TMEM11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM11
Entrez Gene ID	8834
Full Name	transmembrane protein 11
Synonyms	C17orf35,PM1,PMI
General protein information	Preferred Names transmembrane protein 11 Names transmembrane protein 11, mitochondrial putative receptor protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p11.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_003876.2	NP_003867.1	transmembrane protein 11, mitochondrial
NM_003876.3	NP_003867.1	transmembrane protein 11, mitochondrial

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TMEM11	NP_001026637.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005550	XP_315554.3
	TMEM11	XP_001103851.1
Xenopus tropicalis (tropical clawed frog)	tmem11	NP_001016689.1
Homo sapiens (human)	TMEM11	NP_003867.1
Canis lupus familiaris (dog)	TMEM11	XP_536671.2
Drosophila melanogaster (fruit fly)	Pmi	NP_001027110.2
Pan troglodytes (chimpanzee)	TMEM11	XP_003315618.1
Bos taurus (cattle)	TMEM11	NP_001091467.1
Mus musculus (house mouse)	Tmem11	NP_775655.1
Rattus norvegicus (Norway rat)	Tmem11	NP_001158015.1
Danio rerio (zebrafish)	tmem11	NP_001017400.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.
Rival T, Macchi M, Arnaun?-Pelloquin L, Poidevin M, Maillet F, Richard F, Fatmi A, Belenguer P, Royet J
EMBO reports12(3)223-30(2011 Mar)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study demonstrates that the Drosophila PMI gene and its human orthologue TMEM11 encode mitochondrial inner-membrane proteins that regulate mitochondrial morphogenesis
Title: Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following TMEM11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31679	NM_003876.3 Latest version!	Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31679	NM_003876.2	Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM11 ( NM_003876.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003867.1 Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31679
Clone ID Related Accession (Same CDS sequence)	NM_003876.2 , NM_003876.3
Accession Version	NM_003876.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	transmembrane protein 11, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087294.18 and X51804.1. On Dec 2, 2008 this sequence version replaced NM_003876.1. Transcript Variant: This variant (1) encodes the functional protein. ##Evidence-Data-START## Transcript exon combination :: BC005268.1, SRR1163657.107588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTT GGGGAAGGAG GCGTCTTGGC CCGGGCAGCA GTGGCGGCAG CGCCCGAGAG 
AGGGTGAGCT TGTCGGCCAC AGACTGCTAC ATTGTGCATG AGATCTACAA TGGGGAGAAT 
GCCCAAGACC AGTTTGAGTA CGAGCTGGAG CAGGCCCTGG AAGCCCAGTA CAAGTACATT 
GTGATTGAGC CCACTCGCAT TGGCGACGAG ACAGCCCGCT GGATCACCGT GGGCAACTGC 
CTGCACAAGA CGGCCGTGCT GGCGGGCACC GCCTGCCTCT TCACCCCGTT GGCGCTGCCC 
TTAGATTATT CCCACTACAT TTCCCTGCCC GCTGGTGTGC TGAGCCTGGC CTGCTGCACC 
CTCTATGGGA TCTCCTGGCA GTTTGACCCT TGCTGCAAGT ACCAAGTGGA GTACGACGCC 
TATAAACTGT CGCGCCTGCC TCTGCACACA CTCACCTCCT CCACCCCGGT GGTGCTGGTC 
CGGAAGGACG ACCTGCACAG AAAGAGACTG CACAACACGA TAGCACTGGC CGCCCTGGTG 
TACTGTGTAA AGAAGATTTA CGAACTCTAT GCCGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003867.1
CDS	444..1022
Translation	MAAWGRRRLGPGSSGGSARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV

Target ORF information:

RefSeq Version	NM_003876.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003876.2

ORF Insert Sequence:

ATGGCCGCTT GGGGAAGGAG GCGTCTTGGC CCGGGCAGCA GTGGCGGCAG CGCCCGAGAG 
AGGGTGAGCT TGTCGGCCAC AGACTGCTAC ATTGTGCATG AGATCTACAA TGGGGAGAAT 
GCCCAAGACC AGTTTGAGTA CGAGCTGGAG CAGGCCCTGG AAGCCCAGTA CAAGTACATT 
GTGATTGAGC CCACTCGCAT TGGCGACGAG ACAGCCCGCT GGATCACCGT GGGCAACTGC 
CTGCACAAGA CGGCCGTGCT GGCGGGCACC GCCTGCCTCT TCACCCCGTT GGCGCTGCCC 
TTAGATTATT CCCACTACAT TTCCCTGCCC GCTGGTGTGC TGAGCCTGGC CTGCTGCACC 
CTCTATGGGA TCTCCTGGCA GTTTGACCCT TGCTGCAAGT ACCAAGTGGA GTACGACGCC 
TATAAACTGT CGCGCCTGCC TCTGCACACA CTCACCTCCT CCACCCCGGT GGTGCTGGTC 
CGGAAGGACG ACCTGCACAG AAAGAGACTG CACAACACGA TAGCACTGGC CGCCCTGGTG 
TACTGTGTAA AGAAGATTTA CGAACTCTAT GCCGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM11 ( NM_003876.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003867.1 Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31679
Clone ID Related Accession (Same CDS sequence)	NM_003876.2 , NM_003876.3
Accession Version	NM_003876.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	transmembrane protein 11, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087294.18 and AC087393.7. On Nov 27, 2019 this sequence version replaced NM_003876.2. Transcript Variant: This variant (1) encodes the functional protein. ##Evidence-Data-START## Transcript exon combination :: BC020815.1, BX386109.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCTT GGGGAAGGAG GCGTCTTGGC CCGGGCAGCA GTGGCGGCAG CGCCCGAGAG 
AGGGTGAGCT TGTCGGCCAC AGACTGCTAC ATTGTGCATG AGATCTACAA TGGGGAGAAT 
GCCCAAGACC AGTTTGAGTA CGAGCTGGAG CAGGCCCTGG AAGCCCAGTA CAAGTACATT 
GTGATTGAGC CCACTCGCAT TGGCGACGAG ACAGCCCGCT GGATCACCGT GGGCAACTGC 
CTGCACAAGA CGGCCGTGCT GGCGGGCACC GCCTGCCTCT TCACCCCGTT GGCGCTGCCC 
TTAGATTATT CCCACTACAT TTCCCTGCCC GCTGGTGTGC TGAGCCTGGC CTGCTGCACC 
CTCTATGGGA TCTCCTGGCA GTTTGACCCT TGCTGCAAGT ACCAAGTGGA GTACGACGCC 
TATAAACTGT CGCGCCTGCC TCTGCACACA CTCACCTCCT CCACCCCGGT GGTGCTGGTC 
CGGAAGGACG ACCTGCACAG AAAGAGACTG CACAACACGA TAGCACTGGC CGCCCTGGTG 
TACTGTGTAA AGAAGATTTA CGAACTCTAT GCCGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003867.1
CDS	10..588
Translation	MAAWGRRRLGPGSSGGSARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV

Target ORF information:

RefSeq Version	NM_003876.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 11 (TMEM11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003876.3

ORF Insert Sequence:

ATGGCCGCTT GGGGAAGGAG GCGTCTTGGC CCGGGCAGCA GTGGCGGCAG CGCCCGAGAG 
AGGGTGAGCT TGTCGGCCAC AGACTGCTAC ATTGTGCATG AGATCTACAA TGGGGAGAAT 
GCCCAAGACC AGTTTGAGTA CGAGCTGGAG CAGGCCCTGG AAGCCCAGTA CAAGTACATT 
GTGATTGAGC CCACTCGCAT TGGCGACGAG ACAGCCCGCT GGATCACCGT GGGCAACTGC 
CTGCACAAGA CGGCCGTGCT GGCGGGCACC GCCTGCCTCT TCACCCCGTT GGCGCTGCCC 
TTAGATTATT CCCACTACAT TTCCCTGCCC GCTGGTGTGC TGAGCCTGGC CTGCTGCACC 
CTCTATGGGA TCTCCTGGCA GTTTGACCCT TGCTGCAAGT ACCAAGTGGA GTACGACGCC 
TATAAACTGT CGCGCCTGCC TCTGCACACA CTCACCTCCT CCACCCCGGT GGTGCTGGTC 
CGGAAGGACG ACCTGCACAG AAAGAGACTG CACAACACGA TAGCACTGGC CGCCCTGGTG 
TACTGTGTAA AGAAGATTTA CGAACTCTAT GCCGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.
EMBO reports12(3)223-30(2011 Mar)
Rival T,Macchi M,Arnaun?-Pelloquin L,Poidevin M,Maillet F,Richard F,Fatmi A,Belenguer P,Royet J

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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TMEM11 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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