H2AC11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2AC11
Entrez Gene ID	8969
Full Name	histone cluster 1 H2A family member g
Synonyms	H2A.1b,H2A/p,H2AFP,H2AG,pH2A/f
General protein information	Preferred Names histone cluster 1 H2A family member g Names histone H2A type 1 H2A histone family, member P H2A.1 histone 1, H2ag histone H2A/p histone H2A/ptl histone cluster 1, H2ag
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015].
Disorder MIM:	615012

mRNA and Protein(s)

mRNA	Protein	Name
NM_021064.4	NP_066408.1	histone H2A type 1
NM_021064.5	NP_066408.1	histone H2A type 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hist1h2an	NP_835491.1
Bos taurus (cattle)	LOC529277	XP_005223785.1
Rattus norvegicus (Norway rat)	Hist1h2ai	XP_577577.1
	HIST1H2AK	XP_001095673.1
Canis lupus familiaris (dog)	LOC488297	XP_545419.1
Homo sapiens (human)	HIST1H2AG	NP_066408.1
Pan troglodytes (chimpanzee)	LOC736529	XP_003311177.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, Glass KC
FEBS letters588(21)3844-54(2014 Nov)

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase.
Kim W, Chakraborty G, Kim S, Shin J, Park CH, Jeong MW, Bharatham N, Yoon HS, Kim KT
The Journal of biological chemistry287(8)5278-89(2012 Feb)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Transcriptional activation of polycomb-repressed genes by ZRF1.
Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L
Nature468(7327)1124-8(2010 Dec)

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Pozuelo-Rubio M
The FEBS journal277(16)3321-42(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Common variants on chromosome 6p22.1 are associated with schizophrenia.

The following H2AC11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2AC11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16513	NM_021064.5 Latest version!	Homo sapiens H2A clustered histone 11 (H2AC11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16513	NM_021064.4	Homo sapiens histone cluster 1 H2A family member g (HIST1H2AG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2AC11 ( NM_021064.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066408.1 Homo sapiens histone cluster 1 H2A family member g (HIST1H2AG), mRNA.

Price & Availability↑

CloneID	OHu16513
Clone ID Related Accession (Same CDS sequence)	NM_021064.4 , NM_021064.5
Accession Version	NM_021064.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	histone H2A type 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312124.1 and BC016677.1. On Apr 25, 2009 this sequence version replaced NM_021064.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGAC GTGGCAAGCA GGGAGGCAAA GCCCGCGCTA AGGCCAAGAC TCGCTCTTCT 
AGGGCCGGTC TCCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA AGGCAACTAT 
GCCGAGCGGG TCGGGGCCGG CGCGCCGGTG TATCTGGCAG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAACTGGC GGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGTCATC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CACAGGGCGG TGTCCTGCCC AACATTCAGG CCGTGCTACT GCCCAAAAAG 
ACTGAGAGCC ACCACAAGGC GAAGGGCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066408.1
CDS	35..427
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Target ORF information:

RefSeq Version	NM_021064.4
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2A family member g (HIST1H2AG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021064.4

ORF Insert Sequence:

ATGTCTGGAC GTGGCAAGCA GGGAGGCAAA GCCCGCGCTA AGGCCAAGAC TCGCTCTTCT 
AGGGCCGGTC TCCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA AGGCAACTAT 
GCCGAGCGGG TCGGGGCCGG CGCGCCGGTG TATCTGGCAG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAACTGGC GGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGTCATC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CACAGGGCGG TGTCCTGCCC AACATTCAGG CCGTGCTACT GCCCAAAAAG 
ACTGAGAGCC ACCACAAGGC GAAGGGCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AC11 ( NM_021064.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_066408.1 Homo sapiens H2A clustered histone 11 (H2AC11), mRNA.

Price & Availability↑

CloneID	OHu16513
Clone ID Related Accession (Same CDS sequence)	NM_021064.4 , NM_021064.5
Accession Version	NM_021064.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	histone H2A type 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL021807.2. On Dec 3, 2019 this sequence version replaced NM_021064.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC067782.1, BU659312.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGAC GTGGCAAGCA GGGAGGCAAA GCCCGCGCTA AGGCCAAGAC TCGCTCTTCT 
AGGGCCGGTC TCCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA AGGCAACTAT 
GCCGAGCGGG TCGGGGCCGG CGCGCCGGTG TATCTGGCAG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAACTGGC GGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGTCATC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CACAGGGCGG TGTCCTGCCC AACATTCAGG CCGTGCTACT GCCCAAAAAG 
ACTGAGAGCC ACCACAAGGC GAAGGGCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066408.1
CDS	30..422
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Target ORF information:

RefSeq Version	NM_021064.5
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A clustered histone 11 (H2AC11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021064.5

ORF Insert Sequence:

ATGTCTGGAC GTGGCAAGCA GGGAGGCAAA GCCCGCGCTA AGGCCAAGAC TCGCTCTTCT 
AGGGCCGGTC TCCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA AGGCAACTAT 
GCCGAGCGGG TCGGGGCCGG CGCGCCGGTG TATCTGGCAG CGGTGCTGGA GTACCTGACC 
GCCGAGATCC TGGAACTGGC GGGCAACGCG GCCCGCGACA ACAAGAAGAC CCGCATCATC 
CCGCGTCATC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CACAGGGCGG TGTCCTGCCC AACATTCAGG CCGTGCTACT GCCCAAAAAG 
ACTGAGAGCC ACCACAAGGC GAAGGGCAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.
FEBS letters588(21)3844-54(2014 Nov)
Lubula MY,Eckenroth BE,Carlson S,Poplawski A,Chruszcz M,Glass KC

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase.
The Journal of biological chemistry287(8)5278-89(2012 Feb)
Kim W,Chakraborty G,Kim S,Shin J,Park CH,Jeong MW,Bharatham N,Yoon HS,Kim KT

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Transcriptional activation of polycomb-repressed genes by ZRF1.
Nature468(7327)1124-8(2010 Dec)
Richly H,Rocha-Viegas L,Ribeiro JD,Demajo S,Gundem G,Lopez-Bigas N,Nakagawa T,Rospert S,Ito T,Di Croce L

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
The FEBS journal277(16)3321-42(2010 Aug)
Pozuelo-Rubio M

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H2AC11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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