SNURF cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNURF
Entrez Gene ID	8926
Full Name	SNRPN upstream reading frame
General protein information	Preferred Names SNRPN upstream reading frame Names SNRPN upstream reading frame protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q11.2
Summary	This gene is located within the Prader-Willi Syndrome critical region on chromosome 15. Transcripts produced from this gene initiate at an imprinting center and are paternally-imprinted. These transcripts may be bicistronic and also encode SNRPN (small nuclear ribonucleoprotein polypeptide N) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. Extensive alternative splicing and promoter usage occurs in this region and the full-length nature of some of these transcripts has not been determined. Alterations in the imprinting center are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022804.3	NP_073715.1	SNRPN upstream reading frame protein
NM_022804.2	NP_073715.1	SNRPN upstream reading frame protein
NM_005678.3	NP_005669.2	SNRPN upstream reading frame protein
NM_005678.4	NP_005669.2	SNRPN upstream reading frame protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC100612044	XP_003317775.1
Bos taurus (cattle)	SNURF	NP_776888.1
Mus musculus (house mouse)	Snurf	NP_149409.1
Rattus norvegicus (Norway rat)	Snurf	NP_001257641.1
Homo sapiens (human)	SNURF	NP_005669.2

Gene Ontology
Bibliography

Related articles in PubMed

A novel deletion of SNURF/SNRPN exon 1 in a patient with Prader-Willi-like phenotype.
Cao Y, AlHumaidi SS, Faqeih EA, Pitel BA, Lundquist P, Aypar U
European journal of medical genetics60(8)416-420(2017 Aug)

Prader-Willi syndrome and atypical submicroscopic 15q11-q13 deletions with or without imprinting defects.
Hassan M, Butler MG
European journal of medical genetics59(11)584-589(2016 Nov)

Small mosaic deletion encompassing the snoRNAs and SNURF-SNRPN results in an atypical Prader-Willi syndrome phenotype.
Anderlid BM, Lundin J, Malmgren H, Lehtihet M, Nordgren A
American journal of medical genetics. Part A164A(2)425-31(2014 Feb)

Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
Izzi B, Francois I, Labarque V, Thys C, Wittevrongel C, Devriendt K, Legius E, Van den Bruel A, D'Hooghe M, Lambrechts D, de Zegher F, Van Geet C, Freson K
PloS one7(6)e38579(2012)

Behavioral phenotype in adults with Prader-Willi syndrome.
Sinnema M, Einfeld SL, Schrander-Stumpel CT, Maaskant MA, Boer H, Curfs LM
Research in developmental disabilities32(2)604-12(2011 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A de novo 6.4 kb deletion at 15q11.2, containing exon 1 of the SNURF gene and exon 1 of the shortest isoform of the SNRPN gene was identified in a patient with Prader-Willi-like phenotype. DNA methylation analysis confirmed the paternal origin of the deletion.
Title: A novel deletion of SNURF/SNRPN exon 1 in a patient with Prader-Willi-like phenotype.

significant IGF2 hypermethylation (20 +/- 10 vs. 14 +/- 7%; p<0.05) and SNURF hypomethylation (23 +/- 6 vs. 32 6%; p<0.001) was found in Albright's hereditary osteodystrophy patients vs. controls.
Title: Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.

Differences between genetic subtypes were also statistically significant in Prader Willi syndrome
Title: Behavioral phenotype in adults with Prader-Willi syndrome.

Identification of cis- and trans-acting regulatory elements within the endogenous SNURF-SNRPN locus.
Title: Characterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus.

The SNURF-SNRPN sense/UBE3A antisense transcription unit spans more than 460 kb.
Title: The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A.

The following SNURF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNURF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03930	NM_022804.3 Latest version!	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03930	NM_005678.4 Latest version!	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03930	NM_022804.2	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03930	NM_005678.3	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNURF ( NM_022804.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073715.1 Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03930
Clone ID Related Accession (Same CDS sequence)	NM_022804.3 , NM_022804.2 , NM_005678.3 , NM_005678.4
Accession Version	NM_022804.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	SNRPN upstream reading frame protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA134019.1 and AW451120.1. On Jun 2, 2019 this sequence version replaced NM_022804.2. Transcript Variant: This variant (2) lacks multiple 3' exons and contains an alternate 3' UTR compared to variant 1. This variant is monocistronic and cannot encode the SNRPN protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI017249.1, AI962680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 10318933 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073715.1
CDS	63..278
Translation	MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQQQVPVVDFQAELRQAFLAETPRGG

Target ORF information:

RefSeq Version	NM_022804.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022804.3

ORF Insert Sequence:

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNURF ( NM_022804.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_073715.1 Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03930
Clone ID Related Accession (Same CDS sequence)	NM_022804.3 , NM_022804.2 , NM_005678.3 , NM_005678.4
Accession Version	NM_022804.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	SNRPN upstream reading frame protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA134019.1 and AW451120.1. On Feb 14, 2007 this sequence version replaced NM_022804.1. Transcript Variant: This variant (2) lacks multiple 3' exons and contains an alternate 3' UTR compared to variant 1. This variant is monocistronic and cannot encode the SNRPN protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW451120.1, HY160621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 10318933 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073715.1
CDS	127..342
Translation	MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQQQVPVVDFQAELRQAFLAETPRGG

Target ORF information:

RefSeq Version	NM_022804.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022804.2

ORF Insert Sequence:

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNURF ( NM_005678.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005669.2 Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03930
Clone ID Related Accession (Same CDS sequence)	NM_022804.3 , NM_022804.2 , NM_005678.3 , NM_005678.4
Accession Version	NM_005678.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	SNRPN upstream reading frame protein
Comment

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005669.2
Translation	MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQQQVPVVDFQAELRQAFLAETPRGG

Target ORF information:

RefSeq Version	NM_005678.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005678.3

ORF Insert Sequence:

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNURF ( NM_005678.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005669.2 Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03930
Clone ID Related Accession (Same CDS sequence)	NM_022804.3 , NM_022804.2 , NM_005678.3 , NM_005678.4
Accession Version	NM_005678.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	SNRPN upstream reading frame protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA369087.1, U41303.1, AC124312.5 and DB554158.1. This sequence is a reference standard in the RefSeqGene project. On Mar 29, 2016 this sequence version replaced NM_005678.3. Transcript Variant: This variant (1) is the predominant splice variant and represents a bicistronic transcript that can also encode the SNRPN protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.228052.1, SRR1803615.168412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 10318933 imprinted gene :: PMID: 10318933 NMD candidate :: PMID: 10318933 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005669.2
CDS	157..372
Translation	MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQQQVPVVDFQAELRQAFLAETPRGG

Target ORF information:

RefSeq Version	NM_005678.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SNRPN upstream reading frame (SNURF), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005678.4

ORF Insert Sequence:

ATGGAGCGGG CAAGGGATCG CTTACACCTG AGACGAACTA CAGAACAGCA CGTACCAGAG 
GTGGAAGTCC AAGTCAAACG CAGAAGGACT GCCTCACTGA GCAACCAAGA GTGTCAGTTG 
TACCCGAGGC GTTCTCAGCA GCAGCAAGTA CCTGTGGTGG ATTTCCAGGC TGAACTGAGG 
CAGGCATTCT TAGCTGAGAC ACCAAGAGGT GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel deletion of SNURF/SNRPN exon 1 in a patient with Prader-Willi-like phenotype.
European journal of medical genetics60(8)416-420(2017 Aug)
Cao Y,AlHumaidi SS,Faqeih EA,Pitel BA,Lundquist P,Aypar U

Prader-Willi syndrome and atypical submicroscopic 15q11-q13 deletions with or without imprinting defects.
European journal of medical genetics59(11)584-589(2016 Nov)
Hassan M,Butler MG

Small mosaic deletion encompassing the snoRNAs and SNURF-SNRPN results in an atypical Prader-Willi syndrome phenotype.
American journal of medical genetics. Part A164A(2)425-31(2014 Feb)
Anderlid BM,Lundin J,Malmgren H,Lehtihet M,Nordgren A

Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
PloS one7(6)e38579(2012)
Izzi B,Francois I,Labarque V,Thys C,Wittevrongel C,Devriendt K,Legius E,Van den Bruel A,D'Hooghe M,Lambrechts D,de Zegher F,Van Geet C,Freson K

Behavioral phenotype in adults with Prader-Willi syndrome.
Research in developmental disabilities32(2)604-12(2011 Mar-Apr)
Sinnema M,Einfeld SL,Schrander-Stumpel CT,Maaskant MA,Boer H,Curfs LM

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SNURF cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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