H3C7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3C7
Entrez Gene ID	8968
Full Name	histone cluster 1 H3 family member f
Synonyms	H3/i,H3FI
General protein information	Preferred Names histone cluster 1 H3 family member f Names histone H3.1 H3 histone family, member I histone 1, H3f histone H3/i histone cluster 1, H3f
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:	602816

mRNA and Protein(s)

mRNA	Protein	Name
NM_021018.2	NP_066298.1	histone H3.1
NM_021018.3	NP_066298.1	histone H3.1

Pathways from BioSystems

Homologies

	LOC695427	XP_001083954.1
Drosophila melanogaster (fruit fly)	His3:CG33818	NP_001027308.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012559	XP_305996.3
Homo sapiens (human)	HIST1H3F	NP_066298.1
Xenopus tropicalis (tropical clawed frog)	LOC100497984	XP_002945363.1
Mus musculus (house mouse)	Hist1h3i	NP_835514.1
Rattus norvegicus (Norway rat)	LOC682330	XP_003751756.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Huang H, Str?mme CB, Saredi G, H?dl M, Strandsby A, Gonz?lez-Aguilera C, Chen S, Groth A, Patel DJ
Nature structural & molecular biology22(8)618-26(2015 Aug)

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H
Biochemistry54(5)1171-9(2015 Feb)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results uncover a novel role of CENP-F in regulation of epigenetic modification on histone H3.
Title: Involvement of CENP-F in histone methylation.

CREB controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro
Title: cAMP-response element-binding protein (CREB) controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro.

The following H3C7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3C7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16241	NM_021018.3 Latest version!	Homo sapiens H3 clustered histone 7 (H3C7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu16241	NM_021018.2	Homo sapiens histone cluster 1 H3 family member f (HIST1H3F), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3C7 ( NM_021018.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066298.1 Homo sapiens histone cluster 1 H3 family member f (HIST1H3F), mRNA.

Price & Availability↑

CloneID	OHu16241
Clone ID Related Accession (Same CDS sequence)	NM_021018.2 , NM_021018.3
Accession Version	NM_021018.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z80786.1. On Jun 12, 2002 this sequence version replaced NM_021018.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA506046.1, DA602236.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACGCA CGAAGCAAAC AGCTCGTAAG TCCACTGGCG GCAAAGCCCC GCGCAAGCAG 
CTGGCCACTA AGGCGGCTCG CAAAAGCGCG CCAGCCACCG GTGGCGTGAA GAAGCCCCAC 
CGCTACAGGC CTGGTACTGT CGCCCTCCGT GAAATCCGCC GCTATCAGAA ATCGACTGAG 
CTACTGATTC GCAAGCTACC ATTCCAGCGT CTGGTACGTG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCTGTG ATGGCGCTGC AGGAGGCCTG CGAGGCTTAC 
CTGGTGGGGC TCTTTGAGGA CACCAACCTG TGTGCTATCC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT CGCTCGCCGC ATTCGCGGAG AGAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066298.1
CDS	3..413
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_021018.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H3 family member f (HIST1H3F), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021018.2

ORF Insert Sequence:

ATGGCACGCA CGAAGCAAAC AGCTCGTAAG TCCACTGGCG GCAAAGCCCC GCGCAAGCAG 
CTGGCCACTA AGGCGGCTCG CAAAAGCGCG CCAGCCACCG GTGGCGTGAA GAAGCCCCAC 
CGCTACAGGC CTGGTACTGT CGCCCTCCGT GAAATCCGCC GCTATCAGAA ATCGACTGAG 
CTACTGATTC GCAAGCTACC ATTCCAGCGT CTGGTACGTG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCTGTG ATGGCGCTGC AGGAGGCCTG CGAGGCTTAC 
CTGGTGGGGC TCTTTGAGGA CACCAACCTG TGTGCTATCC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT CGCTCGCCGC ATTCGCGGAG AGAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H3C7 ( NM_021018.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066298.1 Homo sapiens H3 clustered histone 7 (H3C7), mRNA.

Price & Availability↑

CloneID	OHu16241
Clone ID Related Accession (Same CDS sequence)	NM_021018.2 , NM_021018.3
Accession Version	NM_021018.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031777.5. On Dec 3, 2019 this sequence version replaced NM_021018.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA506046.1, BC069818.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACGCA CGAAGCAAAC AGCTCGTAAG TCCACTGGCG GCAAAGCCCC GCGCAAGCAG 
CTGGCCACTA AGGCGGCTCG CAAAAGCGCG CCAGCCACCG GTGGCGTGAA GAAGCCCCAC 
CGCTACAGGC CTGGTACTGT CGCCCTCCGT GAAATCCGCC GCTATCAGAA ATCGACTGAG 
CTACTGATTC GCAAGCTACC ATTCCAGCGT CTGGTACGTG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCTGTG ATGGCGCTGC AGGAGGCCTG CGAGGCTTAC 
CTGGTGGGGC TCTTTGAGGA CACCAACCTG TGTGCTATCC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT CGCTCGCCGC ATTCGCGGAG AGAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066298.1
CDS	31..441
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_021018.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H3 clustered histone 7 (H3C7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021018.3

ORF Insert Sequence:

ATGGCACGCA CGAAGCAAAC AGCTCGTAAG TCCACTGGCG GCAAAGCCCC GCGCAAGCAG 
CTGGCCACTA AGGCGGCTCG CAAAAGCGCG CCAGCCACCG GTGGCGTGAA GAAGCCCCAC 
CGCTACAGGC CTGGTACTGT CGCCCTCCGT GAAATCCGCC GCTATCAGAA ATCGACTGAG 
CTACTGATTC GCAAGCTACC ATTCCAGCGT CTGGTACGTG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCTGTG ATGGCGCTGC AGGAGGCCTG CGAGGCTTAC 
CTGGTGGGGC TCTTTGAGGA CACCAACCTG TGTGCTATCC ACGCCAAGCG AGTGACTATC 
ATGCCCAAGG ACATCCAGCT CGCTCGCCGC ATTCGCGGAG AGAGGGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
Nature structural & molecular biology22(8)618-26(2015 Aug)
Huang H,Str?mme CB,Saredi G,H?dl M,Strandsby A,Gonz?lez-Aguilera C,Chen S,Groth A,Patel DJ

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Biochemistry54(5)1171-9(2015 Feb)
Kato D,Osakabe A,Tachiwana H,Tanaka H,Kurumizaka H

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

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H3C7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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