTGGGATC CAATGGAATA TGATGGCATT GAGACTCTTC GCGTTCCTGC AGATAAGATT 
TGGAAGCCCG ACATTGTTCT CTATAACAAT GCTGTTGGTG ACTTCCAAGT AGAAGGCAAA 
ACAAAAGCTC TTCTTAAATA CAATGGCATG ATAACCTGGA CTCCACCAGC TATTTTTAAG 
AGTTCCTGCC CTATGGATAT CACCTTTTTC CCTTTTGATC ATCAAAACTG TTCCCTAAAA 
TTTGGTTCCT GGACGTATGA CAAAGCTGAA ATTGATCTTC TAATCATTGG ATCAAAAGTG 
GATATGAATG ATTTTTGGGA AAACAGTGAA TGGGAAATCA TTGATGCCTC TGGCTACAAA 
CATGACATCA AATACAACTG TTGTGAAGAG ATATACACAG ATATAACCTA TTCTTTCTAC 
ATTAGAAGAT TGCCGATGTT TTACACGATT AATCTGATCA TCCCTTGTCT CTTTATTTCA 
TTTCTAACCG TGTTGGTCTT TTACCTTCCT TCGGACTGTG GTGAAAAAGT GACGCTTTGT 
ATTTCAGTCC TGCTTTCTCT GACTGTGTTT TTGCTGGTCA TCACAGAAAC CATCCCATCC 
ACATCTCTGG TGGTCCCACT GGTGGGTGAG TACCTGCTGT TCACCATGAT CTTTGTCACA 
CTGTCCATCG TGGTGACTGT GTTTGTGTTG AACATACACT ACCGCACCCC AACCACGCAC 
ACAATGCCCA GGTGGGTGAA GACAGTTTTC CTGAAGCTGC TGCCCCAGGT CCTGCTGATG 
AGGTGGCCTC TGGACAAGAC AAGGGGCACA GGCTCTGATG CAGTGCCCAG AGGCCTTGCC 
AGGAGGCCTG CCAAAGGCAA GCTTGCAAGC CATGGGGAAC CCAGACATCT TAAAGAATGC 
TTCCATTGTC ACAAATCAAA TGAGCTTGCC ACAAGCAAGA GAAGATTAAG TCATCAGCCA 
TTACAGTGGG TGGTGGAAAA TTCGGAGCAC TCGCCTGAAG TTGAAGATGT GATTAACAGT 
GTTCAGTTCA TAGCAGAAAA CATGAAGAGC CACAATGAAA CCAAGGAGGT AGAAGATGAC 
TGGAAATACG TGGCCATGGT GGTGGACAGA GTATTTCTTT GGGTATTTAT AATTGTCTGT 
GTATTTGGAA CTGCAGGGCT ATTTCTACAG CCACTACTTG GGAACACAGG AAAATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186208.1
CDS	357..1796
Translation	MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGNTGKS

Target ORF information:

RefSeq Version	NM_001199279.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic alpha 6 subunit (CHRNA6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199279.1

ORF Insert Sequence:

ATGCTGACCA GCAAGGGGCA GGGATTCCTT CATGGGGGCT TGTGTCTCTG GCTGTGTGTG 
TTCACACCTT TCTTTAAAGG CTGTGTGGGC TGTGCAACTG AGGAGAGGCT CTTCCACAAA 
CTGTTTTCTC ATTACAACCA GTTCATCAGG CCTGTGGAAA ACGTTTCCGA CCCTGTCACG 
GTACACTTTG AAGTGGCCAT CACCCAGCTG GCCAACGTGA TCTGGAATGA TTATAAATTG 
CGCTGGGATC CAATGGAATA TGATGGCATT GAGACTCTTC GCGTTCCTGC AGATAAGATT 
TGGAAGCCCG ACATTGTTCT CTATAACAAT GCTGTTGGTG ACTTCCAAGT AGAAGGCAAA 
ACAAAAGCTC TTCTTAAATA CAATGGCATG ATAACCTGGA CTCCACCAGC TATTTTTAAG 
AGTTCCTGCC CTATGGATAT CACCTTTTTC CCTTTTGATC ATCAAAACTG TTCCCTAAAA 
TTTGGTTCCT GGACGTATGA CAAAGCTGAA ATTGATCTTC TAATCATTGG ATCAAAAGTG 
GATATGAATG ATTTTTGGGA AAACAGTGAA TGGGAAATCA TTGATGCCTC TGGCTACAAA 
CATGACATCA AATACAACTG TTGTGAAGAG ATATACACAG ATATAACCTA TTCTTTCTAC 
ATTAGAAGAT TGCCGATGTT TTACACGATT AATCTGATCA TCCCTTGTCT CTTTATTTCA 
TTTCTAACCG TGTTGGTCTT TTACCTTCCT TCGGACTGTG GTGAAAAAGT GACGCTTTGT 
ATTTCAGTCC TGCTTTCTCT GACTGTGTTT TTGCTGGTCA TCACAGAAAC CATCCCATCC 
ACATCTCTGG TGGTCCCACT GGTGGGTGAG TACCTGCTGT TCACCATGAT CTTTGTCACA 
CTGTCCATCG TGGTGACTGT GTTTGTGTTG AACATACACT ACCGCACCCC AACCACGCAC 
ACAATGCCCA GGTGGGTGAA GACAGTTTTC CTGAAGCTGC TGCCCCAGGT CCTGCTGATG 
AGGTGGCCTC TGGACAAGAC AAGGGGCACA GGCTCTGATG CAGTGCCCAG AGGCCTTGCC 
AGGAGGCCTG CCAAAGGCAA GCTTGCAAGC CATGGGGAAC CCAGACATCT TAAAGAATGC 
TTCCATTGTC ACAAATCAAA TGAGCTTGCC ACAAGCAAGA GAAGATTAAG TCATCAGCCA 
TTACAGTGGG TGGTGGAAAA TTCGGAGCAC TCGCCTGAAG TTGAAGATGT GATTAACAGT 
GTTCAGTTCA TAGCAGAAAA CATGAAGAGC CACAATGAAA CCAAGGAGGT AGAAGATGAC 
TGGAAATACG TGGCCATGGT GGTGGACAGA GTATTTCTTT GGGTATTTAT AATTGTCTGT 
GTATTTGGAA CTGCAGGGCT ATTTCTACAG CCACTACTTG GGAACACAGG AAAATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.
Scientific reports7(1)9745(2017 Aug)
Wen L,Han H,Liu Q,Su K,Yang Z,Cui W,Yuan W,Ma Y,Fan R,Chen J,Jiang K,Jiang X,Payne TJ,Wang J,Li MD

Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.
Behavior genetics46(5)693-704(2016 Sep)
Kamens HM,Corley RP,Richmond PA,Darlington TM,Dowell R,Hopfer CJ,Stallings MC,Hewitt JK,Brown SA,Ehringer MA

Functional interaction between Lypd6 and nicotinic acetylcholine receptors.
Journal of neurochemistry138(6)806-20(2016 09)
Arvaniti M,Jensen MM,Soni N,Wang H,Klein AB,Thiriet N,Pinborg LH,Muldoon PP,Wienecke J,Imad Damaj M,Kohlmeier KA,Gondr?-Lewis MC,Mikkelsen JD,Thomsen MS

Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.
Translational psychiatry6(6)e843(2016 06)
Wen L,Yang Z,Cui W,Li MD

The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.
Human molecular genetics17(5)724-34(2008 Mar)
Zeiger JS,Haberstick BC,Schlaepfer I,Collins AC,Corley RP,Crowley TJ,Hewitt JK,Hopfer CJ,Lessem J,McQueen MB,Rhee SH,Ehringer MA

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CHRNA6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報