SKAP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SKAP2
Entrez Gene ID	8935
Full Name	src kinase associated phosphoprotein 2
Synonyms	PRAP,RA70,SAPS,SCAP2,SKAP-HOM,SKAP55R
General protein information	Preferred Names src kinase associated phosphoprotein 2 Names src kinase-associated phosphoprotein 2 Fyn-associated phosphoprotein SKAP55 homologue Pyk2/RAFTK-associated protein SKAP-55HOM SKAP55 homolog retinoic acid-induced protein 70 src family-associated phosphoprotein 2 src kinase-associated phosphoprotein of 55-related protein src-associated adapter protein with PH and SH3 domains
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p15.2
Summary	The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015].
Disorder MIM:	605215

mRNA and Protein(s)

mRNA	Protein	Name
XM_017012771.1	XP_016868260.1	src kinase-associated phosphoprotein 2 isoform X1
XM_017012771.2	XP_016868260.1	src kinase-associated phosphoprotein 2 isoform X1
NM_001303468.1	NP_001290397.1	src kinase-associated phosphoprotein 2 isoform 2
NM_003930.5	NP_003921.2	src kinase-associated phosphoprotein 2 isoform 1
NM_003930.4	NP_003921.2	src kinase-associated phosphoprotein 2 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SKAP2	NP_003921.2
Canis lupus familiaris (dog)	SKAP2	XP_539483.2
Xenopus tropicalis (tropical clawed frog)	skap2	NP_001107684.1
Mus musculus (house mouse)	Skap2	NP_061243.1
Rattus norvegicus (Norway rat)	Skap2	NP_569097.1
Gallus gallus (chicken)	SKAP2	XP_418727.3
Danio rerio (zebrafish)	skap2	NP_956922.1
Pan troglodytes (chimpanzee)	SKAP2	XP_519007.2
	SKAP2	XP_001093819.1
Bos taurus (cattle)	SKAP2	NP_001033303.1

Gene Ontology
Bibliography

Related articles in PubMed

SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.
Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N
Cancer research76(2)358-69(2016 Jan)

Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.
Kuranami S, Yokobori T, Mogi A, Altan B, Yajima T, Onozato R, Azuma Y, Iijima M, Kosaka T, Kuwano H
Anticancer research35(4)2411-5(2015 Apr)

The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.
Shimamura S, Sasaki K, Tanaka M
The Journal of biological chemistry288(2)1171-83(2013 Jan)

Macrophages require Skap2 and Sirp? for integrin-stimulated cytoskeletal rearrangement.
Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD
Journal of cell science125(Pt 22)5535-45(2012 Nov)

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP
The Journal of biological chemistry275(43)33427-34(2000 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs.
Title: SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.

SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for Non-small cell lung cancer treatment.
Title: Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.

results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2-cortactin complex
Title: The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.

Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement.
Title: Macrophages require Skap2 and Sirp? for integrin-stimulated cytoskeletal rearrangement.

analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
Title: Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.

The following SKAP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SKAP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03619	NM_003930.5 Latest version!	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu03619	XM_017012771.2 Latest version!	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu62352	NM_001303468.1 Latest version!	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu03619	XM_017012771.1	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu03619	NM_003930.4	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SKAP2 ( NM_003930.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003921.2 Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03619
Clone ID Related Accession (Same CDS sequence)	XM_017012771.1 , XM_017012771.2 , NM_003930.5 , NM_003930.4
Accession Version	NM_003930.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	src kinase-associated phosphoprotein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY044523.1, AK313209.1, BC002893.2, BC036044.1 and BQ433993.1. On Nov 23, 2018 this sequence version replaced NM_003930.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036044.1, SRR1803614.275728.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000345317.7/ ENSP00000005587.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003921.2
CDS	162..1241
Translation	MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI

Target ORF information:

RefSeq Version	NM_003930.5
Organism	Homo sapiens(human)
Definition	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003930.5

ORF Insert Sequence:

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SKAP2 ( NM_003930.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003921.2 Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03619
Clone ID Related Accession (Same CDS sequence)	XM_017012771.1 , XM_017012771.2 , NM_003930.5 , NM_003930.4
Accession Version	NM_003930.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	src kinase-associated phosphoprotein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY044523.1, AK313209.1, BC002893.2, BC036044.1, BQ433993.1 and CA423048.1. On Jan 7, 2015 this sequence version replaced NM_003930.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036044.1, SRR1803614.275728.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003921.2
CDS	315..1394
Translation	MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI

Target ORF information:

RefSeq Version	NM_003930.4
Organism	Homo sapiens(human)
Definition	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003930.4

ORF Insert Sequence:

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SKAP2 ( XM_017012771.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016868260.1 Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03619
Clone ID Related Accession (Same CDS sequence)	XM_017012771.1 , XM_017012771.2 , NM_003930.5 , NM_003930.4
Accession Version	XM_017012771.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	src kinase-associated phosphoprotein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016868260.1
CDS	277..1356
Translation	MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI

Target ORF information:

RefSeq Version	XM_017012771.1
Organism	Homo sapiens(human)
Definition	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017012771.1

ORF Insert Sequence:

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SKAP2 ( XM_017012771.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016868260.1 Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant X1, mRNA.

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CloneID	OHu03619
Clone ID Related Accession (Same CDS sequence)	XM_017012771.1 , XM_017012771.2 , NM_003930.5 , NM_003930.4
Accession Version	XM_017012771.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	src kinase-associated phosphoprotein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017012771.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016868260.1
CDS	195..1274
Translation	MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI

Target ORF information:

RefSeq Version	XM_017012771.2
Organism	Homo sapiens(human)
Definition	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017012771.2

ORF Insert Sequence:

ATGCCCAACC CCAGCAGCAC CTCCTCTCCC TACCCCCTCC CTGAGGAAAT TAGGAACCTG 
TTGGCAGATG TTGAAACATT TGTAGCAGAT ATACTGAAAG GAGAAAATTT ATCCAAGAAA 
GCAAAGGAAA AGAGAGAATC CCTTATTAAG AAGATAAAAG ATGTAAAGTC TATCTATCTT 
CAGGAATTTC AAGACAAAGG TGATGCAGAA GATGGGGAAG AATATGATGA CCCTTTTGCT 
GGGCCTCCAG ACACTATTTC ATTAGCCTCA GAACGATATG ATAAAGACGA TGAAGCCCCC 
TCTGATGGAG CCCAGTTTCC TCCAATTGCA GCACAAGACC TTCCTTTTGT TCTAAAGGCT 
GGCTACCTTG AAAAACGCAG AAAAGATCAC AGCTTTCTGG GATTTGAATG GCAGAAACGG 
TGGTGTGCTC TCAGTAAAAC GGTATTCTAT TATTATGGAA GTGATAAAGA CAAACAACAG 
AAAGGTGAAT TTGCAATAGA TGGCTACAGT GTCAGAATGA ATAACACTCT AAGAAAGGAT 
GGAAAGAAAG ATTGCTGTTT TGAAATCTCT GCTCCTGATA AACGTATATA TCAGTTTACA 
GCAGCTTCTC CCAAAGATGC TGAAGAATGG GTACAGCAGC TGAAATTTGT ATTGCAAGAT 
ATGGAATCTG ATATTATTCC TGAGGATTAT GATGAGAGAG GAGAATTATA TGATGATGTT 
GATCATCCTC TACCAATAAG CAATCCACTA ACAAGCAGTC AACCAATAGA TGATGAAATT 
TATGAAGAAC TTCCAGAAGA AGAAGAGGAC AGTGCTCCAG TGAAAGTGGA AGAACAAAGG 
AAGATGAGTC AGGATAGTGT CCATCACACC TCAGGGGATA AGAGCACTGA TTATGCTAAT 
TTTTACCAGG GATTGTGGGA TTGTACTGGA GCTTTTTCTG ATGAGTTGTC ATTTAAGCGT 
GGTGATGTGA TTTACATTCT TAGCAAGGAA TACAATAGAT ATGGCTGGTG GGTAGGAGAA 
ATGAAGGGAG CCATTGGCTT GGTGCCTAAA GCCTACATAA TGGAGATGTA TGATATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SKAP2 ( NM_001303468.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290397.1 Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu62352
Clone ID Related Accession (Same CDS sequence)	NM_001303468.1
Accession Version	NM_001303468.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	src kinase-associated phosphoprotein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA714447.1, DA738803.1, AK299317.1, BC002893.2, BC036044.1, BQ433993.1 and CA423048.1. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299317.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATAACA CTCTAAGAAA GGATGGAAAG AAAGATTGCT GTTTTGAAAT CTCTGCTCCT 
GATAAACGTA TATATCAGTT TACAGCAGCT TCTCCCAAAG ATGCTGAAGA ATGGGTACAG 
CAGCTGAAAT TTGTATTGCA AGATATGGAA TCTGATATTA TTCCTGAGGA TTATGATGAG 
AGAGGAGAAT TATATGATGA TGTTGATCAT CCTCTACCAA TAAGCAATCC ACTAACAAGC 
AGTCAACCAA TAGATGATGA AATTTATGAA GAACTTCCAG AAGAAGAAGA GGACAGTGCT 
CCAGTGAAAG TGGAAGAACA AAGGAAGATG AGTCAGGATA GTGTCCATCA CACCTCAGGG 
GATAAGAGCA CTGATTATGC TAATTTTTAC CAGGGATTGT GGGATTGTAC TGGAGCTTTT 
TCTGATGAGT TGTCATTTAA GCGTGGTGAT GTGATTTACA TTCTTAGCAA GGAATACAAT 
AGATATGGCT GGTGGGTAGG AGAAATGAAG GGAGCCATTG GCTTGGTGCC TAAAGCCTAC 
ATAATGGAGA TGTATGATAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290397.1
CDS	723..1286
Translation	MNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI

Target ORF information:

RefSeq Version	NM_001303468.1
Organism	Homo sapiens(human)
Definition	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303468.1

ORF Insert Sequence:

ATGAATAACA CTCTAAGAAA GGATGGAAAG AAAGATTGCT GTTTTGAAAT CTCTGCTCCT 
GATAAACGTA TATATCAGTT TACAGCAGCT TCTCCCAAAG ATGCTGAAGA ATGGGTACAG 
CAGCTGAAAT TTGTATTGCA AGATATGGAA TCTGATATTA TTCCTGAGGA TTATGATGAG 
AGAGGAGAAT TATATGATGA TGTTGATCAT CCTCTACCAA TAAGCAATCC ACTAACAAGC 
AGTCAACCAA TAGATGATGA AATTTATGAA GAACTTCCAG AAGAAGAAGA GGACAGTGCT 
CCAGTGAAAG TGGAAGAACA AAGGAAGATG AGTCAGGATA GTGTCCATCA CACCTCAGGG 
GATAAGAGCA CTGATTATGC TAATTTTTAC CAGGGATTGT GGGATTGTAC TGGAGCTTTT 
TCTGATGAGT TGTCATTTAA GCGTGGTGAT GTGATTTACA TTCTTAGCAA GGAATACAAT 
AGATATGGCT GGTGGGTAGG AGAAATGAAG GGAGCCATTG GCTTGGTGCC TAAAGCCTAC 
ATAATGGAGA TGTATGATAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.
Cancer research76(2)358-69(2016 Jan)
Tanaka M,Shimamura S,Kuriyama S,Maeda D,Goto A,Aiba N

Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.
Anticancer research35(4)2411-5(2015 Apr)
Kuranami S,Yokobori T,Mogi A,Altan B,Yajima T,Onozato R,Azuma Y,Iijima M,Kosaka T,Kuwano H

The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.
The Journal of biological chemistry288(2)1171-83(2013 Jan)
Shimamura S,Sasaki K,Tanaka M

Macrophages require Skap2 and Sirp? for integrin-stimulated cytoskeletal rearrangement.
Journal of cell science125(Pt 22)5535-45(2012 Nov)
Alenghat FJ,Baca QJ,Rubin NT,Pao LI,Matozaki T,Lowell CA,Golan DE,Neel BG,Swanson KD

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
The Journal of biological chemistry275(43)33427-34(2000 Oct)
Asazuma N,Wilde JI,Berlanga O,Leduc M,Leo A,Schweighoffer E,Tybulewicz V,Bon C,Liu SK,McGlade CJ,Schraven B,Watson SP

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SKAP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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