ACTN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACTN3
Entrez Gene ID	89
Full Name	actinin alpha 3 (gene/pseudogene)
Synonyms	ACTN3D
General protein information	Preferred Names actinin alpha 3 (gene/pseudogene) Names alpha-actinin-3 F-actin cross-linking protein actinin, alpha 3 alpha-actinin skeletal muscle
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014].
Disorder MIM:	102574
Disorder Html:	[Alpha-actinin-3 deficiency], 617749 (3); [Sprinting performance], 617749 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001104.3	NP_001095.2	alpha-actinin-3 isoform 1
NM_001104.4	NP_001095.2	alpha-actinin-3 isoform 1
NM_001258371.2	NP_001245300.2	alpha-actinin-3 isoform 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-?B degradation and cell growth suppression in neuroblastoma.
Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K
Oncogene36(41)5745-5756(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 that is involved in NF-kappaB degradation and cell cycle suppression in neuroblastoma cells.
Title: A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-?B degradation and cell growth suppression in neuroblastoma.

It appears that the response of bone remodelling markers and undercarboxylated osteocalcin to exercise is not explained by the ACTN3 genotype
Title: The influence of ?-actinin-3 deficiency on bone remodelling markers in young men.

The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.
Title: Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts.

p16(INK4a) expression in MCF7 breast cancer cells leads to increased cell size, weakened intercellular adhesion and cortical re-distribution of cytoskeletal F-actin.
Title: [Subcellular re-distribution of F-actin in MCF7 cells upon inducible expression of CDKN2A/p16

The elite soccer players showed a tendency to a prevalence of ACTN3 RR and ACE DD genotypes both independently and in co-occurrence, in comparison with a general population.
Title: ACTN3/ACE genotypes and mitochondrial genome in professional soccer players performance.

The following ACTN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACTN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22003	NM_001258371.2 Latest version!	Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu27737	NM_001104.4 Latest version!	Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu27737	NM_001104.3	Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACTN3 ( NM_001258371.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001245300.2 Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 2, mRNA.

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CloneID	OHu22003
Clone ID Related Accession (Same CDS sequence)	NM_001258371.2
Accession Version	NM_001258371.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2835bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	alpha-actinin-3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303044.1, BC099647.3, AP002748.4 and AJ346025.1. On Feb 19, 2014 this sequence version replaced NM_001258371.1. Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 10192379 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGATAG GGCTCTGTGT CCCACCAGCG AGGTGCTGGA AGAGGCTCAC GAGGAGCTCC 
AGAGGGCAGC CTCTAGAGCG GCCCGCGGCC ACTATTATTA TCGGCCTTTC TATTGTGGAG 
AGGAGTAAAC AGACTCAGAG AGGTCCCGTG GATTTCTCAA GGTCACACAG CGCCCCAGCA 
GCGGAGCAGG AATGCAAACC CAGGATCTCC GCCGCGAGAT CCACCCCGGC GCCCCCGAGT 
CCCGCAGTTC CCGGCTTCAG GACAACCCCT TGCCAGACCT TCACTGCCTG GTGCAACTCA 
CACCTGCGCA AGGCAGGCAC CCAGATCGAG AACATCGAGG AAGATTTCCG CAATGGCCTC 
AAACTCATGC TGCTCCTGGA GGTCATTTCA GGTGAGAGGC TGCCTAGGCC AGATAAAGGC 
AAGATGCGCT TCCACAAAAT CGCCAACGTT AACAAGGCCC TGGACTTCAT TGCCAGCAAG 
GGGGTTAAAC TGGTGTCCAT TGGTGCTGAA GAGATTGTTG ACGGGAACCT GAAGATGACC 
CTGGGCATGA TCTGGACCAT CATCCTTCGC TTCGCCATCC AGGACATCTC TGTGGAAGAA 
ACCTCAGCCA AGGAAGGCTT GCTTCTGTGG TGCCAGAGGA AGACAGCACC GTACCGCAAC 
GTCAACGTGC AGAACTTCCA CACCAGCTGG AAGGATGGCC TGGCCCTCTG TGCCCTCATC 
CACCGACACC GCCCTGACCT CATCGACTAC GCCAAACTGC GAAAGGATGA CCCCATCGGA 
AACCTGAACA CTGCCTTTGA GGTGGCAGAG AAATACCTGG ACATCCCCAA GATGTTGGAT 
GCAGAAGACA TTGTGAACAC CCCAAAGCCG GATGAGAAGG CCATCATGAC CTATGTGTCC 
TGCTTCTACC ATGCCTTTGC CGGGGCTGAG CAGGCAGAGA CAGCTGCCAA CAGGATCTGC 
AAGGTGCTGG CAGTGAACCA GGAAAACGAG AAGCTGATGG AGGAGTATGA GAAGCTTGCC 
AGTGAGCTGC TGGAGTGGAT CCGCCGCACT GTCCCATGGC TGGAGAACCG TGTGGGTGAG 
CCCAGCATGA GTGCCATGCA GCGCAAACTA GAGGACTTTC GGGACTACCG GCGTCTGCAC 
AAGCCGCCCC GCATTCAGGA AAAGTGCCAG CTGGAGATCA ACTTCAACAC ACTGCAGACC 
AAGTTGCGGC TCAGCCACCG GCCTGCCTTC ATGCCCTCCG AGGGCAAGCT GGTCTCGGAC 
ATCGCCAACG CCTGGCGGGG GCTGGAGCAG GTGGAAAAGG GCTATGAGGA CTGGCTGCTC 
TCGGAGATCC GGCGCCTGCA GCGACTCCAG CACCTGGCTG AGAAGTTCCG GCAGAAGGCC 
TCCCTGCACG AAGCCTGGAC CCGGGGAAAG GAGGAGATGC TGAGCCAGCG CGACTACGAT 
TCGGCTTTGC TACAGGAGGT GCGGGCGTTG CTGCGGCGCC ACGAGGCCTT TGAGAGCGAC 
CTGGCGGCGC ACCAGGACCG CGTGGAGCAC ATTGCCGCGC TGGCCCAGGA GCTCAATGAG 
CTGGACTACC ACGAGGCAGC CTCAGTGAAT AGCCGCTGCC AGGCCATCTG CGATCAGTGG 
GACAACCTGG GCACCCTGAC CCAGAAGAGG CGGGATGCGC TAGAGCGGAT GGAGAAGCTC 
CTGGAGACCA TTGACCGGCT GCAACTGGAG TTTGCCCGGC GGGCCGCGCC CTTCAACAAC 
TGGCTGGATG GTGCCGTGGA GGACCTGCAG GACGTGTGGC TGGTACACTC TGTGGAGGAG 
ACCCAGAGCC TGCTGACAGC GCACGATCAG TTCAAGGCAA CACTGCCCGA GGCTGACCGA 
GAGCGAGGTG CCATCATGGG CATCCAGGGT GAGATCCAGA AGATCTGCCA GACGTATGGG 
CTGCGGCCCT GCTCCACCAA TCCCTACATC ACCCTCAGCC CGCAGGACAT CAACACCAAG 
TGGGATATGG TCCGAAAGCT GGTGCCCAGC TGTGACCAGA CACTGCAGGA GGAGCTGGCA 
CGGCAGCAGG TAAACGAGAG GCTCCGGCGA CAGTTTGCGG CCCAGGCCAA TGCCATTGGA 
CCCTGGATCC AGGCGAAGGT GGAGGAAGTG GGGCGGCTGG CAGCAGGGCT AGCTGGCTCT 
CTGGAGGAGC AGATGGCTGG GCTACGGCAG CAGGAGCAGA ACATTATCAA CTACAAGACT 
AACATTGACC GGCTGGAGGG TGACCACCAG CTGCTGCAGG AGAGCCTGGT GTTCGACAAT 
AAGCACACCG TCTACAGCAT GGAGCACATC CGCGTGGGCT GGGAGCAGCT GCTCACCTCC 
ATTGCCCGCA CCATCAATGA AGTGGAGAAC CAGGTACTGA CCCGAGACGC CAAGGGACTG 
AGCCAGGAGC AGCTCAACGA GTTCCGAGCA TCCTTCAACC ACTTTGACAG GAAGCAGAAT 
GGGATGATGG AGCCTGATGA CTTCCGAGCT TGCCTCATCT CCATGGGCTA TGACCTGGGG 
GAAGTGGAGT TTGCTCGCAT CATGACCATG GTGGACCCCA ACGCAGCTGG GGTGGTGACC 
TTCCAGGCCT TCATAGACTT CATGACCCGA GAGACAGCCG AGACTGACAC GACTGAGCAA 
GTTGTAGCTT CCTTCAAGAT CTTGGCAGGA GACAAGAACT ACATCACCCC CGAGGAGCTG 
CGGCGCGAGC TCCCTGCCAA GCAGGCCGAG TACTGCATCC GCCGTATGGT GCCCTACAAG 
GGATCCGGGG CCCCGGCTGG AGCCCTGGAC TACGTGGCCT TCTCCAGTGC CCTCTATGGG 
GAGAGCGACC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001245300.2
CDS	117..2951
Translation	MGIGLCVPPARCWKRLTRSSRGQPLERPAATIIIGLSIVERSKQTQRGPVDFSRSHSAPAAEQECKPRISAARSTPAPPSPAVPGFRTTPCQTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL

Target ORF information:

RefSeq Version	NM_001258371.2
Organism	Homo sapiens(human)
Definition	Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001258371.2

ORF Insert Sequence:

ATGGGGATAG GGCTCTGTGT CCCACCAGCG AGGTGCTGGA AGAGGCTCAC GAGGAGCTCC 
AGAGGGCAGC CTCTAGAGCG GCCCGCGGCC ACTATTATTA TCGGCCTTTC TATTGTGGAG 
AGGAGTAAAC AGACTCAGAG AGGTCCCGTG GATTTCTCAA GGTCACACAG CGCCCCAGCA 
GCGGAGCAGG AATGCAAACC CAGGATCTCC GCCGCGAGAT CCACCCCGGC GCCCCCGAGT 
CCCGCAGTTC CCGGCTTCAG GACAACCCCT TGCCAGACCT TCACTGCCTG GTGCAACTCA 
CACCTGCGCA AGGCAGGCAC CCAGATCGAG AACATCGAGG AAGATTTCCG CAATGGCCTC 
AAACTCATGC TGCTCCTGGA GGTCATTTCA GGTGAGAGGC TGCCTAGGCC AGATAAAGGC 
AAGATGCGCT TCCACAAAAT CGCCAACGTT AACAAGGCCC TGGACTTCAT TGCCAGCAAG 
GGGGTTAAAC TGGTGTCCAT TGGTGCTGAA GAGATTGTTG ACGGGAACCT GAAGATGACC 
CTGGGCATGA TCTGGACCAT CATCCTTCGC TTCGCCATCC AGGACATCTC TGTGGAAGAA 
ACCTCAGCCA AGGAAGGCTT GCTTCTGTGG TGCCAGAGGA AGACAGCACC GTACCGCAAC 
GTCAACGTGC AGAACTTCCA CACCAGCTGG AAGGATGGCC TGGCCCTCTG TGCCCTCATC 
CACCGACACC GCCCTGACCT CATCGACTAC GCCAAACTGC GAAAGGATGA CCCCATCGGA 
AACCTGAACA CTGCCTTTGA GGTGGCAGAG AAATACCTGG ACATCCCCAA GATGTTGGAT 
GCAGAAGACA TTGTGAACAC CCCAAAGCCG GATGAGAAGG CCATCATGAC CTATGTGTCC 
TGCTTCTACC ATGCCTTTGC CGGGGCTGAG CAGGCAGAGA CAGCTGCCAA CAGGATCTGC 
AAGGTGCTGG CAGTGAACCA GGAAAACGAG AAGCTGATGG AGGAGTATGA GAAGCTTGCC 
AGTGAGCTGC TGGAGTGGAT CCGCCGCACT GTCCCATGGC TGGAGAACCG TGTGGGTGAG 
CCCAGCATGA GTGCCATGCA GCGCAAACTA GAGGACTTTC GGGACTACCG GCGTCTGCAC 
AAGCCGCCCC GCATTCAGGA AAAGTGCCAG CTGGAGATCA ACTTCAACAC ACTGCAGACC 
AAGTTGCGGC TCAGCCACCG GCCTGCCTTC ATGCCCTCCG AGGGCAAGCT GGTCTCGGAC 
ATCGCCAACG CCTGGCGGGG GCTGGAGCAG GTGGAAAAGG GCTATGAGGA CTGGCTGCTC 
TCGGAGATCC GGCGCCTGCA GCGACTCCAG CACCTGGCTG AGAAGTTCCG GCAGAAGGCC 
TCCCTGCACG AAGCCTGGAC CCGGGGAAAG GAGGAGATGC TGAGCCAGCG CGACTACGAT 
TCGGCTTTGC TACAGGAGGT GCGGGCGTTG CTGCGGCGCC ACGAGGCCTT TGAGAGCGAC 
CTGGCGGCGC ACCAGGACCG CGTGGAGCAC ATTGCCGCGC TGGCCCAGGA GCTCAATGAG 
CTGGACTACC ACGAGGCAGC CTCAGTGAAT AGCCGCTGCC AGGCCATCTG CGATCAGTGG 
GACAACCTGG GCACCCTGAC CCAGAAGAGG CGGGATGCGC TAGAGCGGAT GGAGAAGCTC 
CTGGAGACCA TTGACCGGCT GCAACTGGAG TTTGCCCGGC GGGCCGCGCC CTTCAACAAC 
TGGCTGGATG GTGCCGTGGA GGACCTGCAG GACGTGTGGC TGGTACACTC TGTGGAGGAG 
ACCCAGAGCC TGCTGACAGC GCACGATCAG TTCAAGGCAA CACTGCCCGA GGCTGACCGA 
GAGCGAGGTG CCATCATGGG CATCCAGGGT GAGATCCAGA AGATCTGCCA GACGTATGGG 
CTGCGGCCCT GCTCCACCAA TCCCTACATC ACCCTCAGCC CGCAGGACAT CAACACCAAG 
TGGGATATGG TCCGAAAGCT GGTGCCCAGC TGTGACCAGA CACTGCAGGA GGAGCTGGCA 
CGGCAGCAGG TAAACGAGAG GCTCCGGCGA CAGTTTGCGG CCCAGGCCAA TGCCATTGGA 
CCCTGGATCC AGGCGAAGGT GGAGGAAGTG GGGCGGCTGG CAGCAGGGCT AGCTGGCTCT 
CTGGAGGAGC AGATGGCTGG GCTACGGCAG CAGGAGCAGA ACATTATCAA CTACAAGACT 
AACATTGACC GGCTGGAGGG TGACCACCAG CTGCTGCAGG AGAGCCTGGT GTTCGACAAT 
AAGCACACCG TCTACAGCAT GGAGCACATC CGCGTGGGCT GGGAGCAGCT GCTCACCTCC 
ATTGCCCGCA CCATCAATGA AGTGGAGAAC CAGGTACTGA CCCGAGACGC CAAGGGACTG 
AGCCAGGAGC AGCTCAACGA GTTCCGAGCA TCCTTCAACC ACTTTGACAG GAAGCAGAAT 
GGGATGATGG AGCCTGATGA CTTCCGAGCT TGCCTCATCT CCATGGGCTA TGACCTGGGG 
GAAGTGGAGT TTGCTCGCAT CATGACCATG GTGGACCCCA ACGCAGCTGG GGTGGTGACC 
TTCCAGGCCT TCATAGACTT CATGACCCGA GAGACAGCCG AGACTGACAC GACTGAGCAA 
GTTGTAGCTT CCTTCAAGAT CTTGGCAGGA GACAAGAACT ACATCACCCC CGAGGAGCTG 
CGGCGCGAGC TCCCTGCCAA GCAGGCCGAG TACTGCATCC GCCGTATGGT GCCCTACAAG 
GGATCCGGGG CCCCGGCTGG AGCCCTGGAC TACGTGGCCT TCTCCAGTGC CCTCTATGGG 
GAGAGCGACC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTN3 ( NM_001104.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001095.2 Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding, mRNA.

Price & Availability↑

CloneID	OHu27737
Clone ID Related Accession (Same CDS sequence)	NM_001104.3 , NM_001104.4
Accession Version	NM_001104.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2706bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	alpha-actinin-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK125851.1, DA915904.1, AP002748.4, BC099647.3, AK303044.1 and AJ346025.1. This sequence is a reference standard in the RefSeqGene project. On Feb 19, 2014 this sequence version replaced NM_001104.2. Transcript Variant: This variant (1, coding) represents the protein-coding allele and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86407.1, BC099647.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 10192379 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATGATGG TTATGCAGCC CGAGGGTCTG GGGGCCGGGG AGGGGCGCTT TGCGGGCGGC 
GGCGGGGGCG GCGAGTACAT GGAACAGGAG GAGGACTGGG ACCGCGACCT GCTGCTGGAC 
CCGGCCTGGG AGAAGCAGCA GCGGAAAACC TTCACTGCCT GGTGCAACTC ACACCTGCGC 
AAGGCAGGCA CCCAGATCGA GAACATCGAG GAAGATTTCC GCAATGGCCT CAAACTCATG 
CTGCTCCTGG AGGTCATTTC AGGTGAGAGG CTGCCTAGGC CAGATAAAGG CAAGATGCGC 
TTCCACAAAA TCGCCAACGT TAACAAGGCC CTGGACTTCA TTGCCAGCAA GGGGGTTAAA 
CTGGTGTCCA TTGGTGCTGA AGAGATTGTT GACGGGAACC TGAAGATGAC CCTGGGCATG 
ATCTGGACCA TCATCCTTCG CTTCGCCATC CAGGACATCT CTGTGGAAGA AACCTCAGCC 
AAGGAAGGCT TGCTTCTGTG GTGCCAGAGG AAGACAGCAC CGTACCGCAA CGTCAACGTG 
CAGAACTTCC ACACCAGCTG GAAGGATGGC CTGGCCCTCT GTGCCCTCAT CCACCGACAC 
CGCCCTGACC TCATCGACTA CGCCAAACTG CGAAAGGATG ACCCCATCGG AAACCTGAAC 
ACTGCCTTTG AGGTGGCAGA GAAATACCTG GACATCCCCA AGATGTTGGA TGCAGAAGAC 
ATTGTGAACA CCCCAAAGCC GGATGAGAAG GCCATCATGA CCTATGTGTC CTGCTTCTAC 
CATGCCTTTG CCGGGGCTGA GCAGGCAGAG ACAGCTGCCA ACAGGATCTG CAAGGTGCTG 
GCAGTGAACC AGGAAAACGA GAAGCTGATG GAGGAGTATG AGAAGCTTGC CAGTGAGCTG 
CTGGAGTGGA TCCGCCGCAC TGTCCCATGG CTGGAGAACC GTGTGGGTGA GCCCAGCATG 
AGTGCCATGC AGCGCAAACT AGAGGACTTT CGGGACTACC GGCGTCTGCA CAAGCCGCCC 
CGCATTCAGG AAAAGTGCCA GCTGGAGATC AACTTCAACA CACTGCAGAC CAAGTTGCGG 
CTCAGCCACC GGCCTGCCTT CATGCCCTCC GAGGGCAAGC TGGTCTCGGA CATCGCCAAC 
GCCTGGCGGG GGCTGGAGCA GGTGGAAAAG GGCTATGAGG ACTGGCTGCT CTCGGAGATC 
CGGCGCCTGC AGCGACTCCA GCACCTGGCT GAGAAGTTCC GGCAGAAGGC CTCCCTGCAC 
GAAGCCTGGA CCCGGGGAAA GGAGGAGATG CTGAGCCAGC GCGACTACGA TTCGGCTTTG 
CTACAGGAGG TGCGGGCGTT GCTGCGGCGC CACGAGGCCT TTGAGAGCGA CCTGGCGGCG 
CACCAGGACC GCGTGGAGCA CATTGCCGCG CTGGCCCAGG AGCTCAATGA GCTGGACTAC 
CACGAGGCAG CCTCAGTGAA TAGCCGCTGC CAGGCCATCT GCGATCAGTG GGACAACCTG 
GGCACCCTGA CCCAGAAGAG GCGGGATGCG CTAGAGCGGA TGGAGAAGCT CCTGGAGACC 
ATTGACCGGC TGCAACTGGA GTTTGCCCGG CGGGCCGCGC CCTTCAACAA CTGGCTGGAT 
GGTGCCGTGG AGGACCTGCA GGACGTGTGG CTGGTACACT CTGTGGAGGA GACCCAGAGC 
CTGCTGACAG CGCACGATCA GTTCAAGGCA ACACTGCCCG AGGCTGACCG AGAGCGAGGT 
GCCATCATGG GCATCCAGGG TGAGATCCAG AAGATCTGCC AGACGTATGG GCTGCGGCCC 
TGCTCCACCA ATCCCTACAT CACCCTCAGC CCGCAGGACA TCAACACCAA GTGGGATATG 
GTCCGAAAGC TGGTGCCCAG CTGTGACCAG ACACTGCAGG AGGAGCTGGC ACGGCAGCAG 
GTAAACGAGA GGCTCCGGCG ACAGTTTGCG GCCCAGGCCA ATGCCATTGG ACCCTGGATC 
CAGGCGAAGG TGGAGGAAGT GGGGCGGCTG GCAGCAGGGC TAGCTGGCTC TCTGGAGGAG 
CAGATGGCTG GGCTACGGCA GCAGGAGCAG AACATTATCA ACTACAAGAC TAACATTGAC 
CGGCTGGAGG GTGACCACCA GCTGCTGCAG GAGAGCCTGG TGTTCGACAA TAAGCACACC 
GTCTACAGCA TGGAGCACAT CCGCGTGGGC TGGGAGCAGC TGCTCACCTC CATTGCCCGC 
ACCATCAATG AAGTGGAGAA CCAGGTACTG ACCCGAGACG CCAAGGGACT GAGCCAGGAG 
CAGCTCAACG AGTTCCGAGC ATCCTTCAAC CACTTTGACA GGAAGCAGAA TGGGATGATG 
GAGCCTGATG ACTTCCGAGC TTGCCTCATC TCCATGGGCT ATGACCTGGG GGAAGTGGAG 
TTTGCTCGCA TCATGACCAT GGTGGACCCC AACGCAGCTG GGGTGGTGAC CTTCCAGGCC 
TTCATAGACT TCATGACCCG AGAGACAGCC GAGACTGACA CGACTGAGCA AGTTGTAGCT 
TCCTTCAAGA TCTTGGCAGG AGACAAGAAC TACATCACCC CCGAGGAGCT GCGGCGCGAG 
CTCCCTGCCA AGCAGGCCGA GTACTGCATC CGCCGTATGG TGCCCTACAA GGGATCCGGG 
GCCCCGGCTG GAGCCCTGGA CTACGTGGCC TTCTCCAGTG CCCTCTATGG GGAGAGCGAC 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095.2
CDS	98..2803
Translation	MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL

Target ORF information:

RefSeq Version	NM_001104.3
Organism	Homo sapiens(human)
Definition	Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001104.3

ORF Insert Sequence:

ATGATGATGG TTATGCAGCC CGAGGGTCTG GGGGCCGGGG AGGGGCGCTT TGCGGGCGGC 
GGCGGGGGCG GCGAGTACAT GGAACAGGAG GAGGACTGGG ACCGCGACCT GCTGCTGGAC 
CCGGCCTGGG AGAAGCAGCA GCGGAAAACC TTCACTGCCT GGTGCAACTC ACACCTGCGC 
AAGGCAGGCA CCCAGATCGA GAACATCGAG GAAGATTTCC GCAATGGCCT CAAACTCATG 
CTGCTCCTGG AGGTCATTTC AGGTGAGAGG CTGCCTAGGC CAGATAAAGG CAAGATGCGC 
TTCCACAAAA TCGCCAACGT TAACAAGGCC CTGGACTTCA TTGCCAGCAA GGGGGTTAAA 
CTGGTGTCCA TTGGTGCTGA AGAGATTGTT GACGGGAACC TGAAGATGAC CCTGGGCATG 
ATCTGGACCA TCATCCTTCG CTTCGCCATC CAGGACATCT CTGTGGAAGA AACCTCAGCC 
AAGGAAGGCT TGCTTCTGTG GTGCCAGAGG AAGACAGCAC CGTACCGCAA CGTCAACGTG 
CAGAACTTCC ACACCAGCTG GAAGGATGGC CTGGCCCTCT GTGCCCTCAT CCACCGACAC 
CGCCCTGACC TCATCGACTA CGCCAAACTG CGAAAGGATG ACCCCATCGG AAACCTGAAC 
ACTGCCTTTG AGGTGGCAGA GAAATACCTG GACATCCCCA AGATGTTGGA TGCAGAAGAC 
ATTGTGAACA CCCCAAAGCC GGATGAGAAG GCCATCATGA CCTATGTGTC CTGCTTCTAC 
CATGCCTTTG CCGGGGCTGA GCAGGCAGAG ACAGCTGCCA ACAGGATCTG CAAGGTGCTG 
GCAGTGAACC AGGAAAACGA GAAGCTGATG GAGGAGTATG AGAAGCTTGC CAGTGAGCTG 
CTGGAGTGGA TCCGCCGCAC TGTCCCATGG CTGGAGAACC GTGTGGGTGA GCCCAGCATG 
AGTGCCATGC AGCGCAAACT AGAGGACTTT CGGGACTACC GGCGTCTGCA CAAGCCGCCC 
CGCATTCAGG AAAAGTGCCA GCTGGAGATC AACTTCAACA CACTGCAGAC CAAGTTGCGG 
CTCAGCCACC GGCCTGCCTT CATGCCCTCC GAGGGCAAGC TGGTCTCGGA CATCGCCAAC 
GCCTGGCGGG GGCTGGAGCA GGTGGAAAAG GGCTATGAGG ACTGGCTGCT CTCGGAGATC 
CGGCGCCTGC AGCGACTCCA GCACCTGGCT GAGAAGTTCC GGCAGAAGGC CTCCCTGCAC 
GAAGCCTGGA CCCGGGGAAA GGAGGAGATG CTGAGCCAGC GCGACTACGA TTCGGCTTTG 
CTACAGGAGG TGCGGGCGTT GCTGCGGCGC CACGAGGCCT TTGAGAGCGA CCTGGCGGCG 
CACCAGGACC GCGTGGAGCA CATTGCCGCG CTGGCCCAGG AGCTCAATGA GCTGGACTAC 
CACGAGGCAG CCTCAGTGAA TAGCCGCTGC CAGGCCATCT GCGATCAGTG GGACAACCTG 
GGCACCCTGA CCCAGAAGAG GCGGGATGCG CTAGAGCGGA TGGAGAAGCT CCTGGAGACC 
ATTGACCGGC TGCAACTGGA GTTTGCCCGG CGGGCCGCGC CCTTCAACAA CTGGCTGGAT 
GGTGCCGTGG AGGACCTGCA GGACGTGTGG CTGGTACACT CTGTGGAGGA GACCCAGAGC 
CTGCTGACAG CGCACGATCA GTTCAAGGCA ACACTGCCCG AGGCTGACCG AGAGCGAGGT 
GCCATCATGG GCATCCAGGG TGAGATCCAG AAGATCTGCC AGACGTATGG GCTGCGGCCC 
TGCTCCACCA ATCCCTACAT CACCCTCAGC CCGCAGGACA TCAACACCAA GTGGGATATG 
GTCCGAAAGC TGGTGCCCAG CTGTGACCAG ACACTGCAGG AGGAGCTGGC ACGGCAGCAG 
GTAAACGAGA GGCTCCGGCG ACAGTTTGCG GCCCAGGCCA ATGCCATTGG ACCCTGGATC 
CAGGCGAAGG TGGAGGAAGT GGGGCGGCTG GCAGCAGGGC TAGCTGGCTC TCTGGAGGAG 
CAGATGGCTG GGCTACGGCA GCAGGAGCAG AACATTATCA ACTACAAGAC TAACATTGAC 
CGGCTGGAGG GTGACCACCA GCTGCTGCAG GAGAGCCTGG TGTTCGACAA TAAGCACACC 
GTCTACAGCA TGGAGCACAT CCGCGTGGGC TGGGAGCAGC TGCTCACCTC CATTGCCCGC 
ACCATCAATG AAGTGGAGAA CCAGGTACTG ACCCGAGACG CCAAGGGACT GAGCCAGGAG 
CAGCTCAACG AGTTCCGAGC ATCCTTCAAC CACTTTGACA GGAAGCAGAA TGGGATGATG 
GAGCCTGATG ACTTCCGAGC TTGCCTCATC TCCATGGGCT ATGACCTGGG GGAAGTGGAG 
TTTGCTCGCA TCATGACCAT GGTGGACCCC AACGCAGCTG GGGTGGTGAC CTTCCAGGCC 
TTCATAGACT TCATGACCCG AGAGACAGCC GAGACTGACA CGACTGAGCA AGTTGTAGCT 
TCCTTCAAGA TCTTGGCAGG AGACAAGAAC TACATCACCC CCGAGGAGCT GCGGCGCGAG 
CTCCCTGCCA AGCAGGCCGA GTACTGCATC CGCCGTATGG TGCCCTACAA GGGATCCGGG 
GCCCCGGCTG GAGCCCTGGA CTACGTGGCC TTCTCCAGTG CCCTCTATGG GGAGAGCGAC 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACTN3 ( NM_001104.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001095.2 Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding, mRNA.

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CloneID	OHu27737
Clone ID Related Accession (Same CDS sequence)	NM_001104.3 , NM_001104.4
Accession Version	NM_001104.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2706bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	alpha-actinin-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK125851.1, DA915904.1, AP002748.4, BC099647.3, AK303044.1 and AJ346025.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001104.3. Transcript Variant: This variant (1, coding) represents the protein-coding allele and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313556.1, M86407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000513398.2/ ENSP00000426797.1 polymorphic pseudogene :: PMID: 10192379 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGATGG TTATGCAGCC CGAGGGTCTG GGGGCCGGGG AGGGGCGCTT TGCGGGCGGC 
GGCGGGGGCG GCGAGTACAT GGAACAGGAG GAGGACTGGG ACCGCGACCT GCTGCTGGAC 
CCGGCCTGGG AGAAGCAGCA GCGGAAAACC TTCACTGCCT GGTGCAACTC ACACCTGCGC 
AAGGCAGGCA CCCAGATCGA GAACATCGAG GAAGATTTCC GCAATGGCCT CAAACTCATG 
CTGCTCCTGG AGGTCATTTC AGGTGAGAGG CTGCCTAGGC CAGATAAAGG CAAGATGCGC 
TTCCACAAAA TCGCCAACGT TAACAAGGCC CTGGACTTCA TTGCCAGCAA GGGGGTTAAA 
CTGGTGTCCA TTGGTGCTGA AGAGATTGTT GACGGGAACC TGAAGATGAC CCTGGGCATG 
ATCTGGACCA TCATCCTTCG CTTCGCCATC CAGGACATCT CTGTGGAAGA AACCTCAGCC 
AAGGAAGGCT TGCTTCTGTG GTGCCAGAGG AAGACAGCAC CGTACCGCAA CGTCAACGTG 
CAGAACTTCC ACACCAGCTG GAAGGATGGC CTGGCCCTCT GTGCCCTCAT CCACCGACAC 
CGCCCTGACC TCATCGACTA CGCCAAACTG CGAAAGGATG ACCCCATCGG AAACCTGAAC 
ACTGCCTTTG AGGTGGCAGA GAAATACCTG GACATCCCCA AGATGTTGGA TGCAGAAGAC 
ATTGTGAACA CCCCAAAGCC GGATGAGAAG GCCATCATGA CCTATGTGTC CTGCTTCTAC 
CATGCCTTTG CCGGGGCTGA GCAGGCAGAG ACAGCTGCCA ACAGGATCTG CAAGGTGCTG 
GCAGTGAACC AGGAAAACGA GAAGCTGATG GAGGAGTATG AGAAGCTTGC CAGTGAGCTG 
CTGGAGTGGA TCCGCCGCAC TGTCCCATGG CTGGAGAACC GTGTGGGTGA GCCCAGCATG 
AGTGCCATGC AGCGCAAACT AGAGGACTTT CGGGACTACC GGCGTCTGCA CAAGCCGCCC 
CGCATTCAGG AAAAGTGCCA GCTGGAGATC AACTTCAACA CACTGCAGAC CAAGTTGCGG 
CTCAGCCACC GGCCTGCCTT CATGCCCTCC GAGGGCAAGC TGGTCTCGGA CATCGCCAAC 
GCCTGGCGGG GGCTGGAGCA GGTGGAAAAG GGCTATGAGG ACTGGCTGCT CTCGGAGATC 
CGGCGCCTGC AGCGACTCCA GCACCTGGCT GAGAAGTTCC GGCAGAAGGC CTCCCTGCAC 
GAAGCCTGGA CCCGGGGAAA GGAGGAGATG CTGAGCCAGC GCGACTACGA TTCGGCTTTG 
CTACAGGAGG TGCGGGCGTT GCTGCGGCGC CACGAGGCCT TTGAGAGCGA CCTGGCGGCG 
CACCAGGACC GCGTGGAGCA CATTGCCGCG CTGGCCCAGG AGCTCAATGA GCTGGACTAC 
CACGAGGCAG CCTCAGTGAA TAGCCGCTGC CAGGCCATCT GCGATCAGTG GGACAACCTG 
GGCACCCTGA CCCAGAAGAG GCGGGATGCG CTAGAGCGGA TGGAGAAGCT CCTGGAGACC 
ATTGACCGGC TGCAACTGGA GTTTGCCCGG CGGGCCGCGC CCTTCAACAA CTGGCTGGAT 
GGTGCCGTGG AGGACCTGCA GGACGTGTGG CTGGTACACT CTGTGGAGGA GACCCAGAGC 
CTGCTGACAG CGCACGATCA GTTCAAGGCA ACACTGCCCG AGGCTGACCG AGAGCGAGGT 
GCCATCATGG GCATCCAGGG TGAGATCCAG AAGATCTGCC AGACGTATGG GCTGCGGCCC 
TGCTCCACCA ATCCCTACAT CACCCTCAGC CCGCAGGACA TCAACACCAA GTGGGATATG 
GTCCGAAAGC TGGTGCCCAG CTGTGACCAG ACACTGCAGG AGGAGCTGGC ACGGCAGCAG 
GTAAACGAGA GGCTCCGGCG ACAGTTTGCG GCCCAGGCCA ATGCCATTGG ACCCTGGATC 
CAGGCGAAGG TGGAGGAAGT GGGGCGGCTG GCAGCAGGGC TAGCTGGCTC TCTGGAGGAG 
CAGATGGCTG GGCTACGGCA GCAGGAGCAG AACATTATCA ACTACAAGAC TAACATTGAC 
CGGCTGGAGG GTGACCACCA GCTGCTGCAG GAGAGCCTGG TGTTCGACAA TAAGCACACC 
GTCTACAGCA TGGAGCACAT CCGCGTGGGC TGGGAGCAGC TGCTCACCTC CATTGCCCGC 
ACCATCAATG AAGTGGAGAA CCAGGTACTG ACCCGAGACG CCAAGGGACT GAGCCAGGAG 
CAGCTCAACG AGTTCCGAGC ATCCTTCAAC CACTTTGACA GGAAGCAGAA TGGGATGATG 
GAGCCTGATG ACTTCCGAGC TTGCCTCATC TCCATGGGCT ATGACCTGGG GGAAGTGGAG 
TTTGCTCGCA TCATGACCAT GGTGGACCCC AACGCAGCTG GGGTGGTGAC CTTCCAGGCC 
TTCATAGACT TCATGACCCG AGAGACAGCC GAGACTGACA CGACTGAGCA AGTTGTAGCT 
TCCTTCAAGA TCTTGGCAGG AGACAAGAAC TACATCACCC CCGAGGAGCT GCGGCGCGAG 
CTCCCTGCCA AGCAGGCCGA GTACTGCATC CGCCGTATGG TGCCCTACAA GGGATCCGGG 
GCCCCGGCTG GAGCCCTGGA CTACGTGGCC TTCTCCAGTG CCCTCTATGG GGAGAGCGAC 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095.2
CDS	36..2741
Translation	MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKQNGMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL

Target ORF information:

RefSeq Version	NM_001104.4
Organism	Homo sapiens(human)
Definition	Homo sapiens actinin alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001104.4

ORF Insert Sequence:

ATGATGATGG TTATGCAGCC CGAGGGTCTG GGGGCCGGGG AGGGGCGCTT TGCGGGCGGC 
GGCGGGGGCG GCGAGTACAT GGAACAGGAG GAGGACTGGG ACCGCGACCT GCTGCTGGAC 
CCGGCCTGGG AGAAGCAGCA GCGGAAAACC TTCACTGCCT GGTGCAACTC ACACCTGCGC 
AAGGCAGGCA CCCAGATCGA GAACATCGAG GAAGATTTCC GCAATGGCCT CAAACTCATG 
CTGCTCCTGG AGGTCATTTC AGGTGAGAGG CTGCCTAGGC CAGATAAAGG CAAGATGCGC 
TTCCACAAAA TCGCCAACGT TAACAAGGCC CTGGACTTCA TTGCCAGCAA GGGGGTTAAA 
CTGGTGTCCA TTGGTGCTGA AGAGATTGTT GACGGGAACC TGAAGATGAC CCTGGGCATG 
ATCTGGACCA TCATCCTTCG CTTCGCCATC CAGGACATCT CTGTGGAAGA AACCTCAGCC 
AAGGAAGGCT TGCTTCTGTG GTGCCAGAGG AAGACAGCAC CGTACCGCAA CGTCAACGTG 
CAGAACTTCC ACACCAGCTG GAAGGATGGC CTGGCCCTCT GTGCCCTCAT CCACCGACAC 
CGCCCTGACC TCATCGACTA CGCCAAACTG CGAAAGGATG ACCCCATCGG AAACCTGAAC 
ACTGCCTTTG AGGTGGCAGA GAAATACCTG GACATCCCCA AGATGTTGGA TGCAGAAGAC 
ATTGTGAACA CCCCAAAGCC GGATGAGAAG GCCATCATGA CCTATGTGTC CTGCTTCTAC 
CATGCCTTTG CCGGGGCTGA GCAGGCAGAG ACAGCTGCCA ACAGGATCTG CAAGGTGCTG 
GCAGTGAACC AGGAAAACGA GAAGCTGATG GAGGAGTATG AGAAGCTTGC CAGTGAGCTG 
CTGGAGTGGA TCCGCCGCAC TGTCCCATGG CTGGAGAACC GTGTGGGTGA GCCCAGCATG 
AGTGCCATGC AGCGCAAACT AGAGGACTTT CGGGACTACC GGCGTCTGCA CAAGCCGCCC 
CGCATTCAGG AAAAGTGCCA GCTGGAGATC AACTTCAACA CACTGCAGAC CAAGTTGCGG 
CTCAGCCACC GGCCTGCCTT CATGCCCTCC GAGGGCAAGC TGGTCTCGGA CATCGCCAAC 
GCCTGGCGGG GGCTGGAGCA GGTGGAAAAG GGCTATGAGG ACTGGCTGCT CTCGGAGATC 
CGGCGCCTGC AGCGACTCCA GCACCTGGCT GAGAAGTTCC GGCAGAAGGC CTCCCTGCAC 
GAAGCCTGGA CCCGGGGAAA GGAGGAGATG CTGAGCCAGC GCGACTACGA TTCGGCTTTG 
CTACAGGAGG TGCGGGCGTT GCTGCGGCGC CACGAGGCCT TTGAGAGCGA CCTGGCGGCG 
CACCAGGACC GCGTGGAGCA CATTGCCGCG CTGGCCCAGG AGCTCAATGA GCTGGACTAC 
CACGAGGCAG CCTCAGTGAA TAGCCGCTGC CAGGCCATCT GCGATCAGTG GGACAACCTG 
GGCACCCTGA CCCAGAAGAG GCGGGATGCG CTAGAGCGGA TGGAGAAGCT CCTGGAGACC 
ATTGACCGGC TGCAACTGGA GTTTGCCCGG CGGGCCGCGC CCTTCAACAA CTGGCTGGAT 
GGTGCCGTGG AGGACCTGCA GGACGTGTGG CTGGTACACT CTGTGGAGGA GACCCAGAGC 
CTGCTGACAG CGCACGATCA GTTCAAGGCA ACACTGCCCG AGGCTGACCG AGAGCGAGGT 
GCCATCATGG GCATCCAGGG TGAGATCCAG AAGATCTGCC AGACGTATGG GCTGCGGCCC 
TGCTCCACCA ATCCCTACAT CACCCTCAGC CCGCAGGACA TCAACACCAA GTGGGATATG 
GTCCGAAAGC TGGTGCCCAG CTGTGACCAG ACACTGCAGG AGGAGCTGGC ACGGCAGCAG 
GTAAACGAGA GGCTCCGGCG ACAGTTTGCG GCCCAGGCCA ATGCCATTGG ACCCTGGATC 
CAGGCGAAGG TGGAGGAAGT GGGGCGGCTG GCAGCAGGGC TAGCTGGCTC TCTGGAGGAG 
CAGATGGCTG GGCTACGGCA GCAGGAGCAG AACATTATCA ACTACAAGAC TAACATTGAC 
CGGCTGGAGG GTGACCACCA GCTGCTGCAG GAGAGCCTGG TGTTCGACAA TAAGCACACC 
GTCTACAGCA TGGAGCACAT CCGCGTGGGC TGGGAGCAGC TGCTCACCTC CATTGCCCGC 
ACCATCAATG AAGTGGAGAA CCAGGTACTG ACCCGAGACG CCAAGGGACT GAGCCAGGAG 
CAGCTCAACG AGTTCCGAGC ATCCTTCAAC CACTTTGACA GGAAGCAGAA TGGGATGATG 
GAGCCTGATG ACTTCCGAGC TTGCCTCATC TCCATGGGCT ATGACCTGGG GGAAGTGGAG 
TTTGCTCGCA TCATGACCAT GGTGGACCCC AACGCAGCTG GGGTGGTGAC CTTCCAGGCC 
TTCATAGACT TCATGACCCG AGAGACAGCC GAGACTGACA CGACTGAGCA AGTTGTAGCT 
TCCTTCAAGA TCTTGGCAGG AGACAAGAAC TACATCACCC CCGAGGAGCT GCGGCGCGAG 
CTCCCTGCCA AGCAGGCCGA GTACTGCATC CGCCGTATGG TGCCCTACAA GGGATCCGGG 
GCCCCGGCTG GAGCCCTGGA CTACGTGGCC TTCTCCAGTG CCCTCTATGG GGAGAGCGAC 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-?B degradation and cell growth suppression in neuroblastoma.
Oncogene36(41)5745-5756(2017 Oct)
Mu P,Akashi T,Lu F,Kishida S,Kadomatsu K

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ACTN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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