CDK5R1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDK5R1
Entrez Gene ID	8851
Full Name	cyclin dependent kinase 5 regulatory subunit 1
Synonyms	CDK5P35,CDK5R,NCK5A,p23,p25,p35,p35nck5a
General protein information	Preferred Names cyclin dependent kinase 5 regulatory subunit 1 Names cyclin-dependent kinase 5 activator 1 CDK5 activator 1 TPKII regulatory subunit neuronal CDK5 activator regulatory partner for CDK5 kinase tau protein kinase II 23kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q11.2
Summary	The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
Disorder MIM:	603460

mRNA and Protein(s)

mRNA	Protein	Name
XM_017025281.2	XP_016880770.1	cyclin-dependent kinase 5 activator 1 isoform X1
NM_003885.3	NP_003876.1	cyclin-dependent kinase 5 activator 1
XM_017025281.1	XP_016880770.1	cyclin-dependent kinase 5 activator 1 isoform X1
NM_003885.2	NP_003876.1	cyclin-dependent kinase 5 activator 1
XM_011525438.1	XP_011523740.1	cyclin-dependent kinase 5 activator 1 isoform X1
XM_011525438.2	XP_011523740.1	cyclin-dependent kinase 5 activator 1 isoform X1

Pathways from BioSystems

Homologies

	CDK5R1	XP_001113136.1
Bos taurus (cattle)	CDK5R1	NP_776937.2
Rattus norvegicus (Norway rat)	Cdk5r1	NP_446343.1
Xenopus tropicalis (tropical clawed frog)	cdk5r1	XP_002935561.1
Canis lupus familiaris (dog)	CDK5R1	XP_005624877.1
Homo sapiens (human)	CDK5R1	NP_003876.1
Pan troglodytes (chimpanzee)	CDK5R1	XP_001158783.2
Mus musculus (house mouse)	Cdk5r1	NP_034001.1
Danio rerio (zebrafish)	cdk5r1b	NP_001002515.1

Gene Ontology
Bibliography

Related articles in PubMed

The miR-15/107 Family of microRNA Genes Regulates CDK5R1/p35 with Implications for Alzheimer's Disease Pathogenesis.
Moncini S, Lunghi M, Valmadre A, Grasso M, Del Vescovo V, Riva P, Denti MA, Venturin M
Molecular neurobiology54(6)4329-4342(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Computational study of the inhibitory mechanism of?the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.
Cardone A, Brady M, Sriram R, Pant HC, Hassan SA
Journal of computer-aided molecular design30(6)513-21(2016 06)

Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability.
Moncini S, Castronovo P, Murgia A, Russo S, Bedeschi MF, Lunghi M, Selicorni A, Bonati MT, Riva P, Venturin M
Journal of human genetics61(4)283-93(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It is shown that p5 binds the kinase at the same CDK5/p25 and CDK5/p35 interfaces, and is thus a non-selective competitor of both activators, in agreement with available experimental data in vitro.
Title: Computational study of the inhibitory mechanism of?the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.

the minor allele of CDK5R1 3'-UTR rs735555 polymorphism was associated with increased risk for NS-ID. In conclusion, our data suggest that mutations and polymorphisms in CDK5 and CDK5R1 genes may contribute to the onset of the NS-ID phenotype
Title: Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability.

Under cell-free in vitro conditions, p35 is covalently modified by SUMO1. SUMO2 is conjugated to p35 in cells. The 2 major SUMO acceptor lysines in p35 are K246 and K290. Different degrees of oxidative stress resulted in differential p35 sumoylation.
Title: Sumoylation of p35 modulates p35/cyclin-dependent kinase (Cdk) 5 complex activity.

Cdk5/p35 is required for motor learning and involved in long-term synaptic plasticity.
Title: Cdk5/p35 is required for motor coordination and cerebellar plasticity.

These results reveal a physiological role of p25 production in synaptic plasticity and memory and provide new insights into the function of p25 in Abeta-associated neurotoxicity and Alzheimer's disease-like pathology.
Title: Activity-dependent p25 generation regulates synaptic plasticity and A?-induced cognitive impairment.

The following CDK5R1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK5R1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03596	NM_003885.3 Latest version!	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03596	XM_017025281.2 Latest version!	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03596	XM_011525438.2 Latest version!	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu03596	XM_017025281.1	Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03596	NM_003885.2	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03596	XM_011525438.1	Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDK5R1 ( NM_003885.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003876.1 Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), mRNA.

Price & Availability↑

CloneID	OHu03596
Clone ID Related Accession (Same CDS sequence)	XM_017025281.2 , NM_003885.3 , XM_017025281.1 , NM_003885.2 , XM_011525438.1 , XM_011525438.2
Accession Version	NM_003885.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 5 activator 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079336.5. On Nov 26, 2018 this sequence version replaced NM_003885.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030792.1, SRR1660805.215685.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313401.4/ ENSP00000318486.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003876.1
CDS	316..1239
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	NM_003885.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003885.3

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5R1 ( NM_003885.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003876.1 Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), mRNA.

Price & Availability↑

CloneID	OHu03596
Clone ID Related Accession (Same CDS sequence)	XM_017025281.2 , NM_003885.3 , XM_017025281.1 , NM_003885.2 , XM_011525438.1 , XM_011525438.2
Accession Version	NM_003885.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 5 activator 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC030792.1. On Aug 27, 2003 this sequence version replaced NM_003885.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030792.1, SRR1660805.215685.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003876.1
CDS	222..1145
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	NM_003885.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003885.2

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5R1 ( XM_017025281.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880770.1 Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03596
Clone ID Related Accession (Same CDS sequence)	XM_017025281.2 , NM_003885.3 , XM_017025281.1 , NM_003885.2 , XM_011525438.1 , XM_011525438.2
Accession Version	XM_017025281.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 5 activator 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017025281.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880770.1
CDS	1357..2280
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	XM_017025281.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025281.2

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5R1 ( XM_017025281.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880770.1 Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu03596
Clone ID Related Accession (Same CDS sequence)	XM_017025281.2 , NM_003885.3 , XM_017025281.1 , NM_003885.2 , XM_011525438.1 , XM_011525438.2
Accession Version	XM_017025281.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 5 activator 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880770.1
CDS	1104..2027
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	XM_017025281.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025281.1

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5R1 ( XM_011525438.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523740.1 Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03596
Clone ID Related Accession (Same CDS sequence)	XM_017025281.2 , NM_003885.3 , XM_017025281.1 , NM_003885.2 , XM_011525438.1 , XM_011525438.2
Accession Version	XM_011525438.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	cyclin-dependent kinase 5 activator 1 isoform X1
Comment

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523740.1
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	XM_011525438.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525438.1

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5R1 ( XM_011525438.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523740.1 Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03596
Clone ID Related Accession (Same CDS sequence)	XM_017025281.2 , NM_003885.3 , XM_017025281.1 , NM_003885.2 , XM_011525438.1 , XM_011525438.2
Accession Version	XM_011525438.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 5 activator 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011525438.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523740.1
CDS	209..1132
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	XM_011525438.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525438.2

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT GTCTCCCAGC TACCGGAAGG CCACGCTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA TACGGCCGTA CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGCC ACTCCATCAT CTCCGTGCTG CCTTGGAAGA GAATCGTGGC CGTGTCGGCC 
AAGAAGAAGA ACTCCAAGAA GGTGCAGCCC AACAGCAGCT ACCAGAACAA CATCACGCAC 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCGTGCGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCACCGG CCCAGCCGCC TGCACCCCCG GCCAGCCAGC TCTCGGGTTC CCAGACCGGG 
GGCTCCTCCT CAGTCAAGAA AGCCCCTCAC CCTGCCGTCA CCTCCGCAGG GACGCCCAAA 
CGGGTCATCG TCCAGGCGTC CACCAGTGAG CTGCTTCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACCTGTCC CCCACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CGCTGCTTCT GCAGGGCTGG CAGGACCAGG GCTTCATCAC GCCGGCCAAC 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTTATCTCCT CCGAGGTGGG CTCGGATCAC 
GAGCTCCAGG CCGTCCTGCT GACATGCCTG TACCTCTCCT ACTCCTACAT GGGCAACGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTG GAGAGCTGCA AGGAGGCCTT TTGGGACCGT 
TGCCTCTCTG TCATCAACCT CATGAGCTCA AAGATGCTGC AGATAAATGC CGACCCACAC 
TACTTCACAC AGGTCTTCTC CGACCTGAAG AACGAGAGCG GCCAGGAGGA CAAGAAGCGG 
CTCCTCCTAG GCCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The miR-15/107 Family of microRNA Genes Regulates CDK5R1/p35 with Implications for Alzheimer's Disease Pathogenesis.
Molecular neurobiology54(6)4329-4342(2017 Aug)
Moncini S,Lunghi M,Valmadre A,Grasso M,Del Vescovo V,Riva P,Denti MA,Venturin M

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Computational study of the inhibitory mechanism of?the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.
Journal of computer-aided molecular design30(6)513-21(2016 06)
Cardone A,Brady M,Sriram R,Pant HC,Hassan SA

Functional characterization of CDK5 and CDK5R1 mutations identified in patients with non-syndromic intellectual disability.
Journal of human genetics61(4)283-93(2016 Apr)
Moncini S,Castronovo P,Murgia A,Russo S,Bedeschi MF,Lunghi M,Selicorni A,Bonati MT,Riva P,Venturin M

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CDK5R1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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