Gene Symbol | BCL10 |
Entrez Gene ID | 8915 |
Full Name | B cell CLL/lymphoma 10 |
Synonyms | CARMEN,CIPER,CLAP,IMD37,c-E10,mE10 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. |
Disorder MIM: | |
Disorder Html: | Lymphoma, MALT, somatic, 137245 (3); {Lymphoma, follicular, somatic}, 605027 (3); {Male germ cell tumor, somatic}, 273300, (3); {Sezary syndrome, somatic}, (3); {Mesothelioma, somatic}, 156240 (3); ?Immunodeficiency 37, 616098 (3) |