EIF2B3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF2B3
Entrez Gene ID	8891
Full Name	eukaryotic translation initiation factor 2B subunit gamma
Synonyms	EIF-2B,EIF2Bgamma
General protein information	Preferred Names eukaryotic translation initiation factor 2B subunit gamma Names translation initiation factor eIF-2B subunit gamma eIF-2B GDP-GTP exchange factor subunit gamma eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.1
Summary	The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Disorder MIM:	606273
Disorder Html:	Leukoencephalopathy with vanishing white matter, 603896 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001166588.2	NP_001160060.1	translation initiation factor eIF-2B subunit gamma isoform 2
NM_001261418.1	NP_001248347.1	translation initiation factor eIF-2B subunit gamma isoform 3
XM_017002745.1	XP_016858234.1	translation initiation factor eIF-2B subunit gamma isoform X1
XM_017002747.1	XP_016858236.1	translation initiation factor eIF-2B subunit gamma isoform X3
NM_020365.5	NP_065098.1	translation initiation factor eIF-2B subunit gamma isoform 1
XM_017002746.1	XP_016858235.1	translation initiation factor eIF-2B subunit gamma isoform X2
NM_020365.4	NP_065098.1	translation initiation factor eIF-2B subunit gamma isoform 1
XM_017002745.2	XP_016858234.1	translation initiation factor eIF-2B subunit gamma isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EIF2B3	XP_001152272.1
	EIF2B3	XP_001094199.2
Bos taurus (cattle)	EIF2B3	NP_001076943.1
Gallus gallus (chicken)	EIF2B3	NP_001026451.1
Drosophila melanogaster (fruit fly)	eIF2B-gamma	NP_611046.2
Neurospora crassa	NCU03548	XP_955772.2
Arabidopsis thaliana (thale cress)	AT5G19485	NP_001031908.1
Homo sapiens (human)	EIF2B3	NP_065098.1
Caenorhabditis elegans (roundworm)	ppp-1	NP_495428.1
Schizosaccharomyces pombe (fission yeast)	tif223	NP_594962.2
Canis lupus familiaris (dog)	EIF2B3	XP_005629136.1
Mus musculus (house mouse)	Eif2b3	NP_001104747.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005210	XP_314112.3
Rattus norvegicus (Norway rat)	Eif2b3	NP_598293.2
Danio rerio (zebrafish)	eif2b3	NP_957368.1
Magnaporthe oryzae (rice blast fungus)	MGG_02390	XP_003709167.1
Oryza sativa (rice)	Os06g0338900	NP_001057561.1
Xenopus tropicalis (tropical clawed frog)	eif2b3	NP_001016997.2

Gene Ontology
Bibliography

Related articles in PubMed

Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy.
Chen N, Dai L, Jiang Y, Wang J, Hao H, Ren Y, Leng X, Zang L, Wu Y
Brain & development38(5)507-15(2016 May)

Fifteen novel EIF2B1-5 mutations identified in Chinese children with leukoencephalopathy with vanishing white matter and a long term follow-up.
Zhang H, Dai L, Chen N, Zang L, Leng X, Du L, Wang J, Jiang Y, Zhang F, Wu X, Wu Y
PloS one10(3)e0118001(2015)

Adult-onset vanishing white matter disease due to a novel EIF2B3 mutation.
La Piana R, Vanderver A, van der Knaap M, Roux L, Tampieri D, Brais B, Bernard G
Archives of neurology69(6)765-68(2012 Jun)

Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5.
Matsukawa T, Wang X, Liu R, Wortham NC, Onuki Y, Kubota A, Hida A, Kowa H, Fukuda Y, Ishiura H, Mitsui J, Takahashi Y, Aoki S, Takizawa S, Shimizu J, Goto J, Proud CG, Tsuji S
Neurogenetics12(3)259-61(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

To determine the tolerance differences to ERS, cell viability and apoptosis rates were detected in oligodendrocyte cell lines transfected with EIF2B3-c.1037T>C or the wild type. We confirmed that oligodendrocytes with mutant EIF2B3 was less tolerant to ERS than the wild type, with decreased cell viability and increased apoptosis rates.
Title: Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy.

Results show significant higher incidence of Chinese patients with EIF2B3 mutations compared with Caucasian patients. The c.1037T>C in EIF2B3 was confirmed to be a founder mutation in Chinese explaining the genotypic differences between ethnicities.
Title: Fifteen novel EIF2B1-5 mutations identified in Chinese children with leukoencephalopathy with vanishing white matter and a long term follow-up.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: No evidence that polymorphisms of the vanishing white matter disease genes are risk factors in multiple sclerosis.

Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon)
Title: Genetic and clinical heterogeneity in eIF2B-related disorder.

The following EIF2B3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF2B3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20758	NM_001261418.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu22727	NM_020365.5 Latest version!	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu27650	NM_001166588.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$244.30 $349.00
OHu90768	XM_017002745.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu90769	XM_017002746.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu90770	XM_017002747.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu22727	NM_020365.4	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu90768	XM_017002745.1	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF2B3 ( NM_001261418.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001248347.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu20758
Clone ID Related Accession (Same CDS sequence)	NM_001261418.1
Accession Version	NM_001261418.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136380.22 and BC018728.1. Transcript Variant: This variant (3) lacks the penultimate exon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018728.1, SRR1803614.297030.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001248347.1
CDS	240..1445
Translation	MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEG

Target ORF information:

RefSeq Version	NM_001261418.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001261418.1

ORF Insert Sequence:

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( NM_020365.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_065098.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22727
Clone ID Related Accession (Same CDS sequence)	NM_020365.5 , NM_020365.4
Accession Version	NM_020365.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from DA162797.1, AK024006.1, AK022399.1, BC018728.1, BF879213.1 and W21485.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_020365.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.159937.1, SRR1660805.44358.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360403.7/ ENSP00000353575.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGAAGCAATA TCCAAGGCAG TGTCATCTGC AACAATGCTG TGATCGAGAA GGGTGCAGAC 
ATCAAGGACT GCTTGATTGG AAGTGGCCAG AGGATTGAAG CCAAAGCTAA ACGAGTGAAT 
GAGGTGATCG TGGGGAATGA CCAGCTCATG GAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065098.1
CDS	113..1471
Translation	MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAKAKRVNEVIVGNDQLMEI

Target ORF information:

RefSeq Version	NM_020365.5
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020365.5

ORF Insert Sequence:

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGAAGCAATA TCCAAGGCAG TGTCATCTGC AACAATGCTG TGATCGAGAA GGGTGCAGAC 
ATCAAGGACT GCTTGATTGG AAGTGGCCAG AGGATTGAAG CCAAAGCTAA ACGAGTGAAT 
GAGGTGATCG TGGGGAATGA CCAGCTCATG GAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( NM_020365.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_065098.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22727
Clone ID Related Accession (Same CDS sequence)	NM_020365.5 , NM_020365.4
Accession Version	NM_020365.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AL136380.22, DA162797.1, AK024006.1, AK022399.1, BC018728.1, BF879213.1 and W21485.1. This sequence is a reference standard in the RefSeqGene project. On May 12, 2012 this sequence version replaced NM_020365.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.207984.1, SRR1660805.44358.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGAAGCAATA TCCAAGGCAG TGTCATCTGC AACAATGCTG TGATCGAGAA GGGTGCAGAC 
ATCAAGGACT GCTTGATTGG AAGTGGCCAG AGGATTGAAG CCAAAGCTAA ACGAGTGAAT 
GAGGTGATCG TGGGGAATGA CCAGCTCATG GAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065098.1
CDS	240..1598
Translation	MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAKAKRVNEVIVGNDQLMEI

Target ORF information:

RefSeq Version	NM_020365.4
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020365.4

ORF Insert Sequence:

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGAAGCAATA TCCAAGGCAG TGTCATCTGC AACAATGCTG TGATCGAGAA GGGTGCAGAC 
ATCAAGGACT GCTTGATTGG AAGTGGCCAG AGGATTGAAG CCAAAGCTAA ACGAGTGAAT 
GAGGTGATCG TGGGGAATGA CCAGCTCATG GAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( NM_001166588.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001160060.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 2, mRNA.

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CloneID	OHu27650
Clone ID Related Accession (Same CDS sequence)	NM_001166588.2
Accession Version	NM_001166588.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA141801.1, DA162797.1, AK024006.1, AW972575.1 and AL834288.1. On May 12, 2012 this sequence version replaced NM_001166588.1. Transcript Variant: This variant (2) differs in the 3' end compared to variant 1, and encodes a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL834288.1, SRR1163655.579111.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGGTATGTTT CCCCCTGTAC CCACTTGAGG CAAAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001160060.1
CDS	240..1478
Translation	MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGYVSPCTHLRQR

Target ORF information:

RefSeq Version	NM_001166588.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166588.2

ORF Insert Sequence:

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGGTATGTTT CCCCCTGTAC CCACTTGAGG CAAAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( XM_017002745.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858234.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X1, mRNA.

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CloneID	OHu90768
Clone ID Related Accession (Same CDS sequence)	XM_017002745.1 , XM_017002745.2
Accession Version	XM_017002745.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGGGTCATGA GTAGTTTAGA AAGCCTGTCA ACTCATCAAA AAAGAAAAGA ACCTCCCCAT 
CCTCAGTTAC TGAGAAGTTT CATGGCTCTT TGCCGAATAT TCTCTAAGTC AATATCTGAA 
GCAGGAGCCC GTGATACAGT GGAGTGTCAC TTTAGGCCTG TGCACATTGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858234.1
CDS	128..1501
Translation	MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGVMSSLESLSTHQKRKEPPHPQLLRSFMALCRIFSKSISEAGARDTVECHFRPVHIA

Target ORF information:

RefSeq Version	XM_017002745.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002745.1

ORF Insert Sequence:

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGGGTCATGA GTAGTTTAGA AAGCCTGTCA ACTCATCAAA AAAGAAAAGA ACCTCCCCAT 
CCTCAGTTAC TGAGAAGTTT CATGGCTCTT TGCCGAATAT TCTCTAAGTC AATATCTGAA 
GCAGGAGCCC GTGATACAGT GGAGTGTCAC TTTAGGCCTG TGCACATTGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( XM_017002745.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858234.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu90768
Clone ID Related Accession (Same CDS sequence)	XM_017002745.1 , XM_017002745.2
Accession Version	XM_017002745.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017002745.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGGGTCATGA GTAGTTTAGA AAGCCTGTCA ACTCATCAAA AAAGAAAAGA ACCTCCCCAT 
CCTCAGTTAC TGAGAAGTTT CATGGCTCTT TGCCGAATAT TCTCTAAGTC AATATCTGAA 
GCAGGAGCCC GTGATACAGT GGAGTGTCAC TTTAGGCCTG TGCACATTGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858234.1
CDS	159..1532
Translation	MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGVMSSLESLSTHQKRKEPPHPQLLRSFMALCRIFSKSISEAGARDTVECHFRPVHIA

Target ORF information:

RefSeq Version	XM_017002745.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002745.2

ORF Insert Sequence:

ATGGAATTTC AAGCAGTAGT GATGGCAGTA GGTGGAGGAT CTCGGATGAC AGACCTAACT 
TCCAGCATTC CCAAACCTCT GCTTCCAGTT GGGAACAAAC CTTTAATTTG GTACCCATTG 
AACCTGCTTG AGCGTGTTGG ATTTGAAGAA GTCATTGTGG TTACAACCAG GGATGTTCAA 
AAGGCTCTAT GTGCAGAATT CAAGATGAAA ATGAAGCCAG ATATTGTGTG TATTCCTGAT 
GACGCTGACA TGGGAACTGC AGATTCTTTG CGCTACATAT ATCCAAAACT TAAGACAGAT 
GTGCTGGTGC TGAGCTGTGA TCTGATAACA GACGTTGCCT TACATGAGGT TGTGGACCTG 
TTTAGAGCTT ATGATGCATC ACTTGCTATG TTGATGAGAA AAGGCCAAGA TAGCATAGAA 
CCTGTTCCCG GTCAAAAGGG GAAAAAAAAA GCAGTGGAGC AGCGTGACTT CATTGGAGTG 
GACAGCACAG GAAAGAGGCT GCTCTTCATG GCTAATGAAG CAGACTTGGA TGAAGAGCTG 
GTCATTAAGG GATCCATCCT ACAGAAGCAT CCTAGAATAC GTTTCCACAC GGGTCTTGTG 
GATGCCCACC TCTACTGTTT GAAAAAATAC ATCGTGGATT TCCTAATGGA AAATGGGTCA 
ATAACTTCTA TCCGGAGTGA ACTGATTCCA TATTTAGTGA GAAAACAGTT TTCCTCAGCT 
TCCTCACAAC AGGGACAAGA AGAAAAAGAG GAGGATCTAA AGAAAAAGGA GCTGAAGTCC 
TTAGATATCT ACAGTTTTAT AAAAGAAGCC AATACACTGA ACCTGGCTCC CTATGATGCC 
TGCTGGAATG CCTGTCGAGG AGACAGGTGG GAAGACTTGT CCAGATCACA GGTGCGCTGC 
TATGTCCACA TCATGAAAGA GGGGCTCTGC TCTCGAGTGA GCACACTGGG ACTCTACATG 
GAAGCAAACA GACAGGTGCC CAAATTGCTG TCTGCTCTCT GTCCAGAAGA ACCACCAGTC 
CATTCGTCAG CCCAGATTGT CAGCAAACAC CTGGTTGGAG TTGACAGCCT CATTGGGCCA 
GAGACACAGA TTGGAGAGAA GTCATCCATT AAGCGCTCAG TCATTGGCTC ATCCTGTCTC 
ATAAAAGATA GAGTGACTAT TACCAATTGC CTTCTCATGA ACTCAGTCAC TGTGGAGGAA 
GGGGTCATGA GTAGTTTAGA AAGCCTGTCA ACTCATCAAA AAAGAAAAGA ACCTCCCCAT 
CCTCAGTTAC TGAGAAGTTT CATGGCTCTT TGCCGAATAT TCTCTAAGTC AATATCTGAA 
GCAGGAGCCC GTGATACAGT GGAGTGTCAC TTTAGGCCTG TGCACATTGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( XM_017002746.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858235.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu90769
Clone ID Related Accession (Same CDS sequence)	XM_017002746.1
Accession Version	XM_017002746.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGATGA GAAAAGGCCA AGATAGCATA GAACCTGTTC CCGGTCAAAA GGGGAAAAAA 
AAAGCAGTGG AGCAGCGTGA CTTCATTGGA GTGGACAGCA CAGGAAAGAG GCTGCTCTTC 
ATGGCTAATG AAGCAGACTT GGATGAAGAG CTGGTCATTA AGGGATCCAT CCTACAGAAG 
CATCCTAGAA TACGTTTCCA CACGGGTCTT GTGGATGCCC ACCTCTACTG TTTGAAAAAA 
TACATCGTGG ATTTCCTAAT GGAAAATGGG TCAATAACTT CTATCCGGAG TGAACTGATT 
CCATATTTAG TGAGAAAACA GTTTTCCTCA GCTTCCTCAC AACAGGGACA AGAAGAAAAA 
GAGGAGGATC TAAAGAAAAA GGAGCTGAAG TCCTTAGATA TCTACAGTTT TATAAAAGAA 
GCCAATACAC TGAACCTGGC TCCCTATGAT GCCTGCTGGA ATGCCTGTCG AGGAGACAGG 
TGGGAAGACT TGTCCAGATC ACAGGTGCGC TGCTATGTCC ACATCATGAA AGAGGGGCTC 
TGCTCTCGAG TGAGCACACT GGGACTCTAC ATGGAAGCAA ACAGACAGGT GCCCAAATTG 
CTGTCTGCTC TCTGTCCAGA AGAACCACCA GTCCATTCGT CAGCCCAGAT TGTCAGCAAA 
CACCTGGTTG GAGTTGACAG CCTCATTGGG CCAGAGACAC AGATTGGAGA GAAGTCATCC 
ATTAAGCGCT CAGTCATTGG CTCATCCTGT CTCATAAAAG ATAGAGTGAC TATTACCAAT 
TGCCTTCTCA TGAACTCAGT CACTGTGGAG GAAGGGGTCA TGAGTAGTTT AGAAAGCCTG 
TCAACTCATC AAAAAAGAAA AGAACCTCCC CATCCTCAGT TACTGAGAAG TTTCATGGCT 
CTTTGCCGAA TATTCTCTAA GTCAATATCT GAAGCAGGAG CCCGTGATAC AGTGGAGTGT 
CACTTTAGGC CTGTGCACAT TGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858235.1
CDS	594..1580
Translation	MLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGVMSSLESLSTHQKRKEPPHPQLLRSFMALCRIFSKSISEAGARDTVECHFRPVHIA

Target ORF information:

RefSeq Version	XM_017002746.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002746.1

ORF Insert Sequence:

ATGTTGATGA GAAAAGGCCA AGATAGCATA GAACCTGTTC CCGGTCAAAA GGGGAAAAAA 
AAAGCAGTGG AGCAGCGTGA CTTCATTGGA GTGGACAGCA CAGGAAAGAG GCTGCTCTTC 
ATGGCTAATG AAGCAGACTT GGATGAAGAG CTGGTCATTA AGGGATCCAT CCTACAGAAG 
CATCCTAGAA TACGTTTCCA CACGGGTCTT GTGGATGCCC ACCTCTACTG TTTGAAAAAA 
TACATCGTGG ATTTCCTAAT GGAAAATGGG TCAATAACTT CTATCCGGAG TGAACTGATT 
CCATATTTAG TGAGAAAACA GTTTTCCTCA GCTTCCTCAC AACAGGGACA AGAAGAAAAA 
GAGGAGGATC TAAAGAAAAA GGAGCTGAAG TCCTTAGATA TCTACAGTTT TATAAAAGAA 
GCCAATACAC TGAACCTGGC TCCCTATGAT GCCTGCTGGA ATGCCTGTCG AGGAGACAGG 
TGGGAAGACT TGTCCAGATC ACAGGTGCGC TGCTATGTCC ACATCATGAA AGAGGGGCTC 
TGCTCTCGAG TGAGCACACT GGGACTCTAC ATGGAAGCAA ACAGACAGGT GCCCAAATTG 
CTGTCTGCTC TCTGTCCAGA AGAACCACCA GTCCATTCGT CAGCCCAGAT TGTCAGCAAA 
CACCTGGTTG GAGTTGACAG CCTCATTGGG CCAGAGACAC AGATTGGAGA GAAGTCATCC 
ATTAAGCGCT CAGTCATTGG CTCATCCTGT CTCATAAAAG ATAGAGTGAC TATTACCAAT 
TGCCTTCTCA TGAACTCAGT CACTGTGGAG GAAGGGGTCA TGAGTAGTTT AGAAAGCCTG 
TCAACTCATC AAAAAAGAAA AGAACCTCCC CATCCTCAGT TACTGAGAAG TTTCATGGCT 
CTTTGCCGAA TATTCTCTAA GTCAATATCT GAAGCAGGAG CCCGTGATAC AGTGGAGTGT 
CACTTTAGGC CTGTGCACAT TGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF2B3 ( XM_017002747.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858236.1 Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu90770
Clone ID Related Accession (Same CDS sequence)	XM_017002747.1
Accession Version	XM_017002747.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	translation initiation factor eIF-2B subunit gamma isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGATGA GAAAAGGCCA AGATAGCATA GAACCTGTTC CCGGTCAAAA GGGGAAAAAA 
AAAGCAGTGG AGCAGCGTGA CTTCATTGGA GTGGACAGCA CAGGAAAGAG GCTGCTCTTC 
ATGGCTAATG AAGCAGACTT GGATGAAGAG CTGGTCATTA AGGGATCCAT CCTACAGAAG 
CATCCTAGAA TACGTTTCCA CACGGGTCTT GTGGATGCCC ACCTCTACTG TTTGAAAAAA 
TACATCGTGG ATTTCCTAAT GGAAAATGGG TCAATAACTT CTATCCGGAG TGAACTGATT 
CCATATTTAG TGAGAAAACA GTTTTCCTCA GCTTCCTCAC AACAGGGACA AGAAGAAAAA 
GAGGAGGATC TAAAGAAAAA GGAGCTGAAG TCCTTAGATA TCTACAGTTT TATAAAAGAA 
GCCAATACAC TGAACCTGGC TCCCTATGAT GCCTGCTGGA ATGCCTGTCG AGGAGACAGG 
TGGGAAGACT TGTCCAGATC ACAGGTGCGC TGCTATGTCC ACATCATGAA AGAGGGGCTC 
TGCTCTCGAG TGAGCACACT GGGACTCTAC ATGGAAGCAA ACAGACAGGT GCCCAAATTG 
CTGTCTGCTC TCTGTCCAGA AGAACCACCA GTCCATTCGT CAGCCCAGAT TGTCAGCAAA 
CACCTGGTTG GAGTTGACAG CCTCATTGGG CCAGAGACAC AGATTGGAGA GAAGTCATCC 
ATTAAGCGCT CAGTCATTGG CTCATCCTGT CTCATAAAAG ATAGAGTGAC TATTACCAAT 
TGCCTTCTCA TGAACTCAGT CACTGTGGAG GAAGGAAGCA ATATCCAAGG CAGTGTCATC 
TGCAACAATG CTGTGATCGA GAAGGGTGCA GACATCAAGG ACTGCTTGAT TGGAAGTGGC 
CAGAGGATTG AAGCCAAAGC TAAACGAGTG AATGAGGTGA TCGTGGGGAA TGACCAGCTC 
ATGGAGATCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858236.1
CDS	588..1559
Translation	MLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAKAKRVNEVIVGNDQLMEI

Target ORF information:

RefSeq Version	XM_017002747.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002747.1

ORF Insert Sequence:

ATGTTGATGA GAAAAGGCCA AGATAGCATA GAACCTGTTC CCGGTCAAAA GGGGAAAAAA 
AAAGCAGTGG AGCAGCGTGA CTTCATTGGA GTGGACAGCA CAGGAAAGAG GCTGCTCTTC 
ATGGCTAATG AAGCAGACTT GGATGAAGAG CTGGTCATTA AGGGATCCAT CCTACAGAAG 
CATCCTAGAA TACGTTTCCA CACGGGTCTT GTGGATGCCC ACCTCTACTG TTTGAAAAAA 
TACATCGTGG ATTTCCTAAT GGAAAATGGG TCAATAACTT CTATCCGGAG TGAACTGATT 
CCATATTTAG TGAGAAAACA GTTTTCCTCA GCTTCCTCAC AACAGGGACA AGAAGAAAAA 
GAGGAGGATC TAAAGAAAAA GGAGCTGAAG TCCTTAGATA TCTACAGTTT TATAAAAGAA 
GCCAATACAC TGAACCTGGC TCCCTATGAT GCCTGCTGGA ATGCCTGTCG AGGAGACAGG 
TGGGAAGACT TGTCCAGATC ACAGGTGCGC TGCTATGTCC ACATCATGAA AGAGGGGCTC 
TGCTCTCGAG TGAGCACACT GGGACTCTAC ATGGAAGCAA ACAGACAGGT GCCCAAATTG 
CTGTCTGCTC TCTGTCCAGA AGAACCACCA GTCCATTCGT CAGCCCAGAT TGTCAGCAAA 
CACCTGGTTG GAGTTGACAG CCTCATTGGG CCAGAGACAC AGATTGGAGA GAAGTCATCC 
ATTAAGCGCT CAGTCATTGG CTCATCCTGT CTCATAAAAG ATAGAGTGAC TATTACCAAT 
TGCCTTCTCA TGAACTCAGT CACTGTGGAG GAAGGAAGCA ATATCCAAGG CAGTGTCATC 
TGCAACAATG CTGTGATCGA GAAGGGTGCA GACATCAAGG ACTGCTTGAT TGGAAGTGGC 
CAGAGGATTG AAGCCAAAGC TAAACGAGTG AATGAGGTGA TCGTGGGGAA TGACCAGCTC 
ATGGAGATCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy.
Brain & development38(5)507-15(2016 May)
Chen N,Dai L,Jiang Y,Wang J,Hao H,Ren Y,Leng X,Zang L,Wu Y

Fifteen novel EIF2B1-5 mutations identified in Chinese children with leukoencephalopathy with vanishing white matter and a long term follow-up.
PloS one10(3)e0118001(2015)
Zhang H,Dai L,Chen N,Zang L,Leng X,Du L,Wang J,Jiang Y,Zhang F,Wu X,Wu Y

Adult-onset vanishing white matter disease due to a novel EIF2B3 mutation.
Archives of neurology69(6)765-68(2012 Jun)
La Piana R,Vanderver A,van der Knaap M,Roux L,Tampieri D,Brais B,Bernard G

Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5.
Neurogenetics12(3)259-61(2011 Aug)
Matsukawa T,Wang X,Liu R,Wortham NC,Onuki Y,Kubota A,Hida A,Kowa H,Fukuda Y,Ishiura H,Mitsui J,Takahashi Y,Aoki S,Takizawa S,Shimizu J,Goto J,Proud CG,Tsuji S

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EIF2B3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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